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Select item 108446791.

Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion

Yasunori Fukumoto, Rin Kyono, Yuka Shibukawa, Yu-ki Tanaka, Noriyuki Suzuki, Yasumitsu Ogra

J Biol Chem. 2024 Feb; 300(2): 105599. Published online 2023 Dec 28. doi: 10.1016/j.jbc.2023.105599

PMCID:: PMC10844679

Abstract Article PDF–3.3M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 94746653.

Molybdenum cofactor catabolism unravels the physiological role of the drug metabolizing enzyme thiopurine S-methyltransferase

Julika Pristup, Elke Schaeffeler, Sita Arjune, Ute Hofmann, Jose Angel Santamaria-Araujo, Patrick Leuthold, Nele Friedrich, Matthias Nauck, Simon Mayr, Mathias Haag, Thomas Muerdter, Franz-Josef Marner, Mary V Relling, William E Evans, Guenter Schwarz, Matthias Schwab

Clin Pharmacol Ther. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: Clin Pharmacol Ther. 2022 Oct; 112(4): 808–816. Published online 2022 May 31. doi: 10.1002/cpt.2637

PMCID:: PMC9474665

Abstract Article PDF–418K

Select item 92792854.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 89733085.

Susceptibility to thiopurine toxicity by TPMT and NUDT15 variants in Colombian children with acute lymphoblastic leukemia

Oscar Correa-Jimenez, Juan José Yunis, Adriana Linares-Ballesteros, Isabel Sarmiento-Urbina

Colomb Med (Cali) 2021 Jul-Sep; 52(3): e2074569. Published online 2021 Sep 30. doi: 10.25100/cm.v52i3.4569

PMCID:: PMC8973308

Abstract Article PDF–1.0M

Select item 87635856.

TPMT、NUDT15基因多态性对成人急性淋巴细胞白血病患者6-巯基嘌呤耐受性的影响

郝其姗, 王哲, 房秋云, 弓晓媛, 刘凯奇, 李艳, 魏辉, 王迎, 李庆华, 王敏, 田征, 王建祥, 秘营昌

Zhonghua Xue Ye Xue Za Zhi. 2021 Nov; 42(11): 911–916. Chinese. doi: 10.3760/cma.j.issn.0253-2727.2021.11.005

PMCID:: PMC8763585

Abstract Article PDF–847K

Select item 86783057.

TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real-World Clinical Results

Alyson L. Dickson, Laura L. Daniel, Jacy Zanussi, W. Dale Plummer, Wei-Qi Wei, Ge Liu, Tyler Reese, Prathima Anandi, Kelly A. Birdwell, Vivian Kawai, Nancy J. Cox, William D. Dupont, Adriana M. Hung, QiPing Feng, C. Michael Stein, Cecilia P. Chung

Clin Pharmacol Ther. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Clin Pharmacol Ther. 2022 Jan; 111(1): 263–271. Published online 2021 Oct 12. doi: 10.1002/cpt.2428

PMCID:: PMC8678305

Abstract Article PDF–959K

Select item 85664738.

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim

Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6

PMCID:: PMC8566473

Abstract Article PDF–2.7M

Select item 83834119.

TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta, Vishal Sharma

BMC Gastroenterol. 2021; 21: 327. Published online 2021 Aug 23. doi: 10.1186/s12876-021-01900-8

PMCID:: PMC8383411

Abstract Article PDF–985K

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 804210811.

Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis

Qiang Miao, Lin Yan, Yanhong Zhou, Yi Li, Yuangao Zou, Lanlan Wang, Yangjuan Bai, Junlong Zhang

Sci Rep. 2021; 11: 7984. Published online 2021 Apr 12. doi: 10.1038/s41598-021-87095-0

PMCID:: PMC8042108

Abstract Article PDF–1.0M

Select item 760147712.

Association between the TPMT*3C (rs1142345) Polymorphism and the Risk of Death in the Treatment of Acute Lymphoblastic Leukemia in Children from the Brazilian Amazon Region

Darlen Cardoso de Carvalho, Luciana Pereira Colares Leitão, Fernando Augusto Rodrigues Mello Junior, Alayde Vieira Wanderley, Tatiane Piedade de Souza, Roberta Borges Andrade de Sá, Amanda Cohen-Paes, Marianne Rodrigues Fernandes, Sidney Santos, André Salim Khayat, Paulo Pimentel de Assumpção, Ney Pereira Carneiro dos Santos

Genes (Basel) 2020 Oct; 11(10): 1132. Published online 2020 Sep 25. doi: 10.3390/genes11101132

PMCID:: PMC7601477

Abstract Article PDF–958K

Select item 717644813.

Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease

Song-Sen Su, Yan-Fang Lin, Hong Zhou

Chin Med J (Engl) 2020 Apr 20; 133(8): 1002–1004. Published online 2020 Apr 20. doi: 10.1097/CM9.0000000000000756

PMCID:: PMC7176448

Article PDF–133K

Select item 675274814.

Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry

Elke Schaeffeler, Simon U. Jaeger, Verena Klumpp, Jun J. Yang, Svitlana Igel, Laura Hinze, Martin Stanulla, Matthias Schwab

Genet Med. 2019; 21(9): 2145–2150. Published online 2019 Feb 7. doi: 10.1038/s41436-019-0448-7

PMCID:: PMC6752748

Abstract Article PDF–511K

Select item 672328815.

Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease Patients

Davide Giuseppe Ribaldone, Alessandro Adriani, Gian Paolo Caviglia, Amedeo De Nicolò, Danilo Agnesod, Marco Simiele, Danila Riganò, Rinaldo Pellicano, Roberto Canaparo, Giovanni Di Perri, Antonio D’Avolio, Francesco Luzza, Ludovico Abenavoli, Giorgio Maria Saracco, Marco Astegiano

Medicina (Kaunas) 2019 Aug; 55(8): 441. Published online 2019 Aug 5. doi: 10.3390/medicina55080441

PMCID:: PMC6723288

Abstract Article PDF–295K

Select item 589098816.

Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study

Arno C. Hessels, Abraham Rutgers, Jan Stephan F. Sanders, Coen A. Stegeman

PLoS One. 2018; 13(4): e0195524. Published online 2018 Apr 9. doi: 10.1371/journal.pone.0195524

PMCID:: PMC5890988

Abstract Article PDF–1.3M

Select item 582915717.

Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease

Hong-Hui Wang, Ying He, Hong-Xian Wang, Cheng-Ling Liao, Yu Peng, Li-Jian Tao, Wei Zhang, Hui-Xiang Yang

World J Gastroenterol. 2018 Feb 28; 24(8): 941–948. Published online 2018 Feb 28. doi: 10.3748/wjg.v24.i8.941

PMCID:: PMC5829157

Abstract Article PDF–1.0M

Select item 574049018.

Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods

Chingiz Asadov, Gunay Aliyeva, Kamala Mustafayeva

Cardiovasc Hematol Agents Med Chem. 2017 Apr; 15(1): 23–30. Published online 2017 Apr. doi: 10.2174/1871525715666170529091921

PMCID:: PMC5740490

Abstract Article PDF–1.3M

Select item 571659919.

Measurements of 6-thioguanine nucleotide levels with TPMT and NUDT15 genotyping in patients with Crohn’s disease

Ji Hyeon Lee, Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang, Li-Hwa Choi, Hye In Woo, Soo-Youn Lee, Young-Ho Kim

PLoS One. 2017; 12(12): e0188925. Published online 2017 Dec 5. doi: 10.1371/journal.pone.0188925

PMCID:: PMC5716599

Abstract Article PDF–1.7M

Select item 543202720.

TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity

Dr Signe Thiesen, Dr Peng Yin, Dr Andrea L Jorgensen, Dr Jieying Eunice Zhang, Dr Valentina Manzo, Mr Laurence McEvoy, Dr Christopher Barton, Dr Susan Picton, Professor Simon Bailey, Dr Penelope Brock, Professor Harish Vyas, Professor David Walker, Dr Guy Makin, Dr Srinivas Bandi, Professor Barry Pizer, Dr Daniel B Hawcutt, Professor Sir Munir Pirmohamed

Pharmacogenet Genomics. Author manuscript; available in PMC 2018 Jun 1.

Published in final edited form as: Pharmacogenet Genomics. 2017 Jun; 27(6): 213–222. doi: 10.1097/FPC.0000000000000281

PMCID:: PMC5432027

Abstract Article PDF–1.1M

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