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Select item 107976951.

SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis

Jianzhi Wu, Liping Gong, Yijie Li, Tiegang Liu, Rong Sun, Kexin Jia, Runping Liu, Fei Dong, Xiaohong Gu, Xiaojiaoyang Li

Int J Biol Sci. 2024; 20(3): 968–986. Published online 2024 Jan 12. doi: 10.7150/ijbs.90808

PMCID:: PMC10797695

Abstract Article PDF–14M

Select item 107661962.

Proteomics on malignant pleural effusions reveals ERα loss in metastatic breast cancer associates with SGK1–NDRG1 deregulation

Isabel Mayayo‐Peralta, Donna O. Debets, Stefan Prekovic, Karianne Schuurman, Suzanne Beerthuijzen, Mathilde Almekinders, Joyce Sanders, Cathy B. Moelans, Sandra Saleiro, Jelle Wesseling, Paul J. van Diest, Rui Henrique, Carmen Jerónimo, Maarten Altelaar, Wilbert Zwart

Mol Oncol. 2024 Jan; 18(1): 156–169. Published online 2023 Nov 2. doi: 10.1002/1878-0261.13540

PMCID:: PMC10766196

Abstract Article PDF–1.1M

Select item 107547633.

Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy

Langen Zhuang, Guoxi Jin, Wang qiong, Xiaoxu Ge, Xiaoyan Pei

Appl Biochem Biotechnol. 2023; 195(12): 7652–7667. Published online 2023 Apr 20. doi: 10.1007/s12010-023-04501-1

PMCID:: PMC10754763

Abstract Article PDF–2.2M

Select item 106432734.

Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion

Xiaoqian Di, Yanzhi Hao, Zibo Duan, Yucong Ma, Ying Cao, Zhanwang Tan, Cuimiao Song, Xiaohua Lin

Reprod Sci. 2023 Nov; 30(11): 3273–3284. Published online 2023 Jun 6. doi: 10.1007/s43032-023-01273-1

PMCID:: PMC10643273

Abstract Article PDF–1.5M

Select item 103724065.

Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation

Wenxue Gu, Hongyan Zheng, Cecilia M. Canessa

J Biol Chem. 2023 Aug; 299(8): 104941. Published online 2023 Jun 19. doi: 10.1016/j.jbc.2023.104941

PMCID:: PMC10372406

Abstract Article PDF–3.3M

Select item 102682546.

ROS signaling–induced mitochondrial Sgk1 expression regulates epithelial cell renewal

Yingxiang Li, Chengdong Liu, Luke Rolling, Veronica Sikora, Zhimin Chen, Jack Gurwin, Caroline Barabell, Jiandie Lin, Cunming Duan

Proc Natl Acad Sci U S A. 2023 Jun 13; 120(24): e2216310120. Published online 2023 Jun 5. doi: 10.1073/pnas.2216310120

PMCID:: PMC10268254

Abstract Article PDF–3.6M

Select item 102286157.

Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Federica Giannetti, Miriam Barbieri, Assad Shiti, Simona Casini, Philip T Sager, Saumya Das, Sabindra Pradhananga, Dinesh Srinivasan, Saranda Nimani, Nicolò Alerni, Julien Louradour, Manuela Mura, Massimiliano Gnecchi, Paul Brink, Manfred Zehender, Gideon Koren, Antonio Zaza, Lia Crotti, Arthur A M Wilde, Peter J Schwartz, Carol Ann Remme, Lior Gepstein, Luca Sala, Katja E Odening

Europace. 2023 May; 25(5): euad094. Published online 2023 Apr 26. doi: 10.1093/europace/euad094

PMCID:: PMC10228615

Abstract Article PDF–1.6M

Select item 102258918.

SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells

Yannis Hara, Viktor T. Lemgart, Nis Halland, Kiana Mahdaviani, Jean-Antoine Ribeil, Samuel Lessard, Alexandra Hicks, David R. Light

Blood Adv. 2023 Jun 13; 7(11): 2317–2323. Published online 2023 Jan 31. doi: 10.1182/bloodadvances.2022008710

PMCID:: PMC10225891

Abstract Article PDF–1.3M

Select item 100729069.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 981817210.

