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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 105658762.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 101326503.

The 3’ UTR polymorphisms rs3742330 in DICER1 and rs10719 in DROSHA genes are not associated with primary open-angle and angle-closure glaucoma: As case-control study

Altaf A. Kondkar, Taif A. Azad, Tahira Sultan, Essam A. Osman, Faisal A. Almobarak, Glenn P. Lobo, Saleh A. Al-Obeidan

PLoS One. 2023; 18(4): e0284852. Published online 2023 Apr 26. doi: 10.1371/journal.pone.0284852

PMCID:: PMC10132650

Abstract Article PDF–1.0M

Select item 100570104.

Downregulation of DROSHA: Could It Affect miRNA Biogenesis in Endometriotic Menstrual Blood Mesenchymal Stem Cells?

Ana Clara Lagazzi Cressoni, Letícia B. C. Penariol, Cristiana Carolina Padovan, Maristela D. Orellana, Júlio Cesar Rosa-e-Silva, Omero Benedicto Poli-Neto, Rui Alberto Ferriani, Cláudia Cristina Paro de Paz, Juliana Meola

Int J Mol Sci. 2023 Mar; 24(6): 5963. Published online 2023 Mar 22. doi: 10.3390/ijms24065963

PMCID:: PMC10057010

Abstract Article PDF–686K

Select item 100267375.

The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8

Yanping Li, Timothy S. Carey, Catherine H. Feng, Hong-Ming Zhu, Xiao-Xin Sun, Mu-Shui Dai

Cancer Res Commun. 2023 Mar; 3(3): 459–470. Published online 2023 Mar 20. doi: 10.1158/2767-9764.CRC-22-0344

PMCID:: PMC10026737

Abstract Article PDF–11M

Select item 97725586.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 97444117.

Immunohistochemical expression of Drosha is reduced in eutopic and ectopic endometrium of women with adenomyosis

I. Ormenezi, A. Ribeiro-Silva, J.C. Rosa-e-Silva, J. Meola, F.J. Candido-dos-Reis, O.B. Poli-Neto

Braz J Med Biol Res. 2022; 55: e12375. Published online 2022 Dec 12. doi: 10.1590/1414-431X2022e12375

PMCID:: PMC9744411

Abstract Article PDF–785K

Select item 95466468.

The Drosha-Independent MicroRNA6778-5p/GSK3β Axis Mediates the Proliferation of Gastric Cancer Cells

Mingjun Ren, Li Xing, Wanping Wang, Wanying Bi, Wanjun Wu, Gui Jiang, Weiji Wang, Xingdong Liang, Manran Liu, Shifu Tang

Comput Intell Neurosci. 2022; 2022: 5932512. Published online 2022 Sep 30. doi: 10.1155/2022/5932512

PMCID:: PMC9546646

Abstract Article PDF–594K

Select item 94337339.

The microRNA processor DROSHA is a candidate gene for a severe progressive neurological disorder

Scott Barish, Mumine Senturk, Kelly Schoch, Amanda L Minogue, Diego Lopergolo, Chiara Fallerini, Jake Harland, Jacob H Seemann, Nicholas Stong, Peter G Kranz, Sujay Kansagra, Mohamad A Mikati, Joan Jasien, Mays El-Dairi, Paolo Galluzzi, Undiagnosed Diseases Network , Francesca Ariani, Alessandra Renieri, Francesca Mari, Michael F Wangler, Swathi Arur, Yong-Hui Jiang, Shinya Yamamoto, Vandana Shashi, Hugo J Bellen

Hum Mol Genet. 2022 Sep 1; 31(17): 2934–2950. Published online 2022 Apr 11. doi: 10.1093/hmg/ddac085

PMCID:: PMC9433733

Abstract Article PDF–1.7M

Select item 934857610.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 934345511.

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis

Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi

Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y

PMCID:: PMC9343455

Abstract Article PDF–3.7M

Select item 929024112.

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Annamaria Salvati, Viola Melone, Assunta Sellitto, Francesca Rizzo, Roberta Tarallo, Tuula A. Nyman, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz

Breast Cancer Res. 2022; 24: 52. Published online 2022 Jul 18. doi: 10.1186/s13058-022-01547-7

PMCID:: PMC9290241

Abstract Article PDF–8.2M

Select item 911973613.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 892911014.

Evaluating the Effect of 3′-UTR Variants in DICER1 and DROSHA on Their Tissue-Specific Expression by miRNA Target Prediction

Dmitrii S. Bug, Artem V. Tishkov, Ivan S. Moiseev, Natalia V. Petukhova

Curr Issues Mol Biol. 2021 Sep; 43(2): 605–617. Published online 2021 Jul 6. doi: 10.3390/cimb43020044

PMCID:: PMC8929110

Abstract Article PDF–1.2M

Select item 867572715.

Sequencing of Argonaute-bound microRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a

Christopher J. Fields, Lu Li, Nicholas M. Hiers, Tianqi Li, Peike Sheng, Taha Huda, Jixiu Shan, Lauren Gay, Tongjun Gu, Jiang Bian, Michael S. Kilberg, Rolf Renne, Mingyi Xie

PLoS Genet. 2021 Dec; 17(12): e1009934. Published online 2021 Dec 16. doi: 10.1371/journal.pgen.1009934