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Select item 94406531.

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy

Shouheng Jin, Xing He, Ling Ma, Zhen Zhuang, Yiliang Wang, Meng Lin, Sihui Cai, Lu Wei, Zheyu Wang, Zhiyao Zhao, Yaoxing Wu, Lin Sun, Chunwei Li, Weihong Xie, Yong Zhao, Zhou Songyang, Ke Peng, Jincun Zhao, Jun Cui

Nat Commun. 2022; 13: 5204. Published online 2022 Sep 3. doi: 10.1038/s41467-022-32957-y

PMCID:: PMC9440653

Abstract Article PDF–2.9M

Select item 88854222.

The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML

Anne Charlet, Max Kappenstein, Philip Keye, Kathrin Kläsener, Cornelia Endres, Teresa Poggio, Sivahari P. Gorantla, Stefanie Kreutmair, Jana Sänger, Anna L. Illert, Cornelius Miething, Michael Reth, Justus Duyster, Christoph Rummelt, Nikolas von Bubnoff

Leukemia. 2022; 36(3): 701–711. Published online 2021 Nov 8. doi: 10.1038/s41375-021-01462-4

PMCID:: PMC8885422

Abstract Article PDF–2.2M

Select item 86072463.

Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer

Mamoon Rashid, Rizwan Ali, Bader Almuzzaini, Hao Song, Alshaimaa AlHallaj, Al Abdulrahman Abdulkarim, Omar Mohamed Baz, Hajar Al Zahrani, Muhammed Mustafa Sabeena, Wardah Alharbi, Mohamed Hussein, Mohamed Boudjelal

Cancer Med. 2021 Nov; 10(22): 8138–8150. Published online 2021 Nov 2. doi: 10.1002/cam4.4106

PMCID:: PMC8607246

Abstract Article PDF–1.0M

Select item 78848404.

Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis

Saori Sakaue, Etsuro Yamaguchi, Yoshikazu Inoue, Meiko Takahashi, Jun Hirata, Ken Suzuki, Satoru Ito, Toru Arai, Masaki Hirose, Yoshinori Tanino, Takefumi Nikaido, Toshio Ichiwata, Shinya Ohkouchi, Taizou Hirano, Toshinori Takada, Satoru Miyawaki, Shogo Dofuku, Yuichi Maeda, Takuro Nii, Toshihiro Kishikawa, Kotaro Ogawa, Tatsuo Masuda, Kenichi Yamamoto, Kyuto Sonehara, Ryushi Tazawa, Konosuke Morimoto, Masahiro Takaki, Satoshi Konno, Masaru Suzuki, Keisuke Tomii, Atsushi Nakagawa, Tomohiro Handa, Kiminobu Tanizawa, Haruyuki Ishii, Manabu Ishida, Toshiyuki Kato, Naoya Takeda, Koshi Yokomura, Takashi Matsui, Masaki Watanabe, Hiromasa Inoue, Kazuyoshi Imaizumi, Yasuhiro Goto, Hiroshi Kida, Tomoyuki Fujisawa, Takafumi Suda, Takashi Yamada, Yasuomi Satake, Hidenori Ibata, Nobuyuki Hizawa, Hideki Mochizuki, Atsushi Kumanogoh, Fumihiko Matsuda, Koh Nakata, Tomomitsu Hirota, Mayumi Tamari, Yukinori Okada

Nat Commun. 2021; 12: 1032. Published online 2021 Feb 15. doi: 10.1038/s41467-021-21011-y

PMCID:: PMC7884840

Abstract Article PDF–1.1M

Select item 73220675.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 63918466.

Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte–Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn’s Disease

Lee A Denson, Ingrid Jurickova, Rebekah Karns, Kelly A Shaw, David J Cutler, David Okou, C Alexander Valencia, Anne Dodd, Kajari Mondal, Bruce J Aronow, Yael Haberman, Aaron Linn, Adam Price, Ramona Bezold, Kathleen Lake, Kimberly Jackson, Thomas D Walters, Anne Griffiths, Robert N Baldassano, Joshua D Noe, Jeffrey S Hyams, Wallace V Crandall, Barbara S Kirschner, Melvin B Heyman, Scott Snapper, Stephen L Guthery, Marla C Dubinsky, Neal S Leleiko, Anthony R Otley, Ramnik J Xavier, Christine Stevens, Mark J Daly, Michael E Zwick, Subra Kugathasan

Inflamm Bowel Dis. 2019 Mar; 25(3): 547–560. Published online 2018 Aug 13. doi: 10.1093/ibd/izy265

PMCID:: PMC6391846

Abstract Article PDF–1.5M

Select item 60395017.

CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia

Qing-Yun Wu, Yuan-Yuan Zhu, Yang Liu, Fang Wei, Yu-Xue Tong, Jiang Cao, Ping Zhou, Ming-Shan Niu, Zhen-Yu Li, Ling-Yu Zeng, Feng Li, Kai-Lin Xu

Cell Death Dis. 2018 Jul; 9(7): 774. Published online 2018 Jul 10. doi: 10.1038/s41419-018-0812-6

PMCID:: PMC6039501

Abstract Article PDF–2.7M

Select item 59853048.

Introduction of Human Flt3-L and GM-CSF into Humanized Mice Enhances the Reconstitution and Maturation of Myeloid Dendritic Cells and the Development of Foxp3⁺CD4⁺ T Cells

Ryutaro Iwabuchi, Shota Ikeno, Mie Kobayashi-Ishihara, Haruko Takeyama, Manabu Ato, Yasuko Tsunetsugu-Yokota, Kazutaka Terahara

Front Immunol. 2018; 9: 1042. Published online 2018 May 28. doi: 10.3389/fimmu.2018.01042

PMCID:: PMC5985304

Abstract Article PDF–3.2M

Select item 57859779.

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Sophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Winnie L. Kan, Emma F. Barry, Mara Dottore, Karen S. Cheung Tung Shing, Craig J. Morton, Urmi Dhagat, Matthew P. Hardy, Nicholas J. Wilson, Matthew T. Downton, Christine Schieber, Timothy P. Hughes, Angel F. Lopez, Michael W. Parker

Nat Commun. 2018; 9: 386. Published online 2018 Jan 26. doi: 10.1038/s41467-017-02633-7

PMCID:: PMC5785977

Abstract Article PDF–6.3M

Select item 564325910.

Genetic Complexity of Crohn’s Disease in Two Large Ashkenazi Jewish Families

Adam P. Levine, Nikolas Pontikos, Elena R. Schiff, Luke Jostins, Doug Speed, NIDDK Inflammatory Bowel Disease Genetics Consortium, Laurence B. Lovat, Jeffrey C. Barrett, Helmut Grasberger, Vincent Plagnol, Anthony W. Segal

Gastroenterology. 2016 Oct; 151(4): 698–709. doi: 10.1053/j.gastro.2016.06.040

PMCID:: PMC5643259

Abstract Article

Select item 503701211.

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn’s Disease and Reduces Monocyte Signaling via GMCSF

Ling-Shiang Chuang, Nicole Villaverde, Ken Y. Hui, Arthur Mortha, Adeeb Rahman, Adam P. Levine, Talin Haritunians, Sok Meng Evelyn Ng, Wei Zhang, Nai-Yun Hsu, Jody-Ann Facey, Tramy Luong, Heriberto Fernandez-Hernandez, Dalin Li, Manuel Rivas, Elena R. Schiff, Alexander Gusev, L. Phillip Schumm, Beatrice M. Bowen, Yashoda Sharma, Kaida Ning, Romain Remark, Sacha Gnjatic, Peter Legnani, James George, Bruce E. Sands, Joanne M. Stempak, Lisa W. Datta, Seth Lipka, Seymour Katz, Adam S. Cheifetz, Nir Barzilai, Nikolas Pontikos, Clara Abraham, Marla J. Dubinsky, Stephan Targan, Kent Taylor, Jerome I Rotter, Ellen J. Scherl, Robert J. Desnick, Maria T. Abreu, Hongyu Zhao, Gil Atzmon, Itsik Pe’er, Subra Kugathasan, Hakon Hakonarson, Jacob L. McCauley, Todd Lencz, Ariel Darvasi, Vincent Plagnol, Mark S. Silverberg, Aleixo M. Muise, Steven R. Brant, Mark J. Daly, Anthony W. Segal, Richard H. Duerr, Miriam Merad, Dermot P.B. McGovern, Inga Peter, Judy H. Cho

Gastroenterology. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Gastroenterology. 2016 Oct; 151(4): 710–723.e2. Published online 2016 Jul 1. doi: 10.1053/j.gastro.2016.06.045

PMCID:: PMC5037012

Abstract Article PDF–2.0M

Select item 446556212.

