PMC Links for GEO Profiles (Select 85478784) - PMC

Select item 108743281.

Functional AGXT2 SNP rs180749 variant and depressive symptoms: Baseline data from the Aidai Cohort Study in Japan

Hiroshi Kumon, Yoshihiro Miyake, Yuta Yoshino, Jun-ichi Iga, Keiko Tanaka, Hidenori Senba, Eizen Kimura, Takashi Higaki, Bunzo Matsuura, Ryuichi Kawamoto, Shu-ichi Ueno

J Neural Transm (Vienna) 2024; 131(3): 267–274. Published online 2024 Jan 23. doi: 10.1007/s00702-024-02742-w

PMCID:: PMC10874328

Abstract Article PDF–666K

Select item 101488052.

Genetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment

Einat Granot-Hershkovitz, Brian Spitzer, Yunju Yang, Wassim Tarraf, Bing Yu, Eric Boerwinkle, Myriam Fornage, Thomas H. Mosley, Charles DeCarli, Bruce S. Kristal, Hector M. González, Tamar Sofer

Transl Psychiatry. 2023; 13: 140. Published online 2023 Apr 29. doi: 10.1038/s41398-023-02437-y

PMCID:: PMC10148805

Abstract Article PDF–1.1M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80592134.

Effects of AGXT2 variants on blood pressure and blood sugar among 750 older Japanese subjects recruited by the complete enumeration survey method

Yuta Yoshino, Hiroshi Kumon, Takaaki Mori, Taku Yoshida, Ayumi Tachibana, Hideaki Shimizu, Jun-ichi Iga, Shu-ichi Ueno

BMC Genomics. 2021; 22: 287. Published online 2021 Apr 20. doi: 10.1186/s12864-021-07612-3

PMCID:: PMC8059213

Abstract Article PDF–716K

Select item 62993685.

The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex

Wentao Zhang, Ning Duan, Qian Zhang, Tao Song, Zhong Li, Xun Chen, Kunzheng Wang

Int J Biol Sci. 2018; 14(14): 2023–2036. Published online 2018 Nov 3. doi: 10.7150/ijbs.28302

PMCID:: PMC6299368

Abstract Article PDF–2.0M

Select item 50827586.

A Novel Pathway for Metabolism of the Cardiovascular Risk Factor Homoarginine by alanine:glyoxylate aminotransferase 2

Roman N. Rodionov, Elisa Oppici, Jens Martens-Lobenhoffer, Natalia Jarzebska, Silke Brilloff, Dmitrii Burdin, Anton Demyanov, Anne Kolouschek, James Leiper, Renke Maas, Barbara Cellini, Norbert Weiss, Stefanie M. Bode-Böger

Sci Rep. 2016; 6: 35277. Published online 2016 Oct 18. doi: 10.1038/srep35277

PMCID:: PMC5082758

Abstract Article PDF–1.1M

Select item 47976377.

Genome-Wide Association Study of L-Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine

Nicole Lüneburg, Wolfgang Lieb, Tanja Zeller, Ming-Huei Chen, Renke Maas, Angela M. Carter, Vanessa Xanthakis, Nicole L Glazer, Edzard Schwedhelm, Sudha Seshadri, M. Arfan Ikram, W.T. Longstreth, Jr, Myriam Fornage, Inke R. König, Christina Loley, Francisco M. Ojeda, Arne Schillert, Thomas J. Wang, Heinrich Sticht, Anja Kittel, Jörg König, Emelia J. Benjamin, Lisa M. Sullivan, Isabel Bernges, Maike Anderssohn, Andreas Ziegler, Christian Gieger, Thomas Illig, Christa Meisinger, H.-Erich Wichmann, Philipp S. Wild, Heribert Schunkert, Bruce M. Psaty, Kerri L. Wiggins, Susan R. Heckbert, Nicholas Smith, Karl Lackner, Kathryn L. Lunetta, Stefan Blankenberg, Jeanette Erdmann, Thomas Munzel, Peter J. Grant, Ramachandran S. Vasan, Rainer H. Böger

Circ Cardiovasc Genet. Author manuscript; available in PMC 2016 Mar 18.

