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Select item 93485761.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 92844272.

JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport

Ricardo Celestino, José B. Gama, Artur F. Castro-Rodrigues, Daniel J. Barbosa, Helder Rocha, Ennio A. d’Amico, Andrea Musacchio, Ana Xavier Carvalho, João H. Morais-Cabral, Reto Gassmann

J Cell Biol. 2022 Aug 1; 221(8): e202110057. Published online 2022 Jul 13. doi: 10.1083/jcb.202110057

PMCID:: PMC9284427

Abstract Article PDF–7.6M

Select item 92626143.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 91063034.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 88970225.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 87489716.

JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton

N. M. Rafiq, L. L. Lyons, S. Gowrishankar, P. De Camilli, S. M. Ferguson

Commun Biol. 2022; 5: 5. Published online 2022 Jan 10. doi: 10.1038/s42003-021-02945-x

PMCID:: PMC8748971

Abstract Article PDF–2.2M

Select item 83515407.

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

Swetha Gowrishankar, Lila Lyons, Nisha Mohd Rafiq, Agnes Roczniak-Ferguson, Pietro De Camilli, Shawn M. Ferguson

Mol Biol Cell. 2021 May 15; 32(11): 1094–1103. doi: 10.1091/mbc.E20-06-0382

PMCID:: PMC8351540

Abstract Article PDF–1.8M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81422819.

Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway

Sydney E. Cason, Peter J. Carman, Claire Van Duyne, Juliet Goldsmith, Roberto Dominguez, Erika L.F. Holzbaur

J Cell Biol. 2021 Jul 5; 220(7): e202010179. Published online 2021 May 20. doi: 10.1083/jcb.202010179

PMCID:: PMC8142281

Abstract Article PDF–9.8M

Select item 761580410.

Molecular mechanism of dynein-dynactin complex assembly by LIS1

Kashish Singh, Clinton K. Lau, Giulia Manigrasso, José B. Gama, Reto Gassmann, Andrew P. Carter

Science. Author manuscript; available in PMC 2024 Apr 4.

Published in final edited form as: Science. 2024 Mar 29; 383(6690): eadk8544. Published online 2024 Mar 29. doi: 10.1126/science.adk8544

PMCID:: PMC7615804

Abstract Article PDF–3.4M

Select item 723748611.

SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation

Peiyuan Zhang, Yingjie Liu, Cheng Lian, Xuan Cao, Yuan Wang, Xiaoxun Li, Min Cong, Pu Tian, Xue Zhang, Gang Wei, Tong Liu, Guohong Hu

Nat Commun. 2020; 11: 2487. Published online 2020 May 19. doi: 10.1038/s41467-020-16051-9

PMCID:: PMC7237486

Abstract Article PDF–1.7M

Select item 716998312.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 710960013.

The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing

Chen Wu, Yaqi Cui, Xiuhua Liu, Feng Zhang, Lin-Yu Lu, Xiaochun Yu

J Mol Cell Biol. 2020 Feb; 12(2): 113–124. Published online 2019 Jun 1. doi: 10.1093/jmcb/mjz045

PMCID:: PMC7109600

Abstract Article PDF–1.3M

Select item 683182714.

Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif

Fernando Vilela, Christophe Velours, Mélanie Chenon, Magali Aumont-Nicaise, Valérie Campanacci, Aurélien Thureau, Olena Pylypenko, Jessica Andreani, Paola Llinas, Julie Ménétrey

Sci Rep. 2019; 9: 16036. Published online 2019 Nov 5. doi: 10.1038/s41598-019-52537-3

PMCID:: PMC6831827

Abstract Article PDF–3.8M

Select item 672468715.

Arf6, JIP3, and dynein shape and mediate macropinocytosis

Chad D. Williamson, Julie G. Donaldson

Mol Biol Cell. 2019 Jun 1; 30(12): 1477–1489. doi: 10.1091/mbc.E19-01-0022

PMCID:: PMC6724687

Abstract Article PDF–3.7M

Select item 662262616.

JIP3 Mediates TrkB Axonal Anterograde Transport and Enhances BDNF Signaling by Directly Bridging TrkB with Kinesin-1

Shu-Hong Huang, Shan Duan, Tao Sun, Jue Wang, Ling Zhao, Zhao Geng, Jing Yan, Hai-Ji Sun, Zhe-Yu Chen

J Neurosci. 2011 Jul 20; 31(29): 10602–10614. doi: 10.1523/JNEUROSCI.0436-11.2011

PMCID:: PMC6622626

Abstract Article PDF–3.3M

Select item 636954017.

De Novo Variants in MAPK8IP3 Cause Intellectual Disability with Variable Brain Anomalies

Konrad Platzer, Heinrich Sticht, Stacey L. Edwards, William Allen, Kaitlin M. Angione, Maria T. Bonati, Campbell Brasington, Megan T. Cho, Laurie A. Demmer, Tzipora Falik-Zaccai, Candace N. Gamble, Yorck Hellenbroich, Maria Iascone, Fernando Kok, Sonal Mahida, Hanna Mandel, Thorsten Marquardt, Kirsty McWalter, Bianca Panis, Alexander Pepler, Hailey Pinz, Luiza Ramos, Deepali N. Shinde, Constance Smith-Hicks, Alexander P.A. Stegmann, Petra Stöbe, Constance T.R.M. Stumpel, Carolyn Wilson, Johannes R. Lemke, Nataliya Di Donato, Kenneth G. Miller, Rami Jamra

Am J Hum Genet. 2019 Feb 7; 104(2): 203–212. Published online 2019 Jan 3. doi: 10.1016/j.ajhg.2018.12.008

PMCID:: PMC6369540

Abstract Article PDF–1.4M

Select item 553161118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549522519.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 503652720.

Panorama of ancient metazoan macromolecular complexes

Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Nature. Author manuscript; available in PMC 2016 Sep 26.

Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877

PMCID:: PMC5036527

Abstract Article PDF–4.7M

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