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Select item 109544791.

Structural insights into the HDAC4–MEF2A–DNA complex and its implication in long-range transcriptional regulation

Shuyan Dai, Liang Guo, Raja Dey, Ming Guo, Xiangqian Zhang, Darren Bates, Justin Cayford, Longying Jiang, Hudie Wei, Zhuchu Chen, Ye Zhang, Lin Chen, Yongheng Chen

Nucleic Acids Res. 2024 Mar 21; 52(5): 2711–2723. Published online 2024 Jan 28. doi: 10.1093/nar/gkae036

PMCID:: PMC10954479

Abstract Article PDF–3.1M

Select item 109366262.

Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer

Li Xia, Tiejian Nie, Fangfang Lu, Lu Huang, Xiaolong Shi, Dongni Ren, Jianjun Lu, Xiaobin Li, Tuo Xu, Bozhou Cui, Qing Wang, Guodong Gao, Qian Yang

Autophagy. 2024; 20(3): 505–524. Published online 2023 Sep 29. doi: 10.1080/15548627.2023.2259735

PMCID:: PMC10936626

Abstract Article PDF–4.8M

Select item 103338843.

Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions

Johanna Kliche, Dimitriya Hristoforova Garvanska, Leandro Simonetti, Dilip Badgujar, Doreen Dobritzsch, Jakob Nilsson, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2023 Jul; 19(7): e11164. Published online 2023 May 23. doi: 10.15252/msb.202211164

PMCID:: PMC10333884

Abstract Article PDF–5.0M

Select item 95765264.

HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation

Ya Gao, Yangdan Liu, Danning Zheng, Chiakang Ho, Dongsheng Wen, Jiaming Sun, Lu Huang, Yuxin Liu, Qingfeng Li, Yifan Zhang

Int J Biol Sci. 2022; 18(15): 5724–5739. Published online 2022 Sep 11. doi: 10.7150/ijbs.76140

PMCID:: PMC9576526

Abstract Article PDF–4.9M

Select item 93664465.

MiRNA-615-3p Alleviates Oxidative Stress Injury of Human Cardiomyocytes Via PI3K/Akt Signaling by Targeting MEF2A

Dongying Zhang, Gang Zhang, Kun Yu, Xiwen Zhang, Aixia Jiang

Anatol J Cardiol. 2022 May; 26(5): 373–381. Published online 2022 May 1. doi: 10.5152/AnatolJCardiol.2021.901

PMCID:: PMC9366446

Abstract Article PDF–6.1M

Select item 88288956.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 85664737.

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim

Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6

PMCID:: PMC8566473

Abstract Article PDF–2.7M

Select item 83628908.

A PGE₂-MEF2A axis enables context-dependent control of inflammatory gene expression

Francesco Cilenti, Giulia Barbiera, Nicoletta Caronni, Dario Iodice, Elisa Montaldo, Simona Barresi, Eleonora Lusito, Vincenzo Cuzzola, Francesco Maria Vittoria, Luca Mezzanzanica, Paolo Miotto, Pietro Di Lucia, Dejan Lazarevic, Daniela Maria Cirillo, Matteo Iannacone, Marco Genua, Renato Ostuni

Immunity. 2021 Aug 10; 54(8): 1665–1682.e14. doi: 10.1016/j.immuni.2021.05.016

PMCID:: PMC8362890

Abstract Article

Select item 82203919.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 811621011.

MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression

Qing Xiao, Yaqi Gan, Yimin Li, Lili Fan, Jiaqi Liu, Pengyan Lu, Jiaxin Liu, Aoao Chen, Guang Shu, Gang Yin

Oncogene. 2021; 40(19): 3364–3377. Published online 2021 Apr 16. doi: 10.1038/s41388-021-01774-w

PMCID:: PMC8116210

Abstract Article PDF–7.7M

Select item 805077512.

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner

Lauriane Vélot, Frédéric Lessard, Félix-Antoine Bérubé-Simard, Christophe Tav, Bertrand Neveu, Valentine Teyssier, Imène Boudaoud, Ugo Dionne, Noémie Lavoie, Steve Bilodeau, Frédéric Pouliot, Nicolas Bisson

Mol Cell Proteomics. 2021; 20: 100064. Published online 2021 Feb 26. doi: 10.1016/j.mcpro.2021.100064

PMCID:: PMC8050775

Abstract Article PDF–3.6M

Select item 789359413.

