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Select item 106432731.

Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion

Xiaoqian Di, Yanzhi Hao, Zibo Duan, Yucong Ma, Ying Cao, Zhanwang Tan, Cuimiao Song, Xiaohua Lin

Reprod Sci. 2023 Nov; 30(11): 3273–3284. Published online 2023 Jun 6. doi: 10.1007/s43032-023-01273-1

PMCID:: PMC10643273

Abstract Article PDF–1.5M

Select item 96691162.

Rare variants in genes encoding subunits of the epithelial Na⁺ channel are associated with blood pressure and kidney function

Brandon M Blobner, Annet Kirabo, Ossama B Kashlan, Shaohu Sheng, Donna K Arnett, Lewis C Becker, Eric Boerwinkle, Jenna C Carlson, Yan Gao, Richard A Gibbs, Jiang He, Marguerite R Irvin, Sharon LR Kardia, Tanika N Kelly, Charles Kooperberg, Stephen T McGarvey, Vipin K Menon, May E Montasser, Take Naseri, Susan Redline, Alexander P Reiner, Muagututi’a S Reupena, Jennifer A Smith, Xiao Sun, Dhananjay Vaidya, Karine A Viaud-Martinez, Daniel E Weeks, Lisa R Yanek, Xiaofeng Zhu, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Ryan L Minster, Thomas R Kleyman

Hypertension. Author manuscript; available in PMC 2023 Nov 1.

Published in final edited form as: Hypertension. 2022 Nov; 79(11): 2573–2582. Published online 2022 Oct 4. doi: 10.1161/HYPERTENSIONAHA.121.18513

PMCID:: PMC9669116

Abstract Article PDF–599K

Select item 93353403.

Elevated intracellular Na⁺ and osmolarity stimulate catalytic activity of the ubiquitin ligase Nedd4-2

Avinash Persaud, Chong Jiang, Zetao Liu, George Kefalas, Wael L. Demian, Daniela Rotin

Proc Natl Acad Sci U S A. 2022 Jul 26; 119(30): e2122495119. Published online 2022 Jul 18. doi: 10.1073/pnas.2122495119

PMCID:: PMC9335340

Abstract Article PDF–2.1M

Select item 88099034.

Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer

Chunyan Cai, Yumei Zhang, Xing Peng

Bioengineered. 2021; 12(2): 9390–9400. Published online 2021 Nov 25. doi: 10.1080/21655979.2021.1978615

PMCID:: PMC8809903

Abstract Article PDF–2.9M

Select item 84771785.

HOXD9-induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial-mesenchymal transformation

Jinhai Chang, Xuguang Hu, Jinniang Nan, Xianghua Zhang, Xintian Jin

Mol Med Rep. 2021 Nov; 24(5): 819. Published online 2021 Sep 22. doi: 10.3892/mmr.2021.12459

PMCID:: PMC8477178

Abstract Article PDF–13M

Select item 82077106.

Novel SCNN1A gene splicing-site mutation causing autosomal recessive pseudohypoaldosteronism type 1 (PHA1) in two Italian patients belonging to the same small town

Gregorio Serra, Vincenzo Antona, Maria Michela D’Alessandro, Maria Cristina Maggio, Vincenzo Verde, Giovanni Corsello

Ital J Pediatr. 2021; 47: 138. Published online 2021 Jun 16. doi: 10.1186/s13052-021-01080-x

PMCID:: PMC8207710

Abstract Article PDF–1.5M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80384518.

DNA Methylation Patterns Correlate with the Expression of SCNN1A, SCNN1B, and SCNN1G (Epithelial Sodium Channel, ENaC) Genes

Silvia Pierandrei, Gessica Truglio, Fabrizio Ceci, Paola Del Porto, Sabina Maria Bruno, Stefano Castellani, Massimo Conese, Fiorentina Ascenzioni, Marco Lucarelli

Int J Mol Sci. 2021 Apr; 22(7): 3754. Published online 2021 Apr 4. doi: 10.3390/ijms22073754

PMCID:: PMC8038451

Abstract Article PDF–2.5M

Select item 78783499.

Epithelial Sodium Channel and Salt-Sensitive Hypertension

Stephanie M. Mutchler, Annet Kirabo, Thomas R. Kleyman

Hypertension. Author manuscript; available in PMC 2022 Mar 3.

Published in final edited form as: Hypertension. 2021 Mar 3; 77(3): 759–767. Published online 2021 Jan 25. doi: 10.1161/HYPERTENSIONAHA.120.14481

PMCID:: PMC7878349

Abstract Article PDF–1.0M

Select item 745028410.

