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Select item 106744031.

Imperatorin Restores Chemosensitivity of Multidrug-Resistant Cancer Cells by Antagonizing ABCG2-Mediated Drug Transport

Chung-Pu Wu, Megumi Murakami, Yen-Ching Li, Yang-Hui Huang, Yu-Tzu Chang, Tai-Ho Hung, Yu-Shan Wu, Suresh V. Ambudkar

Pharmaceuticals (Basel) 2023 Nov; 16(11): 1595. Published online 2023 Nov 12. doi: 10.3390/ph16111595

PMCID:: PMC10674403

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Select item 106418132.

4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells

Domiziana Masci, Michela Puxeddu, Laura Di Magno, Michele D’Ambrosio, Anastasia Parisi, Marianna Nalli, Ruoli Bai, Antonio Coluccia, Pietro Sciò, Viviana Orlando, Sara D’Angelo, Stefano Biagioni, Andrea Urbani, Ernest Hamel, Alessio Nocentini, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Cinzia Fionda, Rosa Bordone, Giorgia Della Rocca, Gianluca Canettieri, Claudiu T. Supuran, Romano Silvestri, Giuseppe La Regina

J Med Chem. 2023 Nov 9; 66(21): 14824–14842. Published online 2023 Oct 30. doi: 10.1021/acs.jmedchem.3c01424

PMCID:: PMC10641813

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Select item 106342413.

A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells

Xinlin Liu, Linli Luan, Xi Liu, Dingwen Jiang, Junwen Deng, Jiazhen Xu, Yang Yuan, Jiyao Xing, Bingguan Chen, Dongming Xing, Haiming Huang

Front Immunol. 2023; 14: 1292839. Published online 2023 Oct 25. doi: 10.3389/fimmu.2023.1292839

PMCID:: PMC10634241

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Select item 105980294.

Nivolumab and ipilimumab in recurrent or refractory cancer of unknown primary: a phase II trial

Maria Pouyiourou, Bianca N. Kraft, Timothy Wohlfromm, Michael Stahl, Boris Kubuschok, Harald Löffler, Ulrich T. Hacker, Gerdt Hübner, Lena Weiss, Michael Bitzer, Thomas Ernst, Philipp Schütt, Thomas Hielscher, Stefan Delorme, Martina Kirchner, Daniel Kazdal, Markus Ball, Klaus Kluck, Albrecht Stenzinger, Tilmann Bochtler, Alwin Krämer

Nat Commun. 2023; 14: 6761. Published online 2023 Oct 24. doi: 10.1038/s41467-023-42400-5

PMCID:: PMC10598029

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Select item 105305585.

The Illustration of Altered Glucose Dependency in Drug-Resistant Cancer Cells

Kausik Bishayee, Seung-Hee Lee, Yong Soo Park

Int J Mol Sci. 2023 Sep; 24(18): 13928. Published online 2023 Sep 11. doi: 10.3390/ijms241813928

PMCID:: PMC10530558

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Select item 105064226.

The multi-targeted tyrosine kinase inhibitor SKLB610 resensitizes ABCG2-overexpressing multidrug-resistant cancer cells to chemotherapeutic drugs

Chung-Pu Wu, Megumi Murakami, Yu-Shan Wu, Chun-Ling Lin, Yan-Qing Li, Yang-Hui Huang, Tai-Ho Hung, Suresh V. Ambudkar

Biomed Pharmacother. Author manuscript; available in PMC 2023 Sep 18.

Published in final edited form as: Biomed Pharmacother. 2022 May; 149: 112922. Published online 2022 Apr 5. doi: 10.1016/j.biopha.2022.112922

PMCID:: PMC10506422

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Select item 104868097.

Role of YY1 in the Regulation of Anti-Apoptotic Gene Products in Drug-Resistant Cancer Cells

Megan Jung, Indy Bui, Benjamin Bonavida

Cancers (Basel) 2023 Sep; 15(17): 4267. Published online 2023 Aug 25. doi: 10.3390/cancers15174267

PMCID:: PMC10486809

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Select item 103474558.

Combination oncolytic virus, radiation therapy, and immune checkpoint inhibitor treatment in anti-PD-1-refractory cancer

Sachin R Jhawar, Shang-Jui Wang, Aditya Thandoni, Praveen K Bommareddy, Jenna H Newman, Amanda L Marzo, Timothy M Kuzel, Vineet Gupta, Jochen Reiser, Preston Daniels, Devora Schiff, Darrion Mitchell, Nicole R LeBoeuf, Christopher Simmons, Sharad Goyal, Ahmed Lasfar, Jose A Guevara-Patino, Bruce G Haffty, Howard L Kaufman, Ann W Silk, Andrew Zloza

J Immunother Cancer. 2023; 11(7): e006780. Published online 2023 Jul 11. doi: 10.1136/jitc-2023-006780

PMCID:: PMC10347455

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Select item 103342489.

Paclitaxel-loaded ginsenoside Rg3 liposomes for drug-resistant cancer therapy by dual targeting of the tumor microenvironment and cancer cells

Ying Zhu, Anni Wang, Shuya Zhang, Jisu Kim, Jiaxuan Xia, Fengxue Zhang, Dan Wang, Qi Wang, Jianxin Wang

J Adv Res. 2023 Jul; 49: 159–173. Published online 2022 Sep 24. doi: 10.1016/j.jare.2022.09.007

PMCID:: PMC10334248

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Select item 1019998610.

Refractory Cancer Pain and Intrathecal Therapy: Critical Review of a Systematic Review

Sebastiano Mercadante

Pain Ther. 2023 Jun; 12(3): 645–654. Published online 2023 Apr 13. doi: 10.1007/s40122-023-00507-z

PMCID:: PMC10199986

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Select item 1017925411.

