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Select item 107575851.

Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans

Simon Kraler, Carolina Balbi, Daria Vdovenko, Tetiana Lapikova-Bryhinska, Giovanni G Camici, Luca Liberale, Nicole Bonetti, Candela Diaz Canestro, Fabienne Burger, Aline Roth, Federico Carbone, Giuseppe Vassalli, François Mach, Shalender Bhasin, Florian A Wenzl, Olivier Muller, Lorenz Räber, Christian M Matter, Fabrizio Montecucco, Thomas F Lüscher, Alexander Akhmedov

Cardiovasc Res. 2023 Dec; 119(17): 2729–2742. Published online 2023 Sep 23. doi: 10.1093/cvr/cvad153

PMCID:: PMC10757585

Abstract Article PDF–7.2M

Select item 107393012.

The regulatory effect of growth differentiation factor 11 on different cells

Yingchun Shao, Ting Liu, Xiaobo Wen, Renshuai Zhang, Xinlin Liu, Dongming Xing

Front Immunol. 2023; 14: 1323670. Published online 2023 Dec 8. doi: 10.3389/fimmu.2023.1323670

PMCID:: PMC10739301

Abstract Article PDF–3.6M

Select item 103625893.

GDF-11 downregulates placental human chorionic gonadotropin expression by activating SMAD2/3 signaling

Ze Wu, Lingling Zhang, Yuanyuan Jia, Beibei Bi, Lanlan Fang, Jung-Chien Cheng

Cell Commun Signal. 2023; 21: 179. Published online 2023 Jul 21. doi: 10.1186/s12964-023-01201-5

PMCID:: PMC10362589

Abstract Article PDF–3.3M

Select item 95287604.

GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/β‐catenin and ALK5/SMAD2/3 pathways

Jan Frohlich, Kristina Kovacovicova, Marco Raffaele, Tereza Virglova, Eliska Cizkova, Jan Kucera, Julie Bienertova‐Vasku, Martin Wabitsch, Marion Peyrou, Francesca Bonomini, Rita Rezzani, George N. Chaldakov, Anton B. Tonchev, Michelino Di Rosa, Nicolas Blavet, Vaclav Hejret, Manlio Vinciguerra

Cell Prolif. 2022 Oct; 55(10): e13310. Published online 2022 Aug 3. doi: 10.1111/cpr.13310

PMCID:: PMC9528760

Abstract Article PDF–3.7M

Select item 92021975.

GDF-11 promotes human trophoblast cell invasion by increasing ID2-mediated MMP2 expression

Ze Wu, Lanlan Fang, Sizhu Yang, Yibo Gao, Zhen Wang, Qingxue Meng, Xuan Dang, Ying-Pu Sun, Jung-Chien Cheng

Cell Commun Signal. 2022; 20: 89. Published online 2022 Jun 15. doi: 10.1186/s12964-022-00899-z

PMCID:: PMC9202197

Abstract Article PDF–4.5M

Select item 90743696.

Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension

Guiling Xiang, Kelu Ying, Pan Jiang, Mengping Jia, Yipeng Sun, Shanqun Li, Xiaodan Wu, Shengyu Hao

Skelet Muscle. 2022; 12: 10. Published online 2022 May 6. doi: 10.1186/s13395-022-00292-x

PMCID:: PMC9074369

Abstract Article PDF–9.1M

Select item 88578107.

Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells

Qiongqiong Jia, Boqun Liu, Xuan Dang, Yanjie Guo, Xiaoyu Han, Tinglin Song, Jung-Chien Cheng, Lanlan Fang

Reprod Biol Endocrinol. 2022; 20: 34. Published online 2022 Feb 19. doi: 10.1186/s12958-022-00912-7

PMCID:: PMC8857810

Abstract Article PDF–3.6M

Select item 84879298.

Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11

Thomas A. Ravenscroft, Jennifer B. Phillips, Elizabeth Fieg, Sameer S. Bajikar, Judy Peirce, Jeremy Wegner, Alia A. Luna, Eric J. Fox, Yi-Lin Yan, Jill A. Rosenfeld, Jonathan Zirin, Oguz Kanca, Undiagnosed Diseases Network, Paul J. Benke, Eric S. Cameron, Vincent Strehlow, Konrad Platzer, Rami Abou Jamra, Chiara Klöckner, Matthew Osmond, Thomas Licata, Samantha Rojas, David Dyment, Josephine S.C. Chong, Sharyn Lincoln, Joan M. Stoler, John H. Postlethwait, Michael F. Wangler, Shinya Yamamoto, Joel Krier, Monte Westerfield, Hugo J. Bellen

Genet Med. Author manuscript; available in PMC 2021 Dec 10.

Published in final edited form as: Genet Med. 2021 Oct; 23(10): 1889–1900. Published online 2021 Jun 10. doi: 10.1038/s41436-021-01216-8

PMCID:: PMC8487929

Abstract Article PDF–1.1M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 805529010.

Longitudinal Relationship Between Growth Differentiation Factor 11 and Physical Activity in Chronic Obstructive Pulmonary Disease

Rie Tanaka, Akira Koarai, Mitsuhiro Yamada, Naoya Fujino, Tomohiro Ichikawa, Tadahisa Numakura, Katsuhiro Onodera, Yorihiko Kyogoku, Tsutomu Tamada, Motohiko Miura, Yoshiaki Minakata, Masakazu Ichinose, Hisatoshi Sugiura

Int J Chron Obstruct Pulmon Dis. 2021; 16: 999–1006. Published online 2021 Apr 15. doi: 10.2147/COPD.S301690

PMCID:: PMC8055290

Abstract Article PDF–1.6M

Select item 793560611.