Cross-Talk between ICAM-1 and Granulocyte-Macrophage Colony-Stimulating Factor Receptor Signaling Modulates Eosinophil Survival and Activation

Konrad Pazdrak, Travis W. Young, Susan Stafford, Barbara Olszewska-Pazdrak, Christof Straub, Vitaliy Starosta, Allan Brasier, Alexander Kurosky

J Immunol. Author manuscript; available in PMC 2015 Jun 14.

Published in final edited form as: J Immunol. 2008 Mar 15; 180(6): 4182–4190. doi: 10.4049/jimmunol.180.6.4182

PMCID:: PMC4465562

Abstract Article PDF–1.0M

Select item 437355013.

GM-CSF CAUSES A PARADOXICAL INCREASE IN THE BH3-ONLY PRO-APOPTOTIC PROTEIN BIM IN HUMAN NEUTROPHILS

Andrew S Cowburn, Charlotte Summers, Benjamin J Dunmore, Neda Farahi, Cristin G Print, Simon J Cook, Edwin R Chilvers

Am J Respir Cell Mol Biol. Author manuscript; available in PMC 2015 Mar 25.

Published in final edited form as: Am J Respir Cell Mol Biol. 2011 Jun; 44(6): 879–887. Published online 2010 Aug 12. doi: 10.1165/rcmb.2010-0101OC

PMCID:: PMC4373550

Abstract Article PDF–1.6M

Select item 403474814.

Association study of CSF2RB with schizophrenia in Irish family and case – control samples

Q Chen, X Wang, FA O’Neill, D Walsh, A Fanous, KS Kendler, X Chen

Mol Psychiatry. Author manuscript; available in PMC 2014 May 27.

Published in final edited form as: Mol Psychiatry. 2008 Oct; 13(10): 930–938. Published online 2007 Jul 31. doi: 10.1038/sj.mp.4002051

PMCID:: PMC4034748

Abstract Article PDF–504K

Select item 397008815.

Gene-wide analyses of genome-wide association datasets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk

V. Moskvina, N. Craddock, P. Holmans, I. Nikolov, J.S. Pahwa, E. Green, Wellcome Trust Case Control Consortium, M.J. Owen, M.C. O’Donovan

Mol Psychiatry. Author manuscript; available in PMC 2014 Mar 31.

Published in final edited form as: Mol Psychiatry. 2009 Mar; 14(3): 252–260. Published online 2008 Dec 9. doi: 10.1038/mp.2008.133

PMCID:: PMC3970088

Abstract Article PDF–598K

Select item 378441516.

SOCS-1 Mediates Ubiquitylation and Degradation of GM-CSF Receptor

Severa Bunda, Kamya Kommaraju, Pardeep Heir, Michael Ohh

PLoS One. 2013; 8(9): e76370. Published online 2013 Sep 26. doi: 10.1371/journal.pone.0076370

PMCID:: PMC3784415

Abstract Article PDF–553K

Select item 365630817.

Vitamin D Enhances Glucocorticoid Action in Human Monocytes: INVOLVEMENT OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND MEDIATOR COMPLEX SUBUNIT 14

Yong Zhang, Donald Y. M. Leung, Elena Goleva

J Biol Chem. 2013 May 17; 288(20): 14544–14553. Published online 2013 Apr 9. doi: 10.1074/jbc.M112.427054

PMCID:: PMC3656308

Abstract Article PDF–2.3M

Select item 347831218.

Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2

Ping-Hung Chen, Fan-Ching Chien, Sue-Ping Lee, Woan-Eng Chan, I-Hsuan Lin, Chun-Shan Liu, Fang-Jen Lee, Jiann-Shiun Lai, Peilin Chen, Hsin-Fang Yang-Yen, Jeffrey Jong-Young Yen

Cell Cycle. 2012 Oct 1; 11(19): 3611–3626. doi: 10.4161/cc.21920

PMCID:: PMC3478312

Abstract Article PDF–6.8M

Select item 322058919.

Three Lysine Residues in the Common β Chain of the Interleukin-5 Receptor Are Required for Janus Kinase (JAK)-dependent Receptor Ubiquitination, Endocytosis, and Signaling

Jonathan T. Lei, Tuhina Mazumdar, Margarita Martinez-Moczygemba

J Biol Chem. 2011 Nov 18; 286(46): 40091–40103. Published online 2011 Sep 30. doi: 10.1074/jbc.M111.273482

PMCID:: PMC3220589

Abstract Article PDF–4.0M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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