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Items: 1 to 20 of 58

1.
AZU1 (HBP/CAP37) and PRKCG (PKC-gamma) may be candidate genes affecting the severity of acute mountain sickness
Zhichao Xu, Qiong Li, Xiaobing Shen
BMC Med Genomics. 2023; 16: 28. Published online 2023 Feb 20. doi: 10.1186/s12920-023-01457-3
PMCID:
PMC9940399
AbstractArticlePDF–2.2M
2.
lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway
Yuanxiu Gan, Jie Long, Yan Zeng, Yan Zhang, Yang Tao
Mediators Inflamm. 2022; 2022: 9923204. Published online 2022 Oct 13. doi: 10.1155/2022/9923204
PMCID:
PMC9584741
AbstractArticlePDF–2.6M
3.
The Emerging Key Role of the mGluR1-PKCγ Signaling Pathway in the Pathogenesis of Spinocerebellar Ataxias: A Neurodevelopmental Viewpoint
Qin-Wei Wu, Josef P. Kapfhammer
Int J Mol Sci. 2022 Aug; 23(16): 9169. Published online 2022 Aug 15. doi: 10.3390/ijms23169169
PMCID:
PMC9409119
AbstractArticlePDF–1.0M
4.
Episodic ataxia and severe infantile phenotype in spinocerebellar ataxia type 14: expansion of the phenotype and novel mutations
Giovanna De Michele, Daniele Galatolo, Serena Galosi, Andrea Mignarri, Gabriella Silvestri, Carlo Casali, Vincenzo Leuzzi, Ivana Ricca, Melissa Barghigiani, Alessandra Tessa, Ettore Cioffi, Caterina Caputi, Vittorio Riso, Maria Teresa Dotti, Francesco Saccà, Giuseppe De Michele, Sirio Cocozza, Alessandro Filla, Filippo M. Santorelli
J Neurol. 2022; 269(3): 1476–1484. Published online 2021 Jul 22. doi: 10.1007/s00415-021-10712-5
PMCID:
PMC8857164
AbstractArticlePDF–805K
5.
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y
PMCID:
PMC8352964
AbstractArticlePDF–4.5M
6.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
7.
Spinocerebellar ataxia type 14: refining clinicogenetic diagnosis in a rare adult‐onset disorder
Tanja Schmitz‐Hübsch, Silke Lux, Peter Bauer, Alexander U. Brandt, Elena Schlapakow, Susanne Greschus, Michael Scheel, Hanna Gärtner, Mehmet E. Kirlangic, Vincent Gras, Dagmar Timmann, Matthis Synofzik, Alejandro Giorgetti, Paolo Carloni, Jon N. Shah, Ludger Schöls, Ute Kopp, Lisa Bußenius, Timm Oberwahrenbrock, Hanna Zimmermann, Caspar Pfueller, Ella‐Maria Kadas, Maria Rönnefarth, Anne‐Sophie Grosch, Matthias Endres, Katrin Amunts, Friedemann Paul, Sarah Doss, Martina Minnerop
Ann Clin Transl Neurol. 2021 Apr; 8(4): 774–789. Published online 2021 Mar 19. doi: 10.1002/acn3.51315
PMCID:
PMC8045942
AbstractArticlePDF–846K
8.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
9.
The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC
L Ren, SH Hong, J Cassavaugh, T Osborne, AJ Chou, SY Kim, R Gorlick, SM Hewitt, C Khanna
Oncogene. Author manuscript; available in PMC 2020 May 11.
Published in final edited form as: Oncogene. 2009 Feb 12; 28(6): 792–802. Published online 2008 Dec 8. doi: 10.1038/onc.2008.437
PMCID:
PMC7213760
AbstractArticlePDF–2.0M
10.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D
Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch
Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9
PMCID:
PMC6981206
AbstractArticlePDF–3.7M
11.
The Role of Cysteine String Protein α Phosphorylation at Serine 10 and 34 by Protein Kinase Cγ for Presynaptic Maintenance
Toshihiko Shirafuji, Takehiko Ueyama, Naoko Adachi, Ken-Ichi Yoshino, Yusuke Sotomaru, Junsuke Uwada, Azumi Kaneoka, Taro Ueda, Shigeru Tanaka, Izumi Hide, Naoaki Saito, Norio Sakai
J Neurosci. 2018 Jan 10; 38(2): 278–290. doi: 10.1523/JNEUROSCI.1649-17.2017
PMCID:
PMC6596106
AbstractArticlePDF–2.2M
12.