Cell-specific expression of ENACα gene by FOXA1 in the glucocorticoid receptor pathway

Young Sun Chung, Hong Lan Jin, Kwang Won Jeong

Int J Immunopathol Pharmacol. 2020 Jan-Dec; 34: 2058738420946192. Published online 2020 Aug 24. doi: 10.1177/2058738420946192

PMCID:: PMC7450284

Abstract Article PDF–1.5M

Select item 710777111.

miR-95 promotes osteosarcoma growth by targeting SCNN1A

Yannan Geng, Shaorong Zhao, Yutao Jia, Gang Xia, Huiming Li, Zhao Fang, Quan Zhang, Rong Tian

Oncol Rep. 2020 May; 43(5): 1429–1436. Published online 2020 Feb 24. doi: 10.3892/or.2020.7514

PMCID:: PMC7107771

Abstract Article PDF–1.2M

Select item 701356312.

Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption

Praveen Kumar Nattramilarasu, Roland Bücker, Fábia Daniela Lobo de Sá, Anja Fromm, Oliver Nagel, In-Fah Maria Lee, Eduard Butkevych, Soraya Mousavi, Claudia Genger, Sigri Kløve, Markus M. Heimesaat, Stefan Bereswill, Michal R. Schweiger, Hans Linde Nielsen, Hanno Troeger, Jörg-Dieter Schulzke

Int J Mol Sci. 2020 Jan; 21(2): 373. Published online 2020 Jan 7. doi: 10.3390/ijms21020373

PMCID:: PMC7013563

Abstract Article PDF–4.0M

Select item 695534913.

Shear force sensing of epithelial Na⁺ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC

Fenja Knoepp, Zoe Ashley, Daniel Barth, Jan-Peter Baldin, Michael Jennings, Marina Kazantseva, Eng Leng Saw, Rajesh Katare, Diego Alvarez de la Rosa, Norbert Weissmann, Martin Fronius

Proc Natl Acad Sci U S A. 2020 Jan 7; 117(1): 717–726. Published online 2019 Dec 23. doi: 10.1073/pnas.1911243117

PMCID:: PMC6955349

Abstract Article PDF–1.5M

Select item 619785714.

Structure of the human epithelial sodium channel by cryo-electron microscopy

Sigrid Noreng, Arpita Bharadwaj, Richard Posert, Craig Yoshioka, Isabelle Baconguis

eLife. 2018; 7: e39340. Published online 2018 Sep 25. doi: 10.7554/eLife.39340

PMCID:: PMC6197857

Abstract Article PDF–4.4M

Select item 602898615.

Epithelial Na⁺ Channel: Reciprocal Control by COMMD10 and Nedd4-2

Adam W. Ware, Tanya T. Cheung, Sahib Rasulov, Ezra Burstein, Fiona J. McDonald

Front Physiol. 2018; 9: 793. Published online 2018 Jun 26. doi: 10.3389/fphys.2018.00793

PMCID:: PMC6028986

Abstract Article PDF–4.0M

Select item 598649216.

Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure

Yoon Jung Yang, Jihye Kim, Chang Keun Kwock

Nutrients. 2018 May; 10(5): 612. Published online 2018 May 14. doi: 10.3390/nu10050612

PMCID:: PMC5986492

Abstract Article PDF–250K

Select item 586153717.

Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study

Xiaoying Gu, Dongfeng Gu, Jiang He, Dabeeru C Rao, James E Hixson, Jichun Chen, Jianxin Li, Jianfeng Huang, Xigui Wu, Treva K Rice, Lawrence C Shimmin, Tanika N Kelly

Am J Hypertens. 2018 Jan; 31(2): 205–211. Published online 2017 Sep 19. doi: 10.1093/ajh/hpx169

PMCID:: PMC5861537

Abstract Article PDF–377K

Select item 584613818.

Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel

Mahmoud Shobair, Konstantin I. Popov, Yan L. Dang, Hong He, M. Jackson Stutts, Nikolay V. Dokholyan

J Biol Chem. 2018 Mar 9; 293(10): 3675–3684. Published online 2018 Jan 22. doi: 10.1074/jbc.RA117.000604

PMCID:: PMC5846138

Abstract Article PDF–1.4M

Select item 566127519.

A Missense Mutation in the Extracellular Domain of αENaC Causes Liddle Syndrome

Mahdi Salih, Ivan Gautschi, Miguel X. van Bemmelen, Michael Di Benedetto, Alice S. Brooks, Dorien Lugtenberg, Laurent Schild, Ewout J. Hoorn

J Am Soc Nephrol. 2017 Nov; 28(11): 3291–3299. Published online 2017 Jul 14. doi: 10.1681/ASN.2016111163

PMCID:: PMC5661275

Abstract Article

Select item 549522520.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

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