PMC Links for GEO Profiles (Select 87914939) - PMC

Daniel A. Bonsor, Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing, Lorenzo I. Finci, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Pablo Rodriguez-Viciana, Andrew G. Stephen, Dhirendra K. Simanshu

Nat Struct Mol Biol. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: Nat Struct Mol Biol. 2022 Oct; 29(10): 966–977. Published online 2022 Sep 29. doi: 10.1038/s41594-022-00841-4

PMCID:: PMC10365013

Abstract Article PDF–6.2M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101776835.

SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus

Wenwen Geng, Meiling Cao, Ke Dong, Junhua An, Haidong Gao

Cancer Biol Ther. 2023; 24(1): 2206362. Published online 2023 May 11. doi: 10.1080/15384047.2023.2206362

PMCID:: PMC10177683

Abstract Article PDF–2.5M

Select item 96943386.

Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex

Jason J. Kwon, Behnoush Hajian, Yuemin Bian, Lucy C. Young, Alvaro J. Amor, James R. Fuller, Cara V. Fraley, Abbey M. Sykes, Jonathan So, Joshua Pan, Laura Baker, Sun Joo Lee, Douglas B. Wheeler, David L. Mayhew, Nicole S. Persky, Xiaoping Yang, David E. Root, Anthony M. Barsotti, Andrew W. Stamford, Charles K. Perry, Alex Burgin, Frank McCormick, Christopher T. Lemke, William C. Hahn, Andrew J. Aguirre

Nature. Author manuscript; available in PMC 2022 Nov 25.

Published in final edited form as: Nature. 2022 Sep; 609(7926): 408–415. Published online 2022 Jul 13. doi: 10.1038/s41586-022-04928-2

PMCID:: PMC9694338

Abstract Article PDF–5.8M

Select item 94523017.

Structural basis for SHOC2 modulation of RAS signalling

Nicholas P. D. Liau, Matthew C. Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, John M. Bruning, Timothy J. Wendorff, Wilson Phung, Sarah G. Hymowitz, Jawahar Sudhamsu

Nature. 2022; 609(7926): 400–407. Published online 2022 Jun 29. doi: 10.1038/s41586-022-04838-3

PMCID:: PMC9452301

Abstract Article PDF–21M

Select item 94522958.

Structure of the MRAS–SHOC2–PP1C phosphatase complex

Zachary J. Hauseman, Michelle Fodor, Anxhela Dhembi, Jessica Viscomi, David Egli, Melusine Bleu, Stephanie Katz, Eunyoung Park, Dong Man Jang, Kathryn A. Porter, Fabian Meili, Hongqiu Guo, Grainne Kerr, Sandra Mollé, Camilo Velez-Vega, Kim S. Beyer, Giorgio G. Galli, Saveur-Michel Maira, Travis Stams, Kirk Clark, Michael J. Eck, Luca Tordella, Claudio R. Thoma, Daniel A. King

Nature. 2022; 609(7926): 416–423. Published online 2022 Jul 13. doi: 10.1038/s41586-022-05086-1

PMCID:: PMC9452295

Abstract Article PDF–21M

Select item 94022409.

Expanding the molecular spectrum of pathogenic SHOC2 variants underlying Mazzanti syndrome

Marialetizia Motta, Maja Solman, Adeline A Bonnard, Alma Kuechler, Francesca Pantaleoni, Manuela Priolo, Balasubramanian Chandramouli, Simona Coppola, Simone Pizzi, Erika Zara, Marco Ferilli, Hülya Kayserili, Roberta Onesimo, Chiara Leoni, Julia Brinkmann, Yoann Vial, Susanne B Kamphausen, Cécile Thomas-Teinturier, Anne Guimier, Viviana Cordeddu, Laura Mazzanti, Giuseppe Zampino, Giovanni Chillemi, Martin Zenker, Hélène Cavé, Jeroen den Hertog, Marco Tartaglia

Hum Mol Genet. 2022 Aug 15; 31(16): 2766–2778. Published online 2022 Mar 26. doi: 10.1093/hmg/ddac071

PMCID:: PMC9402240

Abstract Article PDF–1.2M

Select item 927928510.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 862756011.

The role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair

Patricia Wilson, Lina Abdelmoti, Rebecca Norcross, Eun Ryoung Jang, Malathy Palayam, Emilia Galperin

J Cell Sci. 2021 Nov 1; 134(21): jcs258922. Published online 2021 Nov 5. doi: 10.1242/jcs.258922

PMCID:: PMC8627560

Abstract Article

Select item 835296412.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 797970514.

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1

Xiahui Li, Shujing Li, Bowen Li, Yanan Li, Sattout Aman, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Huijian Wu

NPJ Precis Oncol. 2021; 5: 20. Published online 2021 Mar 19. doi: 10.1038/s41698-021-00158-3

PMCID:: PMC7979705

Abstract Article PDF–6.8M

Select item 795899315.

The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease

HyeIn Jang, Payton Stevens, Tianyan Gao, Emilia Galperin

FEBS J. Author manuscript; available in PMC 2021 Mar 15.

Published in final edited form as: FEBS J. 2021 Feb; 288(3): 721–739. Published online 2020 Jul 6. doi: 10.1111/febs.15450

PMCID:: PMC7958993

Abstract Article PDF–1.1M

Select item 773761016.

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy

Amelia E Ohnstad, Jose M Delgado, Brian J North, Isha Nasa, Arminja N Kettenbach, Sebastian W Schultz, Christopher J Shoemaker

EMBO J. 2020 Dec 15; 39(24): e104948. Published online 2020 Nov 23. doi: 10.15252/embj.2020104948

PMCID:: PMC7737610

Abstract Article PDF–3.7M

Select item 752544117.

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion

Hyeon Gyu Seo, Han Byeol Kim, Ji Young Yoon, Tae Hyun Kweon, Yun Soo Park, Jingu Kang, Jinwoo Jung, SeongJin Son, Eugene C. Yi, Tae Ho Lee, Won Ho Yang, Jin Won Cho

Cell Death Dis. 2020 Sep; 11(9): 815. Published online 2020 Sep 29. doi: 10.1038/s41419-020-02999-5

PMCID:: PMC7525441

Abstract Article PDF–3.7M

Select item 698120618.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9