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Select item 112714841.

Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression

Gloria Asantewaa, Emily T. Tuttle, Nathan P. Ward, Yun Pyo Kang, Yumi Kim, Madeline E. Kavanagh, Nomeda Girnius, Ying Chen, Katherine Rodriguez, Fabio Hecht, Marco Zocchi, Leonid Smorodintsev-Schiller, TashJaé Q. Scales, Kira Taylor, Fatemeh Alimohammadi, Renae P. Duncan, Zachary R. Sechrist, Diana Agostini-Vulaj, Xenia L. Schafer, Hayley Chang, Zachary R. Smith, Thomas N. O’Connor, Sarah Whelan, Laura M. Selfors, Jett Crowdis, G. Kenneth Gray, Roderick T. Bronson, Dirk Brenner, Alessandro Rufini, Robert T. Dirksen, Aram F. Hezel, Aaron R. Huber, Joshua Munger, Benjamin F. Cravatt, Vasilis Vasiliou, Calvin L. Cole, Gina M. DeNicola, Isaac S. Harris

Nat Commun. 2024; 15: 6152. Published online 2024 Jul 21. doi: 10.1038/s41467-024-50454-2

PMCID:: PMC11271484

Abstract Article PDF–3.2M

Select item 110516662.

Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation

Zongbo Wei, Caili Hao, Kazi Rafsan Radeen, Ramkumar Srinivasagan, Jian-Kang Chen, Shruti Sharma, Meghan E. McGee-Lawrence, Mark W. Hamrick, Vincent M. Monnier, Xingjun Fan

Sci Adv. 2024 Apr 26; 10(17): eadl1088. Published online 2024 Apr 26. doi: 10.1126/sciadv.adl1088

PMCID:: PMC11051666

Abstract Article PDF–6.6M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105437234.

Glutathione limits RUNX2 oxidation and degradation to regulate bone formation

Guoli Hu, Yilin Yu, Deepika Sharma, Shondra M. Pruett-Miller, Yinshi Ren, Guo-Fang Zhang, Courtney M. Karner

JCI Insight. 2023 Aug 22; 8(16): e166888. Published online 2023 Aug 22. doi: 10.1172/jci.insight.166888

PMCID:: PMC10543723

Abstract Article PDF–11M

Select item 102840675.

Cystine/Glutamate Xc^– Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis

Karina Orlowska, Russ R. Fling, Rance Nault, Anthony L. Schilmiller, Timothy R. Zacharewski

Chem Res Toxicol. 2023 Jun 19; 36(6): 900–915. Published online 2023 May 15. doi: 10.1021/acs.chemrestox.3c00017

PMCID:: PMC10284067

Abstract Article PDF–5.5M

Select item 98597986.

Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation

Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Naoto Watamura, Hiroki Sasaguri, Yuhei Takado, Yoshihiro Yoshihara, Takashi Saito, Takaomi C. Saido

Sci Rep. 2023; 13: 1109. Published online 2023 Jan 20. doi: 10.1038/s41598-023-27653-w

PMCID:: PMC9859798

Abstract Article PDF–3.1M

Select item 97443847.

Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages

Wei He, Antonia Henne, Mario Lauterbach, Eike Geißmar, Fabian Nikolka, Celia Kho, Alexander Heinz, Catherine Dostert, Melanie Grusdat, Thekla Cordes, Janika Härm, Oliver Goldmann, Anouk Ewen, Charlène Verschueren, Julia Blay-Cadanet, Robert Geffers, Hendrikus Garritsen, Manfred Kneiling, Christian K. Holm, Christian M. Metallo, Eva Medina, Zeinab Abdullah, Eicke Latz, Dirk Brenner, Karsten Hiller

Nat Metab. Author manuscript; available in PMC 2023 Jun 2.

Published in final edited form as: Nat Metab. 2022 May; 4(5): 524–533. Published online 2022 Jun 2. doi: 10.1038/s42255-022-00565-1

PMCID:: PMC9744384

Abstract Article PDF–3.6M

Select item 89800228.

Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells

Davide G. Franchina, Henry Kurniawan, Melanie Grusdat, Carole Binsfeld, Luana Guerra, Lynn Bonetti, Leticia Soriano-Baguet, Anouk Ewen, Takumi Kobayashi, Sophie Farinelle, Anna Rita Minafra, Niels Vandamme, Anaïs Carpentier, Felix K. Borgmann, Christian Jäger, Ying Chen, Markus Kleinewietfeld, Vasilis Vasiliou, Michel Mittelbronn, Karsten Hiller, Philipp A. Lang, Dirk Brenner

Nat Commun. 2022; 13: 1789. Published online 2022 Apr 4. doi: 10.1038/s41467-022-29426-x

PMCID:: PMC8980022

Abstract Article PDF–3.0M

Select item 83041859.

IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss

Adelaida M. Celaya, Lourdes Rodríguez-de la Rosa, Jose M. Bermúdez-Muñoz, José M. Zubeldia, Carlos Romá-Mateo, Carlos Avendaño, Federico V. Pallardó, Isabel Varela-Nieto

Cells. 2021 Jul; 10(7): 1686. Published online 2021 Jul 3. doi: 10.3390/cells10071686

PMCID:: PMC8304185

Abstract Article PDF–7.1M

Select item 820101610.

Carnosic Acid Attenuates an Early Increase in ROS Levels during Adipocyte Differentiation by Suppressing Translation of Nox4 and Inducing Translation of Antioxidant Enzymes

Dae-Kun Lee, Hae-Dong Jang

Int J Mol Sci. 2021 Jun; 22(11): 6096. Published online 2021 Jun 5. doi: 10.3390/ijms22116096

PMCID:: PMC8201016

Abstract Article PDF–1.8M

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 726517212.

Glutathione restricts serine metabolism to preserve regulatory T cell function

Henry Kurniawan, Davide G. Franchina, Luana Guerra, Lynn Bonetti, Leticia Soriano-Baguet, Melanie Grusdat, Lisa Schlicker, Oliver Hunewald, Catherine Dostert, Myriam P. Merz, Carole Binsfeld, Gordon S. Duncan, Sophie Farinelle, Yannic Nonnenmacher, Jillian Haight, Dennis Das Gupta, Anouk Ewen, Rabia Taskesen, Rashi Halder, Ying Chen, Christian Jäger, Markus Ollert, Paul Wilmes, Vasilis Vasiliou, Isaac S. Harris, Christiane B. Knobbe-Thomsen, Jonathan D. Turner, Tak W. Mak, Michael Lohoff, Johannes Meiser, Karsten Hiller, Dirk Brenner

Cell Metab. Author manuscript; available in PMC 2021 May 5.

Published in final edited form as: Cell Metab. 2020 May 5; 31(5): 920–936.e7. Published online 2020 Mar 25. doi: 10.1016/j.cmet.2020.03.004

PMCID:: PMC7265172

Abstract Article PDF–2.8M

Select item 667352513.

Inducible Alterations of Glutathione Levels in Adult Dopaminergic Midbrain Neurons Result in Nigrostriatal Degeneration

Shankar J. Chinta, M. J. Kumar, Michael Hsu, Subramanian Rajagopalan, Deepinder Kaur, Anand Rane, David G. Nicholls, Jinah Choi, Julie K. Andersen

J Neurosci. 2007 Dec 19; 27(51): 13997–14006. doi: 10.1523/JNEUROSCI.3885-07.2007

PMCID:: PMC6673525

Abstract Article PDF–447K

Select item 660240714.

Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma

Abigail G Zieman, Brian G Poll, Jingqun Ma, Pierre A Coulombe

Hum Mol Genet. 2019 Jul 1; 28(13): 2255–2270. Published online 2019 Mar 20. doi: 10.1093/hmg/ddz050

PMCID:: PMC6602407

Abstract Article PDF–3.5M

Select item 646478615.

Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

Adelaida M Celaya, Isabel Sánchez-Pérez, Jose M Bermúdez-Muñoz, Lourdes Rodríguez-de la Rosa, Laura Pintado-Berninches, Rosario Perona, Silvia Murillo-Cuesta, Isabel Varela-Nieto

eLife. 2019; 8: e39159. Published online 2019 Apr 2. doi: 10.7554/eLife.39159

PMCID:: PMC6464786

Abstract Article PDF–5.9M

Select item 646392316.

Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia

Teresa Partearroyo, Silvia Murillo-Cuesta, Néstor Vallecillo, Jose M. Bermúdez-Muñoz, Lourdes Rodríguez-de la Rosa, Giacomo Mandruzzato, Adelaida M. Celaya, Steven H. Zeisel, María A. Pajares, Gregorio Varela-Moreiras, Isabel Varela-Nieto

FASEB J. 2019 May; 33(5): 5942–5956. Published online 2019 Feb 12. doi: 10.1096/fj.201801533R

PMCID:: PMC6463923

Abstract Article

Select item 645951017.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 626277718.

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher

J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214

PMCID:: PMC6262777

Abstract Article

Select item 615279619.

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

Gaojian Lian, JN Rashida Gnanaprakasam, Tingting Wang, Ruohan Wu, Xuyong Chen, Lingling Liu, Yuqing Shen, Mao Yang, Jun Yang, Ying Chen, Vasilis Vasiliou, Teresa A Cassel, Douglas R Green, Yusen Liu, Teresa WM Fan, Ruoning Wang

eLife. 2018; 7: e36158. Published online 2018 Sep 10. doi: 10.7554/eLife.36158