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Select item 108805891.

Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of The Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential

Marta Sans, Yuki Makino, Jimin Min, Kimal I. Rajapakshe, Michele Yip-Schneider, C Max Schmidt, Mark W. Hurd, Jared K. Burks, Javier A. Gomez, Fredrik I. Thege, Johannes F. Fahrmann, Robert A. Wolff, Michael P. Kim, Paola A. Guerrero, Anirban Maitra

Cancer Discov. Author manuscript; available in PMC 2024 Feb 21.

Published in final edited form as: Cancer Discov. 2023 Aug 4; 13(8): 1844–1861. doi: 10.1158/2159-8290.CD-22-1200

PMCID:: PMC10880589

Article PDF–5.5M

Select item 108360442.

Discrimination of pancreato-biliary cancer and pancreatitis patients by non-invasive liquid biopsy

Christina Hartwig, Jan Müller, Hagen Klett, Dina Kouhestani, Anke Mittelstädt, Anna Anthuber, Paul David, Maximilian Brunner, Anne Jacobsen, Karolina Glanz, Izabela Swierzy, Lotta Roßdeutsch, Bettina Klösch, Robert Grützmann, Timo Wittenberger, Kai Sohn, Georg F. Weber

Mol Cancer. 2024; 23: 28. Published online 2024 Feb 2. doi: 10.1186/s12943-024-01943-x

PMCID:: PMC10836044

Article PDF–1.8M

Select item 105637953.

Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project

Alexander Semaan, Vincent Bernard, Justin Wong, Yuki Makino, Daniel B. Swartzlander, Kimal I. Rajapakshe, Jaewon J. Lee, Adam Officer, Christian Max Schmidt, Howard H. Wu, Courtney L. Scaife, Kajsa E. Affolter, Daniela Nachmanson, Matthew A. Firpo, Michele Yip-Schneider, Andrew M. Lowy, Olivier Harismendy, Subrata Sen, Anirban Maitra, Yasminka A. Jakubek, Paola A. Guerrero

Cancer Res Commun. 2023 Oct; 3(10): 2062–2073. Published online 2023 Oct 10. doi: 10.1158/2767-9764.CRC-22-0419

PMCID:: PMC10563795

Article PDF–8.0M

Select item 101028464.

Blood-Based Diagnosis and Risk Stratification of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN)

Chaoyang Zhang, Fawaz N. Al-Shaheri, Mohamed Saiel Saeed Alhamdani, Andrea S. Bauer, Jörg D. Hoheisel, Miriam Schenk, Ulf Hinz, Philipp Goedecke, Karam Al-Halabi, Markus W. Büchler, Nathalia A. Giese, Thilo Hackert, Susanne Roth

Clin Cancer Res. 2023 Apr 14; 29(8): 1535–1545. Published online 2022 Dec 14. doi: 10.1158/1078-0432.CCR-22-2531

PMCID:: PMC10102846

Article PDF–3.5M

Select item 100229065.

Digital spatial profiling of intraductal papillary mucinous neoplasms: Toward a molecular framework for risk stratification

Matthew K. Iyer, Chanjuan Shi, Austin M. Eckhoff, Ashley Fletcher, Daniel P. Nussbaum, Peter J. Allen

Sci Adv. 2023 Mar; 9(11): eade4582. Published online 2023 Mar 17. doi: 10.1126/sciadv.ade4582

PMCID:: PMC10022906

Article PDF–2.4M

Select item 99498936.

Multidimensional Immunophenotyping of Intraductal Papillary Mucinous Neoplasms Reveals Novel T Cell and Macrophage Signature

Austin M. Eckhoff, Ashley A. Fletcher, Karenia Landa, Matthew Iyer, Daniel P. Nussbaum, Chanjuan Shi, Smita K. Nair, Peter J. Allen

Ann Surg Oncol. Author manuscript; available in PMC 2023 Feb 23.

Published in final edited form as: Ann Surg Oncol. 2022 Nov; 29(12): 7781–7788. Published online 2022 Jul 13. doi: 10.1245/s10434-022-12157-0

PMCID:: PMC9949893

Article PDF–1.1M

Select item 99423827.

Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms

Ankit Chhoda, Anup Sharma, Bethsebie Sailo, Haoyu Tang, Nensi Ruzgar, Wan Ying Tan, Lee Ying, Rishabh Khatri, Anand Narayanan, Shrikant Mane, Bony De Kumar, Laura D. Wood, Christine Iacobuzio-Donahue, Christopher L. Wolfgang, John W. Kunstman, Ronald R. Salem, James J. Farrell, Nita Ahuja

Clin Epigenetics. 2023; 15: 28. Published online 2023 Feb 20. doi: 10.1186/s13148-023-01429-5

PMCID:: PMC9942382

Article PDF–1.2M

Select item 99331748.

Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotype

Sven-Thorsten Liffers, Laura Godfrey, Lisa Frohn, Lena Haeberle, Aslihan Yavas, Rita Vesce, Wolfgang Goering, Friederike V Opitz, Nickolas Stoecklein, Wolfram Trudo Knoefel, Anna Melissa Schlitter, Guenter Klöppel, Elisa Espinet, Andreas Trumpp, Jens T Siveke, Irene Esposito

Gut. 2023 Mar; 72(3): 522–534. Published online 2022 Aug 9. doi: 10.1136/gutjnl-2021-326550

PMCID:: PMC9933174

Article PDF–5.2M

Select item 99110509.

A pilot study to evaluate tissue- and plasma-based DNA driver mutations in a cohort of patients with pancreatic intraductal papillary mucinous neoplasms

Margaret A Park, Thinzar Zaw, Sean J Yoder, Maria Gomez, Maria Genilo-Delgado, Toni Basinski, Esther Katende, Aamir Dam, Shaffer R S Mok, Alvaro Monteiro, Amir Mohammadi, Daniel K Jeong, Kun Jiang, Barbara A Centeno, Pamela Hodul, Mokenge Malafa, Jason Fleming, Dung-Tsa Chen, Qianxing Mo, Jamie K Teer, Jennifer B Permuth

G3 (Bethesda) 2023 Feb; 13(2): jkac314. Published online 2022 Dec 1. doi: 10.1093/g3journal/jkac314

PMCID:: PMC9911050

Article PDF–464K

Select item 982872610.

Mechanisms of development and progression of pancreatic neoplasms

Toru Furukawa

Pathol Int. 2022 Nov; 72(11): 529–540. Published online 2022 Sep 26. doi: 10.1111/pin.13272

PMCID:: PMC9828726

Article PDF–3.5M

Select item 874861711.

Relevance of gene mutations and methylation to the growth of pancreatic intraductal papillary mucinous neoplasms based on pyrosequencing

Go Asano, Katsuyuki Miyabe, Hiroyuki Kato, Michihiro Yoshida, Takeshi Sawada, Yasuyuki Okamoto, Hidenori Sahashi, Naoki Atsuta, Kenta Kachi, Akihisa Kato, Naruomi Jinno, Makoto Natsume, Yasuki Hori, Itaru Naitoh, Kazuki Hayashi, Yoichi Matsuo, Satoru Takahashi, Hiromu Suzuki, Hiromi Kataoka

Sci Rep. 2022; 12: 419. Published online 2022 Jan 10. doi: 10.1038/s41598-021-04335-z

PMCID:: PMC8748617

Article PDF–2.0M

Select item 866744212.

Pancreatic medullary carcinoma developed on a pancreatic intraductal papillary mucinous neoplasm with loss of MSH2 and MSH6 expression: a case report

Camille Verocq, Marie-Lucie Racu, Dominique Bafort, Gloria Butorano, Luis Perez-Casanova Garcia, Julie Navez, Marc Witterwulghe, Kieran Sheahan, Niall Swan, Jean Closset, Jean-Luc Van Laethem, Calliope Maris, Nicky D’Haene

Diagn Pathol. 2021; 16: 117. Published online 2021 Dec 13. doi: 10.1186/s13000-021-01178-0

PMCID:: PMC8667442

Article PDF–1.5M

Select item 865785713.

Humoral Predictors of Malignancy in IPMN: A Review of the Literature

Enrico C. Nista, Tommaso Schepis, Marcello Candelli, Lucia Giuli, Giulia Pignataro, Francesco Franceschi, Antonio Gasbarrini, Veronica Ojetti

Int J Mol Sci. 2021 Dec; 22(23): 12839. Published online 2021 Nov 27. doi: 10.3390/ijms222312839

PMCID:: PMC8657857

Article PDF–903K

Select item 826251014.

Multi-region Whole Exome Sequencing of Intraductal Papillary Mucinous Neoplasms Reveals Frequent Somatic KLF4 Mutations Predominantly in Low-Grade Regions

Kohei Fujikura, Waki Hosoda, Matthäus Felsenstein, Qianqian Song, Johannes G. Reiter, Lily Zheng, Violeta Beleva Guthrie, Natalia Rincon, Marco Dal Molin, Jonathan Dudley, Joshua D. Cohen, Pei Wang, Catherine G. Fischer, Alicia M. Braxton, Michaël Noë, Martine Jongepier, Carlos Fernández-del Castillo, Mari Mino-Kenudson, C. Max Schmidt, Michele T. Yip-Schneider, Rita T. Lawlor, Roberto Salvia, Nicholas J. Roberts, Elizabeth D. Thompson, Rachel Karchin, Anne Marie Lennon, Yuchen Jiao, Laura D. Wood

Gut. Author manuscript; available in PMC 2022 May 1.

