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Select item 85664731.

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim

Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6

PMCID:: PMC8566473

Abstract Article PDF–2.7M

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79284913.

Maegan M. Weltzin, Andrew A. George, Ronald J. Lukas, Paul Whiteaker

PLoS One. 2021; 16(3): e0247825. Published online 2021 Mar 3. doi: 10.1371/journal.pone.0247825

PMCID:: PMC7928491

Abstract Article PDF–4.5M

Select item 66743794.

Human Tobacco Smokers in Early Abstinence Have Higher Levels of β₂* Nicotinic Acetylcholine Receptors than Nonsmokers

Julie K. Staley, Suchitra Krishnan-Sarin, Kelly P. Cosgrove, Erica Krantzler, Erin Frohlich, Edward Perry, Joel A. Dubin, Kristina Estok, Eric Brenner, Ronald M. Baldwin, Gilles D. Tamagnan, John P. Seibyl, Peter Jatlow, Marina R. Picciotto, Edythe D. London, Stephanie O'Malley, Christopher H. van Dyck

J Neurosci. 2006 Aug 23; 26(34): 8707–8714. doi: 10.1523/JNEUROSCI.0546-06.2006

PMCID:: PMC6674379

Abstract Article PDF–282K

Select item 66489895.

Association of idiopathic generalized epilepsy with polymorphisms in the neuronal nicotinic acetylcholine receptor subunits

Cheng‐Chun Lee, I‐Ching Chou, Chang‐Hai Tsai, Lei Wan, Yu‐An Shu, Yuhsin Tsai, Tsai‐Chung Li, Fuu‐Jen Tsai

J Clin Lab Anal. 2007; 21(2): 67–70. Published online 2007 Mar 26. doi: 10.1002/jcla.20155

PMCID:: PMC6648989

Abstract Article PDF–119K

Select item 65792026.

Human α4β2 Neuronal Nicotinic Acetylcholine Receptor in HEK 293 Cells: A Patch-Clamp Study

Bruno Buisson, Murali Gopalakrishnan, Stephen P. Arneric, James P. Sullivan, Daniel Bertrand

J Neurosci. 1996 Dec 15; 16(24): 7880–7891. doi: 10.1523/JNEUROSCI.16-24-07880.1996

PMCID:: PMC6579202

Abstract Article PDF–431K

Select item 61320597.

Structural principles of distinct assemblies of the human α4β2 nicotinic receptor

Richard M. Walsh, Jr., Soung-Hun Roh, Anant Gharpure, Claudio L. Morales-Perez, Jinfeng Teng, Ryan E. Hibbs

Nature. Author manuscript; available in PMC 2018 Nov 2.

Published in final edited form as: Nature. 2018 May; 557(7704): 261–265. Published online 2018 May 2. doi: 10.1038/s41586-018-0081-7

PMCID:: PMC6132059

Abstract Article PDF–2.9M

Select item 59789518.

The fifth subunit of the (α4β2)₂β2 nicotinic ACh receptor modulates maximal ACh responses

Karina New, Silvia Garcia Del Villar, Simone Mazzaferro, Constanza Alcaino, Isabel Bermudez

Br J Pharmacol. 2018 Jun; 175(11): 1822–1837. Published online 2017 Jul 14. doi: 10.1111/bph.13905

PMCID:: PMC5978951

Abstract Article PDF–1.5M

Select item 59186329.

MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes

Elvira Ganic, Tania Singh, Cheng Luan, João Fadista, Jenny K. Johansson, Holly Ann Cyphert, Hedvig Bennet, Petter Storm, Gaëlle Prost, Henrik Ahlenius, Erik Renström, Roland Stein, Leif Groop, Malin Fex, Isabella Artner

Cell Rep. Author manuscript; available in PMC 2018 Apr 26.

Published in final edited form as: Cell Rep. 2016 Mar 1; 14(8): 1991–2002. Published online 2016 Feb 18. doi: 10.1016/j.celrep.2016.02.002

PMCID:: PMC5918632

Abstract Article PDF–2.5M

Select item 547325010.

Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses

Ze-Jun Wang, Farah Deba, Tasnim S. Mohamed, David C. Chiara, Kara Ramos, Ayman K. Hamouda

J Biol Chem. 2017 Jun 16; 292(24): 9988–10001. Published online 2017 Apr 26. doi: 10.1074/jbc.M116.771246

PMCID:: PMC5473250

Abstract Article PDF–4.9M

Select item 526752011.

The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4β2 Receptors

Xiaochun Jin, Megan M. McCollum, Allison L. Germann, Gustav Akk, Joe Henry Steinbach

Mol Pharmacol. 2017 Feb; 91(2): 100–109. Published online 2017 Feb. doi: 10.1124/mol.116.106484

PMCID:: PMC5267520

Abstract Article PDF–688K

Select item 516157312.

X-ray structure of the human a4ß2 nicotinic receptor

Claudio L. Morales-Perez, Colleen M. Noviello, Ryan E. Hibbs

Nature. Author manuscript; available in PMC 2017 Apr 3.

Published in final edited form as: Nature. 2016 Oct 20; 538(7625): 411–415. Published online 2016 Oct 3. doi: 10.1038/nature19785

PMCID:: PMC5161573

Abstract Article PDF–3.7M

Select item 509540113.

Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors

Akansha Jain, Alexander Kuryatov, Jingyi Wang, Theodore M. Kamenecka, Jon Lindstrom

J Biol Chem. 2016 Nov 4; 291(45): 23452–23463. Published online 2016 Sep 19. doi: 10.1074/jbc.M116.749150

PMCID:: PMC5095401

Abstract Article PDF–3.1M

Select item 501790614.

Functional interaction between Lypd6 and nicotinic acetylcholine receptors

Maria Arvaniti, Majbrit M. Jensen, Neeraj Soni, Hong Wang, Anders B. Klein, Nathalie Thiriet, Lars H. Pinborg, Pretal P. Muldoon, Jacob Wienecke, M. Imad Damaj, Kristi A. Kohlmeier, Marjorie C. Gondré‐Lewis, Jens D. Mikkelsen, Morten S. Thomsen

J Neurochem. 2016 Sep; 138(6): 806–820. Published online 2016 Aug 15. doi: 10.1111/jnc.13718

PMCID:: PMC5017906

Abstract Article PDF–1.2M

Select item 473222615.

Differential α4(+)/(−)β2 Agonist-binding Site Contributions to α4β2 Nicotinic Acetylcholine Receptor Function within and between Isoforms

Linda M. Lucero, Maegan M. Weltzin, J. Brek Eaton, John F. Cooper, Jon M. Lindstrom, Ronald J. Lukas, Paul Whiteaker

J Biol Chem. 2016 Jan 29; 291(5): 2444–2459. Published online 2015 Dec 7. doi: 10.1074/jbc.M115.684373

PMCID:: PMC4732226

Abstract Article PDF–3.2M

Select item 463463716.

Brain Nicotinic Acetylcholine Receptor Availability and Response to Smoking Cessation Treatment A Randomized Trial

Arthur L. Brody, Alexey G. Mukhin, Michael S. Mamoun, Trinh Luu, Meaghan Neary, Lidia Liang, Jennifer Shieh, Catherine A. Sugar, Jed E. Rose, Mark A. Mandelkern

JAMA Psychiatry. Author manuscript; available in PMC 2015 Nov 5.

Published in final edited form as: JAMA Psychiatry. 2014 Jul 1; 71(7): 797–805. doi: 10.1001/jamapsychiatry.2014.138