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Select item 111732731.

Distinct Responses to Menin Inhibition and Synergy with DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic and Myeloid Leukemia

Fabienne R. S. Adriaanse, Pauline Schneider, Susan T. C. J. M. Arentsen-Peters, Ana M. Neves da Fonseca, Janine Stutterheim, Rob Pieters, C. Michel Zwaan, Ronald W. Stam

Int J Mol Sci. 2024 Jun; 25(11): 6020. Published online 2024 May 30. doi: 10.3390/ijms25116020

PMCID:: PMC11173273

Abstract Article PDF–4.5M

Select item 111481842.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 107647083.

The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases

Min Tao, Yingfeng Shi, Hui Chen, Jinqing Li, Yi Wang, Xiaoyan Ma, Lin Du, Yishu Wang, Xinyu Yang, Yan Hu, Xun Zhou, Qin Zhong, Danying Yan, Andong Qiu, Shougang Zhuang, Na Liu

Mol Biomed. 2024 Dec; 5: 3. Published online 2024 Jan 4. doi: 10.1186/s43556-023-00161-z

PMCID:: PMC10764708

Abstract Article PDF–12M

Select item 106455504.

Rare de novo gain-of-function missense variants in DOT1L are associated with developmental delay and congenital anomalies

Zelha Nil, Ashish R. Deshwar, Yan Huang, Scott Barish, Xi Zhang, Sanaa Choufani, Polona Le Quesne Stabej, Ian Hayes, Patrick Yap, Chad Haldeman-Englert, Carolyn Wilson, Trine Prescott, Kristian Tveten, Arve Vøllo, Devon Haynes, Patricia G. Wheeler, Jessica Zon, Cheryl Cytrynbaum, Rebekah Jobling, Moira Blyth, Siddharth Banka, Alexandra Afenjar, Cyril Mignot, Florence Robin-Renaldo, Boris Keren, Oguz Kanca, Xiao Mao, Daniel J. Wegner, Kathleen Sisco, Marwan Shinawi, Undiagnosed Disease Network, Michael F. Wangler, Rosanna Weksberg, Shinya Yamamoto, Gregory Costain, Hugo J. Bellen

Am J Hum Genet. 2023 Nov 2; 110(11): 1919–1937. Published online 2023 Oct 11. doi: 10.1016/j.ajhg.2023.09.009

PMCID:: PMC10645550

Abstract Article PDF–4.7M

Select item 105658765.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 105385546.

DOT1L Epigenetically Regulates Autophagy and Mitochondria Fusion in Cell Lines of Renal Cancer

Yanguang Hou, Jiachen Liu, Shiyu Huang, Lei Wang, Juncheng Hu, Xiuheng Liu

Technol Cancer Res Treat. 2023; 22: 15330338231167249. Published online 2023 Jun 27. doi: 10.1177/15330338231167249

PMCID:: PMC10538554

Abstract Article PDF–2.9M

Select item 104136747.

Gain-of-function mutations in the catalytic domain of DOT1L promote lung cancer malignant phenotypes via the MAPK/ERK signaling pathway

Jiayu Zhang, Ting Yang, Mei Han, Xiaoxuan Wang, Weiming Yang, Ning Guo, Yong Ren, Wei Cui, Shangxiao Li, Yongshan Zhao, Xin Zhai, Lina Jia, Jingyu Yang, Chunfu Wu, Lihui Wang

Sci Adv. 2023 Jun 2; 9(22): eadc9273. Published online 2023 May 31. doi: 10.1126/sciadv.adc9273

PMCID:: PMC10413674

Abstract Article PDF–2.9M

Select item 98981438.

DOT1L Regulates Ovarian Cancer Stem Cells by Activating β-catenin Signaling

Yaqi Zhang, Yinu Wang, Andres Valdivia, Hao Huang, Daniela Matei

Mol Cancer Res. Author manuscript; available in PMC 2023 Aug 1.

Published in final edited form as: Mol Cancer Res. 2023 Feb 1; 21(2): 140–154. doi: 10.1158/1541-7786.MCR-22-0418

PMCID:: PMC9898143

Abstract Article PDF–1.1M

Select item 98628089.

Neuronal Dot1l Activity Acts as a Mitochondrial Gene-Repressor Associated with Human Brain Aging via H3K79 Hypermethylation

Hendrikus J. Van Heesbeen, Lars Von Oerthel, Paul M. De Vries, Cindy M. R. J. Wagemans, Marten P. Smidt

Int J Mol Sci. 2023 Jan; 24(2): 1387. Published online 2023 Jan 10. doi: 10.3390/ijms24021387

PMCID:: PMC9862808

Abstract Article PDF–6.0M

Select item 984014710.