PPARα Targeting GDF11 Inhibits Vascular Endothelial Cell Senescence in an Atherosclerosis Model

Fangfang Dou, Beiling Wu, Jiulin Chen, Te Liu, Zhihua Yu, Chuan Chen

Oxid Med Cell Longev. 2021; 2021: 2045259. Published online 2021 Feb 25. doi: 10.1155/2021/2045259

PMCID:: PMC7935606

Abstract Article PDF–3.2M

Select item 785814112.

Serum growth differentiation factor 11 is closely related to metabolic syndrome in a Chinese cohort

Bo Xu, Yan Huang, Rong Zhang, Mengyang Tang, Zhen He, Li Jin, Yicen Zong, Cheng Hu, Weiping Jia

J Diabetes Investig. 2021 Feb; 12(2): 234–243. Published online 2020 Aug 5. doi: 10.1111/jdi.13337

PMCID:: PMC7858141

Abstract Article PDF–674K

Select item 773328013.

GDF11 contributes to hepatic HAMP inhibition through SMURF1-mediated BMP-SMAD signalling suppression

Zheng Fang, Zesen Zhu, Haihang Zhang, Yuanliang Peng, Jin Liu, Hongyu Lu, Jiang Li, Long Liang, Shenghua Xia, Qiguang Wang, Bin Fu, Kunlu Wu, Lingqiang Zhang, Yelena Ginzburg, Jing Liu, Huiyong Chen

Br J Haematol. Author manuscript; available in PMC 2020 Dec 12.

Published in final edited form as: Br J Haematol. 2020 Jan; 188(2): 321–331. Published online 2019 Aug 16. doi: 10.1111/bjh.16156

PMCID:: PMC7733280

Abstract Article PDF–735K

Select item 773056114.

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

Michael Dussiot, Thiago T Maciel, Aurélie Fricot, Céline Chartier, Olivier Negre, Joel Veiga, Damien Grapton, Etienne Paubelle, Emmanuel Payen, Yves Beuzard, Philippe Leboulch, Jean-Antoine Ribeil, Jean-Benoit Arlet, Francine Coté, Geneviève Courtois, Yelena Z Ginzburg, Thomas O Daniel, Rajesh Chopra, Victoria Sung, Olivier Hermine, Ivan C Moura

Nat Med. Author manuscript; available in PMC 2020 Dec 11.

Published in final edited form as: Nat Med. 2014 Apr; 20(4): 398–407. Published online 2014 Mar 23. doi: 10.1038/nm.3468

PMCID:: PMC7730561

Abstract Article PDF–3.0M

Select item 765520215.

GDF11 induces mild hepatic fibrosis independent of metabolic health

Jan Frohlich, Kristina Kovacovicova, Tommaso Mazza, Maria R. Emma, Daniela Cabibi, Michelangelo Foti, Cyril Sobolewski, Jude A. Oben, Marion Peyrou, Francesc Villarroya, Maurizio Soresi, Rita Rezzani, Melchiorre Cervello, Francesca Bonomini, Anna Alisi, Manlio Vinciguerra

Aging (Albany NY) 2020 Oct 31; 12(20): 20024–20046. Published online 2020 Oct 28. doi: 10.18632/aging.104182

PMCID:: PMC7655202

Abstract Article PDF–1.8M

Select item 757626916.

Endogenous GDF11 regulates odontogenic differentiation of dental pulp stem cells

Xingying Qi, Qingyue Xiao, Rui Sheng, Shuang Jiang, Quan Yuan, Weiqing Liu

J Cell Mol Med. 2020 Oct; 24(19): 11457–11464. Published online 2020 Aug 26. doi: 10.1111/jcmm.15754

PMCID:: PMC7576269

Abstract Article PDF–875K

Select item 743221017.

RAP-011 Rescues the Disease Phenotype in a Cellular Model of Congenital Dyserythropoietic Anemia Type II by Inhibiting the SMAD2-3 Pathway

Gianluca De Rosa, Immacolata Andolfo, Roberta Marra, Francesco Manna, Barbara Eleni Rosato, Achille Iolascon, Roberta Russo

Int J Mol Sci. 2020 Aug; 21(15): 5577. Published online 2020 Aug 4. doi: 10.3390/ijms21155577

PMCID:: PMC7432210

Abstract Article PDF–1.6M

Select item 728255718.

Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells

Zhen Dai, Guangqi Song, Asha Balakrishnan, Taihua Yang, Qinggong Yuan, Selina Möbus, Anna-Carina Weiss, Martin Bentler, Jimin Zhu, Xuemei Jiang, Xizhong Shen, Heike Bantel, Elmar Jaeckel, Andreas Kispert, Arndt Vogel, Anna Saborowski, Hildegard Büning, Michael Manns, Tobias Cantz, Michael Ott, Amar Deep Sharma

Gut. 2020 Jun; 69(6): 1104–1115. Published online 2019 Nov 25. doi: 10.1136/gutjnl-2019-318812

Correction in:: Gut. 2022 May; 71(5): e6.

PMCID:: PMC7282557

Abstract Article PDF–9.9M

Select item 719618519.

Hypoxia-induced miR-1260b regulates vascular smooth muscle cell proliferation by targeting GDF11

Minhyeong Seong, Hara Kang

BMB Rep. 2020 Apr 30; 53(4): 206–211. Published online 2020 Apr 30. doi: 10.5483/BMBRep.2020.53.4.136

PMCID:: PMC7196185

Abstract Article PDF–8.3M

Select item 677813720.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

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