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Select item 98570651.

Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration

Attila Varga, Minh Tu Nguyen, Kinga Pénzes, Bence Bátai, Pál Gyulavári, Bianka Gurbi, József Murányi, Péter Csermely, Miklós Csala, Tibor Vántus, Csaba Sőti

Cells. 2023 Jan; 12(2): 212. Published online 2023 Jan 4. doi: 10.3390/cells12020212

PMCID:: PMC9857065

Abstract Article PDF–4.3M

Select item 90200812.

Addressing the role of PKD3 in the T cell compartment with knockout mice

Jiří Koutník, Verena Neururer, Thomas Gruber, Sebastian Peer, Natascha Hermann-Kleiter, William J. Olson, Verena Labi, Michael Leitges, Gottfried Baier, Kerstin Siegmund

Cell Commun Signal. 2022; 20: 54. Published online 2022 Apr 19. doi: 10.1186/s12964-022-00864-w

PMCID:: PMC9020081

Abstract Article PDF–2.7M

Select item 88770733.

The GEF-H1/PKD3 signaling pathway promotes the maintenance of triple negative breast cancer stem cells.

Wolfgang Sebastian Lieb, Cristiana Lungu, Raluca Tamas, Hannah Berreth, Philipp Rathert, Peter Storz, Monilola A. Olayioye, Angelika Hausser

Int J Cancer. Author manuscript; available in PMC 2022 Feb 25.

Published in final edited form as: Int J Cancer. 2020 Jun 15; 146(12): 3423–3434. Published online 2019 Dec 14. doi: 10.1002/ijc.32798

PMCID:: PMC8877073

Abstract Article PDF–1.9M

Select item 85363924.

TRIM47 activates NF-κB signaling via PKC-ε/PKD3 stabilization and contributes to endocrine therapy resistance in breast cancer

Kotaro Azuma, Kazuhiro Ikeda, Takashi Suzuki, Kenjiro Aogi, Kuniko Horie-Inoue, Satoshi Inoue

Proc Natl Acad Sci U S A. 2021 Aug 31; 118(35): e2100784118. Published online 2021 Aug 25. doi: 10.1073/pnas.2100784118

PMCID:: PMC8536392

Abstract Article PDF–1.5M

Select item 83216625.

A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism

Angel Loza-Valdes, Alexander E Mayer, Toufic Kassouf, Jonathan Trujillo-Viera, Werner Schmitz, Filip Dziaczkowski, Michael Leitges, Andreas Schlosser, Grzegorz Sumara

Life Sci Alliance. 2021 Aug; 4(8): e202000863. Published online 2021 Jun 18. doi: 10.26508/lsa.202000863

PMCID:: PMC8321662

Abstract Article PDF–2.3M

Select item 79469596.

PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling

Bomiao Cui, Jiao Chen, Min Luo, Yiying Liu, Hongli Chen, Die Lü, Liwei Wang, Yingzhu Kang, Yun Feng, Libin Huang, Ping Zhang

Int J Oral Sci. 2021; 13: 8. Published online 2021 Mar 10. doi: 10.1038/s41368-021-00112-w

PMCID:: PMC7946959

Abstract Article PDF–3.8M

Select item 76121467.

The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling

Alexander E. Mayer, Mona C. Löffler, Angel E. Loza Valdés, Werner Schmitz, Rabih El-Merahbi, Jonathan Trujillo Viera, Manuela Erk, Thianzhou Zhang, Ursula Braun, Mathias Heikenwalder, Michael Leitges, Almut Schulze, Grzegorz Sumara

Sci Signal. Author manuscript; available in PMC 2022 Jan 3.

Published in final edited form as: Sci Signal. 2019 Aug 6; 12(593): eaav9150. Published online 2019 Aug 6. doi: 10.1126/scisignal.aav9150

PMCID:: PMC7612146

Abstract Article PDF–2.2M

Select item 68567308.

Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells

Ling Li, Liang Hua, Huihui Fan, Yu He, Wanfu Xu, Lin Zhang, Jie Yang, Fan Deng, Fangyin Zeng

J Cancer. 2019; 10(25): 6395–6404. Published online 2019 Oct 19. doi: 10.7150/jca.31254

PMCID:: PMC6856730

Abstract Article PDF–1.7M

Select item 66764039.

Original tumour suppressor gene polycystic kidney and hepatic disease 1-like 1 is associated with thyroid cancer cell progression

Chen Zheng, Ruida Quan, Er-Jie Xia, Adheesh Bhandari, Xiaohua Zhang

Oncol Lett. 2019 Sep; 18(3): 3227–3235. Published online 2019 Jul 18. doi: 10.3892/ol.2019.10632

PMCID:: PMC6676403

Abstract Article PDF–986K

Select item 613428210.

Polycystic kidney and hepatic disease 1 gene mutations in von Meyenburg complexes: Case report

Su Lin, Tian-Yu Shang, Ming-Fang Wang, Jian Lin, Xiao-Jian Ye, Da-Wu Zeng, Jiao-Feng Huang, Nan-Wen Zhang, Yi-Long Wu, Yue-Yong Zhu

World J Clin Cases. 2018 Sep 6; 6(9): 296–300. Published online 2018 Sep 6. doi: 10.12998/wjcc.v6.i9.296

PMCID:: PMC6134282

Abstract Article PDF–1.4M

Select item 510733811.