Published in final edited form as: Circ Cardiovasc Genet. 2014 Dec; 7(6): 864–872. Published online 2014 Sep 21. doi: 10.1161/CIRCGENETICS.113.000264

PMCID:: PMC4797637

Abstract Article PDF–2.2M

Select item 47947148.

Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke

Ilkka Seppälä, Marcus E. Kleber, Steve Bevan, Leo-Pekka Lyytikäinen, Niku Oksala, Jussi A. Hernesniemi, Kari-Matti Mäkelä, Peter M. Rothwell, Cathie Sudlow, Martin Dichgans, Nina Mononen, Efthymia Vlachopoulou, Juha Sinisalo, Graciela E. Delgado, Reijo Laaksonen, Tuomas Koskinen, Hubert Scharnagl, Mika Kähönen, Hugh S. Markus, Winfried März, Terho Lehtimäki

Sci Rep. 2016; 6: 23207. Published online 2016 Mar 17. doi: 10.1038/srep23207

PMCID:: PMC4794714

Abstract Article PDF–781K

Select item 42541139.

AGXT2: a promiscuous aminotransferase

Roman N. Rodionov, Natalia Jarzebska, Norbert Weiss, Steven R. Lentz

Trends Pharmacol Sci. Author manuscript; available in PMC 2015 Nov 1.

Published in final edited form as: Trends Pharmacol Sci. 2014 Nov; 35(11): 575–582. Published online 2014 Oct 13. doi: 10.1016/j.tips.2014.09.005

PMCID:: PMC4254113

Abstract Article PDF–1.0M

Select item 397315810.

A Genome-Wide Association Study of the Human Metabolome in a Community-Based Cohort

Eugene P. Rhee, Jennifer E. Ho, Ming-Huei Chen, Dongxiao Shen, Susan Cheng, Martin G. Larson, Anahita Ghorbani, Xu Shi, Iiro T. Helenius, Christopher J. O’Donnell, Amanda L. Souza, Amy Deik, Kerry A. Pierce, Kevin Bullock, Geoffrey A. Walford, Ramachandran S. Vasan, Jose C. Florez, Clary Clish, J.-R. Joanna Yeh, Thomas J. Wang, Robert E. Gerszten

Cell Metab. Author manuscript; available in PMC 2014 Apr 2.

Published in final edited form as: Cell Metab. 2013 Jul 2; 18(1): 130–143. doi: 10.1016/j.cmet.2013.06.013

PMCID:: PMC3973158

Abstract Article PDF–3.5M

Select item 393332911.

Alanine-glyoxylate aminotransferase 2 (AGXT2) Polymorphisms Have Considerable Impact on Methylarginine and β-aminoisobutyrate Metabolism in Healthy Volunteers

Anja Kittel, Fabian Müller, Jörg König, Maren Mieth, Heinrich Sticht, Oliver Zolk, Ana Kralj, Markus R. Heinrich, Martin F. Fromm, Renke Maas

PLoS One. 2014; 9(2): e88544. Published online 2014 Feb 24. doi: 10.1371/journal.pone.0088544

PMCID:: PMC3933329

Abstract Article PDF–3.4M

Select item 393051012.

Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links

Rico Rueedi, Mirko Ledda, Andrew W. Nicholls, Reza M. Salek, Pedro Marques-Vidal, Edgard Morya, Koichi Sameshima, Ivan Montoliu, Laeticia Da Silva, Sebastiano Collino, François-Pierre Martin, Serge Rezzi, Christoph Steinbeck, Dawn M. Waterworth, Gérard Waeber, Peter Vollenweider, Jacques S. Beckmann, Johannes Le Coutre, Vincent Mooser, Sven Bergmann, Ulrich K. Genick, Zoltán Kutalik

PLoS Genet. 2014 Feb; 10(2): e1004132. Published online 2014 Feb 20. doi: 10.1371/journal.pgen.1004132

PMCID:: PMC3930510

Abstract Article PDF–491K

Select item 326170813.

