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Select item 108579391.

Myeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential therapeutic target

Marina G. Ferrari, Alexis P. Jimenez-Uribe, Li Wang, Luke H. Hoeppner, Paari Murugan, Eunsil Hahm, Jindan Yu, Timothy M. Kuzel, Sergio A. Gradilone, Adrian P. Mansini

Oncogene. 2024; 43(7): 484–494. Published online 2023 Dec 23. doi: 10.1038/s41388-023-02925-x

PMCID:: PMC10857939

Abstract Article PDF–13M

Select item 80330042.

Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells

Ping Zhang, Julia Nguyen, Fuad Abdulla, Alexander T. Nelson, Joan D. Beckman, Gregory M. Vercellotti, John D. Belcher

Front Immunol. 2021; 12: 632709. Published online 2021 Mar 26. doi: 10.3389/fimmu.2021.632709

PMCID:: PMC8033004

Abstract Article PDF–932K

Select item 79805243.

Structural and functional understanding of the toll‐like receptors

Jinta Asami, Toshiyuki Shimizu

Protein Sci. 2021 Apr; 30(4): 761–772. Published online 2021 Feb 24. doi: 10.1002/pro.4043

PMCID:: PMC7980524

Abstract Article PDF–6.6M

Select item 79061784.

Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling

Shushi Huang, Shengban You, Jinfu Qian, Chengyi Dai, Siyuan Shen, Jun Wang, Weijian Huang, Guang Liang, Gaojun Wu

Aging (Albany NY) 2021 Feb 15; 13(3): 4409–4427. Published online 2021 Jan 20. doi: 10.18632/aging.202402

PMCID:: PMC7906178

Abstract Article PDF–1.9M

Select item 72352185.

HIV-1 Tat – TLR4/MD2 interaction drives the expression of IDO-1 in monocytes derived dendritic cells through NF-κB dependent pathway

Elmostafa Bahraoui, Manutea Serrero, Rémi Planès

Sci Rep. 2020; 10: 8177. Published online 2020 May 18. doi: 10.1038/s41598-020-64847-y

PMCID:: PMC7235218

Abstract Article PDF–1.8M

Select item 71699836.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 69006447.

Expression of human TLR4/myeloid differentiation factor 2 directs an early innate immune response associated with modest increases in bacterial burden during Coxiella burnetii infection

Amanda Robison, Deann T Snyder, Kelly Christensen, Emily Kimmel, Adeline M Hajjar, Mark A Jutila, Jodi F Hedges

Innate Immun. 2019 Oct; 25(7): 401–411. Published online 2019 Jun 10. doi: 10.1177/1753425919855420

PMCID:: PMC6900644

Abstract Article PDF–955K

Select item 57449528.

Candida albicans-derived mannoproteins activate NF-κB in reporter cells expressing TLR4, MD2 and CD14

Traci Ness, Mahmud Abdallah, Jaime Adams, Claudia Alvarado, Edwin Gunn, Brittany House, John Lamb, Jack Macguire, Emily Norris, Rebekah Robinson, Morgan Sapp, Jill Sharma, Ronald Garner

PLoS One. 2017; 12(12): e0189939. Published online 2017 Dec 27. doi: 10.1371/journal.pone.0189939

PMCID:: PMC5744952

Abstract Article PDF–2.9M

Select item 48828679.

Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor

Sarah Daakour, Leon Juvenal Hajingabo, Despoina Kerselidou, Aurelie Devresse, Richard Kettmann, Nicolas Simonis, Franck Dequiedt, Jean-Claude Twizere

BMC Cancer. 2016; 16: 335. Published online 2016 May 26. doi: 10.1186/s12885-016-2374-2

PMCID:: PMC4882867

Abstract Article PDF–1.8M

Select item 486018010.

MD2 facilitates pollen and cat dander-induced innate and allergic airway inflammation

Koa Hosoki, Istvan Boldogh, Aguilera-Aguirre Leopoldo, Qian Sun, Toshiko Itazawa, Tapas Hazra, Allan R. Brasier, Alexander Kurosky, Sanjiv Sur

J Allergy Clin Immunol. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: J Allergy Clin Immunol. 2016 May; 137(5): 1506–1513.e2. Published online 2015 Nov 14. doi: 10.1016/j.jaci.2015.09.036

PMCID:: PMC4860180

Abstract Article PDF–3.2M

Select item 483570311.

Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4

Jinju Yang, Nannan Qin, Hongwei Zhang, Rui Yang, Benqiong Xiang, Qun Wei

Sci Rep. 2016; 6: 24346. Published online 2016 Apr 19. doi: 10.1038/srep24346

PMCID:: PMC4835703

Abstract Article PDF–1.6M

Select item 480914112.

Genome-Wide Association Study of New-Onset Atrial Fibrillation after Coronary Artery Bypass Grafting Surgery

Miklos D. Kertai, Yi-Ju Li, Yunqi Ji, Wenjing Qi, Frederick W. Lombard, Svati H. Shah, William E. Kraus, Mark Stafford-Smith, Mark F. Newman, Carmelo A. Milano, Nathan Waldron, Mihai V. Podgoreanu, Joseph P. Mathew

Am Heart J. Author manuscript; available in PMC 2016 Mar 28.

Published in final edited form as: Am Heart J. 2015 Sep; 170(3): 580–90.e28. Published online 2015 Jun 17. doi: 10.1016/j.ahj.2015.06.009

PMCID:: PMC4809141

Abstract Article PDF–1.0M

Select item 462399213.

Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses

Daiva M. Mattis, Adam Chervin, Diana Ranoa, Stacy Kelley, Richard Tapping, David M. Kranz

Mol Immunol. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Mol Immunol. 2015 Dec; 68(2 0 0): 203–212. Published online 2015 Aug 28. doi: 10.1016/j.molimm.2015.08.008

PMCID:: PMC4623992

Abstract Article PDF–1.7M

Select item 457186114.

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia

Flaviana Di Lorenzo, Łukasz Kubik, Alja Oblak, Nicola Ivan Lorè, Cristina Cigana, Rosa Lanzetta, Michelangelo Parrilli, Mohamad A. Hamad, Anthony De Soyza, Alba Silipo, Roman Jerala, Alessandra Bragonzi, Miguel A. Valvano, Sonsoles Martín-Santamaría, Antonio Molinaro

J Biol Chem. 2015 Aug 28; 290(35): 21305–21319. Published online 2015 Jul 9. doi: 10.1074/jbc.M115.649087