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Select item 104151391.

CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins

Mengqian Chen, Jing Li, Li Zhang, Lili Wang, Chen Cheng, Hao Ji, Serena Altilia, Xiaokai Ding, Guoshuai Cai, Diego Altomare, Michael Shtutman, Stephanie D Byrum, Samuel G Mackintosh, Alexey Feoktistov, Nataliya Soshnikova, Vladislav A Mogila, Victor Tatarskiy, Maksim Erokhin, Darya Chetverina, Angga Prawira, Yi Ni, Stephan Urban, Campbell McInnes, Eugenia V Broude, Igor B Roninson

Nucleic Acids Res. 2023 Aug 11; 51(14): 7288–7313. Published online 2023 Jun 28. doi: 10.1093/nar/gkad538

PMCID:: PMC10415139

Abstract Article PDF–11M

Select item 95668902.

CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF

Marius V. Dannappel, Danxi Zhu, Xin Sun, Hui Kheng Chua, Marle Poppelaars, Monica Suehiro, Subash Khadka, Terry C.C. Lim Kam Sian, Dhanya Sooraj, Melissa Loi, Hugh Gao, Daniel Croagh, Roger J. Daly, Pouya Faridi, Thomas G. Boyer, Ron Firestein

J Clin Invest. 2022 Oct 17; 132(20): e158593. Published online 2022 Oct 17. doi: 10.1172/JCI158593

PMCID:: PMC9566890

Abstract Article PDF–9.1M

Select item 91197363.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 90337024.

Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis

Lili Fan, Han Lei, Ying Lin, Zhengwei Zhou, Juanni Li, Anqi Wu, Guang Shu, Sébastien Roger, Gang Yin

Cell Mol Life Sci. 2022 May; 79(5): 254. Published online 2022 Apr 22. doi: 10.1007/s00018-022-04250-0

PMCID:: PMC9033702

Abstract Article PDF–8.3M

Select item 85181655.

Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma

Xiaopeng Cai, Jingwen Deng, Jiaming zhou, Huiqiang Cai, Zhi Chen

BMC Gastroenterol. 2021; 21: 377. Published online 2021 Oct 14. doi: 10.1186/s12876-021-01962-8

PMCID:: PMC8518165

Abstract Article PDF–4.1M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81080937.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 80407378.

A novel variant of CDK19 causes a severe neurodevelopmental disorder with infantile spasms

Shenghai Yang, Weishi Yu, Qian Chen, Xiaodong Wang

Cold Spring Harb Mol Case Stud. 2021 Apr; 7(2): a006082. doi: 10.1101/mcs.a006082

PMCID:: PMC8040737

Abstract Article PDF–2.8M

Select item 74327559.

CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC

Finn-Ole Paulsen, Christian Idel, Julika Ribbat-Idel, Patrick Kuppler, Luise Klapper, Dirk Rades, Karl-Ludwig Bruchhage, Barbara Wollenberg, Johannes Brägelmann, Sven Perner, Anne Offermann

Int J Mol Sci. 2020 Aug; 21(15): 5508. Published online 2020 Jul 31. doi: 10.3390/ijms21155508

PMCID:: PMC7432755

Abstract Article PDF–4.0M

Select item 742732710.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 735459911.

Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection

Molly Butler, Nunya Chotiwan, Connie D. Brewster, James E. DiLisio, David F. Ackart, Brendan K. Podell, Randall J. Basaraba, Rushika Perera, Sandra L. Quackenbush, Joel Rovnak

Viruses. 2020 Jun; 12(6): 654. Published online 2020 Jun 17. doi: 10.3390/v12060654

PMCID:: PMC7354599

Abstract Article PDF–3.0M

Select item 721248112.

De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy

Hyung-lok Chung, Xiao Mao, Hua Wang, Ye-Jin Park, Paul C. Marcogliese, Jill A. Rosenfeld, Lindsay C. Burrage, Pengfei Liu, David R. Murdock, Shinya Yamamoto, Michael F. Wangler, Undiagnosed Diseases Network, Hsiao-Tuan Chao, Hongyu Long, Li Feng, Carlos A. Bacino, Hugo J. Bellen, Bo Xiao

Am J Hum Genet. 2020 May 7; 106(5): 717–725. Published online 2020 Apr 23. doi: 10.1016/j.ajhg.2020.04.001

PMCID:: PMC7212481

Abstract Article PDF–2.8M

Select item 668811513.

HIV Transcription Is Independent of Mediator Kinases

Daniele C. Cary, Mona Rheinberger, Ajda Rojc, B. Matija Peterlin

AIDS Res Hum Retroviruses. 2019 Aug 1; 35(8): 710–717. Published online 2019 Aug 1. doi: 10.1089/aid.2019.0039

PMCID:: PMC6688115

Abstract Article PDF–314K

Select item 660256714.

Regulatory functions of the Mediator kinases CDK8 and CDK19

Charli B. Fant, Dylan J. Taatjes

Transcription. 2019; 10(2): 76–90. Published online 2018 Dec 26. doi: 10.1080/21541264.2018.1556915

PMCID:: PMC6602567

Abstract Article PDF–1.5M

Select item 655243215.

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression

Jung-Sik Kim, Xiaoyuan He, Jie Liu, Zhijun Duan, Taeyeon Kim, Julia Gerard, Brian Kim, Manoj M. Pillai, William S. Lane, William S. Noble, Bogdan Budnik, Todd Waldman

J Biol Chem. 2019 May 31; 294(22): 8760–8772. Published online 2019 Apr 22. doi: 10.1074/jbc.RA119.007832

PMCID:: PMC6552432

Abstract Article PDF–3.5M

Select item 637714816.

The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7

Kerstin Köhler, Luis Sanchez-Pulido, Verena Höfer, Anika Marko, Chris P. Ponting, Ambrosius P. Snijders, Regina Feederle, Aloys Schepers, Dominik Boos

PLoS Biol. 2019 Jan; 17(1): e2006767. Published online 2019 Jan 29. doi: 10.1371/journal.pbio.2006767

PMCID:: PMC6377148

Abstract Article PDF–4.1M

Select item 588013917.

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

Min Ju Park, Hailian Shen, Jason M. Spaeth, Jaana H. Tolvanen, Courtney Failor, Jennifer F. Knudtson, Jessica McLaughlin, Sunil K. Halder, Qiwei Yang, Serdar E. Bulun, Ayman Al-Hendy, Robert S. Schenken, Lauri A. Aaltonen, Thomas G. Boyer

J Biol Chem. 2018 Mar 30; 293(13): 4870–4882. Published online 2018 Feb 13. doi: 10.1074/jbc.RA118.001725

PMCID:: PMC5880139

Abstract Article PDF–2.4M

Select item 583915818.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 561729919.

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

Mengqian Chen, Jiaxin Liang, Hao Ji, Zhengguan Yang, Serena Altilia, Bing Hu, Adam Schronce, Martina S. J. McDermott, Gary P. Schools, Chang-uk Lim, David Oliver, Michael S. Shtutman, Tao Lu, George R. Stark, Donald C. Porter, Eugenia V. Broude, Igor B. Roninson

Proc Natl Acad Sci U S A. 2017 Sep 19; 114(38): 10208–10213. Published online 2017 Aug 30. doi: 10.1073/pnas.1710467114

PMCID:: PMC5617299

Abstract Article PDF–1.1M

Select item 553161120.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

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