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Select item 110732361.

G-quadruplex structural dynamics at MAPK12 promoter dictates transcriptional switch to determine stemness in breast cancer

Pallabi Sengupta, Anindya Dutta, Y. V. Suseela, Tanaya Roychowdhury, Nilanjan Banerjee, Ananya Dutta, Satyajit Halder, Kuladip Jana, Gopeswar Mukherjee, Samit Chattopadhyay, Thimmaiah Govindaraju, Subhrangsu Chatterjee

Cell Mol Life Sci. 2024 Dec; 81(1): 33. Published online 2024 Jan 12. doi: 10.1007/s00018-023-05046-6

PMCID:: PMC11073236

Abstract Article PDF–6.7M

Select item 110341842.

Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line

Angel García-Lora, Marisol Martinez, Susana Pedrinaci, Federico Garrido

Cancer Immunol Immunother. 2003 Jan; 52(1): 59–64. Published online 2002 Oct 17. doi: 10.1007/s00262-002-0336-9

PMCID:: PMC11034184

Abstract Article PDF–327K

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 92792854.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 88974215.

The pro-tumorigenic activity of p38γ overexpression in nasopharyngeal carcinoma

De-Pei Yin, Yu-Fan Zheng, Peng Sun, Ming-Yu Yao, Li-xiao Xie, Xun-Wu Dou, Ye Tian, Ji-Sheng Liu

Cell Death Dis. 2022 Mar; 13(3): 210. Published online 2022 Mar 4. doi: 10.1038/s41419-022-04637-8

PMCID:: PMC8897421

Abstract Article PDF–5.0M

Select item 88970226.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 88954437.

Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice

Sreeram Vallabhaneni, Jian Liu, Marion Morel, Jixin Wang, Francesco J. DeMayo, Weiwen Long

Mol Oncol. 2022 Mar; 16(5): 1184–1199. Published online 2021 Dec 14. doi: 10.1002/1878-0261.13132

PMCID:: PMC8895443

Abstract Article PDF–7.2M

Select item 83789968.

The atypical MAPK ERK3 potently suppresses melanoma cell growth and invasiveness

Minyi Chen, Amanda K. Myers, Michael P. Markey, Weiwen Long

J Cell Physiol. Author manuscript; available in PMC 2021 Aug 20.

Published in final edited form as: J Cell Physiol. 2019 Aug; 234(8): 13220–13232. Published online 2018 Dec 19. doi: 10.1002/jcp.27994

PMCID:: PMC8378996

Abstract Article PDF–4.5M

Select item 83145479.

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang

Cell Biosci. 2021; 11: 146. Published online 2021 Jul 27. doi: 10.1186/s13578-021-00659-5

PMCID:: PMC8314547

Abstract Article PDF–3.7M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 742732711.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 668424012.

IFNγ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5

Diana Saleiro, Gavin T. Blyth, Ewa M. Kosciuczuk, Patrick A. Ozark, Beata Majchrzak-Kita, Ahmet D. Arslan, Mariafausta Fischietti, Neha K. Reddy, Curt M. Horvath, Roger J. Davis, Eleanor N. Fish, Leonidas C. Platanias

Sci Signal. Author manuscript; available in PMC 2019 Nov 20.

Published in final edited form as: Sci Signal. 2018 Nov 20; 11(557): eaap9921. Published online 2018 Nov 20. doi: 10.1126/scisignal.aap9921

PMCID:: PMC6684240

Abstract Article PDF–2.2M

Select item 642845213.

Role of p38γ MAPK in Regulation of EMT and Cancer Stem Cells

Mei Xu, Siying Wang, Yongchao Wang, Huaxun Wu, Jacqueline A Frank, Zhuo Zhang, Jia Luo

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2018 Nov; 1864(11): 3605–3617. Published online 2018 Aug 18. doi: 10.1016/j.bbadis.2018.08.024

PMCID:: PMC6428452

Abstract Article PDF–3.4M

Select item 620093014.

Activation loop phosphorylation of ERK3 is important for its kinase activity and ability to promote lung cancer cell invasiveness

Lobna Elkhadragy, Hadel Alsaran, Marion Morel, Weiwen Long

J Biol Chem. 2018 Oct 19; 293(42): 16193–16205. Published online 2018 Aug 30. doi: 10.1074/jbc.RA118.003699

PMCID:: PMC6200930

Abstract Article PDF–2.2M

Select item 610072415.

Proteome‐wide analysis of phospho‐regulated PDZ domain interactions

Gustav N Sundell, Roland Arnold, Muhammad Ali, Piangfan Naksukpaiboon, Julien Orts, Peter Güntert, Celestine N Chi, Ylva Ivarsson

Mol Syst Biol. 2018 Aug; 14(8): e8129. Published online 2018 Aug 20. doi: 10.15252/msb.20178129

PMCID:: PMC6100724

Abstract Article PDF–2.4M

Select item 567858116.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 567024117.

L290P/V mutations increase ERK3’s cytoplasmic localization and migration/invasion-promoting capability in cancer cells

Hadel Alsaran, Lobna Elkhadragy, Astha Shakya, Weiwen Long

Sci Rep. 2017; 7: 14979. Published online 2017 Nov 3. doi: 10.1038/s41598-017-15135-9

PMCID:: PMC5670241

Abstract Article PDF–4.0M

Select item 555729218.

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Kyuho Han, Edwin E. Jeng, Gaelen T. Hess, David W. Morgens, Amy Li, Michael C. Bassik

Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 20.

Published in final edited form as: Nat Biotechnol. 2017 May; 35(5): 463–474. Published online 2017 Mar 20. doi: 10.1038/nbt.3834

PMCID:: PMC5557292

Abstract Article PDF–3.4M

Select item 553161119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 533315720.

Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2

Maria Perander, Rania Al-Mahdi, Thomas C. Jensen, Jennifer A. L. Nunn, Hanne Kildalsen, Bjarne Johansen, Mads Gabrielsen, Stephen M. Keyse, Ole-Morten Seternes

Sci Rep. 2017; 7: 43471. Published online 2017 Mar 2. doi: 10.1038/srep43471

PMCID:: PMC5333157

Abstract Article PDF–2.4M

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