Toward an understanding of the protein interaction network of the human liver

Jian Wang, Keke Huo, Lixin Ma, Liujun Tang, Dong Li, Xiaobi Huang, Yanzhi Yuan, Chunhua Li, Wei Wang, Wei Guan, Hui Chen, Chaozhi Jin, Junchen Wei, Wanqiao Zhang, Yongsheng Yang, Qiongming Liu, Ying Zhou, Cuili Zhang, Zhihao Wu, Wangxiang Xu, Ying Zhang, Tao Liu, Donghui Yu, Yaping Zhang, Liang Chen, Dewu Zhu, Xing Zhong, Lixin Kang, Xiang Gan, Xiaolan Yu, Qi Ma, Jing Yan, Li Zhou, Zhongyang Liu, Yunping Zhu, Tao Zhou, Fuchu He, Xiaoming Yang

Mol Syst Biol. 2011; 7: 536. Published online 2011 Oct 11. doi: 10.1038/msb.2011.67

Correction in:: Mol Syst Biol. 2017 Dec; 13(12): 965.

PMCID:: PMC3261708

Abstract Article PDF–2.0M

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316952915.

A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

George Nicholson, Mattias Rantalainen, Jia V. Li, Anthony D. Maher, Daniel Malmodin, Kourosh R. Ahmadi, Johan H. Faber, Amy Barrett, Josine L. Min, N. William Rayner, Henrik Toft, Maria Krestyaninova, Juris Viksna, Sudeshna Guha Neogi, Marc-Emmanuel Dumas, Ugis Sarkans, The MolPAGE Consortium, Peter Donnelly, Thomas Illig, Jerzy Adamski, Karsten Suhre, Maxine Allen, Krina T. Zondervan, Tim D. Spector, Jeremy K. Nicholson, John C. Lindon, Dorrit Baunsgaard, Elaine Holmes, Mark I. McCarthy, Chris C. Holmes

PLoS Genet. 2011 Sep; 7(9): e1002270. Published online 2011 Sep 8. doi: 10.1371/journal.pgen.1002270

PMCID:: PMC3169529

Abstract Article PDF–1016K

Select item 294347616.

Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

Sher L. Hendrickson, James A. Lautenberger, Leslie Wei Chinn, Michael Malasky, Efe Sezgin, Lawrence A. Kingsley, James J. Goedert, Gregory D. Kirk, Edward D. Gomperts, Susan P. Buchbinder, Jennifer L. Troyer, Stephen J. O'Brien

PLoS One. 2010; 5(9): e12862. Published online 2010 Sep 21. doi: 10.1371/journal.pone.0012862

PMCID:: PMC2943476

Abstract Article PDF–461K

Select item 282076717.

Human Alanine-Glyoxylate Aminotransferase 2 Lowers Asymmetric Dimethylarginine and Protects from Inhibition of Nitric Oxide Production

Roman N. Rodionov, Daryl J. Murry, Sarah F. Vaulman, Jeff W. Stevens, Steven R. Lentz

J Biol Chem. 2010 Feb 19; 285(8): 5385–5391. Published online 2009 Dec 14. doi: 10.1074/jbc.M109.091280

PMCID:: PMC2820767

Abstract Article PDF–1.9M

Select item 135612918.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 51531619.

Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions

Yutaka Suzuki, Riu Yamashita, Matsuyuki Shirota, Yuta Sakakibara, Joe Chiba, Junko Mizushima-Sugano, Kenta Nakai, Sumio Sugano

Genome Res. 2004 Sep; 14(9): 1711–1718. doi: 10.1101/gr.2435604

PMCID:: PMC515316

Abstract Article PDF–181K

Select item 13924120.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

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