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Select item 111451411.

MFN2 suppresses the accumulation of lipid droplets and the progression of clear cell renal cell carcinoma

Zhiduan Cai, Wenjun Luo, Haoran Wang, Rui Zhu, Yaoji Yuan, Xiangyu Zhan, Mengyuan Xie, Haoquan Zhuang, Haoyu Chen, Yuyu Xu, Xiezhao Li, Leyuan Liu, Guibin Xu

Cancer Sci. 2024 Jun; 115(6): 1791–1807. Published online 2024 Mar 13. doi: 10.1111/cas.16151

PMCID:: PMC11145141

Abstract Article PDF–36M

Select item 110583602.

Mitofusin-2 enhances cervical cancer progression through Wnt/β-catenin signaling

Sung Yong Ahn

BMB Rep. 2024 Apr 30; 57(4): 194–199. Published online 2024 Mar 21. doi: 10.5483/BMBRep.2023-0205

PMCID:: PMC11058360

Abstract Article PDF–4.5M

Select item 108974903.

MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion

Andres Goldman, Michael Mullokandov, Yehudit Zaltsman, Limor Regev, Smadar Levin-Zaidman, Atan Gross

EMBO Rep. 2024 Jan; 25(1): 45–67. Published online 2023 Dec 14. doi: 10.1038/s44319-023-00009-1

PMCID:: PMC10897490

Abstract Article PDF–9.2M

Select item 107341944.

Clinicopathologic features of two unrelated autopsied patients with Charcot-Marie-Tooth disease carrying MFN2 gene mutation

Hideki Hayashi, Rie Saito, Hidetomo Tanaka, Norikazu Hara, Shin Koide, Yosuke Yonemochi, Tetsuo Ozawa, Mariko Hokari, Yasuko Toyoshima, Akinori Miyashita, Osamu Onodera, Kouichirou Okamoto, Takeshi Ikeuchi, Takashi Nakajima, Akiyoshi Kakita

Acta Neuropathol Commun. 2023; 11: 207. Published online 2023 Dec 20. doi: 10.1186/s40478-023-01692-w

PMCID:: PMC10734194

Article PDF–1.6M

Select item 107265945.

Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease

Chenfei Li, Qi Liu, Qing Chang, Meiqin Xie, Jiali Weng, Xiaohui Wang, Mengnan Li, Jiani Chen, Yan Huang, Xiaohua Yang, Kai Wang, Na Zhang, Kian Fan Chung, Ian M. Adcock, Hai Zhang, Feng Li

Respir Res. 2023; 24: 319. Published online 2023 Dec 18. doi: 10.1186/s12931-023-02634-9

PMCID:: PMC10726594

Abstract Article PDF–9.6M

Select item 106199786.

A human mitofusin 2 mutation can cause mitophagic cardiomyopathy

Antonietta Franco, Jiajia Li, Daniel P Kelly, Ray E Hershberger, Ali J Marian, Renate M Lewis, Moshi Song, Xiawei Dang, Alina D Schmidt, Mary E Mathyer, John R Edwards, Cristina de Guzman Strong, Gerald W Dorn

eLife. 2023; 12: e84235. Published online 2023 Nov 1. doi: 10.7554/eLife.84235

PMCID:: PMC10619978

Abstract Article PDF–15M

Select item 106162117.

DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress

Gautham Yepuri, Lisa M. Ramirez, Gregory G. Theophall, Sergei V. Reverdatto, Nosirudeen Quadri, Syed Nurul Hasan, Lei Bu, Devi Thiagarajan, Robin Wilson, Raquel López Díez, Paul F. Gugger, Kaamashri Mangar, Navneet Narula, Stuart D. Katz, Boyan Zhou, Huilin Li, Aleksandr B. Stotland, Roberta A. Gottlieb, Ann Marie Schmidt, Alexander Shekhtman, Ravichandran Ramasamy

Nat Commun. 2023; 14: 6900. Published online 2023 Oct 30. doi: 10.1038/s41467-023-42521-x

PMCID:: PMC10616211

Abstract Article PDF–12M

Select item 104704208.

LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity

Shun Zhang, Subo Qian, Hailong Liu, Ding Xu, Weimin Xia, Huangqi Duan, Chen Wang, Shenggen Yu, Yingying Chen, Ping Ji, Shujun Wang, Xingang Cui, Ying Wang, Haibo Shen

Redox Biol. 2023 Oct; 66: 102860. Published online 2023 Aug 22. doi: 10.1016/j.redox.2023.102860

PMCID:: PMC10470420

Abstract Article PDF–24M

Select item 103786569.

