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Select item 102488831.

Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin₂ G protein–coupled receptor

Katie M. Babin, Jordan A. Karim, Peyton H. Gordon, James Lennon, Alex Dickson, Augen A. Pioszak

J Biol Chem. 2023 Jun; 299(6): 104785. Published online 2023 May 4. doi: 10.1016/j.jbc.2023.104785

PMCID:: PMC10248883

Abstract Article PDF–4.6M

Select item 83894282.

CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2

Harsha Nagar, Seonhee Kim, Ikjun Lee, Su-Jeong Choi, Shuyu Piao, Byeong Hwa Jeon, Minho Shong, Cuk-Seong Kim

PLoS One. 2021; 16(8): e0256646. Published online 2021 Aug 26. doi: 10.1371/journal.pone.0256646

PMCID:: PMC8389428

Abstract Article PDF–2.9M

Select item 83825223.

Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/β-Catenin Signaling Pathway

Yanhong Wang, Juanjuan Wang, Jia Yang, Jing Kang, Fuping Xue, Sijia Chang, He Ji, Haojing Zang, Xiaoshuang Zhou, Guiqin Wang, Weiping Fan, Xianyan Yan, Jinli Guo, Xiaojun Ren, Jihua Tian

Oxid Med Cell Longev. 2021; 2021: 8889408. Published online 2021 Aug 14. doi: 10.1155/2021/8889408

PMCID:: PMC8382522

Abstract Article PDF–4.5M

Select item 82222764.

CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells

Ashley J. Clark, Niamh Mullooly, Dewi Safitri, Matthew Harris, Tessa de Vries, Antoinette MaassenVanDenBrink, David R. Poyner, Davide Gianni, Mark Wigglesworth, Graham Ladds

Commun Biol. 2021; 4: 776. Published online 2021 Jun 23. doi: 10.1038/s42003-021-02293-w

PMCID:: PMC8222276

Abstract Article PDF–3.1M

Select item 79502885.

Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway

Xian-Qiang Ni, Ya-Rong Zhang, Li-Xin Jia, Wei-Wei Lu, Qing Zhu, Jin-Ling Ren, Yao Chen, Lin-Shuang Zhang, Xin Liu, Yan-Rong Yu, Mo-Zhi Jia, Zhong-Ping Ning, Jie Du, Chao-Shu Tang, Yong-Fen Qi

Aging (Albany NY) 2021 Feb 28; 13(4): 5164–5184. Published online 2021 Feb 1. doi: 10.18632/aging.202436

PMCID:: PMC7950288

Abstract Article PDF–2.4M

Select item 78037436.

Intermedin facilitates hepatocellular carcinoma cell survival and invasion via ERK1/2-EGR1/DDIT3 signaling cascade

Fei Xiao, Hongyu Li, Zhongxue Feng, Luping Huang, Lingmiao Kong, Min Li, Denian Wang, Fei Liu, Zhijun Zhu, Yong’gang Wei, Wei Zhang

Sci Rep. 2021; 11: 488. Published online 2021 Jan 12. doi: 10.1038/s41598-020-80066-x

PMCID:: PMC7803743

Abstract Article PDF–12M

Select item 77862637.

Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expression

Changdai Gu, Sohae Park, Jin Seok, Hee Yeon Jang, Yong Ju Bang, G I Jin Kim

Biol Reprod. 2021 Jan; 104(1): 159–169. Published online 2020 Sep 30. doi: 10.1093/biolre/ioaa178

PMCID:: PMC7786263

Abstract Article PDF–1.1M

Select item 65443378.

Development of chimeric and bifunctional antagonists for CLR/RAMP receptors

Chia Lin Chang, Sheau Yu Teddy Hsu

PLoS One. 2019; 14(5): e0216996. Published online 2019 May 31. doi: 10.1371/journal.pone.0216996

PMCID:: PMC6544337

Abstract Article PDF–2.8M

Select item 64504719.

Intermedin protects HUVECs from ischemia reperfusion injury via Wnt/β-catenin signaling pathway

Yanhong Wang, Zhijing Wu, Jihua Tian, Yang Mi, Xiaojun Ren, Jing Kang, Wan Zhang, Xiaoshuang Zhou, Guiqin Wang, Rongshan Li

Ren Fail. 2019; 41(1): 159–166. Published online 2019 Apr 1. doi: 10.1080/0886022X.2019.1587468

PMCID:: PMC6450471

Abstract Article PDF–1.1M

Select item 618761510.

Structure–function analyses reveal a triple β-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design

Amanda M. Roehrkasse, Jason M. Booe, Sang-Min Lee, Margaret L. Warner, Augen A. Pioszak

J Biol Chem. 2018 Oct 12; 293(41): 15840–15854. Published online 2018 Aug 23. doi: 10.1074/jbc.RA118.005062

PMCID:: PMC6187615

Abstract Article PDF–3.5M

Select item 603518911.

Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses

Fei Xiao, Denian Wang, Lingmiao Kong, Min Li, Zhongxue Feng, Bingxing Shuai, Lijun Wang, Yong’gang Wei, Hongyu Li, Sisi Wu, Chun Tan, Huan Zhao, Xuejiao Hu, Jin Liu, Yan Kang, Xuelian Liao, Yan Zhou, Wei Zhang

Nat Commun. 2018; 9: 2644. Published online 2018 Jul 6. doi: 10.1038/s41467-018-05062-2

PMCID:: PMC6035189

Abstract Article PDF–6.1M

Select item 509539612.

Adrenomedullin 2 Enhances Beiging in White Adipose Tissue Directly in an Adipocyte-autonomous Manner and Indirectly through Activation of M2 Macrophages

Ying Lv, Song-Yang Zhang, Xianyi Liang, Heng Zhang, Zhi Xu, Bo Liu, Ming-Jiang Xu, Changtao Jiang, Jin Shang, Xian Wang

J Biol Chem. 2016 Nov 4; 291(45): 23390–23402. Published online 2016 Sep 12. doi: 10.1074/jbc.M116.735563

PMCID:: PMC5095396

Abstract Article PDF–2.9M

Select item 471269513.

Adrenomedullin 2 (ADM2) Regulates Mucin 1 at the Maternal-Fetal Interface in Human Pregnancy

Madhu Chauhan, Meena Balakrishnan, Rexanna Chan, Chandrasekhar Yallampalli

Biol Reprod. 2015 Dec; 93(6): 136. Published online 2015 Oct 28. doi: 10.1095/biolreprod.115.134296

PMCID:: PMC4712695

Abstract Article PDF–1.4M

Select item 465716114.

PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion

Anna E. Dart, Gary M. Box, William Court, Madeline E. Gale, John P. Brown, Sarah E. Pinder, Suzanne A. Eccles, Claire M. Wells

J Cell Biol. 2015 Nov 23; 211(4): 863–879. doi: 10.1083/jcb.201501072

PMCID:: PMC4657161

Abstract Article PDF–8.1M

Select item 356511015.

Intermedin/Adrenomedullin 2 Is Associated With Implantation and Placentation via Trophoblast Invasion in Human Pregnancy

Dara Havemann, Meena Balakrishnan, Mostafa Borahay, Regan Theiler, Kristofer Jennings, Janice Endsley, John Phelps, Gary D. V. Hankins, Chandra Yallampalli, Madhu Chauhan

J Clin Endocrinol Metab. 2013 Feb; 98(2): 695–703. Published online 2013 Jan 21. doi: 10.1210/jc.2012-2172