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Items: 1 to 20 of 147

1.
Infiltrating epitheliosis of the breast: characterization of histologic features, immunophenotype and genomic profile
Carey A Eberle, Salvatore Piscuoglio, Emad A Rakha, Charlotte KY Ng, Felipe C Geyer, Marcia Edelweiss, Rita A Sakr, Britta Weigelt, Jorge S Reis-Filho, Ian O Ellis
Histopathology. Author manuscript; available in PMC 2017 Jun 1.
Published in final edited form as: Histopathology. 2016 Jun; 68(7): 1030–1039. Published online 2016 Jan 7. doi: 10.1111/his.12897
PMCID:
PMC4957818
AbstractArticlePDF–3.1M
2.
ESR1 Mutations Affect Anti-proliferative Responses to Tamoxifen through Enhanced Cross-Talk with IGF Signaling
Luca Gelsomino, Guowei Gu, Yassine Rechoum, Amanda R Beyer, Sasha M Pejerrey, Anna Tsimelzon, Tao Wang, Kenneth Huffman, Andrew Ludlow, Sebastiano Ando’, Suzanne AW Fuqua
Breast Cancer Res Treat. Author manuscript; available in PMC 2017 Jul 14.
Published in final edited form as: Breast Cancer Res Treat. 2016 Jun; 157(2): 253–265. Published online 2016 May 13. doi: 10.1007/s10549-016-3829-5
Correction in:
Breast Cancer Res Treat. 2017 Jun; 163(3): 639–640.
PMCID:
PMC5510243
AbstractArticlePDF–910K
3.
PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α
Lauren M. Thorpe, Jennifer M. Spangle, Carolynn E. Ohlson, Hailing Cheng, Thomas M. Roberts, Lewis C. Cantley, Jean J. Zhao
Proc Natl Acad Sci U S A. 2017 Jul 3; 114(27): 7095–7100. Published online 2017 Jun 19. doi: 10.1073/pnas.1704706114
PMCID:
PMC5502636
AbstractArticlePDF–1.5M
4.
IGFBP2 expression predicts IDH-mutant glioma patient survival
Lin Eric Huang, Adam L. Cohen, Howard Colman, Randy L. Jensen, Daniel W. Fults, William T. Couldwell
Oncotarget. 2017 Jan 3; 8(1): 191–202. Published online 2016 Nov 12. doi: 10.18632/oncotarget.13329
PMCID:
PMC5352106
AbstractArticlePDF–3.6M
5.
Targeted next generation sequencing of endoscopic ultrasound acquired cytology from ampullary and pancreatic adenocarcinoma has the potential to aid patient stratification for optimal therapy selection
Ferga C. Gleeson, Sarah E. Kerr, Benjamin R. Kipp, Jesse S. Voss, Douglas M. Minot, Zheng Jin Tu, Michael R. Henry, Rondell P. Graham, George Vasmatzis, John C. Cheville, Konstantinos N. Lazaridis, Michael J. Levy
Oncotarget. 2016 Aug 23; 7(34): 54526–54536. Published online 2016 May 18. doi: 10.18632/oncotarget.9440
PMCID:
PMC5342360
AbstractArticlePDF–1.9M
6.
PI3Kδ and primary immunodeficiencies
Carrie L. Lucas, Anita Chandra, Sergey Nejentsev, Alison M. Condliffe, Klaus Okkenhaug
Nat Rev Immunol. Author manuscript; available in PMC 2017 May 1.
Published in final edited form as: Nat Rev Immunol. 2016 Nov; 16(11): 702–714. Published online 2016 Sep 12. doi: 10.1038/nri.2016.93
PMCID:
PMC5291318
AbstractArticlePDF–1.8M
7.
Tumor mutational analysis of GOG248, a phase II study of temsirolimus or temsirolimus and alternating megestrol acetate and tamoxifen for advanced endometrial cancer (EC): An NRG Oncology/Gynecologic Oncology Group study
Andrea P. Myers, Virginia L. Filiaci, Yuping Zhang, Michael Pearl, Kian Behbakht, Vicky Makker, Parviz Hanjani, Susan Zweizig, James J. Burke, II, Gordon Downey, Kimberly K. Leslie, Paul Van Hummelen, Michael J. Birrer, Gini F. Fleming
Gynecol Oncol. Author manuscript; available in PMC 2016 Nov 22.
Published in final edited form as: Gynecol Oncol. 2016 Apr; 141(1): 43–48. doi: 10.1016/j.ygyno.2016.02.025
PMCID:
PMC5119517
AbstractArticlePDF–2.3M
8.
Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas
Victoria E Clark, Akdes Serin Harmancı, Hanwen Bai, Mark W Youngblood, Tong Ihn Lee, Jacob F Baranoski, A Gulhan Ercan-Sencicek, Brian J Abraham, Abraham S Weintraub, Denes Hnisz, Matthias Simon, Boris Krischek, E Zeynep Erson-Omay, Octavian Henegariu, Geneive Carrión-Grant, Ketu Mishra-Gorur, Daniel Durán, Johanna E Goldmann, Johannes Schramm, Roland Goldbrunner, Joseph M Piepmeier, Alexander O Vortmeyer, Jennifer Moliterno Günel, Kaya Bilgüvar, Katsuhito Yasuno, Richard A Young, Murat Günel
Nat Genet. Author manuscript; available in PMC 2016 Nov 17.
Published in final edited form as: Nat Genet. 2016 Oct; 48(10): 1253–1259. Published online 2016 Aug 22. doi: 10.1038/ng.3651
PMCID:
PMC5114141
AbstractArticlePDF–966K
9.
Systematic Discovery of Complex Indels in Human Cancers
Kai Ye, Jiayin Wang, Reyka Jayasinghe, Eric-Wubbo Lameijer, Joshua F. McMichael, Jie Ning, Michael D. McLellan, Mingchao Xie, Song Cao, Venkata Yellapantula, Kuan-lin Huang, Adam Scott, Steven Foltz, Beifang Niu, Kimberly J. Johnson, Matthijs Moed, P. Eline Slagboom, Feng Chen, Michael C. Wendl, Li Ding
Nat Med. Author manuscript; available in PMC 2016 Aug 30.
Published in final edited form as: Nat Med. 2016 Jan; 22(1): 97–104. Published online 2015 Dec 14. doi: 10.1038/nm.4002
PMCID:
PMC5003782
AbstractArticlePDF–1.6M
10.
The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas
Charlotte K. Y. Ng, Salvatore Piscuoglio, Felipe C. Geyer, Kathleen A. Burke, Fresia Pareja, Carey A. Eberle, Raymond S Lim, Rachael Natrajan, Nadeem Riaz, Odette Mariani, Larry Norton, Anne Vincent-Salomon, Y. Hannah Wen, Britta Weigelt, Jorge S. Reis-Filho
Clin Cancer Res. Author manuscript; available in PMC 2018 Jul 15.
Published in final edited form as: Clin Cancer Res. 2017 Jul 15; 23(14): 3859–3870. Published online 2017 Feb 2. doi: 10.1158/1078-0432.CCR-16-2857
PMCID:
PMC5511565
AbstractArticlePDF–1.0M
11.
Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
Hamid Nikbakht, Eshini Panditharatna, Leonie G. Mikael, Rui Li, Tenzin Gayden, Matthew Osmond, Cheng-Ying Ho, Madhuri Kambhampati, Eugene I. Hwang, Damien Faury, Alan Siu, Simon Papillon-Cavanagh, Denise Bechet, Keith L. Ligon, Benjamin Ellezam, Wendy J. Ingram, Caedyn Stinson, Andrew S. Moore, Katherine E. Warren, Jason Karamchandani, Roger J. Packer, Nada Jabado, Jacek Majewski, Javad Nazarian
Nat Commun. 2016; 7: 11185. Published online 2016 Apr 6. doi: 10.1038/ncomms11185
PMCID:
PMC4823825
AbstractArticlePDF–1.2M
12.
HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B
Daniel C. Kirouac, Jinyan Du, Johanna Lahdenranta, Matthew D. Onsum, Ulrik B. Nielsen, Birgit Schoeberl, Charlotte F. McDonagh
PLoS Comput Biol. 2016 Apr; 12(4): e1004827. Published online 2016 Apr 1. doi: 10.1371/journal.pcbi.1004827
PMCID:
PMC4818107
AbstractArticlePDF–1.9M
13.
PI3-kinase mutation linked to insulin and growth factor resistance in vivo
Jonathon N. Winnay, Marie H. Solheim, Ercument Dirice, Masaji Sakaguchi, Hye-Lim Noh, Hee Joon Kang, Hirokazu Takahashi, Kishan K. Chudasama, Jason K. Kim, Anders Molven, C. Ronald Kahn, Pål R. Njølstad
J Clin Invest. 2016 Apr 1; 126(4): 1401–1412. Published online 2016 Mar 14. doi: 10.1172/JCI84005
PMCID:
PMC4811129
AbstractArticlePDF–2.2M
14.
Activating PI3Kδ mutations in a cohort of 669 patients with primary immunodeficiency
M. Elgizouli, D. M. Lowe, C. Speckmann, D. Schubert, J. Hülsdünker, Z. Eskandarian, A. Dudek, A. Schmitt‐Graeff, J. Wanders, S. F. Jørgensen, B. Fevang, U. Salzer, A. Nieters, S. Burns, B. Grimbacher
Clin Exp Immunol. 2016 Feb; 183(2): 221–229. Published online 2015 Nov 9. doi: 10.1111/cei.12706
PMCID:
PMC4711166
AbstractArticlePDF–325K
15.