MEF2A-mediated lncRNA HCP5 Inhibits Gastric Cancer Progression via MiR-106b-5p/p21 Axis

Weiwei Chen, Kundong Zhang, Yuhan Yang, Zengya Guo, Xiaofeng Wang, Buwei Teng, Qian Zhao, Chen Huang, Zhengjun Qiu

Int J Biol Sci. 2021; 17(2): 623–634. Published online 2021 Jan 16. doi: 10.7150/ijbs.55020

PMCID:: PMC7893594

Abstract Article PDF–2.6M

Select item 745625114.

Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction

Lin Liu, Chenyun Ding, Tingting Fu, Zhenhua Feng, Ji-Eun Lee, Liwei Xiao, Zhisheng Xu, Yujing Yin, Qiqi Guo, Zongchao Sun, Wanping Sun, Yan Mao, Likun Yang, Zheng Zhou, Danxia Zhou, Leilei Xu, Zezhang Zhu, Yong Qiu, Kai Ge, Zhenji Gan

J Clin Invest. 2020 Sep 1; 130(9): 4710–4725. Published online 2020 Aug 4. doi: 10.1172/JCI136155

PMCID:: PMC7456251

Abstract Article PDF–9.2M

Select item 738709615.

miR-144-3p inhibits the proliferation, migration and angiogenesis of multiple myeloma cells by targeting myocyte enhancer factor 2A

Fei Tian, Huihan Wang, Huanxin Ma, Yuan Zhong, Aijun Liao

Int J Mol Med. 2020 Sep; 46(3): 1155–1165. Published online 2020 Jul 6. doi: 10.3892/ijmm.2020.4670

PMCID:: PMC7387096

Abstract Article PDF–1.7M

Select item 716998316.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 659482017.

Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway

Benrong Liu, Lin Wang, Wenyi Jiang, Yujuan Xiong, Lihua Pang, Yun Zhong, Chongyu Zhang, Wenchao Ou, Chaowei Tian, Xiaohui Chen, Shi-Ming Liu

Aging (Albany NY) 2019 Jun 15; 11(11): 3768–3784. Published online 2019 Jun 10. doi: 10.18632/aging.102015

PMCID:: PMC6594820

Abstract Article PDF–4.5M

Select item 642375718.

MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells

Yujuan Xiong, Lin Wang, Wenyi Jiang, Lihua Pang, Weihua Liu, Aiqun Li, Yun Zhong, Wenchao Ou, Benrong Liu, Shi-ming Liu

BMC Mol Biol. 2019; 20: 8. Published online 2019 Mar 18. doi: 10.1186/s12867-019-0125-z

PMCID:: PMC6423757

Abstract Article PDF–3.8M

Select item 619387219.

Rearrangement of the Protein Phosphatase 1 Interactome during Heart Failure Progression

David Y. Chiang, Katherina M. Alsina, Eleonora Corradini, Martin Fitzpatrick, Li Ni, Satadru K. Lahiri, Julia Reynolds, Xiaolu Pan, Larry Scott, Jr, Albert J.R. Heck, Xander H.T. Wehrens

Circulation. Author manuscript; available in PMC 2019 Oct 9.

Published in final edited form as: Circulation. 2018 Oct 9; 138(15): 1569–1581. doi: 10.1161/CIRCULATIONAHA.118.034361

PMCID:: PMC6193872

Abstract Article PDF–2.4M

Select item 605967020.

MEF2-activated long non-coding RNA PCGEM1 promotes cell proliferation in hormone-refractory prostate cancer through downregulation of miR-148a

Shibao Zhang, Zongwu Li, Longyang Zhang, Zhonghua Xu

Mol Med Rep. 2018 Jul; 18(1): 202–208. Published online 2018 May 4. doi: 10.3892/mmr.2018.8977

PMCID:: PMC6059670

Abstract Article PDF–1.0M

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