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Select item 109596701.

Mechanistic insights into the C-type lectin receptor CLEC12A-mediated immune recognition of monosodium urate crystal

Hua Tang, Yuelong Xiao, Lei Qian, Zibin Wang, Ming Lu, Nan Yao, Ting Zhou, Fang Tian, Longxing Cao, Peng Zheng, Xianchi Dong

J Biol Chem. 2024 Mar; 300(3): 105765. Published online 2024 Feb 16. doi: 10.1016/j.jbc.2024.105765

PMCID:: PMC10959670

Abstract Article PDF–2.3M

Select item 100913772.

Behçet syndrome: The disturbed balance between anti‐ (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions

Ali Kemal Oğuz, Çağdaş Şahap Oygür, Seda Taşır, Hilal Özdağ, Mehmet Nejat Akar

Immun Inflamm Dis. 2023 Apr; 11(4): e836. Published online 2023 Apr 12. doi: 10.1002/iid3.836

PMCID:: PMC10091377

Abstract Article PDF–2.6M

Select item 100194373.

Identification of two early blood biomarkers ACHE and CLEC12A for improved risk stratification of critically ill COVID-19 patients

Simone Kattner, Jan Müller, Karolina Glanz, Mehdi Manoochehri, Caroline Sylvester, Yevhen Vainshtein, Marc Moritz Berger, Thorsten Brenner, Kai Sohn

Sci Rep. 2023; 13: 4388. Published online 2023 Mar 16. doi: 10.1038/s41598-023-30158-1

PMCID:: PMC10019437

Abstract Article PDF–4.5M

Select item 88421654.

CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system

Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629

PMCID:: PMC8842165

Abstract Article PDF–3.0M

Select item 86251505.

The Fusion of CLEC12A and MIR223HG Arises from a trans-Splicing Event in Normal and Transformed Human Cells

Bijay P. Dhungel, Geoffray Monteuuis, Caroline Giardina, Mehdi S. Tabar, Yue Feng, Cynthia Metierre, Sarah Ho, Rajini Nagarajah, Angela R. M. Fontaine, Jaynish S. Shah, Divya Gokal, Charles G. Bailey, Ulf Schmitz, John E. J. Rasko

Int J Mol Sci. 2021 Nov; 22(22): 12178. Published online 2021 Nov 10. doi: 10.3390/ijms222212178

PMCID:: PMC8625150

Abstract Article PDF–4.0M

Select item 85190346.

Exploring blast composition in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms: CD45RA and CD371 improve diagnostic value of flow cytometry through assessment of myeloblast heterogeneity and stem cell aberrancy

Afshin Shameli, Poonam Dharmani‐Khan, Joanne Luider, Iwona Auer, Meer‐Taher Shabani‐Rad

Cytometry B Clin Cytom. 2021 Sep; 100(5): 574–589. Published online 2020 Dec 24. doi: 10.1002/cyto.b.21983

PMCID:: PMC8519034

Abstract Article PDF–3.9M

Select item 85085117.

Regulation of the Expression, Oligomerisation and Signaling of the Inhibitory Receptor CLEC12A by Cysteine Residues in the Stalk Region

Julien Vitry, Guillaume Paré, Andréa Murru, Xavier Charest-Morin, Halim Maaroufi, Kenneth R. McLeish, Paul H. Naccache, Maria J. Fernandes

Int J Mol Sci. 2021 Oct; 22(19): 10207. Published online 2021 Sep 22. doi: 10.3390/ijms221910207

PMCID:: PMC8508511

Abstract Article PDF–3.3M

Select item 84570798.

Bimodal expression of potential drug target CLL‐1 (CLEC12A) on CD34+ blasts of AML patients

Lok Lam Ngai, Connie Y. Ma, Orla Maguire, An D. Do, Alberto Robert, Aaron C. Logan, Elizabeth A. Griffiths, Michael J. Nemeth, Cherie Green, Tony Pourmohamad, Bo J. van Kuijk, Alexander N. Snel, Zinia W. Kwidama, Bianca Venniker‐Punt, James Cooper, Markus G. Manz, Bjørn T. Gjertsen, Linda Smit, Gert J. Ossenkoppele, Jeroen J. W. M. Janssen, Jacqueline Cloos, Teiko Sumiyoshi

Eur J Haematol. 2021 Sep; 107(3): 343–353. Published online 2021 Jun 26. doi: 10.1111/ejh.13672

PMCID:: PMC8457079

Abstract Article PDF–925K

Select item 82568729.

