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Select item 111585121.

ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array‐based comparative genomic hybridization

Takaya Ishihara, Hitoshi Tsuda, Akiko Hotta, Ken‐ichi Kozaki, Akira Yoshida, Jaeduk Yoshimura Noh, Koichi Ito, Issei Imoto, Johji Inazawa

Cancer Sci. 2008 Oct; 99(10): 1940–1949. Published online 2008 Oct 17. doi: 10.1111/j.1349-7006.2008.00900.x

PMCID:: PMC11158512

Abstract Article PDF–539K

Select item 111094832.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 110227193.

Myofibrillogenesis Regulator‐1 Regulates the Ubiquitin Lysosomal Pathway of Notch3 Intracellular Domain Through E3 Ubiquitin‐Protein Ligase Itchy Homolog in the Metastasis of Non‐Small Cell Lung Cancer

Wenxia Zhao, Yang Li, Hanzeng Cheng, Mengyan Wang, Zhishuo Zhang, Meilian Cai, Cong Zhao, Xiaoming Xi, Xiaojun Zhao, Wuli Zhao, Yajun Yang, Rongguang Shao

Adv Sci (Weinh) 2024 Apr; 11(15): 2306472. Published online 2024 Feb 11. doi: 10.1002/advs.202306472

PMCID:: PMC11022719

Abstract Article PDF–6.1M

Select item 110067474.

The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation

Max Zachrisson Totland, Lars Mørland Knudsen, Nikoline Lander Rasmussen, Yasufumi Omori, Vigdis Sørensen, Vilde C. Wivestad Elster, Jakob Mørkved Stenersen, Mathias Larsen, Caroline Lunder Jensen, Anna A. Zickfeldt Lade, Emilie Bruusgaard, Sebastian Basing, Kushtrim Kryeziu, Andreas Brech, Trond Aasen, Ragnhild A. Lothe, Edward Leithe

Cell Mol Life Sci. 2024 Dec; 81(1): 171. Published online 2024 Apr 10. doi: 10.1007/s00018-024-05165-8

PMCID:: PMC11006747

Abstract Article PDF–10M

Select item 109457075.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 109361666.

Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity

Yifan Wang, L. Robert Hollingsworth, Lamba Omar Sangaré, Tatiana C. Paredes-Santos, Shruthi Krishnamurthy, Bennett H. Penn, Hao Wu, Jeroen P. J. Saeij

mBio. 2024 Mar; 15(3): e03302-23. Published online 2024 Feb 20. doi: 10.1128/mbio.03302-23

PMCID:: PMC10936166

Abstract Article PDF–2.2M

Select item 107869087.

The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis

James Holloway, Aidan Seeley, Neville Cobbe, Richard C. Turkington, Daniel B. Longley, Emma Evergren

Cell Death Dis. 2024 Jan; 15(1): 40. Published online 2024 Jan 12. doi: 10.1038/s41419-023-06417-4

PMCID:: PMC10786908

Abstract Article PDF–5.9M

Select item 106436748.

UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis

Christophe Le Clorennec, Divya Subramonian, Yuchen Huo, Peter E. Zage

Cell Death Dis. 2023 Nov; 14(11): 739. Published online 2023 Nov 13. doi: 10.1038/s41419-023-06252-7

PMCID:: PMC10643674

Abstract Article PDF–10M

Select item 103338849.

Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions

Johanna Kliche, Dimitriya Hristoforova Garvanska, Leandro Simonetti, Dilip Badgujar, Doreen Dobritzsch, Jakob Nilsson, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2023 Jul; 19(7): e11164. Published online 2023 May 23. doi: 10.15252/msb.202211164

PMCID:: PMC10333884

Abstract Article PDF–5.0M

Select item 1023742210.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1017409111.

Cytoplasmic YAP1‐mediated ESCRT‐III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer

Yan Guo, Yuqing Cui, Yangyang Li, Xiaoying Jin, Dandan Wang, Mengxia Lei, Fengzhi Chen, Yali Liu, Jinwen Xu, Guanyu Yao, Guangchun Zeng, Xuesong Chen

Cancer Commun (Lond) 2023 May; 43(5): 582–612. Published online 2023 Apr 2. doi: 10.1002/cac2.12417

PMCID:: PMC10174091

Abstract Article PDF–22M

Select item 1015993312.

