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Select item 105658761.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 100729652.

Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway

Benhuo Zhao, Jiaojiao Wu, Xiuli Cha, Guangtong Mao, Hengliang Shi, Sujuan Fei, Bei Miao

Anal Cell Pathol (Amst) 2023; 2023: 5617875. Published online 2023 Mar 28. doi: 10.1155/2023/5617875

PMCID:: PMC10072965

Abstract Article PDF–6.6M

Select item 98452413.

Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination

Jianjian Hu, Wenxue Jiang, Jiaqi Zuo, Dujuan Shi, Xiaoqi Chen, Xiao Yang, Wenhui Zhang, Lixin Ma, Zhu Liu, Qiong Xing

Commun Biol. 2023; 6: 59. Published online 2023 Jan 17. doi: 10.1038/s42003-023-04458-1

PMCID:: PMC9845241

Abstract Article PDF–3.3M

Select item 96181494.

A COP1-GATA2 axis suppresses AR signaling and prostate cancer

Tao Shen, Bingning Dong, Yanling Meng, David D. Moore, Feng Yang

Proc Natl Acad Sci U S A. 2022 Oct 25; 119(43): e2205350119. Published online 2022 Oct 17. doi: 10.1073/pnas.2205350119

PMCID:: PMC9618149

Abstract Article PDF–2.2M

Select item 91197365.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 89230576.

Transcription Factor Protein Interactomes Reveal Genetic Determinants in Heart Disease

Barbara Gonzalez-Teran, Maureen Pittman, Franco Felix, Reuben Thomas, Desmond Richmond-Buccola, Ruth Hüttenhain, Krishna Choudhary, Elisabetta Moroni, Mauro W. Costa, Yu Huang, Arun Padmanabhan, Michael Alexanian, Clara Youngna Lee, Bonnie E. J. Maven, Kaitlen Samse-Knapp, Sarah U. Morton, Michael McGregor, Casey A. Gifford, J. G. Seidman, Christine E. Seidman, Bruce D. Gelb, Giorgio Colombo, Bruce R. Conklin, Brian L. Black, Benoit G. Bruneau, Nevan J. Krogan, Katherine S. Pollard, Deepak Srivastava

Cell. Author manuscript; available in PMC 2023 Mar 3.

Published in final edited form as: Cell. 2022 Mar 3; 185(5): 794–814.e30. Published online 2022 Feb 18. doi: 10.1016/j.cell.2022.01.021

PMCID:: PMC8923057

Abstract Article PDF–2.5M

Select item 88288957.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 85032628.

RFWD2 Knockdown as a Blocker to Reverse the Oncogenic Role of TRIB2 in Lung Adenocarcinoma

Ruimin Hao, Jinxia Hu, Yuemei Liu, Dongmin Liang, Yan-Mei Li, Ranran Wang, Shucui Zhang, Pingyu Wang, You-Jie Li, Shuyang Xie

Front Oncol. 2021; 11: 733175. Published online 2021 Sep 27. doi: 10.3389/fonc.2021.733175

PMCID:: PMC8503262

Abstract Article PDF–5.7M

Select item 84411429.

A methyltransferase‐like 14/miR‐99a‐5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2‐mediated epigenetic modulation in esophageal squamous cell carcinoma

Zhenchuan Liu, Kaiqing Wu, Shaorui Gu, Wenli Wang, Shiliang Xie, Tiancheng Lu, Lei Li, Chenglai Dong, Xishi Wang, Yongxin Zhou

Clin Transl Med. 2021 Sep; 11(9): e545. Published online 2021 Sep 15. doi: 10.1002/ctm2.545

Correction in:: Clin Transl Med. 2022 Jun; 12(6): e741.

PMCID:: PMC8441142

Abstract Article PDF–4.8M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 812022711.

KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1

Wenxue Liu, Zhiyan Zhan, Meiying Zhang, Bowen Sun, Qiqi Shi, Fei Luo, Mingda Zhang, Weiwei Zhang, Yanli Hou, Xiuying Xiao, Yanxin Li, Haizhong Feng

Theranostics. 2021; 11(13): 6278–6292. Published online 2021 Apr 15. doi: 10.7150/thno.57455

PMCID:: PMC8120227

Abstract Article PDF–2.7M

Select item 808063112.

IP₆-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion

Hong Lin, Yuan Yan, Yifan Luo, Wing Yan So, Xiayun Wei, Xiaozhe Zhang, Xiaoli Yang, Jun Zhang, Yang Su, Xiuyan Yang, Bobo Zhang, Kangjun Zhang, Nan Jiang, Billy Kwok Chong Chow, Weiping Han, Fengchao Wang, Feng Rao

Nat Commun. 2021; 12: 2461. Published online 2021 Apr 28. doi: 10.1038/s41467-021-22941-3

PMCID:: PMC8080631

Abstract Article PDF–3.1M

Select item 757886413.

EGF Relays Signals to COP1 and Facilitates FOXO4 Degradation to Promote Tumorigenesis

Hyun Ho Choi, Shaomin Zou, Jian‐lin Wu, Huashe Wang, Liem Phan, Kai Li, Peng Zhang, Daici Chen, Qingxin Liu, Baifu Qin, Thu Anh Thai Nguyen, Sai‐Ching J. Yeung, Lekun Fang, Mong‐Hong Lee

Adv Sci (Weinh) 2020 Oct; 7(20): 2000681. Published online 2020 Sep 23. doi: 10.1002/advs.202000681

PMCID:: PMC7578864

Abstract Article PDF–5.0M

Select item 756688114.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 742732715.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 704916416.

Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates

Weiming Ouyang, Pengfei Guo, Kazuyo Takeda, Qiong Fu, Hui Fang, David M. Frucht

Proc Natl Acad Sci U S A. 2020 Feb 25; 117(8): 4078–4087. Published online 2020 Feb 10. doi: 10.1073/pnas.1913698117

PMCID:: PMC7049164

Abstract Article PDF–1.5M

Select item 698120617.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

Select item 658157418.

Cryptochromes-mediated Inhibition of the CRL4^Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism

Luca Rizzini, Daniel C. Levine, Mark Perelis, Joseph Bass, Clara B. Peek, Michele Pagano

Curr Biol. Author manuscript; available in PMC 2020 Jun 17.

Published in final edited form as: Curr Biol. 2019 Jun 17; 29(12): 1954–1962.e4. Published online 2019 May 30. doi: 10.1016/j.cub.2019.04.073

PMCID:: PMC6581574

Abstract Article PDF–1.1M

Select item 642409819.

PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ

Gunnar Dittmar, Daniel Perez Hernandez, Elisabeth Kowenz-Leutz, Marieluise Kirchner, Günther Kahlert, Radoslaw Wesolowski, Katharina Baum, Maria Knoblich, Maria Hofstätter, Arnaud Muller, Jana Wolf, Ulf Reimer, Achim Leutz

iScience. 2019 Mar 29; 13: 351–370. Published online 2019 Mar 1. doi: 10.1016/j.isci.2019.02.026

PMCID:: PMC6424098

Abstract Article PDF–11M

Select item 637627420.

The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export

Jennifer E Kung, Natalia Jura

EMBO J. 2019 Feb 15; 38(4): e99708. Published online 2019 Jan 29. doi: 10.15252/embj.201899708

PMCID:: PMC6376274

Abstract Article PDF–1.6M

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