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Select item 109472961.

The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho‐physiological background

Zehra Irshad, Jenny Lund, Anne Sillars, Nils Gunnar Løvsletten, Seley Gharanei, Ian P. Salt, Dilys J. Freeman, Jason M. R. Gill, G. Hege Thoresen, Arild C. Rustan, Victor A. Zammit

FASEB J. 2023 Nov; 37(11): e23209. Published online 2023 Oct 1. doi: 10.1096/fj.202300960RR

PMCID:: PMC10947296

Abstract Article PDF–6.2M

Select item 109461542.

The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications

Boer Deng, Weimin Kong, Xiaochang Shen, Chao Han, Ziyi Zhao, Shuning Chen, Chunxiao Zhou, Victoria Bae-Jump

J Transl Med. 2024; 22: 290. Published online 2024 Mar 18. doi: 10.1186/s12967-024-05084-z

PMCID:: PMC10946154

Abstract Article PDF–1.2M

Select item 105665643.

Lipid droplets in Zika neuroinfection: Potential targets for intervention?

Suelen Silva Gomes Dias, Tamires Cunha-Fernandes, Vinicius Cardoso Soares, Cecília JG de Almeida, Patricia T Bozza

Mem Inst Oswaldo Cruz. 2023; 118: e230044. Published online 2023 Oct 9. doi: 10.1590/0074-02760230044

PMCID:: PMC10566564

Abstract Article PDF–508K

Select item 98738214.

DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma

Hyunkoo Kang, Haksoo Lee, Kyeongmin Kim, Eunguk Shin, Byeongsoo Kim, JiHoon Kang, Bohkyung Kim, Jung Sub Lee, Jae-Myung Lee, HyeSook Youn, BuHyun Youn

Cell Rep Med. 2023 Jan 17; 4(1): 100880. Published online 2023 Jan 4. doi: 10.1016/j.xcrm.2022.100880

PMCID:: PMC9873821

Abstract Article PDF–6.4M

Select item 93913205.

An Oncogenic JMJD6-DGAT1 Axis Tunes Epigenetic Regulation of Lipid Droplet Formation in Clear Cell Renal Cell Carcinoma

Jin Zhou, Jeremy M. Simon, Chengheng Liao, Cheng Zhang, Lianxin Hu, Giada Zurlo, Xijuan Liu, Cheng Fan, Austin Hepperla, Liwei Jia, Vanina Toffessi Tcheuyap, Hua Zhong, Roy Elias, Jin Ye, W. Mike Henne, Payal Kapur, Deepak Nijhawan, James Brugarolas, Qing Zhang

Mol Cell. Author manuscript; available in PMC 2023 Aug 18.

Published in final edited form as: Mol Cell. 2022 Aug 18; 82(16): 3030–3044.e8. Published online 2022 Jun 27. doi: 10.1016/j.molcel.2022.06.003

PMCID:: PMC9391320

Abstract Article PDF–3.0M

Select item 92316236.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 88970227.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 82170888.

Loss of Ephrin B2 Receptor (EPHB2) Sets Lipid Rheostat by Regulating Proteins DGAT1 and ATGL Inducing Lipid Droplet Storage in Prostate Cancer Cells

Alejandro Morales, Max Greenberg, Francesca Nardi, Victoria Gil, Simon W. Hayward, Susan E. Crawford, Omar E. Franco

Lab Invest. Author manuscript; available in PMC 2021 Oct 6.

Published in final edited form as: Lab Invest. 2021 Jul; 101(7): 921–934. Published online 2021 Apr 6. doi: 10.1038/s41374-021-00583-9

PMCID:: PMC8217088

Abstract Article PDF–1.8M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 814127110.

DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis

Leilei Xia, Ye Wang, Shengyun Cai, Mingjuan Xu

J Immunol Res. 2021; 2021: 6636791. Published online 2021 May 14. doi: 10.1155/2021/6636791

PMCID:: PMC8141271

Abstract Article PDF–1.8M

Select item 794192611.

Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer

Ping He, Shihuan Cheng, Feng Hu, Zhanchuan Ma, Yan Xia

BMC Cancer. 2021; 21: 252. Published online 2021 Mar 9. doi: 10.1186/s12885-021-07976-5

PMCID:: PMC7941926

Abstract Article PDF–2.2M

Select item 741572112.

Targeting DGAT1 ameliorates glioblastoma by increasing fat catabolism and oxidative stress

Xiang Cheng, Feng Geng, Meixia Pan, Xiaoning Wu, Yaogang Zhong, Chunyan Wang, Zhihua Tian, Chunming Cheng, Rui Zhang, Vinay Puduvalli, Craig Horbinski, Xiaokui Mo, Xianlin Han, Arnab Chakravarti, Deliang Guo

Cell Metab. Author manuscript; available in PMC 2021 Aug 4.

