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Select item 103808521.

The Sigma-1 Receptor Is a Novel Target for Improving Cold Preservation in Rodent Kidney Transplants

Adam Hosszu, Akos R. Toth, Tamas Lakat, Ganna Stepanova, Zsuzsanna Antal, Laszlo J. Wagner, Attila J. Szabo, Andrea Fekete

Int J Mol Sci. 2023 Jul; 24(14): 11630. Published online 2023 Jul 19. doi: 10.3390/ijms241411630

PMCID:: PMC10380852

Abstract Article PDF–3.4M

Select item 102580072.

Sig1R activates extracellular matrix-induced bladder cancer cell proliferation and angiogenesis by combing β-integrin

Feng Zhao, Tianli Yang, Liuhua Zhou, Rongfei Li, Jingyu Liu, Jun Zhao, Ruipeng Jia

Aging (Albany NY) 2023 May 31; 15(10): 4182–4201. Published online 2023 May 16. doi: 10.18632/aging.204721

PMCID:: PMC10258007

Abstract Article PDF–3.0M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101786364.

SIGMAR1 Confers Innate Resilience against Neurodegeneration

Simon Couly, Yuko Yasui, Tsung-Ping Su

Int J Mol Sci. 2023 May; 24(9): 7767. Published online 2023 Apr 24. doi: 10.3390/ijms24097767

PMCID:: PMC10178636

Abstract Article PDF–1.5M

Select item 100944505.

Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands

Gianmarco Pascarella, Lorenzo Antonelli, Daniele Narzi, Theo Battista, Annarita Fiorillo, Gianni Colotti, Leonardo Guidoni, Veronica Morea, Andrea Ilari

Int J Mol Sci. 2023 Apr; 24(7): 6367. Published online 2023 Mar 28. doi: 10.3390/ijms24076367

PMCID:: PMC10094450

Abstract Article PDF–4.7M

Select item 99249076.

TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy

Aida Marcotti, Jorge Fernández-Trillo, Alejandro González, Marta Vizcaíno-Escoto, Pablo Ros-Arlanzón, Luz Romero, José Miguel Vela, Ana Gomis, Félix Viana, Elvira de la Peña

Brain. 2023 Feb; 146(2): 475–491. Published online 2022 Jul 24. doi: 10.1093/brain/awac273

PMCID:: PMC9924907

Abstract Article PDF–1.1M

Select item 99162677.

Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection

Véronik Lachance, Sara-Maude Bélanger, Célia Hay, Victoria Le Corvec, Vina Banouvong, Mathieu Lapalme, Khadija Tarmoun, Guillaume Beaucaire, Marc P. Lussier, Saïd Kourrich

Int J Mol Sci. 2023 Feb; 24(3): 1971. Published online 2023 Jan 19. doi: 10.3390/ijms24031971

PMCID:: PMC9916267

Abstract Article PDF–4.2M

Select item 99162168.

Sigma-1 Receptor Signaling: In Search of New Therapeutic Alternatives for Cardiovascular and Renal Diseases

Francisco Javier Munguia-Galaviz, Alejandra Guillermina Miranda-Diaz, Miguel Alejandro Cardenas-Sosa, Raquel Echavarria

Int J Mol Sci. 2023 Feb; 24(3): 1997. Published online 2023 Jan 19. doi: 10.3390/ijms24031997

PMCID:: PMC9916216

Abstract Article PDF–3.7M

Select item 98519739.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 952364510.

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

Jun-yi Zhu, Guanglei Wang, Xiaohu Huang, Hangnoh Lee, Jin-Gu Lee, Penghua Yang, Joyce van de Leemput, Weiliang Huang, Maureen A. Kane, Peixin Yang, Zhe Han

Commun Biol. 2022; 5: 1039. Published online 2022 Sep 30. doi: 10.1038/s42003-022-03986-6

PMCID:: PMC9523645

Abstract Article PDF–3.9M

Select item 948193311.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 932161812.

Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms

Zifen Xu, Yushuang Lei, Huan Qin, Shiyao Zhang, Ping Li, Kai Yao

Int J Mol Sci. 2022 Jul; 23(14): 7572. Published online 2022 Jul 8. doi: 10.3390/ijms23147572

PMCID:: PMC9321618

Abstract Article PDF–2.5M

Select item 926020813.

Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2

Xiaoan Wei, Zeyu Zheng, Zhenhua Feng, Lin Zheng, Siyue Tao, Bingjie Zheng, Bao Huang, Xuyang Zhang, Junhui Liu, Yilei Chen, Wentian Zong, Zhi Shan, Shunwu Fan, Jian Chen, Fengdong Zhao

EMBO Mol Med. 2022 Jul; 14(7): e15373. Published online 2022 May 25. doi: 10.15252/emmm.202115373

PMCID:: PMC9260208

Abstract Article PDF–3.5M

Select item 923162314.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 901471115.

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

Fabian Hosp, Hannes Vossfeldt, Matthias Heinig, Djordje Vasiljevic, Anup Arumughan, Emanuel Wyler, Genetic and Environmental Risk for Alzheimer’s Disease (GERAD1) Consortium, Markus Landthaler, Norbert Hubner, Erich E. Wanker, Lars Lannfelt, Martin Ingelsson, Maciej Lalowski, Aaron Voigt, Matthias Selbach

Cell Rep. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Cell Rep. 2015 May 19; 11(7): 1134–1146. Published online 2015 May 7. doi: 10.1016/j.celrep.2015.04.030

PMCID:: PMC9014711

Abstract Article PDF–2.2M

Select item 856100116.

The Sigma-1 receptor is an ER-localized type II membrane protein

Neeraj Sharma, Chaitanya Patel, Marina Shenkman, Amit Kessel, Nir Ben-Tal, Gerardo Z. Lederkremer

J Biol Chem. 2021 Nov; 297(5): 101299. Published online 2021 Oct 11. doi: 10.1016/j.jbc.2021.101299

PMCID:: PMC8561001

Abstract Article PDF–2.6M

Select item 846739217.

Sigma-1 Receptor Agonists Acting on Aquaporin-Mediated H₂O₂ Permeability: New Tools for Counteracting Oxidative Stress

Giorgia Pellavio, Giacomo Rossino, Giulia Gastaldi, Daniela Rossi, Pasquale Linciano, Simona Collina, Umberto Laforenza

Int J Mol Sci. 2021 Sep; 22(18): 9790. Published online 2021 Sep 10. doi: 10.3390/ijms22189790

PMCID:: PMC8467392

Abstract Article PDF–2.6M

Select item 822056918.

Involvement of Sigma Receptor-1 in Lymphatic Endothelial Barrier Integrity and Bioenergetic Regulation

Zeinab Y. Motawe, Salma S. Abdelmaboud, Jerome W. Breslin

Lymphat Res Biol. June 2021; 19(3): 231–239. Published online 2021 Jun 15. doi: 10.1089/lrb.2020.0060

PMCID:: PMC8220569

Abstract Article PDF–505K

Select item 816503019.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 811286620.

The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

Vladimir Zhemkov, Jonathon A Ditlev, Wan-Ru Lee, Mikaela Wilson, Jen Liou, Michael K Rosen, Ilya Bezprozvanny

eLife. 2021; 10: e65192. Published online 2021 May 11. doi: 10.7554/eLife.65192

PMCID:: PMC8112866

Abstract Article PDF–6.2M

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