The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases

Pierce Colpman, Asish Dasgupta, Stephen L. Archer

Cells. 2023 Jul; 12(14): 1897. Published online 2023 Jul 20. doi: 10.3390/cells12141897

PMCID:: PMC10378656

Abstract Article PDF–4.9M

Select item 1024034810.

MFN2 deficiency affects calcium homeostasis in lung adenocarcinoma cells via downregulation of UCP4

Jingjing Zhang, Lifang Pan, Qiang Zhang, Yanyan Zhao, Wenwen Wang, Nengming Lin, Shirong Zhang, Qiong Wu

FEBS Open Bio. 2023 Jun; 13(6): 1107–1124. Published online 2023 Mar 14. doi: 10.1002/2211-5463.13591

PMCID:: PMC10240348

Abstract Article PDF–4.8M

Select item 1023742211.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 971188312.

A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle

Xun Wang, Yuemeng Jia, Jiawei Zhao, Nicholas P. Lesner, Cameron J. Menezes, Spencer D. Shelton, Siva Sai Krishna Venigalla, Jian Xu, Chunyu Cai, Prashant Mishra

J Clin Invest. 2022 Dec 1; 132(23): e161638. Published online 2022 Dec 1. doi: 10.1172/JCI161638

PMCID:: PMC9711883

Abstract Article PDF–56M

Select item 967372113.

Disruption of Sarcoplasmic Reticulum‐Mitochondrial Contacts Underlies Contractile Dysfunction in Experimental and Human Atrial Fibrillation: A Key Role of Mitofusin 2

Jin Li, Xi Qi, Kennedy S. Ramos, Eva Lanters, Jaap Keijer, Natasja de Groot, Bianca Brundel, Deli Zhang

J Am Heart Assoc. 2022 Oct 4; 11(19): e024478. Published online 2022 Sep 29. doi: 10.1161/JAHA.121.024478

PMCID:: PMC9673721

Abstract Article PDF–4.1M

Select item 926261414.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 911973615.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 905883616.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 900801217.

Clinical and genetic features of a cohort of patients with MFN2-related neuropathy

Elena Abati, Arianna Manini, Daniele Velardo, Roberto Del Bo, Laura Napoli, Federica Rizzo, Maurizio Moggio, Nereo Bresolin, Emilia Bellone, Maria Teresa Bassi, Maria Grazia D’Angelo, Giacomo Pietro Comi, Stefania Corti

Sci Rep. 2022; 12: 6181. Published online 2022 Apr 13. doi: 10.1038/s41598-022-10220-0

PMCID:: PMC9008012

Abstract Article PDF–1.5M

Select item 900657518.

MFN2 knockdown promotes osteogenic differentiation of iPSC-MSCs through aerobic glycolysis mediated by the Wnt/β-catenin signaling pathway

Lidi Deng, Siqi Yi, Xiaohui Yin, Yang Li, Qingxian Luan

Stem Cell Res Ther. 2022; 13: 162. Published online 2022 Apr 12. doi: 10.1186/s13287-022-02836-w

PMCID:: PMC9006575

Abstract Article PDF–13M

Select item 878648019.

Mitofusin-2 Restrains Hepatic Stellate Cells' Proliferation via PI3K/Akt Signaling Pathway and Inhibits Liver Fibrosis in Rats

Zhiping Chen, Zeyu Lin, Jiandong Yu, Haifeng Zhong, Xianhua Zhuo, Changku Jia, Yunle Wan

J Healthc Eng. 2022; 2022: 6731335. Published online 2022 Jan 17. doi: 10.1155/2022/6731335

PMCID:: PMC8786480

Abstract Article PDF–4.4M

Select item 876719620.

Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria

Marta Vranas, Yang Lu, Shafqat Rasool, Nathalie Croteau, Jonathan D. Krett, Véronique Sauvé, Kalle Gehring, Edward A. Fon, Thomas M. Durcan, Jean-François Trempe

Open Biol. 2022 Jan; 12(1): 210255. Published online January 19, 2022. doi: 10.1098/rsob.210255

PMCID:: PMC8767196

Abstract Article PDF–2.5M

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PMC Links for GEO Profiles (Select 98535598) (140)
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dbVar
EST448286 Rat Gene Index, normalized rat, Rattus norvegicus cDNA Rattus norvegic...
EST448286 Rat Gene Index, normalized rat, Rattus norvegicus cDNA Rattus norvegicus cDNA clone RGIEF57 3' sequence, mRNA sequence
gi|11214765|gnl|dbEST|6740976|gb|BF 5.1|

Nucleotide
Rattus norvegicus GIY-YIG domain containing 2, mRNA (cDNA clone MGC:94602 IMAGE:...
Rattus norvegicus GIY-YIG domain containing 2, mRNA (cDNA clone MGC:94602 IMAGE:7190632), complete cds
gi|56268880|gb|BC087090.1|

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