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Select item 112256751.

Optimized cytogenetic risk-group stratification of KMT2A-rearranged pediatric acute myeloid leukemia

Romy E. van Weelderen, Christine J. Harrison, Kim Klein, Yilin Jiang, Jonas Abrahamsson, Todd Alonzo, Richard Aplenc, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael N. Dworzak, Sarah Elitzur, José M. Fernández Navarro, Alan Gamis, Robert B. Gerbing, Bianca F. Goemans, Hester A. de Groot-Kruseman, Erin Guest, Shau-Yin Ha, Henrik Hasle, Charikleia Kelaidi, Hélène Lapillonne, Guy Leverger, Franco Locatelli, Takako Miyamura, Ulrika Norén-Nyström, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E. Rubnitz, Jan Stary, Anne Tierens, Daisuke Tomizawa, C. Michel Zwaan, Gertjan J. L. Kaspers

Blood Adv. 2024 Jun 25; 8(12): 3200–3213. Published online 2024 Apr 16. doi: 10.1182/bloodadvances.2023011771

PMCID:: PMC11225675

Abstract Article PDF–1.5M

Select item 112153852.

Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842

Haiping Luo, Qiqi Li, Jiaxin Hong, Zhibin Huang, Wenhui Deng, Kunpeng Wei, Siyu Lu, Hailong Wang, Wenqing Zhang, Wei Liu

Haematologica. 2024 Jul 1; 109(7): 2092–2110. Published online 2024 Feb 22. doi: 10.3324/haematol.2023.283647

PMCID:: PMC11215385

Abstract Article PDF–9.5M

Select item 111950423.

Therapeutic targeting in pediatric acute myeloid leukemia with aberrant HOX/MEIS1 expression

Kristian L. Juul-Dam, Neerav N. Shukla, Todd M. Cooper, Branko Cuglievan, Olaf Heidenreich, E Anders Kolb, Milad Rasouli, Henrik Hasle, C Michel Zwaan

Eur J Med Genet. Author manuscript; available in PMC 2024 Jun 24.

Published in final edited form as: Eur J Med Genet. 2023 Dec; 66(12): 104869. Published online 2023 Oct 29. doi: 10.1016/j.ejmg.2023.104869

PMCID:: PMC11195042

Abstract Article PDF–885K

Select item 111416454.

Chimeric antigen receptor T-cell therapy in childhood acute myeloid leukemia: how far are we from a clinical application?

Swati Naik, M. Paulina Velasquez, Stephen Gottschalk

Haematologica. 2024 Jun 1; 109(6): 1656–1667. Published online 2024 Jun 1. doi: 10.3324/haematol.2023.283817

PMCID:: PMC11141645

Abstract Article PDF–1.9M

Select item 111031715.

SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma

Mohammad Hamdy Abdelrazak Morsy, Ingrid Lilienthal, Martin Lord, Magali Merrien, Agata Magdalena Wasik, Marta Sureda-Gómez, Virginia Amador, Henrik J. Johansson, Janne Lehtiö, Beatriz Garcia-Torre, Jose Ignacio Martin-Subero, Nikolaos Tsesmetzis, Sijia Tao, Raymond F. Schinazi, Baek Kim, Agnes L. Sorteberg, Malin Wickström, Devon Sheppard, Georgios Z. Rassidakis, Ian A. Taylor, Birger Christensson, Elias Campo, Nikolas Herold, Birgitta Sander

Blood. 2024 May 9; 143(19): 1953–1964. Published online 2024 Jan 20. doi: 10.1182/blood.2023022241

PMCID:: PMC11103171

Abstract Article

Select item 110718656.

A RUNX1/ETO-SKP2-CDKN1B axis regulates expression of telomerase in t (8;21) acute myeloid leukemia

Emmanuel J. Moses, Adam Azlan, Kang Zi Khor, Yee Yik Mot, Saleem Mohamed, Azman Seeni, Farnaz Barneh, Olaf Heidenreich, Narazah Yusoff

Cell Mol Life Sci. 2023 Mar; 80(3): 70. Published online 2023 Feb 23. doi: 10.1007/s00018-023-04713-y

PMCID:: PMC11071865

Abstract Article PDF–1.4M

Select item 110449127.