PHOS-TAG SDS-PAGE RESOLVES AGONIST- AND ISOFORM-SPECIFIC ACTIVATION PATTERNS FOR PKD2 AND PKD3 IN CARDIOMYOCYTES AND CARDIAC FIBROBLASTS

Weihua Qiu, Susan F. Steinberg

J Mol Cell Cardiol. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: J Mol Cell Cardiol. 2016 Oct; 99: 14–22. Published online 2016 Aug 8. doi: 10.1016/j.yjmcc.2016.08.005

PMCID:: PMC5107338

Abstract Article PDF–1.1M

Select item 496889812.

PKD3 deficiency causes alterations in microtubule dynamics during the cell cycle

Tianzhou Zhang, Ursula Braun, Michael Leitges

Cell Cycle. 2016; 15(14): 1844–1854. Published online 2016 May 31. doi: 10.1080/15384101.2016.1188237

PMCID:: PMC4968898

Abstract Article PDF–980K

Select item 419031813.

Congenital Hepatic Fibrosis in the Franches-Montagnes Horse Is Associated with the Polycystic Kidney and Hepatic Disease 1 (PKHD1) Gene

Michaela Drögemüller, Vidhya Jagannathan, Monika M. Welle, Claudia Graubner, Reto Straub, Vinzenz Gerber, Dominik Burger, Heidi Signer-Hasler, Pierre-André Poncet, Stéphane Klopfenstein, Ruedi von Niederhäusern, Jens Tetens, Georg Thaller, Stefan Rieder, Cord Drögemüller, Tosso Leeb

PLoS One. 2014; 9(10): e110125. Published online 2014 Oct 8. doi: 10.1371/journal.pone.0110125

PMCID:: PMC4190318

Abstract Article PDF–1.0M

Select item 407428414.

PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-κB- and HDAC1-mediated expression and activation of uPA

Zhipeng Zou, Fangyin Zeng, Wanfu Xu, Chunxia Wang, Zhiyong Ke, Q. Jane Wang, Fan Deng

J Cell Sci. 2012 Oct 15; 125(20): 4800–4811. doi: 10.1242/jcs.106542

PMCID:: PMC4074284

Abstract Article

Select item 391651915.

Elevated Protein Kinase D3 (PKD3) Expression Supports Proliferation of Triple-negative Breast Cancer Cells and Contributes to mTORC1-S6K1 Pathway Activation

Bettina Huck, Stephan Duss, Angelika Hausser, Monilola A. Olayioye

J Biol Chem. 2014 Feb 7; 289(6): 3138–3147. Published online 2013 Dec 11. doi: 10.1074/jbc.M113.502633

PMCID:: PMC3916519

Abstract Article PDF–2.3M

Select item 388395316.

Evidence of a third ADPKD locus is not supported by reanalysis of designated PKD3 families

Binu M. Paul, Mark B. Consugar, Moonnoh Ryan Lee, Jamie L. Sundsbak, Christina M. Heyer, Sandro Rossetti, Vickie J. Kubly, Katharina Hopp, Vicente E. Torres, Eliecer Coto, Maurizio Clementi, Nadja Bogdanova, Edgar de Almeida, Daniel G. Bichet, Peter C. Harris

Kidney Int. Author manuscript; available in PMC 2014 Aug 1.

Published in final edited form as: Kidney Int. 2014 Feb; 85(2): 383–392. Published online 2013 Jun 12. doi: 10.1038/ki.2013.227

PMCID:: PMC3883953

Abstract Article PDF–1.3M

Select item 346456617.

GIT1 Phosphorylation on Serine 46 by PKD3 Regulates Paxillin Trafficking and Cellular Protrusive Activity

Bettina Huck, Ralf Kemkemer, Mirita Franz-Wachtel, Boris Macek, Angelika Hausser, Monilola A. Olayioye

J Biol Chem. 2012 Oct 5; 287(41): 34604–34613. Published online 2012 Aug 13. doi: 10.1074/jbc.M112.374652

PMCID:: PMC3464566

Abstract Article PDF–1.5M

Select item 262909618.

PKD3 Is the Predominant Protein Kinase D Isoform in Mouse Exocrine Pancreas and Promotes Hormone-induced Amylase Secretion

L. Andy Chen, Jing Li, Scott R. Silva, Lindsey N. Jackson, Yuning Zhou, Hiroaki Watanabe, Kirk L. Ives, Mark R. Hellmich, B. Mark Evers

J Biol Chem. 2009 Jan 23; 284(4): 2459–2471. doi: 10.1074/jbc.M801697200

PMCID:: PMC2629096

Abstract Article PDF–981K

Select item 44760519.

PKHD1, the Polycystic Kidney and Hepatic Disease 1 Gene, Encodes a Novel Large Protein Containing Multiple Immunoglobulin-Like Plexin-Transcription–Factor Domains and Parallel Beta-Helix 1 Repeats

Luiz F. Onuchic, Laszlo Furu, Yasuyuki Nagasawa, Xiaoying Hou, Thomas Eggermann, Zhiyong Ren, Carsten Bergmann, Jan Senderek, Ernie Esquivel, Raoul Zeltner, Sabine Rudnik-Schöneborn, Michael Mrug, William Sweeney, Ellis D. Avner, Klaus Zerres, Lisa M. Guay-Woodford, Stefan Somlo, Gregory G. Germino

Am J Hum Genet. 2002 May; 70(5): 1305–1317. Published online 2002 Mar 15. doi: 10.1086/340448