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Select item 111056661.

Low density lipoprotein receptor-related protein 1 couples β1 integrin activation to degradation

Lukasz Wujak, Ralph T. Böttcher, Oleg Pak, Helena Frey, Elie El Agha, Ying Chen, Sigrid Schmitt, Saverio Bellusci, Liliana Schaefer, Norbert ‎Weissmann, Reinhard Fässler, Malgorzata Wygrecka

Cell Mol Life Sci. 2018 May; 75(9): 1671–1685. Published online 2017 Nov 7. doi: 10.1007/s00018-017-2707-6

PMCID:: PMC11105666

Abstract Article PDF–11M

Select item 111053022.

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA

Simone Eggert, A. C. Gonzalez, C. Thomas, S. Schilling, S. M. Schwarz, C. Tischer, V. Adam, P. Strecker, V. Schmidt, T. E. Willnow, G. Hermey, C. U. Pietrzik, E. H. Koo, Stefan Kins

Cell Mol Life Sci. 2018 Jan; 75(2): 301–322. Published online 2017 Aug 10. doi: 10.1007/s00018-017-2625-7

PMCID:: PMC11105302

Abstract Article PDF–6.9M

Select item 107333003.

ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells

Jiyeon Lee, Haeryung Lee, Hyein Lee, Miram Shin, Min-Gi Shin, Jinsoo Seo, Eun Jeong Lee, Sun Ah Park, Soochul Park

Nat Commun. 2023; 14: 8463. Published online 2023 Dec 20. doi: 10.1038/s41467-023-44319-3

Correction in:: Nat Commun. 2024; 15: 3062.

PMCID:: PMC10733300

Abstract Article PDF–6.2M

Select item 106558864.

Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer

Lingyuan He, Mengchen Shi, Shuwei Ren, Jingdan Zhang, Yu Tian, Xiangling Yang, Huanliang Liu

Biomol Biomed. 2023 Dec 1; 23(6): 1026–1037. Published online 2023 Dec 1. doi: 10.17305/bb.2023.9248

PMCID:: PMC10655886

Abstract Article PDF–3.0M

Select item 105387025.

The endocytic receptor protein LRP-1 modulate P-glycoprotein mediated drug resistance in MCF-7 cells

Aubery Henry, Marine Mauperin, Jerome Devy, Stephane Dedieu, Lise Chazee, Cathy Hachet, Christine Terryn, Laurent Duca, Laurent Martiny, Emmanuelle Devarenne-Charpentier, Hassan El Btaouri

PLoS One. 2023; 18(9): e0285834. Published online 2023 Sep 28. doi: 10.1371/journal.pone.0285834

PMCID:: PMC10538702

Abstract Article PDF–2.1M

Select item 102485566.

Exome-wide analysis reveals role of LRP1 and additional novel loci in cognition

Shreya Chakraborty, Bratati Kahali

HGG Adv. 2023 Jul 13; 4(3): 100208. Published online 2023 May 20. doi: 10.1016/j.xhgg.2023.100208

PMCID:: PMC10248556

Abstract Article PDF–3.8M

Select item 102374227.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101988198.

Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer’s disease pathogenesis in the brain during peripheral chronic inflammation

Hana Na, Jack B. Yang, Zhengrong Zhang, Qini Gan, Hua Tian, Ibraheem M. Rajab, Lawrence A. Potempa, Qiushan Tao, Wei Qiao Qiu

Neurobiol Aging. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: Neurobiol Aging. 2023 Jul; 127: 54–69. Published online 2023 Mar 7. doi: 10.1016/j.neurobiolaging.2023.02.013

PMCID:: PMC10198819

Abstract Article PDF–3.2M

Select item 101379349.

Contribution of LRP1 in Human Congenital Heart Disease Correlates with Its Roles in the Outflow Tract and Atrioventricular Cushion Development

Angelo B. Arrigo, Wenjuan Zhu, Kylia A. Williams, Carla Guzman-Moreno, Cecilia Lo, Jiuann-Huey I. Lin

Genes (Basel) 2023 Apr; 14(4): 947. Published online 2023 Apr 21. doi: 10.3390/genes14040947

PMCID:: PMC10137934

Abstract Article PDF–31M

Select item 1013215810.

LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4

Hiroshi Oue, Yu Yamazaki, Wenhui Qiao, Chen Yuanxin, Yingxue Ren, Aishe Kurti, Francis Shue, Tammee M. Parsons, Ralph B. Perkerson, Keiji Kawatani, Ni Wang, Skylar C. Starling, Bhaskar Roy, Ioana-Emilia Mosneag, Tomonori Aikawa, Marie-Louise Holm, Chia-Chen Liu, Yasuteru Inoue, Patrick M. Sullivan, Yan W. Asmann, Betty Y.S. Kim, Guojun Bu, Takahisa Kanekiyo

JCI Insight. 2023 Apr 10; 8(7): e163822. Published online 2023 Apr 10. doi: 10.1172/jci.insight.163822

PMCID:: PMC10132158

Abstract Article PDF–1.4M

Select item 1011436211.

Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA viruses

Stephanie Devignot, Tim Wai Sha, Thomas R Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi, Ulrich Elling, Josef M Penninger, Friedemann Weber

Life Sci Alliance. 2023 Jul; 6(7): e202302005. Published online 2023 Apr 18. doi: 10.26508/lsa.202302005

PMCID:: PMC10114362

Abstract Article PDF–2.8M

Select item 1011389412.

Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell

Wei Zhou, Jiachen Ma, Han Zhao, Qing Wang, Xiaoli Guo, Linna Chen, Zhonghui Cao, Jiahao Xu, Bei Zhang, Xueyan Zhou

Mol Cell Proteomics. 2023 Apr; 22(4): 100520. Published online 2023 Feb 25. doi: 10.1016/j.mcpro.2023.100520

PMCID:: PMC10113894

Abstract Article PDF–5.1M

Select item 999896613.

Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption

Lingxin Zhu, Yi Tang, Xiao-Yan Li, Samuel A. Kerk, Costas A. Lyssiotis, Xiaoyue Sun, Zijun Wang, Jung-Sun Cho, Jun Ma, Stephen J. Weiss

J Cell Biol. 2023 Apr 3; 222(4): e202206121. Published online 2023 Mar 2. doi: 10.1083/jcb.202206121

PMCID:: PMC9998966

Abstract Article PDF–10M

Select item 986810214.

LRP-1 Links Post-Translational Modifications to Efficient Presentation of Celiac Disease-Specific T Cell Antigens

Elise Loppinet, Harrison A. Besser, Agnele Sylvia Sewa, Fu-Chen Yang, Bana Jabri, Chaitan Khosla

Cell Chem Biol. Author manuscript; available in PMC 2024 Jan 19.

Published in final edited form as: Cell Chem Biol. 2023 Jan 19; 30(1): 55–68.e10. Published online 2023 Jan 5. doi: 10.1016/j.chembiol.2022.12.002

PMCID:: PMC9868102

Abstract Article PDF–3.5M

Select item 980439015.

Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts

Haarin Chun, James H. Kurasawa, Philip Olivares, Ekaterina S. Marakasova, Svetlana A. Shestopal, Gabriela U. Hassink, Elena Karnaukhova, Mary Migliorini, Juliet O. Obi, Ally K. Smith, Patrick L. Wintrode, Prasannavenkatesh Durai, Keunwan Park, Daniel Deredge, Dudley K. Strickland, Andrey G. Sarafanov

J Thromb Haemost. 2022 Oct; 20(10): 2255–2269. Published online 2022 Aug 4. doi: 10.1111/jth.15817

PMCID:: PMC9804390

Abstract Article PDF–16M

Select item 969285616.

MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells

Jonathan Pratt, Khadidja Haidara, Borhane Annabi

Int J Mol Sci. 2022 Nov; 23(22): 14214. Published online 2022 Nov 17. doi: 10.3390/ijms232214214

PMCID:: PMC9692856

Abstract Article PDF–2.5M

Select item 962954717.

Multitarget Activities of Müller Glial Cells and Low-Density Lipoprotein Receptor-Related Protein 1 in Proliferative Retinopathies

María C. Sanchez, Gustavo A. Chiabrando

ASN Neuro. 2022 Jan-Dec; 14: 17590914221136365. Published online 2022 Oct 31. doi: 10.1177/17590914221136365

PMCID:: PMC9629547

Abstract Article PDF–1.4M

Select item 947738918.

Heterozygous LRP1 deficiency causes developmental dysplasia of the hip by impairing triradiate chondrocytes differentiation due to inhibition of autophagy

Wenjin Yan, Liming Zheng, Xingquan Xu, Zheng Hao, Yibo Zhang, Jun Lu, Ziying Sun, Jin Dai, Dongquan Shi, Baosheng Guo, Qing Jiang

Proc Natl Acad Sci U S A. 2022 Sep 13; 119(37): e2203557119. Published online 2022 Sep 6. doi: 10.1073/pnas.2203557119

PMCID:: PMC9477389

Abstract Article PDF–2.9M

Select item 943822919.

LRP1 is a neuronal receptor for α-synuclein uptake and spread

Kai Chen, Yuka A. Martens, Axel Meneses, Daniel H. Ryu, Wenyan Lu, Ana Caroline Raulin, Fuyao Li, Jing Zhao, Yixing Chen, Yunjung Jin, Cynthia Linares, Marshall Goodwin, Yonghe Li, Chia-Chen Liu, Takahisa Kanekiyo, David M. Holtzman, Todd E. Golde, Guojun Bu, Na Zhao

Mol Neurodegener. 2022; 17: 57. Published online 2022 Sep 2. doi: 10.1186/s13024-022-00560-w

PMCID:: PMC9438229

Abstract Article PDF–6.0M

Select item 938814620.

Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1

Madeline M. Schwarz, David A. Price, Safder S. Ganaie, Annie Feng, Nawneet Mishra, Ryan M. Hoehl, Farheen Fatma, Sarah H. Stubbs, Sean P. J. Whelan, Xiaoxia Cui, Takeshi Egawa, Daisy W. Leung, Gaya K. Amarasinghe, Amy L. Hartman

Proc Natl Acad Sci U S A. 2022 Aug 16; 119(33): e2204706119. Published online 2022 Aug 8. doi: 10.1073/pnas.2204706119

PMCID:: PMC9388146

Abstract Article PDF–2.1M

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