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Select item 111592181.

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2

Chihiro Ohtsubo, Daisuke Shiokawa, Masami Kodama, Christian Gaiddon, Hitoshi Nakagama, Aart G. Jochemsen, Yoichi Taya, Koji Okamoto

Cancer Sci. 2009 Jul; 100(7): 1291–1299. Published online 2009 Apr 15. doi: 10.1111/j.1349-7006.2009.01180.x

PMCID:: PMC11159218

Abstract Article PDF–3.5M

Select item 111481842.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 108764953.

miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway

Jinmei Wei, Yan Chen, Tingmei Feng, Yuihui Wei, Caizhen Yang, Changwen Zhang, Wentao Li, Guangnan Liu

Funct Integr Genomics. 2024; 24(2): 37. Published online 2024 Feb 20. doi: 10.1007/s10142-024-01317-y

PMCID:: PMC10876495

Abstract Article PDF–2.1M

Select item 108212404.

MDM4 was associated with poor prognosis and tumor-immune infiltration of cancers

Jie Liu, Jie Yang, Qilong Pan, Xiangyu Wang, Xinyin Wang, Han Chen, Xiaoling Zheng, Qingling Huang

Eur J Med Res. 2024; 29: 79. Published online 2024 Jan 27. doi: 10.1186/s40001-024-01684-z

PMCID:: PMC10821240

Abstract Article PDF–5.6M

Select item 101581215.

BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models

Xiaoguang Hao, Ravinder K Bahia, Orsolya Cseh, Danielle A Bozek, Sophia Blake, Jörg Rinnenthal, Ulrike Weyer-Czernilofsky, Dorothea Rudolph, H Artee Luchman

Neuro Oncol. 2023 May; 25(5): 913–926. Published online 2022 Dec 15. doi: 10.1093/neuonc/noac271

PMCID:: PMC10158121

Abstract Article PDF–21M

Select item 93894626.

Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status

Rati Lama, Chao Xu, Samuel L. Galster, Javier Querol-García, Scott Portwood, Cory K. Mavis, Federico M. Ruiz, Diana Martin, Jin Wu, Marianna C. Giorgi, Jill Bargonetti, Eunice S. Wang, Francisco J. Hernandez-Ilizaliturri, Gerald B. Koudelka, Sherry R. Chemler, Inés G. Muñoz, Xinjiang Wang

Front Oncol. 2022; 12: 933446. Published online 2022 Aug 5. doi: 10.3389/fonc.2022.933446

PMCID:: PMC9389462

Abstract Article PDF–11M

Select item 92546667.

Cryptic in vitro ubiquitin ligase activity of HDMX towards p53 is probably regulated by an induced fit mechanism

Karla Gisel Calderon-González, Ixaura Medina-Medina, Lucia Haronikova, Lenka Hernychova, Ondrej Bonczek, Lukas Uhrik, Vaclav Hrabal, Borivoj Vojtesek, Robin Fahraeus, Jesús Hernández-Monge, Vanesa Olivares-Illana

Biosci Rep. 2022 Jul 29; 42(7): BSR20220186. Published online 2022 Jul 4. doi: 10.1042/BSR20220186

PMCID:: PMC9254666

Abstract Article PDF–3.7M

Select item 91197368.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 87690729.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 876736910.

Circular RNA CCDC66 Improves Murine Double Minute 4 (MDM4) Expression through Targeting miR-370 in Colorectal Cancer

Yang Mo, Qin Lu, Qi Zhang, Jie Chen, Youming Deng, Ke Zhang, Ran Tao, Weidong Liu, Yiming Wang

Comput Math Methods Med. 2022; 2022: 7723995. Published online 2022 Jan 11. doi: 10.1155/2022/7723995

PMCID:: PMC8767369

Abstract Article PDF–1.7M

Select item 861235511.

MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53

Alyssa M. Klein, Lynn Biderman, David Tong, Bita Alaghebandan, Sakina A. Plumber, Helen S. Mueller, Anne van Vlimmeren, Chen Katz, Carol Prives

Proc Natl Acad Sci U S A. 2021 Nov 2; 118(44): e2102420118. Published online 2021 Oct 29. doi: 10.1073/pnas.2102420118

PMCID:: PMC8612355

Abstract Article PDF–1.6M

Select item 859283612.

Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature

Christian Koelsche, Jamal K. Benhamida, Felix K. F. Kommoss, Damian Stichel, David T. W. Jones, Stefan M. Pfister, Christoph E. Heilig, Stefan Fröhling, Albrecht Stenzinger, Rolf Buslei, Thomas Mentzel, Daniel Baumhoer, Marc Ladanyi, Cristina R. Antonescu, Uta Flucke, Joost van Gorp, Beata Bode-Lesniewska, Andreas von Deimling, Gunhild Mechtersheimer

Mod Pathol. 2021; 34(12): 2122–2129. Published online 2021 Jul 26. doi: 10.1038/s41379-021-00874-y

PMCID:: PMC8592836

Abstract Article PDF–3.2M

Select item 857566113.

MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism

Koki Ueda, Rajni Kumari, Emily Schwenger, Justin C. Wheat, Oliver Bohorquez, Swathi-Rao Narayanagari, Samuel J. Taylor, Luis A. Carvajal, Kith Pradhan, Boris Bartholdy, Tihomira I. Todorova, Hiroki Goto, Daqian Sun, Jiahao Chen, Jidong Shan, Yinghui Song, Cristina Montagna, Shunbin Xiong, Guillermina Lozano, Andrea Pellagatti, Jacqueline Boultwood, Amit Verma, Ulrich Steidl

Cancer Cell. Author manuscript; available in PMC 2022 Apr 12.

Published in final edited form as: Cancer Cell. 2021 Apr 12; 39(4): 529–547.e7. Published online 2021 Mar 4. doi: 10.1016/j.ccell.2021.02.006

PMCID:: PMC8575661

Abstract Article PDF–3.7M

Select item 856100614.

The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation

Herui Wang, Bin Li, Kulsum Asha, Ryan L. Pangilinan, Asha Thuraisamy, Harman Chopra, Susumu Rokudai, Yong Yu, Carol L. Prives, Yan Zhu

J Biol Chem. 2021 Nov; 297(5): 101292. Published online 2021 Oct 8. doi: 10.1016/j.jbc.2021.101292

PMCID:: PMC8561006

Abstract Article PDF–3.4M

Select item 845946115.

MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail

Jack D. Sanford, Jing Yang, Jing Han, Laura A. Tollini, Aiwen Jin, Yanping Zhang

BMC Mol Cell Biol. 2021; 22: 46. Published online 2021 Sep 22. doi: 10.1186/s12860-021-00385-3

PMCID:: PMC8459461

Abstract Article PDF–1.1M

Select item 827429916.

PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA

Kimiyoshi Yano, Ryou-u Takahashi, Bunsyo Shiotani, Junko Abe, Tomoki Shidooka, Yuki Sudo, Yusuke Yamamoto, Shisei Kan, Hiroki Sakagami, Hidetoshi Tahara

J Biol Chem. 2021 Jul; 297(1): 100882. Published online 2021 Jun 16. doi: 10.1016/j.jbc.2021.100882

PMCID:: PMC8274299

Abstract Article PDF–2.3M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 816463518.

Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties

Rossella Lucà, Maria Rita Assenza, Fabio Maiullari, Luisa Pieroni, Silvia Maiullari, Giulia Federici, Federica Marini, Roberto Rizzi, Andrea Urbani, Silvia Soddu, Fabiola Moretti

Cell Death Dis. 2021 Jun; 12(6): 558. Published online 2021 May 29. doi: 10.1038/s41419-021-03828-z

PMCID:: PMC8164635

Abstract Article PDF–7.0M

Select item 813169619.

CPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4

Kaping Lee, Qiufan Zheng, Qianyi Lu, Fei Xu, Ge Qin, Qinglian Zhai, Ruoxi Hong, Miao Chen, Wuguo Deng, Shusen Wang

Signal Transduct Target Ther. 2021; 6: 184. Published online 2021 May 19. doi: 10.1038/s41392-021-00565-9

PMCID:: PMC8131696

Article PDF–1.4M

Select item 804593220.

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition

Yahya Benslimane, María Sánchez‐Osuna, Jasmin Coulombe‐Huntington, Thierry Bertomeu, Danielle Henry, Caroline Huard, Éric Bonneil, Pierre Thibault, Mike Tyers, Lea Harrington

Aging Cell. 2021 Apr; 20(4): e13331. Published online 2021 Mar 4. doi: 10.1111/acel.13331

PMCID:: PMC8045932

Abstract Article PDF–1.9M

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