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Select item 108403341.

Clinical interpretation of KCNH2 variants using a robust PS3/BS3 functional patch-clamp assay

Kate L. Thomson, Connie Jiang, Ebony Richardson, Dominik S. Westphal, Tobias Burkard, Cordula M. Wolf, Matteo Vatta, Steven M. Harrison, Jodie Ingles, Connie R. Bezzina, Brett M. Kroncke, Jamie I. Vandenberg, Chai-Ann Ng

HGG Adv. 2024 Apr 11; 5(2): 100270. Published online 2024 Jan 14. doi: 10.1016/j.xhgg.2024.100270

PMCID:: PMC10840334

Article PDF–1.8M

Select item 108196572.

Inherited Arrhythmias in the Pediatric Population: An Updated Overview

Marco Valerio Mariani, Nicola Pierucci, Francesca Fanisio, Domenico Laviola, Giacomo Silvetti, Agostino Piro, Vincenzo Mirco La Fazia, Cristina Chimenti, Marco Rebecchi, Fabrizio Drago, Fabio Miraldi, Andrea Natale, Carmine Dario Vizza, Carlo Lavalle

Medicina (Kaunas) 2024 Jan; 60(1): 94. Published online 2024 Jan 3. doi: 10.3390/medicina60010094

PMCID:: PMC10819657

Article PDF–2.7M

Select item 107632953.

Transfer RNA-derived small RNA tRF-Glu-CTC attenuates neointimal formation via inhibition of fibromodulin

Qi-Lan Jiang, Jia-Ying Xu, Qing-Ping Yao, Rui Jiang, Qin Xu, Bo-Tao Zhang, Tao Li, Jun Jiang

Cell Mol Biol Lett. 2024; 29: 2. Published online 2024 Jan 3. doi: 10.1186/s11658-023-00523-z

PMCID:: PMC10763295

Article PDF–5.2M

Select item 104187014.

Pharmacological Screening of Kv7.1 and Kv7.1/KCNE1 Activators as Potential Antiarrhythmic Drugs in the Zebrafish Heart

Alicia De la Cruz, Xiaoan Wu, Quinn C. Rainer, Irene Hiniesto-Iñigo, Marta E. Perez, Isak Edler, Sara I. Liin, H. Peter Larsson

Int J Mol Sci. 2023 Aug; 24(15): 12092. Published online 2023 Jul 28. doi: 10.3390/ijms241512092

PMCID:: PMC10418701

Article PDF–3.4M

Select item 103749825.

Arrhythmogenic mechanism of a novel ryanodine receptor mutation underlying sudden cardiac death

Yunyun Qian, Dongchuan Zuo, Jing Xiong, Yihen Yin, Ruxi Qi, Xiaomin Ma, An Yan, Yawen Yang, Ping Liu, Jingying Zhang, Kai Tang, Wenhui Peng, Yawei Xu, Zheng Liu

Europace. 2023 Jul; 25(7): euad220. Published online 2023 Jul 19. doi: 10.1093/europace/euad220

PMCID:: PMC10374982

Article PDF–17M

Select item 102998966.

Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome

Giovanna Nasilli, Loukia Yiangou, Chiara Palandri, Elisabetta Cerbai, Richard P Davis, Arie O Verkerk, Simona Casini, Carol Ann Remme

Europace. 2023 Jun; 25(6): euad154. Published online 2023 Jun 27. doi: 10.1093/europace/euad154

PMCID:: PMC10299896

Article PDF–1018K

Select item 102537537.

Functional Characterisation of the Rare SCN5A p.E1225K Variant, Segregating in a Brugada Syndrome Familial Case, in Human Cardiomyocytes from Pluripotent Stem Cells

Nicolò Salvarani, Giovanni Peretto, Crasto Silvia, Andrea Villatore, Cecilia Thairi, Anna Santoni, Camilla Galli, Paola Carrera, Simone Sala, Sara Benedetti, Elisa Di Pasquale, Chiara Di Resta

Int J Mol Sci. 2023 Jun; 24(11): 9548. Published online 2023 May 31. doi: 10.3390/ijms24119548

PMCID:: PMC10253753

Article PDF–1.6M

Select item 102286158.

Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Federica Giannetti, Miriam Barbieri, Assad Shiti, Simona Casini, Philip T Sager, Saumya Das, Sabindra Pradhananga, Dinesh Srinivasan, Saranda Nimani, Nicolò Alerni, Julien Louradour, Manuela Mura, Massimiliano Gnecchi, Paul Brink, Manfred Zehender, Gideon Koren, Antonio Zaza, Lia Crotti, Arthur A M Wilde, Peter J Schwartz, Carol Ann Remme, Lior Gepstein, Luca Sala, Katja E Odening

Europace. 2023 May; 25(5): euad094. Published online 2023 Apr 26. doi: 10.1093/europace/euad094

PMCID:: PMC10228615

Article PDF–1.6M

Select item 100262569.

Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance

Jaël S Copier, Marianne Bootsma, Chai A Ng, Arthur A M Wilde, Robin A Bertels, Hennie Bikker, Imke Christiaans, Saskia N van der Crabben, Janna A Hol, Tamara T Koopmann, Jeroen Knijnenburg, Aafke A J Lommerse, Jasper J van der Smagt, Connie R Bezzina, Jamie I Vandenberg, Arie O Verkerk, Daniela Q C M Barge-Schaapveld, Elisabeth M Lodder

Hum Mol Genet. 2023 Apr 1; 32(7): 1072–1082. Published online 2022 Oct 21. doi: 10.1093/hmg/ddac261

PMCID:: PMC10026256

Article PDF–1.7M

Select item 995826210.

Endocannabinoids enhance hK_V7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval

Irene Hiniesto-Iñigo, Laura M. Castro-Gonzalez, Valentina Corradi, Mark A. Skarsfeldt, Samira Yazdi, Siri Lundholm, Johan Nikesjö, Sergei Yu Noskov, Bo Hjorth Bentzen, D. Peter Tieleman, Sara I. Liin

eBioMedicine. 2023 Mar; 89: 104459. Published online 2023 Feb 14. doi: 10.1016/j.ebiom.2023.104459

PMCID:: PMC9958262

Article PDF–2.6M

Select item 983037411.

Calmodulin variant E140G associated with long QT syndrome impairs CaMKIIδ autophosphorylation and L-type calcium channel inactivation

Ohm Prakash, Nitika Gupta, Amy Milburn, Liam McCormick, Vishvangi Deugi, Pauline Fisch, Jacob Wyles, N Lowri Thomas, Svetlana Antonyuk, Caroline Dart, Nordine Helassa

J Biol Chem. 2023 Jan; 299(1): 102777. Published online 2022 Dec 8. doi: 10.1016/j.jbc.2022.102777

PMCID:: PMC9830374

Article PDF–2.6M

Select item 966353012.

Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation

Hongrui Wang, Tong Wu, Zhuo Huang, Jinghan Huang, Ze Geng, Bing Cui, Yupeng Yan, Yu Zhang, Yibo Wang

J Biol Chem. 2022 Nov; 298(11): 102599. Published online 2022 Oct 14. doi: 10.1016/j.jbc.2022.102599

PMCID:: PMC9663530

Article PDF–4.4M

Select item 957914513.

Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts

Allen C. T. Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J. Williams, Aaron Au, Wenliang Chen, Neal I. Callaghan, Farigol Hakem Zadeh, Yu-Qing Zhou, Meena Fatah, Diptendu Chatterjee, L. Jane Jourdan, Jack Liu, Craig A. Simmons, Thomas Kislinger, Christopher M. Yip, Peter H. Backx, Robert G. Gourdie, Robert M. Hamilton, Anthony O. Gramolini

Nat Commun. 2022; 13: 6166. Published online 2022 Oct 18. doi: 10.1038/s41467-022-33303-y

PMCID:: PMC9579145

Article PDF–11M

Select item 950006714.

Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function

Aleksandar R. Wood, Simote T. Foliaki, Bradley R. Groveman, Ryan O. Walters, Katie Williams, Jue Yuan, Wen-Quan Zou, Cathryn L. Haigh

Sci Rep. 2022; 12: 15788. Published online 2022 Sep 22. doi: 10.1038/s41598-022-19631-5

PMCID:: PMC9500067

Article PDF–7.5M

Select item 945615315.

Bioenergetic and Metabolic Impairments in Induced Pluripotent Stem Cell-Derived Cardiomyocytes Generated from Duchenne Muscular Dystrophy Patients

Lubna Willi, Ifat Abramovich, Jonatan Fernandez-Garcia, Bella Agranovich, Margarita Shulman, Helena Milman, Polina Baskin, Binyamin Eisen, Daniel E. Michele, Michael Arad, Ofer Binah, Eyal Gottlieb

Int J Mol Sci. 2022 Sep; 23(17): 9808. Published online 2022 Aug 29. doi: 10.3390/ijms23179808

PMCID:: PMC9456153

Article PDF–5.4M

Select item 940644816.

In Vitro Drug Screening Using iPSC-Derived Cardiomyocytes of a Long QT-Syndrome Patient Carrying KCNQ1 & TRPM4 Dual Mutation: An Experimental Personalized Treatment

Feifei Wang, Yafan Han, Wanyue Sang, Lu Wang, Xiaoyan Liang, Liang Wang, Qiang Xing, Yankai Guo, Jianghua Zhang, Ling Zhang, Tuerhong Zukela, Jiasuoer Xiaokereti, Yanmei Lu, Xianhui Zhou, Baopeng Tang, Yaodong Li

Cells. 2022 Aug; 11(16): 2495. Published online 2022 Aug 11. doi: 10.3390/cells11162495

PMCID:: PMC9406448

Article PDF–5.3M

Select item 929679817.

Aging‐induced atrial fibrosis in I_f current change and its effect on atrial fibrillation in dogs

Fei‐Fei Wang, Ya‐Fan Han, Xiao‐Yan Liang, Ge‐Ge Zhang, Yan‐Mei Lu, Yao‐Dong Li, Bao‐Peng Tang

Ann Noninvasive Electrocardiol. 2022 Jul; 27(4): e12951. Published online 2022 Apr 11. doi: 10.1111/anec.12951

PMCID:: PMC9296798

Article PDF–5.1M

Select item 903510218.

Multilayer Control of Cardiac Electrophysiology by MicroRNAs

Dandan Yang, Isabelle Deschênes, Ji-Dong Fu

J Mol Cell Cardiol. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: J Mol Cell Cardiol. 2022 May; 166: 107–115. Published online 2022 Mar 3. doi: 10.1016/j.yjmcc.2022.02.007

PMCID:: PMC9035102

Article PDF–868K

Select item 864927719.

LAMP2 Cardiomyopathy: Consequences of Impaired Autophagy in the Heart

Ronny Alcalai, Michael Arad, Hiroko Wakimoto, Dor Yadin, Joshua Gorham, Libin Wang, Elia Burns, Barry J. Maron, William C. Roberts, Tetsuo Konno, David A. Conner, Antonio R. Perez‐Atayde, Jon G. Seidman, Christine E. Seidman

J Am Heart Assoc. 2021 Sep 7; 10(17): e018829. Published online 2021 Aug 28. doi: 10.1161/JAHA.120.018829

PMCID:: PMC8649277

Article PDF–1.8M

Select item 856376020.

Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43

Jia-dan Wang, Ying Shao, Dan Liu, Nuo-ya Liu, Dan-yan Zhu

Acta Pharmacol Sin. 2021 Nov; 42(11): 1790–1797. Published online 2021 Feb 5. doi: 10.1038/s41401-020-00591-3

Correction in:: Acta Pharmacol Sin. 2023 Feb; 44(2): 488.

PMCID:: PMC8563760

Article PDF–3.1M

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