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Select item 109122831.

Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer

Shuyu Mao, Chong Xie, Yufeng Liu, Ye Zhao, Mengxia Li, Han Gao, Yue Xiao, Yongkang Zou, Zhiguo Zheng, Ya Gao, Juan Xie, Bing Tian, Liangyan Wang, Yuejin Hua, Hong Xu

Cell Mol Life Sci. 2024 Dec; 81(1): 113. Published online 2024 Mar 4. doi: 10.1007/s00018-023-05086-y

PMCID:: PMC10912283

Abstract Article PDF–4.6M

Select item 107787682.

Back-Up Base Excision DNA Repair in Human Cells Deficient in the Major AP Endonuclease, APE1

Daria V. Kim, Evgeniia A. Diatlova, Timofey D. Zharkov, Vasily S. Melentyev, Anna V. Yudkina, Anton V. Endutkin, Dmitry O. Zharkov

Int J Mol Sci. 2024 Jan; 25(1): 64. Published online 2023 Dec 20. doi: 10.3390/ijms25010064

PMCID:: PMC10778768

Abstract Article PDF–2.0M

Select item 107492803.

In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer

M. Mijit, E. Kpenu, N.N. Chowdhury, S. Gampala, R. Wireman, S. Liu, O. Babb, M.M. Georgiadis, J. Wan, M.L. Fishel, M.R. Kelley

Redox Biol. 2024 Feb; 69: 102977. Published online 2023 Dec 1. doi: 10.1016/j.redox.2023.102977

PMCID:: PMC10749280

Abstract Article PDF–6.6M

Select item 105005014.

Expression of Apurinic/Apyrimidinic Endonuclease 1 in Colorectal Cancer and its Relation to Tumor Progression and Prognosis

JI-YUN HONG, HYUNG-HOON OH, SUN-YOUNG PARK, YOUNG-LAN PARK, SUNG-BUM CHO*, YOUNG-EUN JOO

In Vivo. 2023 Sep-Oct; 37(5): 2070–2077. Published online 2023 Sep 3. doi: 10.21873/invivo.13304

PMCID:: PMC10500501

Abstract Article PDF–2.2M

Select item 103781825.

Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons

Matilde Clarissa Malfatti, Alessia Bellina, Giulia Antoniali, Gianluca Tell

Cells. 2023 Jul; 12(14): 1895. Published online 2023 Jul 20. doi: 10.3390/cells12141895

PMCID:: PMC10378182

Abstract Article PDF–3.7M

Select item 103596156.

Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics

Nicole M Hoitsma, Jessica Norris, Thu H Khoang, Vikas Kaushik, Rahul Chadda, Edwin Antony, Mark Hedglin, Bret D Freudenthal

Nucleic Acids Res. 2023 Jul 21; 51(13): 6738–6753. Published online 2023 Jun 2. doi: 10.1093/nar/gkad481

PMCID:: PMC10359615

Abstract Article PDF–2.0M

Select item 103232527.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468

PMCID:: PMC10323252

Abstract Article

Select item 102374228.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 99786359.

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson

J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888

PMCID:: PMC9978635

Abstract Article PDF–10M

Select item 988565010.

Long non-coding RNA SLC25A21-AS1 inhibits the development of epithelial ovarian cancer by specifically inducing PTBP3 degradation

Sihui Li, Shizhen Shen, Wanzhong Ge, Yixuan Cen, Songfa Zhang, Xiaodong Cheng, Xinyu Wang, Xing Xie, Weiguo Lu

Biomark Res. 2023; 11: 12. Published online 2023 Jan 30. doi: 10.1186/s40364-022-00432-x

PMCID:: PMC9885650

Abstract Article PDF–11M

Select item 981605911.

CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1

Dongbao Li, Yuhong Wang, Chao Dong, Tao Chen, Anqi Dong, Jiayu Ren, Weikang Li, Gege Shu, Jiaoyang Yang, Wenhao Shen, Lei Qin, Lin Hu, Jin Zhou

Oncogene. 2023; 42(2): 83–98. Published online 2022 Nov 12. doi: 10.1038/s41388-022-02537-x

PMCID:: PMC9816059

Abstract Article PDF–7.6M

Select item 978919812.

Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in esophageal adenocarcinoma

Lei Chen, Heng Lu, Dunfa Peng, Longlong Cao, Farah Ballout, Kannappan Sriramajayam, Zheng Chen, Ajaz Bhat, Timothy C. Wang, Anthony Capobianco, Jianwen Que, Oliver G McDonald, Alexander Zaika, Shutian Zhang, Wael El-Rifai

Gut. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: Gut. 2023 Mar; 72(3): 421–432. Published online 2022 Jun 24. doi: 10.1136/gutjnl-2022-327076

PMCID:: PMC9789198

Abstract Article PDF–2.8M

Select item 970808613.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 959621214.

APEX1 promotes the oncogenicity of hepatocellular carcinoma via regulation of MAP2K6

Zhipeng Sun, Guangyang Chen, Liang Wang, Qing Sang, Guangzhong Xu, Nengwei Zhang

Aging (Albany NY) 2022 Oct 15; 14(19): 7959–7971. Published online 2022 Oct 4. doi: 10.18632/aging.204325

PMCID:: PMC9596212

Abstract Article PDF–1.2M

Select item 954034515.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 943486816.

APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas

Farah Ballout, Heng Lu, Lei Chen, Kannappan Sriramajayam, Jianwen Que, Zhipeng Meng, Timothy C. Wang, Silvia Giordano, Alexander Zaika, Oliver McDonald, Dunfa Peng, Wael El-Rifai

J Exp Clin Cancer Res. 2022; 41: 264. Published online 2022 Sep 1. doi: 10.1186/s13046-022-02472-5

PMCID:: PMC9434868

Abstract Article PDF–10M

Select item 940936517.

Dual Function of Secreted APE1/Ref-1 in TNBC Tumorigenesis: An Apoptotic Initiator and a Regulator of Chronic Inflammatory Signaling

Sunga Choi, Yu-Ran Lee, Ki-Mo Kim, Euna Choi, Byeong-Hwa Jeon

Int J Mol Sci. 2022 Aug; 23(16): 9021. Published online 2022 Aug 12. doi: 10.3390/ijms23169021

PMCID:: PMC9409365

Abstract Article PDF–3.8M

Select item 936044318.

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner

Lucía García-Gutiérrez, Emma Fallahi, Nourhan Aboud, Niall Quinn, David Matallanas

Cell Death Dis. 2022 Aug; 13(8): 692. Published online 2022 Aug 8. doi: 10.1038/s41419-022-05147-3

PMCID:: PMC9360443

Abstract Article PDF–5.8M

Select item 933831319.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4