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Select item 111870621.

Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3

Nao Shiraishi, Tsuyoshi Konuma, Yoshie Chiba, Sayaka Hokazono, Nao Nakamura, Md Hadiul Islam, Makoto Nakanishi, Atsuya Nishiyama, Kyohei Arita

Commun Biol. 2024; 7: 746. Published online 2024 Jun 19. doi: 10.1038/s42003-024-06434-9

PMCID:: PMC11187062

Abstract Article PDF–3.2M

Select item 111267002.

The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling

Muneera Vakayil, Aisha Y. Madani, Maha V. Agha, Yasser Majeed, Shahina Hayat, Shameem Yonuskunju, Yasmin Ali Mohamoud, Joel Malek, Karsten Suhre, Nayef A. Mazloum

Sci Rep. 2024; 14: 11886. Published online 2024 May 24. doi: 10.1038/s41598-024-62508-y

PMCID:: PMC11126700

Abstract Article PDF–8.0M

Select item 111094833.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 110574174.

YTHDF1 promotes gallbladder cancer progression via post‐transcriptional regulation of the m6A/UHRF1 axis

Jiemin Chen, Xuesong Bai, Wenqin Zhang, Zhiyu Yan, Yongru Liu, Shengnan Zhou, Xi Wu, Xiaodong He, Aiming Yang

J Cell Mol Med. 2024 May; 28(9): e18328. Published online 2024 Apr 29. doi: 10.1111/jcmm.18328

PMCID:: PMC11057417

Abstract Article PDF–14M

Select item 110054365.

CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells

Ujjwal Rathore, Paige Haas, Vigneshwari Easwar Kumar, Joseph Hiatt, Kelsey M. Haas, Mehdi Bouhaddou, Danielle L. Swaney, Erica Stevenson, Lorena Zuliani-Alvarez, Michael J. McGregor, Autumn Turner-Groth, Charles Ochieng' Olwal, Yaw Bediako, Hannes Braberg, Margaret Soucheray, Melanie Ott, Manon Eckhardt, Judd F. Hultquist, Alexander Marson, Robyn M. Kaake, Nevan J. Krogan

mBio. 2024 Apr; 15(4): e02222-23. Published online 2024 Feb 27. doi: 10.1128/mbio.02222-23

PMCID:: PMC11005436

Abstract Article PDF–1.7M

Select item 109976096.

Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells

Kosuke Yamaguchi, Xiaoying Chen, Brianna Rodgers, Fumihito Miura, Pavel Bashtrykov, Frédéric Bonhomme, Catalina Salinas-Luypaert, Deis Haxholli, Nicole Gutekunst, Bihter Özdemir Aygenli, Laure Ferry, Olivier Kirsh, Marthe Laisné, Andrea Scelfo, Enes Ugur, Paola B. Arimondo, Heinrich Leonhardt, Masato T. Kanemaki, Till Bartke, Daniele Fachinetti, Albert Jeltsch, Takashi Ito, Pierre-Antoine Defossez

Nat Commun. 2024; 15: 2960. Published online 2024 Apr 5. doi: 10.1038/s41467-024-47314-4

PMCID:: PMC10997609

Abstract Article PDF–2.1M

Select item 109332677.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 105107438.

UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination

Xuli Qi, Youhong Liu, Yuchong Peng, Yuxin Fu, Yongming Fu, Linglong Yin, Xiong Li

J Cell Biol. 2023 Nov 6; 222(11): e202210093. Published online 2023 Sep 20. doi: 10.1083/jcb.202210093

PMCID:: PMC10510743

Abstract Article PDF–5.3M

Select item 104770239.

Interfering with the Expression of Ubiquitin-Like with PHD and Ring Finger Domains 1 Can Inhibit the Invasion of Human Renal Cell Carcinoma

Susu Wu, Xiao Pan, Yanqun Cai, Caiqin Li

Comput Math Methods Med. 2022; 2022: 6971131. Published online 2022 May 18. doi: 10.1155/2022/6971131

Retraction in:: Comput Math Methods Med. 2023; 2023: 9891043.