Targeting inflammatory macrophages rebuilds therapeutic efficacy of DOT1L inhibition in hepatocellular carcinoma

Yi-Bin Yang, Cai-Yuan Wu, Xu-Yan Wang, Jia Deng, Wen-Jie Cao, Yun-Zhi Tang, Chao-Chao Wan, Zhi-Tian Chen, Wan-Yu Zhan, Hong Shan, Dong-Ming Kuang, Yuan Wei

Mol Ther. 2023 Jan 4; 31(1): 105–118. Published online 2022 Sep 30. doi: 10.1016/j.ymthe.2022.09.019

PMCID:: PMC9840147

Abstract Article PDF–4.6M

Select item 954034511.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 936534412.

DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

Hetakshi Kurani, Seyedeh Fatemeh Razavipour, Kuzhuvelil B. Harikumar, Matthew Dunworth, Andrew J. Ewald, Apsra Nasir, Gray Pearson, Derek Van Booven, Zhiqun Zhou, Diana Azzam, Claes Wahlestedt, Joyce Slingerland

Clin Cancer Res. 2022 May 2; 28(9): 1948–1965. Published online 2022 Feb 7. doi: 10.1158/1078-0432.CCR-21-1299

PMCID:: PMC9365344

Abstract Article PDF–1.1M

Select item 929024113.

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Annamaria Salvati, Viola Melone, Assunta Sellitto, Francesca Rizzo, Roberta Tarallo, Tuula A. Nyman, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz

Breast Cancer Res. 2022; 24: 52. Published online 2022 Jul 18. doi: 10.1186/s13058-022-01547-7

PMCID:: PMC9290241

Abstract Article PDF–8.2M

Select item 926261414.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 897306915.

Histone methyltransferase Dot1L inhibits pancreatic cancer cell apoptosis by promoting NUPR1 expression

Lin Shan, Chen Hao, Zheng Jun, Cai Qinghe

J Int Med Res. 2022 Mar; 50(3): 03000605221088431. Published online 2022 Mar 29. doi: 10.1177/03000605221088431

PMCID:: PMC8973069

Abstract Article PDF–546K

Select item 892879216.

DOT1L affects colorectal carcinogenesis via altering T cell subsets and oncogenic pathway

Danfeng Sun, Weichao Wang, Fangfang Guo, Michael R. Pitter, Wan Du, Shuang Wei, Sara Grove, Linda Vatan, Yingxuan Chen, Ilona Kryczek, Eric R. Fearon, Jing-Yuan Fang, Weiping Zou

Oncoimmunology. 2022; 11(1): 2052640. Published online 2022 Mar 16. doi: 10.1080/2162402X.2022.2052640

PMCID:: PMC8928792

Abstract Article PDF–3.7M

Select item 891919317.

DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding

Cathy J. Spangler, Satya P. Yadav, Dongxu Li, Carinne N. Geil, Charlotte B. Smith, Gang Greg Wang, Tae-Hee Lee, Robert K. McGinty

Cell Rep. Author manuscript; available in PMC 2022 Mar 14.

Published in final edited form as: Cell Rep. 2022 Feb 15; 38(7): 110369. doi: 10.1016/j.celrep.2022.110369

PMCID:: PMC8919193

Abstract Article PDF–1.7M

Select item 882889518.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 867117919.

Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1‐like (DOT1L) and partnering complexes involved in leukemogenesis

Timothy J. Stodola, Young‐In Chi, Thiago M. De Assuncao, Elise N. Leverence, Swarnendu Tripathi, Nikita R. Dsouza, Angela J. Mathison, Brian F. Volkman, Brian C. Smith, Gwen Lomberk, Michael T. Zimmermann, Raul Urrutia

Proteins. 2022 Jan; 90(1): 282–298. Published online 2021 Sep 12. doi: 10.1002/prot.26219

PMCID:: PMC8671179

Abstract Article PDF–5.7M

Select item 862939020.

ATRX proximal protein associations boast roles beyond histone deposition

William A. Scott, Erum Z. Dhanji, Boris J. A. Dyakov, Ema S. Dreseris, Jonathon S. Asa, Laura J. Grange, Mila Mirceta, Christopher E. Pearson, Grant S. Stewart, Anne-Claude Gingras, Eric I. Campos

PLoS Genet. 2021 Nov; 17(11): e1009909. Published online 2021 Nov 15. doi: 10.1371/journal.pgen.1009909

PMCID:: PMC8629390

Abstract Article PDF–4.0M

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