PMC Links for GEO Profiles (Select 85059744) - PMC

Guojie Xu, Lei Zhao, Qingling Hua, Lanqing Wang, Hongli Liu, Zhenyu Lin, Min Jin, Jing Wang, Pengfei Zhou, Kunyu Yang, Gang Wu, Dandan Yu, Dejun Zhang, Tao Zhang

Cell Death Dis. 2023 Feb; 14(2): 167. Published online 2023 Feb 27. doi: 10.1038/s41419-023-05644-z

PMCID:: PMC9971195

Abstract Article PDF–15M

Select item 98691785.

A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation and reduced inflammation in obstructive airway diseases

Alessandra Ghigo, Alessandra Murabito, Valentina Sala, Anna Rita Pisano, Serena Bertolini, Ambra Gianotti, Emanuela Caci, Alessio Montresor, Aiswarya Premchandar, Flora Pirozzi, Kai Ren, Angela Della Sala, Marco Mergiotti, Wito Richter, Eyleen de Poel, Michaela Matthey, Sara Caldrer, Rosa A. Cardone, Federica Civiletti, Andrea Costamagna, Nancy L. Quinney, Cosmin Butnarasu, Sonja Visentin, Maria Rosaria Ruggiero, Simona Baroni, Simonetta Geninatti Crich, Damien Ramel, Muriel Laffargue, Carlo G. Tocchetti, Renzo Levi, Marco Conti, Xiao-Yun Lu, Paola Melotti, Claudio Sorio, Virginia De Rose, Fabrizio Facchinetti, Vito Fanelli, Daniela Wenzel, Bernd K. Fleischmann, Marcus A. Mall, Jeffrey Beekman, Carlo Laudanna, Martina Gentzsch, Gergely L. Lukacs, Nicoletta Pedemonte, Emilio Hirsch

Sci Transl Med. Author manuscript; available in PMC 2023 Mar 30.

Published in final edited form as: Sci Transl Med. 2022 Mar 30; 14(638): eabl6328. Published online 2022 Mar 30. doi: 10.1126/scitranslmed.abl6328

PMCID:: PMC9869178

Abstract Article PDF–2.4M

Select item 88064626.

MicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma

Xijing Zhuang, Feng Gao, Lei Shi, Wei Liu, Wenjun Wang, Xuezhi He, Yang Gao

Bioengineered. 2021; 12(1): 2627–2638. Published online 2021 Jun 11. doi: 10.1080/21655979.2021.1937904

PMCID:: PMC8806462

Abstract Article PDF–2.3M

Select item 80054437.

Biophysical and structural characterization of novel RAS-binding domains (RBDs) of PI3Kα and PI3Kγ

Nicholas G. Martinez, David F. Thieker, Leiah M. Carey, Juhi A. Rasquinha, Samantha K. Kistler, Brian A. Kuhlman, Sharon L. Campbell

J Mol Biol. Author manuscript; available in PMC 2022 Apr 16.

Published in final edited form as: J Mol Biol. 2021 Apr 16; 433(8): 166838. Published online 2021 Feb 1. doi: 10.1016/j.jmb.2021.166838

PMCID:: PMC8005443

Abstract Article PDF–1.4M

Select item 79558108.

Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke

eLife. 2021; 10: e64691. Published online 2021 Mar 4. doi: 10.7554/eLife.64691

PMCID:: PMC7955810

Abstract Article PDF–3.7M

Select item 79491139.

G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers

Mostafa Khater, Zhe Wei, Xin Xu, Wei Huang, Bal L. Lokeshwar, Nevin A. Lambert, Guangyu Wu

J Biol Chem. 2021 Jan-Jun; 296: 100325. Published online 2021 Jan 23. doi: 10.1016/j.jbc.2021.100325

PMCID:: PMC7949113

Abstract Article PDF–2.0M

Select item 725342310.

Quassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kγ isoform

Yonggang Pei, Nicky Hwang, Fengchao Lang, Lanlan Zhou, Josiah Hiu-yuen Wong, Rajnish Kumar Singh, Hem Chandra Jha, Wafik S. El-Deiry, Yanming Du, Erle S. Robertson

Commun Biol. 2020; 3: 267. Published online 2020 May 27. doi: 10.1038/s42003-020-0996-z

PMCID:: PMC7253423

Abstract Article PDF–3.9M

Select item 719857111.

LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3Kγ promoter

Hongyan Ni, Peiwei Chai, Jie Yu, Yue Xing, Shaoyun Wang, Jiayan Fan, Shengfang Ge, Yefei Wang, Renbing Jia, Xianqun Fan

Cell Death Dis. 2020 May; 11(5): 306. Published online 2020 May 4. doi: 10.1038/s41419-020-2524-y

PMCID:: PMC7198571

Abstract Article PDF–11M

Select item 712771812.

Infection of Human Immunodeficiency Virus and Intracellular Viral Tat Protein Exert a Pro-survival Effect in a Human Microglial Cell Line

Pauline Chugh, Shongshan Fan, Vicente Planelles, Sanjay B. Maggirwar, Stephen Dewhurst, Baek Kim

J Mol Biol. 2007 Feb 9; 366(1): 67–81. Published online 2006 Nov 10. doi: 10.1016/j.jmb.2006.11.011

PMCID:: PMC7127718

Abstract Article PDF–1.1M

Select item 709818613.

Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy

Jan Balzarini

Nat Rev Microbiol. 2007; 5(8): 583–597. doi: 10.1038/nrmicro1707

PMCID:: PMC7098186

Abstract Article PDF–1.1M

Select item 700195914.

Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation

Lisa M. Grove, Maradumane L. Mohan, Susamma Abraham, Rachel G. Scheraga, Brian D. Southern, James F. Crish, Sathyamangla V. Naga Prasad, Mitchell A. Olman

Sci Signal. Author manuscript; available in PMC 2020 Feb 5.

Published in final edited form as: Sci Signal. 2019 Nov 12; 12(607): eaau1533. Published online 2019 Nov 12. doi: 10.1126/scisignal.aau1533

PMCID:: PMC7001959

Abstract Article PDF–2.7M

Select item 677813715.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 677044316.

Function, Regulation and Biological Roles of PI3Kγ Variants

Bernd Nürnberg, Sandra Beer-Hammer

Biomolecules. 2019 Sep; 9(9): 427. Published online 2019 Aug 30. doi: 10.3390/biom9090427

PMCID:: PMC6770443

Abstract Article PDF–1.4M

Select item 676112317.

Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology

Andrew J. Takeda, Timothy J. Maher, Yu Zhang, Stephen M. Lanahan, Molly L. Bucklin, Susan R. Compton, Paul M. Tyler, William A. Comrie, Makoto Matsuda, Kenneth N. Olivier, Stefania Pittaluga, Joshua J. McElwee, Debra A. Long Priel, Douglas B. Kuhns, Roger L. Williams, Peter J. Mustillo, Matthias P. Wymann, V. Koneti Rao, Carrie L. Lucas

Nat Commun. 2019; 10: 4364. Published online 2019 Sep 25. doi: 10.1038/s41467-019-12311-5

PMCID:: PMC6761123

Abstract Article PDF–1.7M

Select item 639274318.

PIK3CG single nucleotide polymorphisms are associated with poor responsiveness to clopidogrel and increased risk of ischemia in patients with coronary heart disease

Ke-Cheng Li, Shu-Hong Yu, Bao-Zhong Zhuge

Medicine (Baltimore) 2017 Sep; 96(36): e7566. Published online 2017 Sep 8. doi: 10.1097/MD.0000000000007566

PMCID:: PMC6392743

Abstract Article PDF–366K

Select item 613093919.

GRK2 mediates TCR-induced transactivation of CXCR4 and TCR–CXCR4 complex formation that drives PI3Kγ/PREX1 signaling and T cell cytokine secretion

Brittney A. Dinkel, Kimberly N. Kremer, Meagan R. Rollins, Michael J. Medlyn, Karen E. Hedin

J Biol Chem. 2018 Sep 7; 293(36): 14022–14039. Published online 2018 Jul 17. doi: 10.1074/jbc.RA118.003097

PMCID:: PMC6130939

Abstract Article PDF–4.4M

Select item 607581720.

PI3Kγ/δ and NOTCH1 cross-regulate pathways that define the T-cell acute lymphoblastic leukemia disease signature

Evgeni Efimenko, Utpal P. Davé, Irina V. Lebedeva, Yao Shen, Maria J. Sanchez-Quintero, Daniel Diolaiti, Andrew Kung, Brian J. Lannutti, Jianchung Chen, Ronald Realubit, Zoya Niatsetskiya, Vadim Ten, Charles Karan, Xi Chen, Andrea Califano, Thomas G. Diacovo

Mol Cancer Ther. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Mol Cancer Ther. 2017 Oct; 16(10): 2069–2082. Published online 2017 Jul 17. doi: 10.1158/1535-7163.MCT-17-0141

PMCID:: PMC6075817

Abstract Article PDF–1.3M

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