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Select item 104392721.

Chromosomal deletions on 16p11.2 encompassing SH2B1 are associated with accelerated metabolic disease

Ruth Hanssen, Chiara Auwerx, Maarja Jõeloo, Marie C. Sadler, Estonian Biobank Research Team, Elana Henning, Julia Keogh, Rebecca Bounds, Miriam Smith, Helen V. Firth, Zoltán Kutalik, I. Sadaf Farooqi, Alexandre Reymond, Katherine Lawler

Cell Rep Med. 2023 Aug 15; 4(8): 101155. Published online 2023 Aug 15. doi: 10.1016/j.xcrm.2023.101155

PMCID:: PMC10439272

Abstract Article PDF–4.0M

Select item 94819332.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 93485763.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 91197364.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 90634355.

BBOX1‐AS1 contributes to colorectal cancer progression by sponging hsa‐miR‐361‐3p and targeting SH2B1

Jiasheng Liu, Jie Zhu, Zhe Xiao, Xufeng Wang, Jianfei Luo

FEBS Open Bio. 2022 May; 12(5): 983–992. Published online 2022 Mar 26. doi: 10.1002/2211-5463.12802

PMCID:: PMC9063435

Abstract Article PDF–3.5M

Select item 87690726.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 77683168.

Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in Endometrial Carcinoma

Bo Wu, Ailing Ren, Ying Tian, Ruizhen Huang

Technol Cancer Res Treat. 2020; 19: 1533033820983079. Published online 2020 Dec 24. doi: 10.1177/1533033820983079

PMCID:: PMC7768316

Abstract Article PDF–1.5M

Select item 72820069.

Association of the SH2B1 rs7359397 Gene Polymorphism with Steatosis Severity in Subjects with Obesity and Non-Alcoholic Fatty Liver Disease

Nuria Perez-Diaz-del-Campo, Itziar Abete, Irene Cantero, Bertha Araceli Marin-Alejandre, J. Ignacio Monreal, Mariana Elorz, José Ignacio Herrero, Alberto Benito-Boillos, Jose I. Riezu-Boj, Fermín I. Milagro, Josep A. Tur, J. Alfredo Martinez, M. Angeles Zulet

Nutrients. 2020 May; 12(5): 1260. Published online 2020 Apr 29. doi: 10.3390/nu12051260

PMCID:: PMC7282006

Abstract Article PDF–1.6M

Select item 716998310.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 708996611.

Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease

Lin Jiang, Haoran Su, Xiaoyin Wu, Hong Shen, Min-Hyun Kim, Yuan Li, Martin G. Myers, Jr, Chung Owyang, Liangyou Rui

Nat Commun. 2020; 11: 1517. Published online 2020 Mar 23. doi: 10.1038/s41467-020-15328-3

Correction in:: Nat Commun. 2020; 11: 5310.

PMCID:: PMC7089966

Abstract Article PDF–5.3M

Select item 698120612.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

Select item 680462513.

Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance

Anabel Flores, Lawrence S. Argetsinger, Lukas K.J. Stadler, Alvaro E. Malaga, Paul B. Vander, Lauren C. DeSantis, Ray M. Joe, Joel M. Cline, Julia M. Keogh, Elana Henning, Ines Barroso, Edson Mendes de Oliveira, Gowri Chandrashekar, Erik S. Clutter, Yixin Hu, Jeanne Stuckey, I. Sadaf Farooqi, Martin G. Myers, Jr., Christin Carter-Su

Diabetes. 2019 Nov; 68(11): 2049–2062. Published online 2019 Aug 22. doi: 10.2337/db19-0608

PMCID:: PMC6804625

Abstract Article PDF–2.3M

Select item 644451514.

Replication of the SH2B1 rs7498665 Association with Obesity in a Belgian Study Population

Sigri Beckers, Doreen Zegers, Luc F. Van Gaal, Wim Van Hul

Obes Facts. 2011 Dec; 4(6): 473–477. Published online 2011 Dec 6. doi: 10.1159/000335305

PMCID:: PMC6444515

Abstract Article PDF–157K

Select item 598166615.

The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus

Johanna Giuranna, Anna-Lena Volckmar, Anna Heinen, Triinu Peters, Börge Schmidt, Anne Spieker, Helena Straub, Harald Grallert, Timo D. Müller, Jochen Antel, Ute Haußmann, Hans Klafki, Rui Liangyou, Johannes Hebebrand, Anke Hinney

Obes Facts. 2018 May; 11(2): 93–108. Published online 2018 Apr 10. doi: 10.1159/000486962

Correction in:: Obes Facts. 2018 Jul; 11(3): 176–180.

PMCID:: PMC5981666

Abstract Article PDF–1.0M

Select item 590527216.

The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling

Filipa Franquinho, Joana Nogueira-Rodrigues, Joana M. Duarte, Sofia S. Esteves, Christin Carter-Su, Anthony P. Monaco, Zoltán Molnár, Antonio Velayos-Baeza, Pedro Brites, Mónica M. Sousa

Cereb Cortex. 2017 Mar; 27(3): 1732–1747. Published online 2017 Feb 17. doi: 10.1093/cercor/bhx023

PMCID:: PMC5905272

Abstract Article PDF–1.7M

Select item 590093017.

SH2B1 promotes epithelial‐mesenchymal transition through the IRS1/β‐catenin signaling axis in lung adenocarcinoma

Shaoqiang Wang, Yuanda Cheng, Yang Gao, Zhiwei He, Wolong Zhou, Ruimin Chang, Zhenzi Peng, Yingying Zheng, Chaojun Duan, Chunfang Zhang

Mol Carcinog. 2018 May; 57(5): 640–652. Published online 2018 Feb 20. doi: 10.1002/mc.22788

PMCID:: PMC5900930

Abstract Article PDF–14M

Select item 553161118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549522519.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 545318120.

Evidence for association between SH2B1 gene variants and glycated hemoglobin in non-diabetic European American young adults: The Add Health study

LESLIE A LANGE, MARIAELISA GRAFF, ETHAN M LANGE, KRISTIN L YOUNG, ANDREA S RICHARDSON, KAREN L MOHLKE, KARI E NORTH, KATHLEEN M HARRIS, PENNY GORDON-LARSEN

Ann Hum Genet. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Ann Hum Genet. 2016 Sep; 80(5): 294–305. doi: 10.1111/ahg.12165

PMCID:: PMC5453181

Abstract Article PDF–372K

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