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Select item 88421651.

CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system

Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629

PMCID:: PMC8842165

Abstract Article PDF–3.0M

Select item 83493182.

An E3 Ubiquitin Ligase RNF139 Serves as a Tumor-Suppressor in Glioma

Xiaofeng Chen, Weiping Kuang, Yong Zhu, Bin Zhou, Xiaosong Li, Xi Zhang, Bo Li, Liang Li, Shucheng Zou

J Mol Neurosci. 2021; 71(8): 1664–1673. Published online 2021 Jun 9. doi: 10.1007/s12031-021-01860-4

PMCID:: PMC8349318

Abstract Article PDF–7.8M

Select item 82360783.

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs

Katherine M. Almasy, Jonathan P. Davies, Lars Plate

Mol Cell Proteomics. 2021; 20: 100120. Published online 2021 Jun 27. doi: 10.1016/j.mcpro.2021.100120

PMCID:: PMC8236078

Abstract Article PDF–4.6M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75668815.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 73322936.

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

Emma J Fenech, Federica Lari, Philip D Charles, Roman Fischer, Marie Laétitia-Thézénas, Katrin Bagola, Adrienne W Paton, James C Paton, Mads Gyrd-Hansen, Benedikt M Kessler, John C Christianson

eLife. 2020; 9: e57306. Published online 2020 Jul 2. doi: 10.7554/eLife.57306

PMCID:: PMC7332293

Abstract Article PDF–2.2M

Select item 72790497.

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired

Marioara Chiritoiu, Gabriela N. Chiritoiu, Cristian V. A. Munteanu, Florin Pastrama, N. Erwin Ivessa, Stefana M. Petrescu

Int J Mol Sci. 2020 May; 21(10): 3468. Published online 2020 May 14. doi: 10.3390/ijms21103468

PMCID:: PMC7279049

Abstract Article PDF–12M

Select item 70531698.

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment

Sathish Kumar, Rina Barouch-Bentov, Fei Xiao, Stanford Schor, Szuyuan Pu, Elise Biquand, Albert Lu, Brett D. Lindenbach, Yves Jacob, Caroline Demeret, Shirit Einav

Cell Rep. Author manuscript; available in PMC 2020 Mar 3.

Published in final edited form as: Cell Rep. 2019 Feb 12; 26(7): 1800–1814.e5. doi: 10.1016/j.celrep.2019.01.075

PMCID:: PMC7053169

Abstract Article PDF–2.3M

Select item 63692749.

Insulin-induced gene 1 (INSIG1) inhibits HIV-1 production by degrading Gag via activity of the ubiquitin ligase TRC8

You Zhang, Jing Lu, Jing Ma, Xinqi Liu

J Biol Chem. 2019 Feb 8; 294(6): 2046–2059. Published online 2018 Dec 18. doi: 10.1074/jbc.RA118.004630

PMCID:: PMC6369274

Abstract Article PDF–4.0M

Select item 593476610.

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail‐anchored proteins

Sandra Stefanovic‐Barrett, Anna S Dickson, Stephen P Burr, James C Williamson, Ian T Lobb, Dick JH van den Boomen, Paul J Lehner, James A Nathan

EMBO Rep. 2018 May; 19(5): e45603. Published online 2018 Mar 8. doi: 10.15252/embr.201745603

PMCID:: PMC5934766

Abstract Article PDF–4.7M

Select item 549300011.

E3 ubiquitin ligase, RNF139, inhibits the progression of tongue cancer

Lina Wang, Wei Yin, Chun Shi

BMC Cancer. 2017; 17: 452. Published online 2017 Jun 29. doi: 10.1186/s12885-017-3438-7

PMCID:: PMC5493000

Abstract Article PDF–1.9M

Select item 531310112.

Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels

Christine Hantouche, Brittany Williamson, William C. Valinsky, Joshua Solomon, Alvin Shrier, Jason C. Young

J Biol Chem. 2017 Feb 10; 292(6): 2287–2300. Published online 2016 Dec 20. doi: 10.1074/jbc.M116.752618

PMCID:: PMC5313101

Abstract Article PDF–2.6M

Select item 467811113.

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I

D.J.H. van den Boomen, P.J. Lehner

Mol Immunol. 2015 Dec; 68(2): 106–111. doi: 10.1016/j.molimm.2015.07.005

PMCID:: PMC4678111

Abstract Article PDF–1002K

Select item 428340714.

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

Chia-yi Chen, Nicole S Malchus, Beate Hehn, Walter Stelzer, Dönem Avci, Dieter Langosch, Marius K Lemberg

EMBO J. 2014 Nov 3; 33(21): 2492–2506. Published online 2014 Sep 19. doi: 10.15252/embj.201488208

PMCID:: PMC4283407

Abstract Article PDF–1.7M

Select item 356453815.

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes

Youngah Jo, Isamu Z. Hartman, Russell A. DeBose-Boyd

Mol Biol Cell. 2013 Feb 1; 24(3): 169–183. doi: 10.1091/mbc.E12-07-0564

PMCID:: PMC3564538

Abstract Article PDF–3.6M

Select item 325115716.

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8

Youngah Jo, Peter C. W. Lee, Peter V. Sguigna, Russell A. DeBose-Boyd

Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51): 20503-20508. Published online 2011 Dec 5. doi: 10.1073/pnas.1112831108

PMCID:: PMC3251157

Abstract Article PDF–1.0M

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 308682518.

TRC8, A KIDNEY CANCER-ASSOCIATED UBIQUITIN LIGASE, IS STEROL-REGULATED AND INTERACTS WITH LIPID AND PROTEIN BIOSYNTHETIC PATHWAYS

Jason P. Lee, Anne Brauweiler, Michael Rudolph, Joan E. Hooper, Harry A. Drabkin, Robert M. Gemmill

Mol Cancer Res. Author manuscript; available in PMC 2011 May 3.

Published in final edited form as: Mol Cancer Res. 2010 Jan; 8(1): 93–106. Published online 2010 Jan 12. doi: 10.1158/1541-7786.MCR-08-0491

PMCID:: PMC3086825

Abstract Article PDF–3.1M

Select item 308320719.

Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase

Youngah Jo, Peter V. Sguigna, Russell A. DeBose-Boyd

J Biol Chem. 2011 Apr 29; 286(17): 15022–15031. Published online 2011 Feb 22. doi: 10.1074/jbc.M110.211326

PMCID:: PMC3083207

Abstract Article PDF–1.4M

Select item 278144620.

The Sterol-sensing Endoplasmic Reticulum (ER) Membrane Protein TRC8 Hampers ER to Golgi Transport of Sterol Regulatory Element-binding Protein-2 (SREBP-2)/SREBP Cleavage-activated Protein and Reduces SREBP-2 Cleavage

Masato Irisawa, Jun Inoue, Nozomi Ozawa, Kazutoshi Mori, Ryuichiro Sato

J Biol Chem. 2009 Oct 16; 284(42): 28995–29004. Published online 2009 Aug 25. doi: 10.1074/jbc.M109.041376

PMCID:: PMC2781446

Abstract Article PDF–959K

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