The Serum/Glucocorticoid-Regulated Kinase 1 Is Targeted by miR-19a in CD4+ T Cells

Julie Weidner, Carina Malmhäll, Vahid Arabkari, Aidan Barrett, Emma Boberg, Linda Ekerljung, Madeleine Rådinger

Cells. 2023 Jan; 12(1): 133. Published online 2022 Dec 29. doi: 10.3390/cells12010133

PMCID:: PMC9818172

Abstract Article PDF–2.5M

Select item 967545911.

Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation

Aneesh Bapat, Guoping Li, Ling Xiao, Ashish Yeri, Maarten Hulsmans, Jana Grune, Masahiro Yamazoe, Maximilian J. Schloss, Yoshiko Iwamoto, Justin Tedeschi, Xinyu Yang, Matthias Nahrendorf, Anthony Rosenzweig, Patrick T. Ellinor, Saumya Das, David Milan

JCI Insight. 2022 Oct 10; 7(19): e160885. Published online 2022 Oct 10. doi: 10.1172/jci.insight.160885

PMCID:: PMC9675459

Abstract Article PDF–5.7M

Select item 889471712.

SGK1 mutation status can further stratify patients with germinal center B‐cell‐like diffuse large B‐cell lymphoma into different prognostic subgroups

Baoping Guo, Yujie Huang, Ying Duan, Chengcheng Liao, Hong Cen

Cancer Med. 2022 Mar; 11(5): 1281–1291. Published online 2022 Feb 1. doi: 10.1002/cam4.4550

PMCID:: PMC8894717

Abstract Article PDF–1.2M

Select item 888096513.

Knockdown of Serum- and Glucocorticoid-Regulated Kinase 1 Enhances Cisplatin Sensitivity of Gastric Cancer Through Suppressing the Nuclear Factor Kappa-B Signaling Pathway

Jishui Zhang, Wenhao Lv, Yagang Liu, Weihua Fu, Baosheng Chen, Qiutong Ma, Xin Gao, Xiuxia Cui

Balkan Med J. 2021 Nov; 38(6): 331–340. Published online 2021 Nov 1. doi: 10.5152/balkanmedj.2021.21114

PMCID:: PMC8880965

Abstract Article PDF–4.5M

Select item 886664914.

SGK1, a Critical Regulator of Immune Modulation and Fibrosis and a Potential Therapeutic Target in Chronic Graft-Versus-Host Disease

Run-qing Lu, Yin-yin Zhang, Hai-qiu Zhao, Rong-qun Guo, Zhong-xing Jiang, Rong Guo

Front Immunol. 2022; 13: 822303. Published online 2022 Feb 10. doi: 10.3389/fimmu.2022.822303

PMCID:: PMC8866649

Abstract Article PDF–617K

Select item 880634815.

The interaction of TEA domain transcription factor 4 (TEAD4) and Yes-associated protein 1 (YAP1) promoted the malignant process mediated by serum/glucocorticoid regulated kinase 1 (SGK1)

Songlin He, Hanlu Zhang, Zongwei Xiao, Sandeep Bhushan, Ke Gao, Wenping Wang

Bioengineered. 2021; 12(1): 601–614. Published online 2021 Feb 10. doi: 10.1080/21655979.2021.1882142

PMCID:: PMC8806348

Abstract Article PDF–7.0M

Select item 870162616.

Whole Blood Adhesion to VCAM-1 and P-Selectin and RBC Mechanical Fragility Can be Compromised in Long COVID-19 Patients with Sickle Cell Disease

Michael Tarasev, Marta Ferranti, Cidney Allen, Xiufeng Gao, Kayla Topping, Marta Ferranti, Biola Makinde-Odesola, Lanetta Bronté-Hall, Patrick Hines

Blood. 2021 Nov 23; 138: 959. Published online 2021 Dec 24. doi: 10.1182/blood-2021-154308

PMCID:: PMC8701626

Abstract PDF–305K

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011