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Select item 110397221.

Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster

Ting Zhou, Jing Pan, Kai Xu, Chenghui Yan, Jing Yuan, Haixu Song, Yaling Han

Sci Rep. 2024; 14: 9274. Published online 2024 Apr 23. doi: 10.1038/s41598-024-59975-8

PMCID:: PMC11039722

Abstract Article PDF–13M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106436473.

The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT)

Gavin Pharaoh, Varun Kamat, Sricharan Kannan, Rudolph S. Stuppard, Jeremy Whitson, Miguel Martín-Pérez, Wei-Jun Qian, Michael J. MacCoss, Judit Villén, Peter Rabinovitch, Matthew D. Campbell, Ian R. Sweet, David J. Marcinek

GeroScience. 2023 Dec; 45(6): 3529–3548. Published online 2023 Jul 18. doi: 10.1007/s11357-023-00861-y

PMCID:: PMC10643647

Abstract Article PDF–1.8M

Select item 104568524.

ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy

Michael J. Bround, Julian R. Havens, Allen J. York, Michelle A. Sargent, Jason Karch, Jeffery D. Molkentin

Sci Adv. 2023 Aug; 9(34): eadi2767. Published online 2023 Aug 25. doi: 10.1126/sciadv.adi2767

PMCID:: PMC10456852

Abstract Article PDF–1.2M

Select item 102086455.

Mitochondrial protein import clogging as a mechanism of disease

Liam P Coyne, Xiaowen Wang, Jiyao Song, Ebbing de Jong, Karin Schneider, Paul T Massa, Frank A Middleton, Thomas Becker, Xin Jie Chen

eLife. 2023; 12: e84330. Published online 2023 May 2. doi: 10.7554/eLife.84330

PMCID:: PMC10208645

Abstract Article PDF–12M

Select item 96466756.

Mitochondrial uncouplers induce proton leak by activating AAC and UCP1

Ambre M. Bertholet, Andrew M. Natale, Paola Bisignano, Junji Suzuki, Andriy Fedorenko, James Hamilton, Tatiana Brustovetsky, Lawrence Kazak, Ryan Garrity, Edward T. Chouchani, Nickolay Brustovetsky, Michael Grabe, Yuriy Kirichok

Nature. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Nature. 2022 Jun; 606(7912): 180–187. Published online 2022 May 25. doi: 10.1038/s41586-022-04747-5

PMCID:: PMC9646675

Abstract Article PDF–2.9M

Select item 96038607.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 94819338.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 94116829.

Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice

Patrick M. Schaefer, Jessica Huang, Arrienne Butic, Caroline Perry, Tal Yardeni, Wendy Tan, Ryan Morrow, Joseph A. Baur, Douglas C. Wallace

Mol Metab. 2022 Oct; 64: 101560. Published online 2022 Aug 6. doi: 10.1016/j.molmet.2022.101560

PMCID:: PMC9411682

Abstract Article PDF–2.7M

Select item 844633810.

ACAA2 is a Ligand-dependent Coactivator for Thyroid Hormone Receptor β1

Wesley Wang, Dolena Ledee

Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 Oct 22.

Published in final edited form as: Biochem Biophys Res Commun. 2021 Oct 22; 576: 15–21. Published online 2021 Aug 28. doi: 10.1016/j.bbrc.2021.08.073

PMCID:: PMC8446338

Abstract Article PDF–830K

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 741599112.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 685857013.

The ATP/ADP translocase drives mitophagy independent of nucleotide exchange

Atsushi Hoshino, Wei–jia Wang, Shogo Wada, Chris McDermott-Roe, Chantell S. Evans, Bridget Gosis, Michael P. Morley, Komal S. Rathi, Jian Li, Kristina Li, Steven Yang, Meagen J. McMannus, Caitlyn Bowman, Prasanth Potluri, Michael Levin, Scott Damrauer, Douglas C. Wallace, Erika L. F. Holzbaur, Zoltan Arany

Nature. Author manuscript; available in PMC 2020 Apr 16.

Published in final edited form as: Nature. 2019 Nov; 575(7782): 375–379. Published online 2019 Oct 16. doi: 10.1038/s41586-019-1667-4

PMCID:: PMC6858570

Abstract Article PDF–3.2M

Select item 671751314.

Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy

Meagan J. McManus, Martin Picard, Hsiao-Wen Chen, Hans J. De Haas, Prasanth Potluri, Jeremy Leipzig, Atif Towheed, Alessia Angelin, Partho Sengupta, Ryan M. Morrow, Brett A. Kauffman, Marc Vermulst, Jagat Narula, Douglas C. Wallace

Cell Metab. Author manuscript; available in PMC 2019 Aug 31.

Published in final edited form as: Cell Metab. 2019 Jan 8; 29(1): 78–90.e5. Published online 2018 Aug 30. doi: 10.1016/j.cmet.2018.08.002

PMCID:: PMC6717513

Abstract Article PDF–1.3M

Select item 671350815.

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

Jason Karch, Michael J. Bround, Hadi Khalil, Michelle A. Sargent, Nadina Latchman, Naohiro Terada, Pablo M. Peixoto, Jeffery D. Molkentin

Sci Adv. 2019 Aug; 5(8): eaaw4597. Published online 2019 Aug 28. doi: 10.1126/sciadv.aaw4597

PMCID:: PMC6713508

Abstract Article PDF–1.4M

Select item 670346216.

The Interaction between Cell Adhesion Molecule L1, Matrix Metalloproteinase 14, and Adenine Nucleotide Translocator at the Plasma Membrane Regulates L1-Mediated Neurite Outgrowth of Murine Cerebellar Neurons

Gabriele Loers, Tatjana Makhina, Ute Bork, Andrea Dörner, Melitta Schachner, Ralf Kleene

J Neurosci. 2012 Mar 14; 32(11): 3917–3930. doi: 10.1523/JNEUROSCI.6165-11.2012

PMCID:: PMC6703462

Abstract Article PDF–1.6M

Select item 666262917.

H⁺ Transport is an Integral Function of the Mitochondrial ADP/ATP Carrier

Ambre M. Bertholet, Edward T. Chouchani, Lawrence Kazak, Alessia Angelin, Andriy Fedorenko, Jonathan Z. Long, Sara Vidoni, Ryan Garrity, Joonseok Cho, Naohiro Terada, Douglas C. Wallace, Bruce M. Spiegelman, Yuriy Kirichok

Nature. Author manuscript; available in PMC 2020 Jan 24.

Published in final edited form as: Nature. 2019 Jul; 571(7766): 515–520. Published online 2019 Jul 24. doi: 10.1038/s41586-019-1400-3

PMCID:: PMC6662629

Abstract Article PDF–4.5M

Select item 645951018.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194