High throughput screening aids clinical decision‐making in refractory acute myeloid leukaemia

S. J. Jessop, N. Fuentos‐Bolanos, C. Mayoh, M. E. M. Dolman, G. Tax, M. Wong‐Erasmus, P. Ajuyah, V. Tyrell, G. M. Marshall, D. S. Ziegler, L. M. S. Lau

Cancer Rep (Hoboken) 2024 Apr; 7(4): e2061. Published online 2024 Apr 25. doi: 10.1002/cnr2.2061

PMCID:: PMC11044912

Abstract Article PDF–750K

Select item 110349948.

Non-chromosomal birth defects and risk of childhood acute leukemia: an assessment in 15,000 leukemia cases and 46,000 controls from the Childhood Cancer and Leukemia International Consortium

Philip J. Lupo, Tiffany M. Chambers, Beth A. Mueller, Jacqueline Clavel, John D. Dockerty, David R. Doody, Friederike Erdmann, Sameera Ezzat, Tommaso Filippini, Johnni Hansen, Julia E. Heck, Claire Infante-Rivard, Alice Y. Kang, Corrado Magnani, Carlotta Malagoli, Catherine Metayer, Helen D. Bailey, Ana M. Mora, Evangelia Ntzani, Eleni Th Petridou, Maria S. Pombo-de-Oliveira, Wafaa M. Rashed, Eve Roman, Joachim Schüz, Catharina Wesseling, Logan G. Spector, Michael E. Scheurer

Int J Cancer. Author manuscript; available in PMC 2024 Apr 22.

Published in final edited form as: Int J Cancer. 2024 Feb 1; 154(3): 434–447. Published online 2023 Sep 11. doi: 10.1002/ijc.34720

PMCID:: PMC11034994

Abstract Article PDF–282K

Select item 109975169.

Inflammatory recruitment of healthy hematopoietic stem and progenitor cells in the acute myeloid leukemia niche

Ding-Wen Chen, Jian-Meng Fan, Julie M. Schrey, Dana V. Mitchell, Seul K. Jung, Stephanie N. Hurwitz, Empar B. Perez, Mauro J. Muraro, Martin Carroll, Deanne M. Taylor, Peter Kurre

Leukemia. 2024; 38(4): 741–750. Published online 2024 Jan 16. doi: 10.1038/s41375-024-02136-7

PMCID:: PMC10997516

Abstract Article PDF–2.4M

Select item 1091202810.

Harnessing upregulated E-selectin while enhancing SDF-1α sensing redirects infused NK cells to the AML-perturbed bone marrow

Laura Sanz-Ortega, Agneta Andersson, Mattias Carlsten

Leukemia. 2024; 38(3): 579–589. Published online 2024 Jan 5. doi: 10.1038/s41375-023-02126-1

PMCID:: PMC10912028

Abstract Article PDF–4.0M

Select item 1090953411.

The tip of the iceberg—The roles of long noncoding RNAs in acute myeloid leukemia

Patrick Connerty, Richard B. Lock

Wiley Interdiscip Rev RNA. 2023 Nov-Dec; 14(6): e1796. Published online 2023 Jun 2. doi: 10.1002/wrna.1796

PMCID:: PMC10909534

Abstract Article PDF–3.0M

Select item 1087462812.

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth

Daniel J.L. Coleman, Peter Keane, Rosario Luque-Martin, Paulynn S. Chin, Helen Blair, Luke Ames, Sophie G. Kellaway, James Griffin, Elizabeth Holmes, Sandeep Potluri, Salam A. Assi, John Bushweller, Olaf Heidenreich, Peter N. Cockerill, Constanze Bonifer

Cell Rep. Author manuscript; available in PMC 2024 Feb 18.

Published in final edited form as: Cell Rep. 2023 Dec 26; 42(12): 113568. Published online 2023 Dec 15. doi: 10.1016/j.celrep.2023.113568

PMCID:: PMC10874628

Abstract Article PDF–3.3M

Select item 1087353613.

Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors

Juan M. Barajas, Milad Rasouli, Masayuki Umeda, Ryan Hiltenbrand, Sherif Abdelhamed, Rebecca Mohnani, Bright Arthur, Tamara Westover, Melvin E. Thomas, III, Minoo Ashtiani, Laura J. Janke, Beisi Xu, Ti-Cheng Chang, Wojciech Rosikiewicz, Emily Xiong, Chandra Rolle, Jonathan Low, Reethu Krishan, Guangchun Song, Michael P. Walsh, Jing Ma, Jeffrey E. Rubnitz, Ilaria Iacobucci, Taosheng Chen, Anja Krippner-Heidenreich, Christian M. Zwaan, Olaf Heidenreich, Jeffery M. Klco

Blood. 2024 Feb 15; 143(7): 619–630. Published online 2023 Oct 31. doi: 10.1182/blood.2023021359

PMCID:: PMC10873536

Abstract Article

Select item 1086379714.

CanCHD Study of Hematopoietic Cancers in Children With and Without Genetic Syndromes

Mohammad Sazzad Hasan, Elie Ganni, Aihua Liu, Liming Guo, Andrew S. Mackie, Jay S. Kaufman, Ariane J. Marelli

J Am Heart Assoc. 2024 Jan 2; 13(1): e026604. Published online 2023 Dec 29. doi: 10.1161/JAHA.122.026604

PMCID:: PMC10863797

Abstract Article PDF–755K

Select item 1080355615.

Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia

Angela Gutierrez-Camino, Chantal Richer, Manon Ouimet, Claire Fuchs, Sylvie Langlois, Fida Khater, Maxime Caron, Patrick Beaulieu, Pascal St-Onge, Alain R. Bataille, Daniel Sinnett

Br J Cancer. 2024 Feb 10; 130(2): 317–326. Published online 2023 Dec 4. doi: 10.1038/s41416-023-02511-8

PMCID:: PMC10803556

Abstract Article PDF–1.1M

Select item 1078725016.

CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-X_L inhibition by navitoclax and DT2216

Verena Gress, Mathieu Roussy, Luc Boulianne, Mélanie Bilodeau, Sophie Cardin, Nehme El-Hachem, Véronique Lisi, Banafsheh Khakipoor, Alexandre Rouette, Azer Farah, Louis Théret, Léo Aubert, Furat Fatima, Éric Audemard, Pierre Thibault, Éric Bonneil, Jalila Chagraoui, Louise Laramée, Patrick Gendron, Loubna Jouan, Safa Jammali, Bastien Paré, Shawn M. Simpson, Thai Hoa Tran, Michel Duval, Pierre Teira, Henrique Bittencourt, Raoul Santiago, Frédéric Barabé, Guy Sauvageau, Martin A. Smith, Josée Hébert, Philippe P. Roux, Tanja A. Gruber, Vincent-Philippe Lavallée, Brian T. Wilhelm, Sonia Cellot

Blood Adv. 2024 Jan 9; 8(1): 112–129. Published online 2023 Sep 22. doi: 10.1182/bloodadvances.2022008899

PMCID:: PMC10787250

Abstract Article PDF–8.8M

Select item 1077639917.

Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study

Marketa Zaliova, Jan Zuna, Lucie Winkowska, Iveta Janotova, Justina Skorepova, Julius Lukes, Claus Meyer, Rolf Marschalek, Zbynek Novak, Jiri Domansky, Jan Stary, Lucie Sramkova, Jan Trka

Leukemia. 2024; 38(1): 21–30. Published online 2023 Nov 24. doi: 10.1038/s41375-023-02083-9

PMCID:: PMC10776399

Abstract Article PDF–2.5M

Select item 1069476818.

Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML

Bogdan Popescu, Carlos Stahlhut, Theodore C. Tarver, Sydney Wishner, Bianca J. Lee, Cheryl A.C. Peretz, Cuyler Luck, Paul Phojanakong, Juan Antonio Camara Serrano, Henry Hongo, Jose M. Rivera, Simayijiang Xirenayi, John A. Chukinas, Veronica Steri, Sarah K. Tasian, Elliot Stieglitz, Catherine C. Smith

Cell Rep Med. 2023 Nov 21; 4(11): 101290. Published online 2023 Nov 21. doi: 10.1016/j.xcrm.2023.101290