Published in final edited form as: Cell Metab. 2020 Aug 4; 32(2): 229–242.e8. Published online 2020 Jun 18. doi: 10.1016/j.cmet.2020.06.002

PMCID:: PMC7415721

Abstract Article PDF–3.7M

Select item 739855713.

Structure and catalytic mechanism of a human triglyceride synthesis enzyme

Xuewu Sui, Kun Wang, Nina L. Gluchowski, Shane D. Elliott, Maofu Liao, Tobias C. Walther, Robert V. Farese, Jr.

Nature. Author manuscript; available in PMC 2020 Nov 13.

Published in final edited form as: Nature. 2020 May; 581(7808): 323–328. Published online 2020 May 13. doi: 10.1038/s41586-020-2289-6

PMCID:: PMC7398557

Abstract Article PDF–6.4M

Select item 725504914.

Structure and mechanism of human diacylglycerol O-acyltransferase-1

Lie Wang, Hongwu Qian, Yin Nian, Yimo Han, Zhenning Ren, Hanzhi Zhang, Liya Hu, B. V. Venkataram Prasad, Arthur Laganowsky, Nieng Yan, Ming Zhou

Nature. Author manuscript; available in PMC 2020 Nov 13.

Published in final edited form as: Nature. 2020 May; 581(7808): 329–332. Published online 2020 May 13. doi: 10.1038/s41586-020-2280-2

PMCID:: PMC7255049

Abstract Article PDF–5.0M

Select item 674682215.

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei

Giovanni Nassa, Giorgio Giurato, Annamaria Salvati, Valerio Gigantino, Giovanni Pecoraro, Jessica Lamberti, Francesca Rizzo, Tuula A. Nyman, Roberta Tarallo, Alessandro Weisz

Sci Data. 2019; 6: 173. Published online 2019 Sep 16. doi: 10.1038/s41597-019-0179-2

PMCID:: PMC6746822

Abstract Article PDF–2.0M

Select item 639566516.

DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130

Francesca Nardi, Omar E. Franco, Philip Fitchev, Alejandro Morales, Renee E. Vickman, Simon W. Hayward, Susan E. Crawford

Sci Rep. 2019; 9: 3035. Published online 2019 Feb 28. doi: 10.1038/s41598-019-39537-z

PMCID:: PMC6395665

Abstract Article PDF–4.2M

Select item 619522617.

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis

Chandramohan Chitraju, Niklas Mejhert, Joel T. Haas, L. Grisell Diaz-Ramirez, Carrie A. Grueter, Jason E. Imbriglio, Shirly Pinto, Suneil K. Koliwad, Tobias C. Walther, Robert V. Farese, Jr

Cell Metab. Author manuscript; available in PMC 2018 Oct 19.

Published in final edited form as: Cell Metab. 2017 Aug 1; 26(2): 407–418.e3. doi: 10.1016/j.cmet.2017.07.012

PMCID:: PMC6195226

Abstract Article PDF–2.7M

Select item 619131518.

Reversible deficits in apical transporter trafficking associated with DGAT1 deficiency

Cameron Schlegel, Lynne A. Lapierre, Victoria G. Weis, Janice A. Williams, Izumi Kaji, Carolina Pinzon-Guzman, Nripesh Prasad, Braden Boone, Angela Jones, Hernan Correa, Shawn E. Levy, Xianlin Han, Miao Wang, Kelly Thomsen, Sari Acra, James R. Goldenring

Traffic. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Traffic. 2018 Nov; 19(11): 879–892. Published online 2018 Sep 21. doi: 10.1111/tra.12608

PMCID:: PMC6191315

Abstract Article PDF–3.2M

Select item 605803519.

Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency

Jorik M. van Rijn, Rico Chandra Ardy, Zarife Kuloğlu, Bettina Härter, Désirée Y. van Haaften-Visser, Hubert P.J. van der Doef, Marliek van Hoesel, Aydan Kansu, Anke H.M. van Vugt, Marini Thian, Freddy T.M. Kokke, Ana Krolo, Meryem Keçeli Başaran, Neslihan Gurcan Kaya, Aysel Ünlüsoy Aksu, Buket Dalgıç, Figen Ozcay, Zeren Baris, Renate Kain, Edwin C.A. Stigter, Klaske D. Lichtenbelt, Maarten P.G. Massink, Karen J. Duran, Joke B.G.M Verheij, Dorien Lugtenberg, Peter G.J. Nikkels, Henricus G.F. Brouwer, Henkjan J. Verkade, René Scheenstra, Bart Spee, Edward E.S. Nieuwenhuis, Paul J. Coffer, Andreas R. Janecke, Gijs van Haaften, Roderick H.J. Houwen, Thomas Müller, Sabine Middendorp, Kaan Boztug

Gastroenterology. 2018 Jul; 155(1): 130–143.e15. doi: 10.1053/j.gastro.2018.03.040

PMCID:: PMC6058035

Abstract Article

Select item 583915820.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

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