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Select item 113045501.

BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma

Yuliang Feng, Liuyang Cai, Martin Pook, Feng Liu, Chao-Hui Chang, Mai Abdel Mouti, Reshma Nibhani, Stefania Militi, James Dunford, Martin Philpott, Yanbo Fan, Guo-Chang Fan, Qi Liu, Jun Qi, Cheng Wang, Wanzi Hong, Hannah Morgan, Mingyang Wang, Sakthivel Sadayappan, Anil G. Jegga, Udo Oppermann, Yigang Wang, Wei Huang, Lei Jiang, Siim Pauklin

Gastroenterology. Author manuscript; available in PMC 2024 Aug 7.

Published in final edited form as: Gastroenterology. 2024 Jan; 166(1): 139–154. Published online 2023 Sep 21. doi: 10.1053/j.gastro.2023.09.021

PMCID:: PMC11304550

Abstract Article PDF–3.2M

Select item 111318352.

Galectin-1 suppresses α2(I) collagen through Smad3 in renal epithelial cells

K. Okano, K. Uchida, K. Nitta, T. Hayashida

Cell Mol Life Sci. 2008 Oct; 65(20): 3304–3311. Published online 2008 Sep 15. doi: 10.1007/s00018-008-8294-9

PMCID:: PMC11131835

Abstract Article PDF–719K

Select item 111264513.

Exosomes derived from adipose tissue-derived stem cells alleviated H₂O₂-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway

Yan Li, Yujie Xiao, Yage Shang, Chaolei Xu, Chao Han, Dahai Hu, Juntao Han, Hongtao Wang

Cell Biol Toxicol. 2024; 40(1): 39. Published online 2024 May 25. doi: 10.1007/s10565-024-09881-6

PMCID:: PMC11126451

Abstract Article PDF–6.5M

Select item 111156444.

Calcium signaling-induced Smad3 nuclear accumulation induces acetylcholinesterase transcription in apoptotic HeLa cells

Wei Gao, Hui Zhu, Jing-Ya Zhang, Xue-Jun Zhang

Cell Mol Life Sci. 2009 Jul; 66(13): 2181–2193. Published online 2009 May 26. doi: 10.1007/s00018-009-0037-z

PMCID:: PMC11115644

Abstract Article PDF–599K

Select item 110769925.

MAP4K4 and WT1 mediate SOX6‐induced cellular senescence by synergistically activating the ATF2–TGFβ2–Smad2/3 signaling pathway in cervical cancer

Han Zheng, Mingchen Liu, Shu Shi, Hongxin Huang, Xingwen Yang, Ziheng Luo, Yarong Song, Qiang Xu, Tingting Li, Lixiang Xue, Fengmin Lu, Jie Wang

Mol Oncol. 2024 May; 18(5): 1327–1346. Published online 2024 Feb 21. doi: 10.1002/1878-0261.13613

PMCID:: PMC11076992

Abstract Article PDF–3.9M

Select item 109635916.

Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC

Heng Ni, Song Tang, Guang Lu, Yuequn Niu, Jinming Xu, Honghe Zhang, Jian Hu, Han-Ming Shen, Yihua Wu, Dajing Xia

Life Sci Alliance. 2024 Jun; 7(6): e202302408. Published online 2024 Mar 25. doi: 10.26508/lsa.202302408

PMCID:: PMC10963591

Abstract Article PDF–4.4M

Select item 109445997.

Single-cell transcriptomic sequencing data reveal aberrant DNA methylation in SMAD3 promoter region in tumor-associated fibroblasts affecting molecular mechanism of radiosensitivity in non-small cell lung cancer

Fushi Han, Shuzhen Chen, Kangwei Zhang, Kunming Zhang, Meng Wang, Peijun Wang

J Transl Med. 2024; 22: 288. Published online 2024 Mar 16. doi: 10.1186/s12967-024-05057-2

PMCID:: PMC10944599

Abstract Article PDF–9.9M

Select item 109428258.

DUSP22 Ameliorates Endothelial-to-Mesenchymal Transition in HUVECs through Smad2/3 and MAPK Signaling Pathways

Lu Chen, Hongyu Su, Zekai Tao, Cui Liang, Zhongzhao Liu, Yiming Dong, Peipei Zheng, Yuan Liu

Cardiovasc Ther. 2024; 2024: 5583961. Published online 2024 Mar 8. doi: 10.1155/2024/5583961

PMCID:: PMC10942825

Abstract Article PDF–4.1M

Select item 108216019.

The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation

Mitsuyoshi Motizuki, Takashi Yokoyama, Masao Saitoh, Keiji Miyazawa

J Biol Chem. 2024 Jan; 300(1): 105580. Published online 2023 Dec 21. doi: 10.1016/j.jbc.2023.105580

PMCID:: PMC10821601

Abstract Article PDF–5.5M

Select item 1072449710.

A novel pathogenic variant located just upstream of the C‐terminal Ser423‐X‐Ser425 phosphorylation motif in SMAD3 causing Loeys–Dietz syndrome

Satoshi Ishii, Takayuki Fujiwara, Hiroki Yagi, Norifumi Takeda, Masahiko Ando, Haruo Yamauchi, Ryo Inuzuka, Yuki Taniguchi, Masaru Hatano, Issei Komuro

Mol Genet Genomic Med. 2023 Dec; 11(12): e2257. Published online 2023 Oct 20. doi: 10.1002/mgg3.2257

PMCID:: PMC10724497

Abstract Article PDF–7.6M

Select item 1071934411.

Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion

Jung Yun Kim, Nayoung Hong, Sehyeon Park, Seok Won Ham, Eun-Jung Kim, Sung-Ok Kim, Junseok Jang, Yoonji Kim, Jun-Kyum Kim, Sung-Chan Kim, Jong-Whi Park, Hyunggee Kim

Cell Death Dis. 2023 Dec; 14(12): 822. Published online 2023 Dec 13. doi: 10.1038/s41419-023-06356-0

PMCID:: PMC10719344

Abstract Article PDF–12M

Select item 1049230612.

circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer

Zhongjie Zhao, Wenbo Yang, Rui Kong, Yangyang Zhang, Le Li, Zengfu Song, Hongze Chen, Yan Luo, Tao Zhang, Chundong Cheng, Guanqun Li, Danxi Liu, Xinglong Geng, Hua Chen, Yongwei Wang, Shangha Pan, Jisheng Hu, Bei Sun

Mol Cancer. 2023; 22: 152. Published online 2023 Sep 9. doi: 10.1186/s12943-023-01847-2

PMCID:: PMC10492306

Abstract Article PDF–16M

Select item 1036258913.

GDF-11 downregulates placental human chorionic gonadotropin expression by activating SMAD2/3 signaling

Ze Wu, Lingling Zhang, Yuanyuan Jia, Beibei Bi, Lanlan Fang, Jung-Chien Cheng

Cell Commun Signal. 2023; 21: 179. Published online 2023 Jul 21. doi: 10.1186/s12964-023-01201-5

PMCID:: PMC10362589

Abstract Article PDF–3.3M

Select item 1033388414.

Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions

Johanna Kliche, Dimitriya Hristoforova Garvanska, Leandro Simonetti, Dilip Badgujar, Doreen Dobritzsch, Jakob Nilsson, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2023 Jul; 19(7): e11164. Published online 2023 May 23. doi: 10.15252/msb.202211164

PMCID:: PMC10333884

Abstract Article PDF–5.0M

Select item 1023742215.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1008570816.

SMAD3 promotes expression and activity of the androgen receptor in prostate cancer

Hee-Young Jeon, Majid Pornour, Hyunju Ryu, Sudeep Khadka, Rui Xu, Jihyun Jang, Deqiang Li, Hegang Chen, Arif Hussain, Ladan Fazli, Martin Gleave, Xuesen Dong, Furong Huang, Qianben Wang, Christopher Barbieri, Jianfei Qi

Nucleic Acids Res. 2023 Apr 11; 51(6): 2655–2670. Published online 2023 Feb 2. doi: 10.1093/nar/gkad043

PMCID:: PMC10085708

Abstract Article PDF–5.5M

Select item 1000616717.

3D collagen migration patterns reveal a SMAD3-dependent and TGF-β1-independent mechanism of recruitment for tumour-associated fibroblasts in lung adenocarcinoma

Yago Juste-Lanas, Natalia Díaz-Valdivia, Alejandro Llorente, Rafael Ikemori, Alejandro Bernardo, Marselina Arshakyan, Carlos Borau, Josep Ramírez, José Carlos Ruffinelli, Ernest Nadal, Noemí Reguart, José M. García-Aznar, Jordi Alcaraz

Br J Cancer. 2023 Apr 6; 128(6): 967–981. Published online 2022 Dec 26. doi: 10.1038/s41416-022-02093-x

PMCID:: PMC10006167

Abstract Article PDF–4.7M

Select item 999017818.

Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein

Zhi-yuan Zhang, Cui-yu Ju, Liu-zheng Wu, Han Yan, Wen-bin Hong, Hang-zi Chen, Peng-bo Yang, Bao-Rui Wang, Tong Gou, Xiao-yan Chen, Zhi-hong Jiang, Wei-jia Wang, Tianwei Lin, Fu-nan Li, Qiao Wu

Cell Chem Biol. 2023 Mar 16; 30(3): 261–277.e8. Published online 2023 Mar 7. doi: 10.1016/j.chembiol.2023.02.004

PMCID:: PMC9990178

Abstract Article PDF–6.9M

Select item 998835019.

Knockdown of LINC00511 enhances radiosensitivity of lung adenocarcinoma via regulating miR-497-5p/SMAD3

Chongxin Li, Yanyan Fu, Yongmei He, Nan Huang, Jun Yue, Yi Miao, Jialing Lv, Youchuan Xiao, Ruoyu Deng, Chao Zhang, Meifang Huang

Cancer Biol Ther. 2023; 24(1): 2165896. Published online 2023 Mar 2. doi: 10.1080/15384047.2023.2165896

PMCID:: PMC9988350

Abstract Article PDF–6.8M

Select item 998681520.

Mouse endothelial OTUD1 promotes angiotensin II‐induced vascular remodeling by deubiquitinating SMAD3

Zhuqi Huang, Sirui Shen, Mengyang Wang, Weixin Li, Gaojun Wu, Weijian Huang, Wu Luo, Guang Liang

EMBO Rep. 2023 Mar; 24(3): e56135. Published online 2022 Dec 29. doi: 10.15252/embr.202256135

PMCID:: PMC9986815

Abstract Article PDF–5.1M

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