Genomic landscape of salivary gland tumors
Shumei Kato, Sheryl K. Elkin, Maria Schwaederle, Brett N. Tomson, Teresa Helsten, Jennifer L. Carter, Razelle Kurzrock
Oncotarget. 2015 Sep 22; 6(28): 25631–25645. Published online 2015 Jul 27. doi: 10.18632/oncotarget.4554
PMCID:
PMC4694855
AbstractArticlePDF–2.2M
16.
Evaluation of efficacy and safety markers in a phase II study of metastatic colorectal cancer treated with aflibercept in the first-line setting
Diether Lambrechts, Bernard Thienpont, Vincent Thuillier, Xavier Sagaert, Matthieu Moisse, Gilian Peuteman, Carles Pericay, Gunnar Folprecht, John Zalcberg, Chiara Zilocchi, Emmanuelle Margherini, Marielle Chiron, Eric Van Cutsem
Br J Cancer. 2015 Sep 29; 113(7): 1027–1034. Published online 2015 Sep 10. doi: 10.1038/bjc.2015.329
PMCID:
PMC4651136
AbstractArticlePDF–292K
17.
PTEN loss is a context‐dependent outcome determinant in obese and non‐obese endometrioid endometrial cancer patients
Shannon N. Westin, Zhenlin Ju, Russell R. Broaddus, Camilla Krakstad, Jane Li, Navdeep Pal, Karen H. Lu, Robert L. Coleman, Bryan T. Hennessy, Samuel J. Klempner, Henrica M.J. Werner, Helga B. Salvesen, Lewis C. Cantley, Gordon B. Mills, Andrea P. Myers
Mol Oncol. 2015 Oct; 9(8): 1694–1703. Published online 2015 May 16. doi: 10.1016/j.molonc.2015.04.014
PMCID:
PMC4584169
AbstractArticlePDF–863K
18.
PI3Kα oncogenic mutations weaken the interactions that stabilize the p110α/p85α heterodimer
Ignacia Echeverria, Yunlong Liu, Sandra B. Gabelli, L. Mario Amzel
FEBS J. Author manuscript; available in PMC 2016 Sep 1.
Published in final edited form as: FEBS J. 2015 Sep; 282(18): 3528–3542. Published online 2015 Jul 24. doi: 10.1111/febs.13365
PMCID:
PMC4573839
AbstractArticlePDF–2.1M
19.
The driver landscape of sporadic chordoma
Patrick S. Tarpey, Sam Behjati, Matthew D. Young, Inigo Martincorena, Ludmil B. Alexandrov, Sarah J. Farndon, Charlotte Guzzo, Claire Hardy, Calli Latimer, Adam P. Butler, Jon W. Teague, Adam Shlien, P. Andrew Futreal, Sohrab Shah, Ali Bashashati, Farzad Jamshidi, Torsten O. Nielsen, David Huntsman, Daniel Baumhoer, Sebastian Brandner, Jay Wunder, Brendan Dickson, Patricia Cogswell, Josh Sommer, Joanna J. Phillips, M. Fernanda Amary, Roberto Tirabosco, Nischalan Pillay, Stephen Yip, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Nat Commun. 2017; 8: 890. Published online 2017 Oct 12. doi: 10.1038/s41467-017-01026-0
PMCID:
PMC5638846
AbstractArticlePDF–938K
20.
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
Felipe C. Geyer, Anqi Li, Anastasios D. Papanastasiou, Alison Smith, Pier Selenica, Kathleen A. Burke, Marcia Edelweiss, Huei-Chi Wen, Salvatore Piscuoglio, Anne M. Schultheis, Luciano G. Martelotto, Fresia Pareja, Rahul Kumar, Alissa Brandes, Dan Fan, Thais Basili, Arnaud Da Cruz Paula, John R. Lozada, Pedro Blecua, Simone Muenst, Achim A. Jungbluth, Maria P. Foschini, Hannah Y. Wen, Edi Brogi, Juan Palazzo, Brian P. Rubin, Charlotte K. Y. Ng, Larry Norton, Zsuzsanna Varga, Ian O. Ellis, Emad A. Rakha, Sarat Chandarlapaty, Britta Weigelt, Jorge S. Reis-Filho
Nat Commun. 2018; 9: 1816. Published online 2018 May 8. doi: 10.1038/s41467-018-04128-5
PMCID:
PMC5940840
AbstractArticlePDF–7.4M

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