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Select item 109045731.

Association of tyrosine hydroxylase 01 (TH01) microsatellite and insulin gene (INS) variable number of tandem repeat (VNTR) with type 2 diabetes and fasting insulin secretion in Mexican population

J. Berumen, L. Orozco, H. Gallardo-Rincón, E. Juárez-Torres, E. Barrera, M. Cruz-López, R. E. Benuto, E. Ramos-Martinez, M. Marin-Madina, A. Alvarado-Silva, A. Valladares-Salgado, J. J. Peralta-Romero, H. García-Ortiz, L. A. Martinez-Juarez, A. Montoya, D. A. Alvarez-Hernández, J. Alegre-Diaz, P. Kuri-Morales, R. Tapia-Conyer

J Endocrinol Invest. 2024; 47(3): 571–583. Published online 2023 Aug 25. doi: 10.1007/s40618-023-02175-4

PMCID:: PMC10904573

Abstract Article PDF–2.2M

Select item 87487672.

Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

María Teresa Bueno-Carrasco, Jorge Cuéllar, Marte I. Flydal, César Santiago, Trond-André Kråkenes, Rune Kleppe, José R. López-Blanco, Miguel Marcilla, Knut Teigen, Sara Alvira, Pablo Chacón, Aurora Martinez, José M. Valpuesta

Nat Commun. 2022; 13: 74. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27657-y

PMCID:: PMC8748767

Abstract Article PDF–3.6M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75409964.

Neuroblastoma patient‐derived cultures are enriched for a mesenchymal gene signature and reflect individual drug response

Esther Hee, Meng Kang Wong, Sheng Hui Tan, Zhang’E Choo, Chik Hong Kuick, Sharon Ling, Min Hwee Yong, Sudhanshi Jain, Derrick W. Q. Lian, Eileen H. Q. Ng, Yvonne F. L. Yong, Mee Hiong Ren, Nurfarhanah Syed Sulaiman, Sharon Y. Y. Low, Yong Wei Chua, Muhammad Fahmy Syed, Tony K. H. Lim, Shui Yen Soh, Prasad Iyer, Michaela S. F. Seng, Joyce C. M. Lam, Enrica E. K. Tan, Mei Yoke Chan, Ah Moy Tan, Yong Chen, Zhixiong Chen, Kenneth T. E. Chang, Amos Hong Pheng Loh

Cancer Sci. 2020 Oct; 111(10): 3780–3792. Published online 2020 Aug 28. doi: 10.1111/cas.14610

PMCID:: PMC7540996

Abstract Article PDF–1.1M

Select item 75202945.

β‐Methylphenylalanine exerts neuroprotective effects in a Parkinson's disease model by protecting against tyrosine hydroxylase depletion

Yan Feng, Jianjun Ma, Lipin Yuan

J Cell Mol Med. 2020 Sep; 24(17): 9871–9880. Published online 2020 Jul 22. doi: 10.1111/jcmm.15571

PMCID:: PMC7520294

Abstract Article PDF–1.5M

Select item 74377666.

Dopa-responsive dystonia caused by tyrosine hydroxylase deficiency: Three cases report and literature review

Han-Yu Dong, Jun-Yan Feng, Xiao-Jing Yue, Ling Shan, Fei-Yong Jia

Medicine (Baltimore) 2020 Aug 14; 99(33): e21753. Published online 2020 Aug 14. doi: 10.1097/MD.0000000000021753

PMCID:: PMC7437766

Abstract Article PDF–239K

Select item 74164987.

Conserved Upstream Regulatory Regions in Mammalian Tyrosine Hydroxylase

Meng Wang, Lilah Fones, John W. Cave

Mol Neurobiol. Author manuscript; available in PMC 2020 Aug 10.

Published in final edited form as: Mol Neurobiol. 2018 Sep; 55(9): 7340–7351. Published online 2018 Feb 5. doi: 10.1007/s12035-018-0936-9

PMCID:: PMC7416498

Abstract Article PDF–1.7M

Select item 72268128.

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

Marissa M. Minor, F. Blaine Hollinger, Adrienne L. McNees, Sung Yun Jung, Antrix Jain, Joseph M. Hyser, Karl-Dimiter Bissig, Betty L. Slagle

Cells. 2020 Apr; 9(4): 834. Published online 2020 Mar 30. doi: 10.3390/cells9040834

PMCID:: PMC7226812

Abstract Article PDF–2.3M

Select item 72146489.

Stimulation of L‐type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells

Malvin Jefri, Scott Bell, Huashan Peng, Nuwan Hettige, Gilles Maussion, Vincent Soubannier, Hanrong Wu, Heika Silveira, Jean‐Francois Theroux, Luc Moquin, Xin Zhang, Zahia Aouabed, Jeyashree Krishnan, Liam A. O'Leary, Lilit Antonyan, Ying Zhang, Vincent McCarty, Naguib Mechawar, Alain Gratton, Andreas Schuppert, Thomas M. Durcan, Edward A. Fon, Carl Ernst

Stem Cells Transl Med. 2020 Jun; 9(6): 697–712. Published online 2020 Mar 10. doi: 10.1002/sctm.18-0180

PMCID:: PMC7214648

Abstract Article PDF–6.1M

Select item 716998310.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 675752411.

A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis

Ruth G. Perez, Jack C. Waymire, Eva Lin, Jen J. Liu, Fengli Guo, Michael J. Zigmond

J Neurosci. 2002 Apr 15; 22(8): 3090–3099. doi: 10.1523/JNEUROSCI.22-08-03090.2002

Correction in:: J Neurosci. 2002 Oct 15; 22(20): 9142.

PMCID:: PMC6757524

Abstract Article PDF–370K

Select item 649980812.

Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis

Shraddha Pai, Peipei Li, Bryan Killinger, Lee Marshall, Peixin Jia, Ji Liao, Arturas Petronis, Piroska E. Szabó, Viviane Labrie

Nat Commun. 2019; 10: 2046. Published online 2019 May 3. doi: 10.1038/s41467-019-09786-7

PMCID:: PMC6499808

Abstract Article PDF–1.2M

Select item 647685913.

Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells

Dennis Paliga, Fabian Raudzus, Stephen H. Leppla, Rolf Heumann, Sebastian Neumann

Mol Neurobiol. 2019; 56(5): 3393–3403. Published online 2018 Aug 18. doi: 10.1007/s12035-018-1311-6

PMCID:: PMC6476859

Abstract Article PDF–1.1M

Select item 581061514.

Dopa-Responsive Dystonia in Han Chinese Patients: One Novel Heterozygous Mutation in GTP Cyclohydrolase 1 (GCH1) and Three Known Mutations in TH

Kunfang Yang, Rongrong Yin, Xiaoping Lan, Yuanfeng Zhang, Hongyi Cheng, Simei Wang, Chunmei Wang, Yanfen Lu, Jiaming Xi, Qin Lu, Jianjun Huang, Yucai Chen

Med Sci Monit. 2018; 24: 751–757. Published online 2018 Feb 6. doi: 10.12659/MSM.907288

PMCID:: PMC5810615

Abstract Article PDF–573K

Select item 557292215.

Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules

Ana Jorge-Finnigan, Rune Kleppe, Kunwar Jung-KC, Ming Ying, Michael Marie, Ivan Rios-Mondragon, Michael F. Salvatore, Jaakko Saraste, Aurora Martinez

J Biol Chem. 2017 Aug 25; 292(34): 14092–14107. Published online 2017 Jun 21. doi: 10.1074/jbc.M116.762344

PMCID:: PMC5572922

Abstract Article PDF–4.0M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366