First-Line Combination Treatment with Low-Dose Bipolar Drugs for ABCB1-Overexpressing Drug-Resistant Cancer Populations

Sungpil Yoon, Hyung Sik Kim

Int J Mol Sci. 2023 May; 24(9): 8389. Published online 2023 May 7. doi: 10.3390/ijms24098389

PMCID:: PMC10179254

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Select item 1016409712.

Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-secreted Cytokines

Yoshinaga Ito, Deng Pan, Wubing Zhang, Xixi Zhang, Tiffany Y. Juan, Jason W. Pyrdol, Oleksandr Kyrysyuk, John G. Doench, X. Shirley Liu, Kai W. Wucherpfennig

Cancer Discov. Author manuscript; available in PMC 2023 Nov 4.

Published in final edited form as: Cancer Discov. 2023 May 4; 13(5): 1186–1209. doi: 10.1158/2159-8290.CD-22-1125

PMCID:: PMC10164097

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Select item 1015789613.

MEN1 mutations mediate clinical resistance to Menin inhibition

Florian Perner, Eytan M. Stein, Daniela V. Wenge, Sukrit Singh, Jeonghyeon Kim, Athina Apazidis, Homa Rahnamoun, Disha Anand, Christian Marinaccio, Charlie Hatton, Yanhe Wen, Richard M. Stone, David Schaller, Shoron Mowla, Wenbin Xiao, Holly A. Gamlen, Aaron J. Stonestrom, Sonali Persaud, Elizabeth Ener, Jevon A. Cutler, John G. Doench, Gerard M. McGeehan, Andrea Volkamer, John D. Chodera, Radosław P. Nowak, Eric S. Fischer, Ross L. Levine, Scott A. Armstrong, Sheng F. Cai

Nature. Author manuscript; available in PMC 2023 Sep 15.

Published in final edited form as: Nature. 2023 Mar; 615(7954): 913–919. Published online 2023 Mar 15. doi: 10.1038/s41586-023-05755-9

PMCID:: PMC10157896

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Select item 1010540314.

Methadone rotation versus other opioid rotation for refractory cancer induced bone pain: protocol of an exploratory randomised controlled open-label study

Natasha Michael, Merlina Sulistio, Robert Wojnar, Alexandra Gorelik

BMC Palliat Care. 2023; 22: 42. Published online 2023 Apr 15. doi: 10.1186/s12904-023-01160-1

PMCID:: PMC10105403

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Select item 1008728715.

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

De-Xuan Hu, Wen-Lin Tang, Yu Zhang, Hao Yang, Wenjie Wang, Keli Agama, Yves Pommier, Lin-Kun An

J Med Chem. Author manuscript; available in PMC 2023 Apr 11.

Published in final edited form as: J Med Chem. 2021 Jun 10; 64(11): 7617–7629. Published online 2021 May 19. doi: 10.1021/acs.jmedchem.1c00318

PMCID:: PMC10087287

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Select item 1004555916.

The Molecular Mechanisms of Oleanane Aldehyde-β-enone Cytotoxicity against Doxorubicin-Resistant Cancer Cells

Natalia Moiseeva, Daria Eroshenko, Lidia Laletina, Ekaterina Rybalkina, Olga Susova, Aida Karamysheva, Irina Tolmacheva, Mikhail Nazarov, Victoria Grishko

Biology (Basel) 2023 Mar; 12(3): 415. Published online 2023 Mar 8. doi: 10.3390/biology12030415

PMCID:: PMC10045559

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Select item 1001062917.

Selective protection of normal cells from chemotherapy, while killing drug-resistant cancer cells

Mikhail V. Blagosklonny

Oncotarget. 2023; 14: 193–206. Published online 2023 Mar 11. doi: 10.18632/oncotarget.28382

PMCID:: PMC10010629

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Select item 997271018.

Bicentre, randomized, parallel-arm, sham-controlled trial of transcranial direct-current stimulation (tDCS) in the treatment of palliative care patients with refractory cancer pain

Jean-Paul Nguyen, Hélène Gaillard, Alcira Suarez, Élie Terzidis-Mallat, Diane Constant-David, Aurélien Van Langhenhove, Adrien Evin, Catherine Malineau, Son V. O. Tan, Alaa Mhalla, Jean-Pascal Lefaucheur, Julien Nizard

BMC Palliat Care. 2023; 22: 15. Published online 2023 Feb 28. doi: 10.1186/s12904-023-01129-0

PMCID:: PMC9972710

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Select item 996335619.

Pinostrobin and Tectochrysin Conquer Multidrug-Resistant Cancer Cells via Inhibiting P-Glycoprotein ATPase

I-Ting Wu, Chan-Yen Kuo, Ching-Hui Su, Yu-Hsuan Lan, Chin-Chuan Hung

Pharmaceuticals (Basel) 2023 Feb; 16(2): 205. Published online 2023 Jan 29. doi: 10.3390/ph16020205

PMCID:: PMC9963356

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Select item 993457520.

Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy

Yaniv Kazansky, Daniel Cameron, Phillip Demarest, Nadia Zaffaroni, Noemi Arrighetti, Valentina Zuco, Yasumichi Kuwahara, Rui Qu, Elisa De Stanchina, Filemon Dela Cruz, Andrew Kung, Mrinal Gounder, Alex Kentsis

Version 1. bioRxiv. Preprint. 2023 Feb 6. doi: 10.1101/2023.02.06.527192

PMCID:: PMC9934575

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