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Select item 112121871.

The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages

Vida Mashayekhi, Annika Schomisch, Sari Rasheed, Ernesto Aparicio-Puerta, Timo Risch, Daniela Yildiz, Marcus Koch, Simon Both, Nicole Ludwig, Thierry M. Legroux, Andreas Keller, Rolf Müller, Gregor Fuhrmann, Jessica Hoppstädter, Alexandra K. Kiemer

Cell Commun Signal. 2024; 22: 344. Published online 2024 Jun 27. doi: 10.1186/s12964-024-01701-y

PMCID:: PMC11212187

Abstract Article PDF–3.5M

Select item 111593512.

Insulin‐like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic conditions

Fumiaki Isohashi, Hiroko Endo, Mutsuko Mukai, Takehiro Inoue, Masahiro Inoue

Cancer Sci. 2008 Dec; 99(12): 2395–2401. Published online 2008 Nov 19. doi: 10.1111/j.1349-7006.2008.00970.x

PMCID:: PMC11159351

Abstract Article PDF–364K

Select item 110681993.

The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study

Wei Li, Lu She, Muyu Zhang, Mei Yang, Wenpei Zheng, Hua He, Ping Wang, Qiong Dai, Zhengtao Gong

PLoS One. 2024; 19(5): e0298063. Published online 2024 May 3. doi: 10.1371/journal.pone.0298063

PMCID:: PMC11068199

Abstract Article PDF–614K

Select item 109930534.

m⁶A‐dependent upregulation of DDX21 by super‐enhancer‐driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia

Yanchun Zhao, Yutong Zhou, Yu Qian, Wenwen Wei, Xiangjie Lin, Shihui Mao, Jie Sun, Jie Jin

Clin Transl Med. 2024 Apr; 14(4): e1628. Published online 2024 Apr 4. doi: 10.1002/ctm2.1628

PMCID:: PMC10993053

Abstract Article PDF–9.7M

Select item 109591845.

IGF2BP2 and IGFBP3 Genotypes, Haplotypes, and Genetic Models Studies in Polycystic Ovary Syndrome

Fatemeh Govahi Kakhki, Saman Sargazi, Farzaneh Montazerifar, Mahdi Majidpour, Atena Karajibani, Mansour Karajibani, Marzieh Ghasemi

J Clin Lab Anal. 2024 Mar; 38(5): e25021. Published online 2024 Mar 11. doi: 10.1002/jcla.25021

PMCID:: PMC10959184

Abstract Article PDF–2.0M

Select item 109400926.

METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2

Weicheng Lu, Xiaohua Yang, Weiqiang Zhong, Guojun Chen, Xinqi Guo, Qingqing Ye, Yixin Xu, Zhenhua Qi, Yaqi Ye, Jingyun Zhang, Yuge Wang, Xintong Wang, Shu Wang, Qiyue Zhao, Weian Zeng, Junting Huang, Huijie Ma, Jingdun Xie

J Clin Invest. 2024 Mar 15; 134(6): e174847. Published online 2024 Feb 6. doi: 10.1172/JCI174847

PMCID:: PMC10940092

Abstract Article PDF–13M

Select item 109136007.

KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma

Hongshi Cai, Jianfeng Liang, Yaoqi Jiang, Ziyi Wang, Hongyu Li, Wenjin Wang, Cheng Wang, Jinsong Hou

J Exp Clin Cancer Res. 2024; 43: 69. Published online 2024 Mar 5. doi: 10.1186/s13046-024-02996-y

PMCID:: PMC10913600

Abstract Article PDF–12M

Select item 109032418.

Insulin-like growth factor 2 mRNA-binding protein 2 is a therapeutic target in ovarian cancer

Jia Yuan, Xin Li, Fanchen Wang, Huiqiang Liu, Wencai Guan, Guoxiong Xu

Exp Biol Med (Maywood) 2023 Dec; 248(23): 2198–2209. Published online 2023 Dec 12. doi: 10.1177/15353702231214268

PMCID:: PMC10903241

Abstract Article PDF–7.0M

Select item 107976989.

IGF2BP2 promotes cell invasion and epithelial-mesenchymal transition through Src-mediated upregulation of EREG in oral cancer

Chiao-Wen Lin, Wei-En Yang, Chun-Wen Su, Hsueh-Ju Lu, Shih-Chi Su, Shun-Fa Yang

Int J Biol Sci. 2024; 20(3): 818–830. Published online 2024 Jan 1. doi: 10.7150/ijbs.91786

PMCID:: PMC10797698

Abstract Article PDF–7.7M

Select item 1076495810.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 1058803811.

ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner

Jinhao Chen, Mujie Ye, Jianan Bai, Zhihui Gong, Lijun Yan, Danyang Gu, Chunhua Hu, Feiyu Lu, Ping Yu, Lin Xu, Yan Wang, Ye Tian, Qiyun Tang

J Transl Med. 2023; 21: 741. Published online 2023 Oct 19. doi: 10.1186/s12967-023-04578-6

PMCID:: PMC10588038

Abstract Article PDF–12M

Select item 1058225712.

ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N ⁶-methyladenosine methylation

Long Bai, Yu Xiang, Minyue Tang, Shuangying Liu, Qingqing Chen, Qichao Chen, Min Zhang, Shan Wan, Yimiao Sang, Qingfang Li, Sisi Wang, Zhekun Li, Yang Song, Xiaoling Hu, Luna Mao, Guofang Feng, Long Cui, Yinghui Ye, Yimin Zhu

Nat Commun. 2023; 14: 6532. Published online 2023 Oct 17. doi: 10.1038/s41467-023-42302-6

PMCID:: PMC10582257

Abstract Article PDF–4.8M

Select item 1057036513.

METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3

Jianmei Yi, Feng Peng, Jingli Zhao, Xiaosong Gong

Sci Rep. 2023; 13: 17292. Published online 2023 Oct 12. doi: 10.1038/s41598-023-44379-x

PMCID:: PMC10570365

Abstract Article PDF–9.0M

Select item 1056587614.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1033340215.

IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia

Shenghao Wu, Changwei Chi, Shanshan Weng, Wenjin Zhou, Zhen Liu

Apoptosis. 2023; 28(7-8): 1035–1047. Published online 2023 Apr 15. doi: 10.1007/s10495-023-01846-0

PMCID:: PMC10333402

Abstract Article PDF–3.4M

Select item 1028868916.

m⁶A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma

Han Fang, Qi Sun, Jin Zhou, Huijuan Zhang, Qiong Song, Hua Zhang, Guohua Yu, Ying Guo, Chengyu Huang, Yakui Mou, Chuanliang Jia, Yingjian Song, Aina Liu, Kaiyu Song, Congxian Lu, Ruxian Tian, Shizhuang Wei, Dengfeng Yang, Yixuan Chen, Ting Li, Kejian Wang, Yilan Yu, Yufeng Lv, Ke Mo, Ping Sun, Xiaofeng Yu, Xicheng Song

Mol Cancer. 2023; 22: 99. Published online 2023 Jun 23. doi: 10.1186/s12943-023-01791-1

PMCID:: PMC10288689

Abstract Article PDF–9.3M

Select item 1023742217.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1022796318.

A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer

Sandra Kendzia, Susanne Franke, Tarek Kröhler, Nicole Golob-Schwarzl, Caroline Schweiger, Anna M. Toeglhofer, Christina Skofler, Stefan Uranitsch, Amin El-Heliebi, Julia Fuchs, Andreas Punschart, Philipp Stiegler, Marlen Keil, Jens Hoffmann, David Henderson, Hans Lehrach, Marie-Laure Yaspo, Christoph Reinhard, Reinhold Schäfer, Ulrich Keilholz, Christian Regenbrecht, Rudolf Schicho, Peter Fickert, Sigurd F. Lax, Frank Erdmann, Marcel H. Schulz, Alexandra K. Kiemer, Johannes Haybaeck, Sonja M. Kessler

Mol Cancer. 2023; 22: 89. Published online 2023 May 30. doi: 10.1186/s12943-023-01787-x

PMCID:: PMC10227963

Abstract Article PDF–2.3M

Select item 1015862419.

The RNA‐binding protein Snd1/Tudor‐SN regulates hypoxia‐responsive gene expression

Juha Saarikettu, Saara Lehmusvaara, Marko Pesu, Ilkka Junttila, Juha Partanen, Petra Sipilä, Matti Poutanen, Jie Yang, Teemu Haikarainen, Olli Silvennoinen

FASEB Bioadv. 2023 May; 5(5): 183–198. Published online 2023 Feb 21. doi: 10.1096/fba.2022-00115

PMCID:: PMC10158624

Abstract Article PDF–7.2M

Select item 1014884320.

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin

Naphat Chantaravisoot, Piriya Wongkongkathep, Nuttiya Kalpongnukul, Narawit Pacharakullanon, Pornchai Kaewsapsak, Chaiyaboot Ariyachet, Joseph A. Loo, Fuyuhiko Tamanoi, Trairak Pisitkun

Sci Rep. 2023; 13: 7037. Published online 2023 Apr 29. doi: 10.1038/s41598-023-33872-y

PMCID:: PMC10148843

Abstract Article PDF–11M

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PMC Links for GEO Profiles (Select 96347432) (262)
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Notch-on and Notch-off effects on T-lymphoblastic leukemia cell line CUTLL1: tim...
Notch-on and Notch-off effects on T-lymphoblastic leukemia cell line CUTLL1: time course
Accession: GDS4289

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Duchenne Muscular Dystrophy response to oxandrolone (HG-U133A)
Duchenne Muscular Dystrophy response to oxandrolone (HG-U133A)
Accession: GDS1333

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Effect of ischemia and tissue procurement conditions on resected renal clear cel...
Effect of ischemia and tissue procurement conditions on resected renal clear cell carcinoma
Accession: GDS4547

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