Genotype‐phenotype correlations, dystonia and disease progression in spinocerebellar ataxia type 14
Viorica Chelban, Sarah Wiethoff, Bjørn K. Fabian‐Jessing, Nourelhoda A. Haridy, Alaa Khan, Stephanie Efthymiou, Esther B. E. Becker, Emer O'Connor, Joshua Hersheson, Katrina Newland, Allan Thomas Hojland, Pernille A. Gregersen, Suzanne G. Lindquist, Michael B. Petersen, Jørgen E. Nielsen, Michael Nielsen, Nicholas W. Wood, Paola Giunti, Henry Houlden
Mov Disord. 2018 Jul; 33(7): 1119–1129. Published online 2018 Mar 30. doi: 10.1002/mds.27334
PMCID:
PMC6175136
AbstractArticlePDF–3.1M
13.
Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation
Maggie M. K. Wong, Stephanie D. Hoekstra, Jane Vowles, Lauren M. Watson, Geraint Fuller, Andrea H. Németh, Sally A. Cowley, Olaf Ansorge, Kevin Talbot, Esther B. E. Becker
Acta Neuropathol Commun. 2018; 6: 99. Published online 2018 Sep 24. doi: 10.1186/s40478-018-0600-7
PMCID:
PMC6151931
AbstractArticlePDF–7.6M
14.
Calcium Signaling, PKC Gamma, IP3R1 and CAR8 Link Spinocerebellar Ataxias and Purkinje Cell Dendritic Development
Etsuko Shimobayashi, Josef P. Kapfhammer
Curr Neuropharmacol. 2018 Feb; 16(2): 151–159. Published online 2018 Feb. doi: 10.2174/1570159X15666170529104000
PMCID:
PMC5883377
AbstractArticlePDF–499K
15.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
16.
Increased biological activity of protein Kinase C gamma is not required in Spinocerebellar ataxia 14
Etsuko Shimobayashi, Josef P. Kapfhammer
Mol Brain. 2017; 10: 34. Published online 2017 Jul 24. doi: 10.1186/s13041-017-0313-z
PMCID:
PMC5525338
AbstractArticlePDF–2.4M
17.
S. pombe Uba1-Ubc15 structure reveals a novel regulatory mechanism of ubiquitin E2 activity
Zongyang Lv, Kimberly A. Rickman, Lingmin Yuan, Katelyn Williams, Shanmugam Panneer Selvam, Alec N. Woosley, Philip H. Howe, Besim Ogretmen, Agata Smogorzewska, Shaun K. Olsen
Mol Cell. Author manuscript; available in PMC 2018 Feb 16.
Published in final edited form as: Mol Cell. 2017 Feb 16; 65(4): 699–714.e6. Published online 2017 Feb 2. doi: 10.1016/j.molcel.2017.01.008
PMCID:
PMC5319395
AbstractArticlePDF–4.3M
18.
Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease
Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman
Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387
PMCID:
PMC5260939
AbstractArticlePDF–1.1M
19.
LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils
Marguerite R. Kelher, Nathan J. D. McLaughlin, Anirban Banerjee, David J. Elzi, Fabia Gamboni, Samina Y. Khan, Xianzhong Meng, Sanchayita Mitra, Christopher C. Silliman
J Leukoc Biol. 2017 Jan; 101(1): 261–273. Published online 2016 Aug 16. doi: 10.1189/jlb.3A0813-420RRR
PMCID:
PMC5166440
AbstractArticle
20.
Tumour suppressor TRIM33 targets nuclear ß-catenin degradation
Jianfei Xue, Yaohui Chen, Yamei Wu, Zhongyong Wang, Aidong Zhou, Sicong Zhang, Kangyu Lin, Kenneth Aldape, Sadhan Majumder, Zhimin Lu, Suyun Huang
Nat Commun. Author manuscript; available in PMC 2015 Aug 2.
Published in final edited form as: Nat Commun. 2015; 6: 6156. Published online 2015 Feb 2. doi: 10.1038/ncomms7156
PMCID:
PMC4315364
AbstractArticlePDF–2.5M

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