PMCID:: PMC10477023

Abstract Article

Select item 1046430410.

Refined read‐out: The hUHRF1 Tandem‐Tudor domain prefers binding to histone H3 tails containing K4me1 in the context of H3K9me2/3

Michel Choudalakis, Goran Kungulovski, Rebekka Mauser, Pavel Bashtrykov, Albert Jeltsch

Protein Sci. 2023 Sep; 32(9): e4760. Published online 2023 Sep 1. doi: 10.1002/pro.4760

PMCID:: PMC10464304

Abstract Article PDF–6.7M

Select item 1032283711.

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma

Kaja Kostyrko, Marta Román, Alex G. Lee, David R. Simpson, Phuong T. Dinh, Stanley G. Leung, Kieren D. Marini, Marcus R. Kelly, Joshua Broyde, Andrea Califano, Peter K. Jackson, E. Alejandro Sweet-Cordero

Nat Commun. 2023; 14: 3966. Published online 2023 Jul 5. doi: 10.1038/s41467-023-39591-2

PMCID:: PMC10322837

Abstract Article PDF–8.8M

Select item 1023742212.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1022840213.

The UHRF1 protein is a key regulator of retrotransposable elements and innate immune response to viral RNA in human cells

RE Irwin, C Scullion, SJ Thursby, M Sun, A Thakur, L Hilman, B Callaghan, PD Thompson, DJ McKenna, SB Rothbart, Guoliang Xu, CP Walsh

Epigenetics. 2023; 18(1): 2216005. Published online 2023 May 29. doi: 10.1080/15592294.2023.2216005

PMCID:: PMC10228402

Abstract Article PDF–3.1M

Select item 1011932214.

RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

Lei Chen, Wenjing Zhang, Dan Chen, Quan Yang, Siwen Sun, Zhenwei Dai, Zhengzheng Li, Xuemei Liang, Chaoqun Chen, Yuexia Jiao, Lili Zhi, Lianmei Zhao, Jinrui Zhang, Xuefeng Liu, Jinyao Zhao, Man Li, Yang Wang, Yangfan Qi

Signal Transduct Target Ther. 2023; 8: 159. Published online 2023 Apr 21. doi: 10.1038/s41392-023-01367-x

PMCID:: PMC10119322

Abstract Article PDF–7.7M

Select item 998370115.

The RNA m⁵C Methylase NSUN2 Modulates Corneal Epithelial Wound Healing

Guangying Luo, Weiwei Xu, Xiaoyan Chen, Wenji Xu, Shuai Yang, Jiao Wang, Yong Lin, Peter S. Reinach, Dongsheng Yan

Invest Ophthalmol Vis Sci. 2023 Mar; 64(3): 5. Published online 2023 Mar 2. doi: 10.1167/iovs.64.3.5

PMCID:: PMC9983701

Abstract Article PDF–3.3M

Select item 994306816.

The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5

Ryota Miyashita, Atsuya Nishiyama, Weihua Qin, Yoshie Chiba, Satomi Kori, Norie Kato, Chieko Konishi, Soichiro Kumamoto, Hiroko Kozuka-Hata, Masaaki Oyama, Yoshitaka Kawasoe, Toshiki Tsurimoto, Tatsuro S Takahashi, Heinrich Leonhardt, Kyohei Arita, Makoto Nakanishi

eLife. 2023; 12: e79013. Published online 2023 Feb 3. doi: 10.7554/eLife.79013

PMCID:: PMC9943068

Abstract Article PDF–6.3M

Select item 980764717.

AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer

Yongming Fu, Tuoyu Cao, Xiaorui Zou, Yubing Ye, Youhong Liu, Yuchong Peng, Tanggang Deng, Linglong Yin, Xiong Li

Oncogenesis. 2023 Dec; 12(1): 1. Published online 2023 Jan 2. doi: 10.1038/s41389-022-00446-y

PMCID:: PMC9807647

Abstract Article PDF–4.6M

Select item 979798818.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144