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Select item 111815691.

Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration

Modestos Nakos Bimpos, Katerina Karali, Christine Antoniou, Dionysios Palermos, Maria Fouka, Anastasios Delis, Iason Tzieras, George Panagiotis Chrousos, Yassemi Koutmani, Leonidas Stefanis, Alexia Polissidis

Acta Neuropathol Commun. 2024; 12: 100. Published online 2024 Jun 17. doi: 10.1186/s40478-024-01797-w

PMCID:: PMC11181569

Abstract Article PDF–7.4M

Select item 111801852.

Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

Sophie E. Mastenbroek, Jacob W. Vogel, Lyduine E. Collij, Geidy E. Serrano, Cécilia Tremblay, Alexandra L. Young, Richard A. Arce, Holly A. Shill, Erika D. Driver-Dunckley, Shyamal H. Mehta, Christine M. Belden, Alireza Atri, Parichita Choudhury, Frederik Barkhof, Charles H. Adler, Rik Ossenkoppele, Thomas G. Beach, Oskar Hansson

Nat Commun. 2024; 15: 5133. Published online 2024 Jun 15. doi: 10.1038/s41467-024-49402-x

PMCID:: PMC11180185

Abstract Article PDF–2.7M

Select item 111405863.

Elevated ApoE, ApoJ and lipoprotein-bound α-synuclein levels in cerebrospinal fluid from Parkinson’s disease patients – Validation in the BioFIND cohort

Wojciech Paslawski, Per Svenningsson

Parkinsonism Relat Disord. Author manuscript; available in PMC 2024 May 31.

Published in final edited form as: Parkinsonism Relat Disord. 2023 Nov; 116: 105765. Published online 2023 Jul 12. doi: 10.1016/j.parkreldis.2023.105765

PMCID:: PMC11140586

Abstract Article PDF–1.2M

Select item 111317744.

Synphilin-1 isoforms in Parkinson’s disease: regulation by phosphorylation and ubiquitylation

R. Szargel, R. Rott, S. Engelender

Cell Mol Life Sci. 2008 Jan; 65(1): 80–88. Published online 2007 Nov 5. doi: 10.1007/s00018-007-7343-0

PMCID:: PMC11131774

Abstract Article PDF–898K

Select item 111316485.

Mitochondrial association of alpha-synuclein causes oxidative stress

M. S. Parihar, A. Parihar, M. Fujita, M. Hashimoto, P. Ghafourifar

Cell Mol Life Sci. 2008 Apr; 65(7-8): 1272–1284. Published online 2008 Feb 25. doi: 10.1007/s00018-008-7589-1

PMCID:: PMC11131648

Abstract Article PDF–2.8M

Select item 111148416.

Synphilin-1 inhibits alpha-synuclein degradation by the proteasome

Beatriz Alvarez-Castelao, José G. Castaño

Cell Mol Life Sci. 2011 Aug; 68(15): 2643–2654. Published online 2010 Nov 20. doi: 10.1007/s00018-010-0592-3

PMCID:: PMC11114841

Abstract Article PDF–595K

Select item 111132657.

Inhibition of 26S proteasome activity by α‐synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1

Dajana Galka, Tariq T. Ali, Alexander Bast, Marie Niederleithinger, Ellen Gerhardt, Ryo Motosugi, Eri Sakata, Michael Knop, Tiago F. Outeiro, Blagovesta Popova, Gerhard H. Braus

Aging Cell. 2024 May; 23(5): e14128. Published online 2024 Feb 28. doi: 10.1111/acel.14128

PMCID:: PMC11113265

Abstract Article PDF–7.8M

Select item 111075548.

Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson’s disease

Sandeep K. Sharma, Smriti Priya

Cell Mol Life Sci. 2017 Feb; 74(4): 617–629. Published online 2016 Aug 13. doi: 10.1007/s00018-016-2340-9

PMCID:: PMC11107554

Abstract Article PDF–1.6M

Select item 111075029.

Synucleinopathies: common features and hippocampal manifestations

Weiwei Yang, Shun Yu

Cell Mol Life Sci. 2017 Apr; 74(8): 1485–1501. Published online 2016 Nov 8. doi: 10.1007/s00018-016-2411-y

PMCID:: PMC11107502

Abstract Article PDF–536K

Select item 1107329310.

A53T mutant α-synuclein fibrils formed in macrophage are spread to neurons

Shogo Moriya, Michiko Hanazono, Takeshi Fukuhara, Katsuro Iwase, Nobutaka Hattori, Masaki Takiguchi

Cell Mol Life Sci. 2022 May; 79(5): 234. Published online 2022 Apr 10. doi: 10.1007/s00018-022-04263-9

PMCID:: PMC11073293

Abstract Article PDF–2.8M

Select item 1107222511.

Restricting α-synuclein transport into mitochondria by inhibition of α-synuclein–VDAC complexation as a potential therapeutic target for Parkinson’s disease treatment

Megha Rajendran, María Queralt-Martín, Philip A. Gurnev, William M. Rosencrans, Amandine Rovini, Daniel Jacobs, Kaitlin Abrantes, David P. Hoogerheide, Sergey M. Bezrukov, Tatiana K. Rostovtseva

Cell Mol Life Sci. 2022 Jul; 79(7): 368. Published online 2022 Jun 19. doi: 10.1007/s00018-022-04389-w

PMCID:: PMC11072225

Abstract Article PDF–2.3M

Select item 1106905412.

Plasma exosomes impair microglial degradation of α‐synuclein through V‐ATPase subunit V1G1

Yunna Li, Yiming Wang, Liang Kou, Sijia Yin, Xiaosa Chi, Yadi Sun, Jiawei Wu, Zongjie Jin, Qiulu Zhou, Wenkai Zou, Tao Wang, Yun Xia

CNS Neurosci Ther. 2024 May; 30(5): e14738. Published online 2024 May 3. doi: 10.1111/cns.14738

PMCID:: PMC11069054

Abstract Article PDF–25M

Select item 1098082613.

Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore, Deborah A. Berthold, Isabelle R. Gordon, Jialu Liu, Moses H. Milchberg, Jennifer Y. O’Shea, Michael J. Rau, Zachary Smith, Soumyo Sen, Brock Summers, John Smith, Owen A. Warmuth, Richard J. Perrin, Joel S. Perlmutter, Qian Chen, James A. J. Fitzpatrick, Charles D. Schwieters, Emad Tajkhorshid, Chad M. Rienstra, Paul T. Kotzbauer

Nat Commun. 2024; 15: 2750. Published online 2024 Mar 29. doi: 10.1038/s41467-024-46832-5