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Select item 111132111.

Syk is indispensable for CpG-induced activation and differentiation of human B cells

Mariann Kremlitzka, Bernadett Mácsik-Valent, Anna Erdei

Cell Mol Life Sci. 2015 Jun; 72(11): 2223–2236. Published online 2014 Dec 28. doi: 10.1007/s00018-014-1806-x

PMCID:: PMC11113211

Abstract Article PDF–1.2M

Select item 111050002.

A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane

Cláudia Almeida Loureiro, Francisco R. Pinto, Patrícia Barros, Paulo Matos, Peter Jordan

Cell Mol Life Sci. 2020 Dec; 77(23): 4997–5015. Published online 2020 Jan 23. doi: 10.1007/s00018-020-03448-4

Correction in:: Cell Mol Life Sci. 2024 Dec; 81(1): 328.

PMCID:: PMC11105000

Abstract Article PDF–4.7M

Select item 110030533.

SIRPB1 regulates inflammatory factor expression in the glioma microenvironment via SYK: functional and bioinformatics insights

Ren Geng, Yao Zhao, Wanzhen Xu, Xiaoshan Ma, Yining Jiang, Xuefei Han, Liyan Zhao, Yunqian Li

J Transl Med. 2024; 22: 338. Published online 2024 Apr 9. doi: 10.1186/s12967-024-05149-z

PMCID:: PMC11003053

Abstract Article PDF–5.8M

Select item 101783614.

Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets

Pengyu Zhang, Fiorella A. Solari, Johan W. M. Heemskerk, Marijke J. E. Kuijpers, Albert Sickmann, Ulrich Walter, Kerstin Jurk

Int J Mol Sci. 2023 May; 24(9): 7776. Published online 2023 Apr 24. doi: 10.3390/ijms24097776

PMCID:: PMC10178361

Abstract Article PDF–3.2M

Select item 100998055.

Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Maria Prendecki, Kavita Gulati, Noelle Pisacano, Damilola Pinheiro, Tejal Bhatt, Marie‐Anne Mawhin, Frederic Toulza, Esteban S. Masuda, Andrew Cowburn, Katharine M. Lodge, Frederick W. K. Tam, Candice Roufosse, Charles D. Pusey, Stephen P. McAdoo

Arthritis Rheumatol. 2023 Jan; 75(1): 84–97. Published online 2022 Nov 25. doi: 10.1002/art.42321

PMCID:: PMC10099805

Abstract Article PDF–2.7M

Select item 100729066.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 98123737.

Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19

Gustaf Wigerblad, Seth A. Warner, Marcos J. Ramos-Benitez, Lela Kardava, Xin Tian, Rui Miao, Robert Reger, Mala Chakraborty, Susan Wong, Yogendra Kanthi, Anthony F. Suffredini, Stefania Dell’Orso, Stephen Brooks, Christopher King, Oksana Shlobin, Steven D. Nathan, Jonathan Cohen, Susan Moir, Richard W. Childs, Mariana J. Kaplan, Daniel S. Chertow, Jeffrey R. Strich

Sci Adv. 2023 Jan; 9(1): eade8272. Published online 2023 Jan 4. doi: 10.1126/sciadv.ade8272

PMCID:: PMC9812373

Abstract Article PDF–1.8M

Select item 92792858.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91989199.

A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas

Manit Munshi, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Maria Luisa Guerrera, Zachary R. Hunter, M. Lia Palomba, Kimon V. Argyropoulos, Christopher J. Patterson, Alexa G. Canning, Kirsten Meid, Joshua Gustine, Andrew R. Branagan, Catherine A. Flynn, Shayna Sarosiek, Jorge J. Castillo, Jinhua Wang, Sara J. Buhrlage, Nathanael S. Gray, Nikhil C. Munshi, Kenneth C. Anderson, Steven P. Treon, Guang Yang

Blood Adv. 2022 Jun 14; 6(11): 3332–3338. Published online 2022 Jun 3. doi: 10.1182/bloodadvances.2021006147

PMCID:: PMC9198919

Abstract Article PDF–1.4M

Select item 874559210.

Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear

Gina Perrella, Samantha J. Montague, Helena C. Brown, Lourdes Garcia Quintanilla, Alexandre Slater, David Stegner, Mark Thomas, Johan W. M. Heemskerk, Steve P. Watson

Int J Mol Sci. 2022 Jan; 23(1): 493. Published online 2022 Jan 1. doi: 10.3390/ijms23010493

PMCID:: PMC8745592

Abstract Article PDF–3.7M

Select item 868956511.

STING-Mediated Interferon Induction by Herpes Simplex Virus 1 Requires the Protein Tyrosine Kinase Syk

Chenyao Wang, Nikhil Sharma, Manoj Veleeparambil, Patricia M. Kessler, Belinda Willard, Ganes C. Sen

mBio. 2021 Nov-Dec; 12(6): e03228-21. Published online 2021 Dec 21. doi: 10.1128/mbio.03228-21

PMCID:: PMC8689565

Abstract Article PDF–4.8M

Select item 860537312.

Differences in the dynamics of the tandem‐SH2 modules of the Syk and ZAP‐70 tyrosine kinases

Helen T. Hobbs, Neel H. Shah, Jean M. Badroos, Christine L. Gee, Susan Marqusee, John Kuriyan

Protein Sci. 2021 Dec; 30(12): 2373–2384. Published online 2021 Oct 23. doi: 10.1002/pro.4199

PMCID:: PMC8605373

Abstract Article PDF–5.8M

Select item 859361813.

SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis

Carmelo Luci, Elodie Vieira, Manon Bourinet, Déborah Rousseau, Stéphanie Bonnafous, Stéphanie Patouraux, Lauren Lefevre, Frederic Larbret, Virginie Prod’homme, Antonio Iannelli, Albert Tran, Rodolphe Anty, Béatrice Bailly-Maitre, Marcel Deckert, Philippe Gual

Cell Mol Gastroenterol Hepatol. 2022; 13(1): 173–191. Published online 2021 Aug 16. doi: 10.1016/j.jcmgh.2021.08.004

PMCID:: PMC8593618

Abstract Article PDF–2.0M

Select item 855165514.

Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling

Laurence M. Gagné, Nadine Morin, Noémie Lavoie, Nicolas Bisson, Jean-Philippe Lambert, Frédérick A. Mallette, Marc-Étienne Huot

J Biol Chem. 2021 Nov; 297(5): 101291. Published online 2021 Oct 9. doi: 10.1016/j.jbc.2021.101291

PMCID:: PMC8551655

Abstract Article PDF–3.5M

Select item 834298715.

TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity

Xueer Wang, Honghai Zhang, Zhugui Shao, Wanxin Zhuang, Chao Sui, Feng Liu, Xiaorong Chen, Jinxiu Hou, Lingli Kong, Hansen Liu, Yi Zheng, Bingyu Liu, Tian Chen, Lei Zhang, Xinming Jia, Chengjiang Gao

Signal Transduct Target Ther. 2021; 6: 298. Published online 2021 Aug 6. doi: 10.1038/s41392-021-00711-3

PMCID:: PMC8342987

Abstract Article PDF–6.2M

Select item 834219616.

Comprehensive analysis of Syk gene methylation in colorectal cancer

Fanqin Bu, Xiaojian Zhu, Sicheng Liu, Kang Lin, Jinfeng Zhu, Jun Huang

Immun Inflamm Dis. 2021 Sep; 9(3): 923–931. Published online 2021 May 12. doi: 10.1002/iid3.449

PMCID:: PMC8342196

Abstract Article PDF–4.8M

Select item 824516117.

Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice

Lin Wang, Dominik Aschenbrenner, Zhiyang Zeng, Xiya Cao, Daniel Mayr, Meera Mehta, Melania Capitani, Neil Warner, Jie Pan, Liren Wang, Qi Li, Tao Zuo, Sarit Cohen-Kedar, Jiawei Lu, Rico Chandra Ardy, Daniel J. Mulder, Dilan Dissanayake, Kaiyue Peng, Zhiheng Huang, Xiaoqin Li, Yuesheng Wang, Xiaobing Wang, Shuchao Li, Samuel Bullers, Anís N. Gammage, Klaus Warnatz, Ana-Iris Schiefer, Gergely Krivan, Vera Goda, Walter H.A. Kahr, Mathieu Lemaire, Genomics England Research Consortium, Chien-Yi Lu, Iram Siddiqui, Michael G. Surette, Daniel Kotlarz, Karin R. Engelhardt, Helen R. Griffin, Robert Rottapel, Hélène Decaluwe, Ronald M. Laxer, Michele Proietti, Sophie Hambleton, Suzanne Elcombe, Cong-Hui Guo, Bodo Grimbacher, Iris Dotan, Siew C. Ng, Spencer A. Freeman, Scott B. Snapper, Christoph Klein, Kaan Boztug, Ying Huang, Dali Li, Holm H. Uhlig, Aleixo M. Muise

Nat Genet. Author manuscript; available in PMC 2021 Sep 29.

Published in final edited form as: Nat Genet. 2021 Apr; 53(4): 500–510. Published online 2021 Mar 29. doi: 10.1038/s41588-021-00803-4

PMCID:: PMC8245161

Abstract Article PDF–5.6M

Select item 823933618.

Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer

Teresa Sadras, Mickaël Martin, Kohei Kume, Mark E. Robinson, Supraja Saravanakumar, Gal Lenz, Zhengshan Chen, Joo Y. Song, Tanya Siddiqi, Laura Oksa, Anne Marie Knapp, Jevon Cutler, Kadriye Nehir Cosgun, Lars Klemm, Veronika Ecker, Janet Winchester, Dana Ghergus, Pauline Soulas-Sprauel, Friedemann Kiefer, Nora Heisterkamp, Akhilesh Pandey, Vu Ngo, Lili Wang, Hassan Jumaa, Maike Buchner, Jürgen Ruland, Wing-Chung Chan, Eric Meffre, Thierry Martin, Markus Müschen

Mol Cell. Author manuscript; available in PMC 2022 May 20.

Published in final edited form as: Mol Cell. 2021 May 20; 81(10): 2094–2111.e9. Published online 2021 Apr 19. doi: 10.1016/j.molcel.2021.03.043

PMCID:: PMC8239336

Abstract Article PDF–3.6M

Select item 822039119.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 797970520.

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1

Xiahui Li, Shujing Li, Bowen Li, Yanan Li, Sattout Aman, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Huijian Wu

NPJ Precis Oncol. 2021; 5: 20. Published online 2021 Mar 19. doi: 10.1038/s41698-021-00158-3

PMCID:: PMC7979705

Abstract Article PDF–6.8M

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