The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release

Guillaume Paré, Julien Vitry, Michael L. Merchant, Myriam Vaillancourt, Andréa Murru, Yunyun Shen, Sabine Elowe, Mireille H. Lahoud, Paul H. Naccache, Kenneth R. McLeish, Maria J. Fernandes

Front Immunol. 2021; 12: 650808. Published online 2021 Jun 21. doi: 10.3389/fimmu.2021.650808

PMCID:: PMC8256872

Abstract Article PDF–7.2M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 797930111.

C-Type Lectin-Like Molecule-1 as a Biomarker for Diagnosis and Prognosis in Acute Myeloid Leukemia: A Preliminary Study

Jinghua Wang, Weida Wang, Hao Chen, Wenmin Li, Tian Huang, Weiya Zhang, Wei Ling, Peilong Lai, Yulian Wang, Suxia Geng, Minming Li, Xin Du, Jianyu Weng

Biomed Res Int. 2021; 2021: 6643948. Published online 2021 Mar 11. doi: 10.1155/2021/6643948

PMCID:: PMC7979301

Abstract Article PDF–1008K

Select item 716998312.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 586706113.

Mapping the CLEC12A expression on myeloid progenitors in normal bone marrow; implications for understanding CLEC12A‐related cancer stem cell biology

Marie Bill, Peter B. van Kooten Niekerk, Petter S. Woll, Laura Laine Herborg, Anne Stidsholt Roug, Peter Hokland, Line Nederby

J Cell Mol Med. 2018 Apr; 22(4): 2311–2318. Published online 2018 Feb 7. doi: 10.1111/jcmm.13519

PMCID:: PMC5867061

Abstract Article PDF–610K

Select item 576120614.

CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia

Jinghua Wang, Siyu Chen, Wei Xiao, Wende Li, Liang Wang, Shuo Yang, Weida Wang, Liping Xu, Shuangye Liao, Wenjian Liu, Yang Wang, Nawei Liu, Jianeng Zhang, Xiaojun Xia, Tiebang Kang, Gong Chen, Xiuyu Cai, Han Yang, Xing Zhang, Yue Lu, Penghui Zhou

J Hematol Oncol. 2018; 11: 7. Published online 2018 Jan 10. doi: 10.1186/s13045-017-0553-5

PMCID:: PMC5761206

Abstract Article PDF–3.0M

Select item 565196015.

Low CLL-1 Expression Is a Novel Adverse Predictor in 123 Patients with De Novo CD34⁺ Acute Myeloid Leukemia

Yan-Yu Wang, Wen-Lian Chen, Xiang-Qin Weng, Yan Sheng, Jing Wu, Jie Hao, Zhan-Yun Liu, Yong-Mei Zhu, Bing Chen, Shu-Min Xiong, Yu Chen, Qiu-Sheng Chen, Hui-Ping Sun, Jun-Min Li, Jin Wang

Stem Cells Dev. 2017 Oct 15; 26(20): 1460–1467. Published online 2017 Oct 15. doi: 10.1089/scd.2016.0310

PMCID:: PMC5651960

Abstract Article PDF–472K

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 529539117.

Acute myeloid leukemia stem cell markers in prognosis and targeted therapy: potential impact of BMI-1, TIM-3 and CLL-1

Noureldien H.E. Darwish, Thangirala Sudha, Kavitha Godugu, Osama Elbaz, Hasan A. Abdelghaffar, Emad E.A. Hassan, Shaker A. Mousa

Oncotarget. 2016 Sep 6; 7(36): 57811–57820. Published online 2016 Aug 5. doi: 10.18632/oncotarget.11063

PMCID:: PMC5295391

Abstract Article PDF–5.7M

Select item 509162618.

Unravelling the relevance of CLEC12A as a cancer stem cell marker in myelodysplastic syndrome

Marie Toft‐Petersen, Line Nederby, Eigil Kjeldsen, Gitte B. Kerndrup, Gordon D. Brown, Peter Hokland, Anne Stidsholt Roug

Br J Haematol. 2016 Nov; 175(3): 393–401. Published online 2016 Sep 9. doi: 10.1111/bjh.14270

PMCID:: PMC5091626

Abstract Article PDF–383K

Select item 462205519.

C-type lectin-like molecule-1 (CLL1)-targeted TRAIL augments the tumoricidal activity of granulocytes and potentiates therapeutic antibody-dependent cell-mediated cytotoxicity

Valerie R Wiersma, Marco de Bruyn, Ce Shi, Marloes JM Gooden, Maartje CA Wouters, Douwe F Samplonius, Djoke Hendriks, Hans W Nijman, Yunwei Wei, Jin Zhou, Wijnand Helfrich, Edwin Bremer

MAbs. 2015 Mar-Apr; 7(2): 321–330. Published online 2015 Mar 11. doi: 10.1080/19420862.2015.1007811

PMCID:: PMC4622055

Abstract Article PDF–954K

Select item 461721120.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

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