The ubiquitin ligase Itch skews light zone selection in germinal centers

Lindsay Renshaw, Peter Kim, Macaul Crici, Hossein Fazelinia, Lynn Spruce, Paula Oliver, Emily Moser

J Immunol. Author manuscript; available in PMC 2024 May 15.

Published in final edited form as: J Immunol. 2023 May 15; 210(10): 1473–1481. doi: 10.4049/jimmunol.2200824

PMCID:: PMC10159933

Abstract Article PDF–1.8M

Select item 1013280513.

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Filip Mihalič, Leandro Simonetti, Girolamo Giudice, Marie Rubin Sander, Richard Lindqvist, Marie Berit Akpiroro Peters, Caroline Benz, Eszter Kassa, Dilip Badgujar, Raviteja Inturi, Muhammad Ali, Izabella Krystkowiak, Ahmed Sayadi, Eva Andersson, Hanna Aronsson, Ola Söderberg, Doreen Dobritzsch, Evangelia Petsalaki, Anna K. Överby, Per Jemth, Norman E. Davey, Ylva Ivarsson

Nat Commun. 2023; 14: 2409. Published online 2023 Apr 26. doi: 10.1038/s41467-023-38015-5

PMCID:: PMC10132805

Abstract Article PDF–4.2M

Select item 995044714.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 994427015.

MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation

Yuan Wang, Zhenchang Jia, Chenxi Liang, Yunfei He, Min Cong, Qiuyao Wu, Pu Tian, Dasa He, Xiang Miao, Beibei Sun, Yue Yin, Chao Peng, Feng Yao, Da Fu, Yajun Liang, Peiyuan Zhang, Hua Xiong, Guohong Hu

Cell Discov. 2023; 9: 20. Published online 2023 Feb 21. doi: 10.1038/s41421-022-00507-x

PMCID:: PMC9944270

Abstract Article PDF–3.2M

Select item 980752616.

ROS inhibits RORα degradation by decreasing its arginine methylation in liver cancer

Hyuntae Im, Hee‐ji Baek, Eunbi Yang, Kyeongkyu Kim, Se Kyu Oh, Jung‐Shin Lee, Hyunkyung Kim, Ji Min Lee

Cancer Sci. 2023 Jan; 114(1): 187–200. Published online 2022 Oct 1. doi: 10.1111/cas.15595

PMCID:: PMC9807526

Abstract Article PDF–7.6M

Select item 976969817.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 943470518.

Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma

David Romano, Lucía García-Gutiérrez, Nourhan Aboud, David J Duffy, Keith T Flaherty, Dennie T Frederick, Walter Kolch, David Matallanas

Life Sci Alliance. 2022 Oct; 5(10): e202201445. Published online 2022 Aug 29. doi: 10.26508/lsa.202201445

PMCID:: PMC9434705

Abstract Article PDF–2.0M

Select item 935720319.

Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance

Zhentao Yang, Yan Wang, Sixue Liu, Weixian Deng, Shirley H. Lomeli, Gatien Moriceau, James Wohlschlegel, Marco Piva, Roger S. Lo

Cancer Discov. 2022 Aug 5; 12(8): 1942–1959. Published online 2022 May 31. doi: 10.1158/2159-8290.CD-21-1463

PMCID:: PMC9357203

Abstract Article PDF–6.8M

Select item 934857620.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

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Mutant p53 depletion effect on MDA-468.shp53 breast tumor cell line
Mutant p53 depletion effect on MDA-468.shp53 breast tumor cell line
Accession: GDS4096

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TGFβ1 effect on HMEC-TR mammary epithelial cell line deficient in Smad4 or TIF1γ...
TGFβ1 effect on HMEC-TR mammary epithelial cell line deficient in Smad4 or TIF1γ
Accession: GDS4071

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