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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 111094832.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 110951403.

Blocking Ubiquitin‐Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl‐CoA Desaturase

Xiaoqing Guan, Yichao Wang, Wenkai Yu, Yong Wei, Yang Lu, Enyu Dai, Xiaowu Dong, Bing Zhao, Can Hu, Li Yuan, Xin Luan, Kai Miao, Bonan Chen, Xiang‐Dong Cheng, Weidong Zhang, Jiang‐Jiang Qin

Adv Sci (Weinh) 2024 May; 11(18): 2307899. Published online 2024 Mar 9. doi: 10.1002/advs.202307899

PMCID:: PMC11095140

Abstract Article PDF–5.6M

Select item 110691464.

The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis

Ruyue Zhang, Daidi Zhang, Fugen Han, Xiaorui Song, Yaodong Zhang, Jie Zhang, Qingwen Zhu, Yanru Qin

J Exp Clin Cancer Res. 2024; 43: 135. Published online 2024 May 4. doi: 10.1186/s13046-024-03056-1

PMCID:: PMC11069146

Abstract Article PDF–11M

Select item 110406975.

Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis

Jie Li, Bin Zhang, Zishan Feng, Dandan An, Zhiyuan Zhou, Chao Wan, Yan Hu, Yajie Sun, Yijun Wang, Xixi Liu, Wenwen Wei, Xiao Yang, Jingshu Meng, Mengjie Che, Yuhan Sheng, Bian Wu, Lu Wen, Fang Huang, Yan Li, Kunyu Yang

J Exp Clin Cancer Res. 2024; 43: 28. Published online 2024 Jan 23. doi: 10.1186/s13046-024-02954-8

PMCID:: PMC11040697

Abstract Article PDF–13M

Select item 110212336.

USP7 promotes cervical cancer progression by stabilizing MTDH expression through deubiquitination

Na Wang, Jing Xu, Yujing Wang, Xuejiao Zhang, Hongzhen Zhang

J Cancer Res Clin Oncol. 2024; 150(4): 196. Published online 2024 Apr 16. doi: 10.1007/s00432-024-05710-9

PMCID:: PMC11021233

Abstract Article PDF–7.8M

Select item 109238767.

Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis

Bin Zhang, Jie Li, Yijun Wang, Xixi Liu, Xiao Yang, Zhiyun Liao, Suke Deng, Yue Deng, Zhiyuan Zhou, Yu Tian, Wenwen Wei, Jingshu Meng, Yan Hu, Chao Wan, Zhanjie Zhang, Fang Huang, Lu Wen, Bian Wu, Yajie Sun, Yan Li, Kunyu Yang

Cell Death Differ. 2024 Mar; 31(3): 309–321. Published online 2024 Jan 29. doi: 10.1038/s41418-024-01257-x

PMCID:: PMC10923876

Abstract Article PDF–8.3M

Select item 108190968.

SP1‐activated USP27X‐AS1 promotes hepatocellular carcinoma progression via USP7‐mediated AKT stabilisation

Chen Su, Haoquan Zhang, Jie Mo, Zhibin Liao, Bixiang Zhang, Peng Zhu

Clin Transl Med. 2024 Jan; 14(1): e1563. Published online 2024 Jan 27. doi: 10.1002/ctm2.1563

PMCID:: PMC10819096

Abstract Article PDF–16M

Select item 107778639.

SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions

Haining Zhou, Wenzhi Feng, Juntao Yu, Tiasha A. Shafiq, Joao A. Paulo, Jiuchun Zhang, Zhenhua Luo, Steven P. Gygi, Danesh Moazed

Cell Rep. Author manuscript; available in PMC 2024 Apr 25.

Published in final edited form as: Cell Rep. 2023 Apr 25; 42(4): 112339. Published online 2023 Apr 3. doi: 10.1016/j.celrep.2023.112339

PMCID:: PMC10777863

Abstract Article PDF–1.9M

Select item 1076620710.

USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression

Xiaojia Liu, Runhui Lu, Qianqian Yang, Jianfeng He, Caihu Huang, Yingting Cao, Zihan Zhou, Jiayi Huang, Lian Li, Ran Chen, Yanli Wang, Jian Huang, Ruiyu Xie, Xian Zhao, Jianxiu Yu

Mol Oncol. 2024 Jan; 18(1): 170–189. Published online 2023 Nov 2. doi: 10.1002/1878-0261.13543

PMCID:: PMC10766207

Abstract Article PDF–2.7M

Select item 1059748411.

USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7

Su Hyoun Lee, Kwang Chul Chung

PLoS One. 2023; 18(10): e0290371. Published online 2023 Oct 24. doi: 10.1371/journal.pone.0290371

Correction in:: PLoS One. 2024; 19(1): e0297970.

PMCID:: PMC10597484

Abstract Article PDF–2.1M

Select item 1053132512.

USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation

Christophe Le Clorennec, Karen Lee, Yuchen Huo, Peter E. Zage

Int J Mol Sci. 2023 Sep; 24(18): 13780. Published online 2023 Sep 7. doi: 10.3390/ijms241813780

PMCID:: PMC10531325

Abstract Article PDF–4.2M

Select item 1048053513.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

Select item 1029810314.

USP15-USP7 Axis and UBE2T Differential Expression May Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm

Luiz Gustavo Almeida de Carvalho, Tatiana Takahasi Komoto, Daniel Antunes Moreno, João Vitor Caetano Goes, Roberta Taiane Germano de Oliveira, Mayara Magna de Lima Melo, Mariela Estefany Gislene Vera Roa, Paola Gyuliane Gonçalves, Carlos Victor Montefusco-Pereira, Ronald Feitosa Pinheiro, Howard Lopes Ribeiro Junior

Int J Mol Sci. 2023 Jun; 24(12): 10058. Published online 2023 Jun 13. doi: 10.3390/ijms241210058

PMCID:: PMC10298103

Abstract Article PDF–2.6M

Select item 1023827015.

De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity

Jingwei Liu, Tingting Zhou, Xiang Dong, Qiqiang Guo, Lixia Zheng, Xiaoxun Wang, Naijin Zhang, Danni Li, Ling Ren, Fei Yi, Ying Zhang, Ziwei Li, Xiwen Wang, Chengsi Deng, Chunlu Li, Hongde Xu, Yi Guan, Xiaoman Li, Yang Yu, Wendong Guo, Zhuo Wang, Bo Jiang, Xuan Wu, Ning Bai, Yanling Feng, Mengtao Ma, Qingquan Kong, Jiayi Wei, Zhenshuang Wang, Hao Li, Songming Lu, Liangzi Cao, Yutong Xiao, Xiaoyu Song, Zhenning Wang, Chengzhong Xing, Liu Cao

Oncogene. 2023; 42(22): 1843–1856. Published online 2023 Apr 20. doi: 10.1038/s41388-023-02667-w

PMCID:: PMC10238270

Abstract Article PDF–6.2M

Select item 1023742216.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1016456417.

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing

Yingxiao Chen, Yanping Li, Roselyn S Dai, Jonathan C Savage, Ujwal Shinde, John Klimek, Larry L David, Emma A Young, Markus Hafner, Rosalie C Sears, Xiao-Xin Sun, Mu-Shui Dai

Nucleic Acids Res. 2023 May 8; 51(8): 3934–3949. Published online 2023 Mar 13. doi: 10.1093/nar/gkad140

PMCID:: PMC10164564

Abstract Article PDF–3.8M

Select item 1014760418.

USP7 controls NGN3 stability and pancreatic endocrine lineage development

Teodora Manea, Jessica Kristine Nelson, Cristina Maria Garrone, Karin Hansson, Ian Evans, Axel Behrens, Rocio Sancho

Nat Commun. 2023; 14: 2457. Published online 2023 Apr 28. doi: 10.1038/s41467-023-38146-9

PMCID:: PMC10147604

Abstract Article PDF–9.0M

Select item 1008090819.

The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia

Sadek Amhaz, Batiste Boëda, Mouna Chouchène, Sabrina Colasse, Florent Dingli, Damarys Loew, Julien Henri, Céline Prunier, Laurence Levy

BMC Biol. 2023; 21: 73. Published online 2023 Apr 7. doi: 10.1186/s12915-023-01576-4

PMCID:: PMC10080908

Abstract Article PDF–3.2M

Select item 1007290620.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

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