Published in final edited form as: Gut. 2021 May; 70(5): 928–939. Published online 2020 Oct 7. doi: 10.1136/gutjnl-2020-321217

PMCID:: PMC8262510

Article PDF–2.6M

Select item 816279415.

Molecular characterization of organoids derived from pancreatic intraductal papillary mucinous neoplasms

Bo Huang, Maria A. Trujillo, Kohei Fujikura, Miaozhen Qiu, Fei Chen, Matthäus Felsenstein, Cancan Zhou, Michael Skaro, Christian Gauthier, Anne Macgregor-Das, Danielle Hutchings, Seung-Mo Hong, Ralph H. Hruban, James R. Eshleman, Elizabeth D. Thompson, Alison P. Klein, Michael Goggins, Laura D. Wood, Nicholas J. Roberts

J Pathol. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: J Pathol. 2020 Nov; 252(3): 252–262. Published online 2020 Sep 19. doi: 10.1002/path.5515

PMCID:: PMC8162794

Article PDF–1.5M

Select item 732185416.

Simple mucinous cysts of the pancreas have heterogeneous somatic mutations

Marc Attiyeh, Lance Zhang, Christine Iacobuzio-Donahue, Peter Allen, Rami Imam, Olca Basturk, David S. Klimstra, Carlie Sigel

Hum Pathol. Author manuscript; available in PMC 2021 Jul 1.

Published in final edited form as: Hum Pathol. 2020 Jul; 101: 1–9. Published online 2020 May 5. doi: 10.1016/j.humpath.2020.04.006

PMCID:: PMC7321854

Article PDF–1.2M

Select item 729445817.

Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing

Shounak Majumder, William R. Taylor, Tracy C. Yab, Calise K. Berger, Brian A. Dukek, Xiaoming Cao, Patrick H. Foote, Chung Wah Wu, Douglas W. Mahoney, Harry R. Aslanian, Carlos Fernández-Del Castillo, Leona A. Doyle, James J. Farrell, William E. Fisher, Linda S. Lee, Yvonne N. Lee, Walter Park, Clifton Rodrigues, Bonnie Elyssa Gould Rothberg, Ronald R. Salem, Diane M. Simeone, Sumithra Urs, George Van Buren, Thomas C. Smyrk, Hatim T. Allawi, Graham P. Lidgard, Massimo Raimondo, Suresh T. Chari, Michael L. Kendrick, John B. Kisiel, Mark D. Topazian, David A. Ahlquist

Am J Gastroenterol. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Am J Gastroenterol. 2019 Sep; 114(9): 1539–1549. doi: 10.14309/ajg.0000000000000284

PMCID:: PMC7294458

Article PDF–1.4M

Select item 723502718.

Upregulation of follistatin and low apoptotic activity in intraductal oncocytic papillary neoplasm of the pancreatobiliary system

Jun Nakahodo, Yuki Fukumura, Tsuyoshi Saito, Kenichi Hirabayashi, Reiko Doi, Takuo Hayashi, Takashi Yao

Sci Rep. 2020; 10: 8179. Published online 2020 May 18. doi: 10.1038/s41598-020-64920-6

PMCID:: PMC7235027

Article PDF–2.3M

Select item 677363319.

Surveillance for pancreatic cancer in high‐risk individuals

I. C. A. W. Konings, M. I. Canto, J. A. Almario, F. Harinck, P. Saxena, A. L. Lucas, F. Kastrinos, D. C. Whitcomb, R. E. Brand, J. Lachter, G. Malleo, S. Paiella, S. Syngal, J. R. Saltzman, E. M. Stoffel, J. E. van Hooft, R. H. Hruban, J. W. Poley, P. Fockens, M. G. Goggins, M. J. Bruno, on behalf of the International CAncer of the Pancreas Screening (CAPS) Consortium

BJS Open. 2019 Oct; 3(5): 656–665. Published online 2019 Jul 2. doi: 10.1002/bjs5.50180

PMCID:: PMC6773633

Article PDF–227K

Select item 675695020.

Intraductal Papillary Mucinous Neoplasms Arise from Multiple Independent Clones, Each With Distinct Mutations

Catherine G. Fischer, Violeta Beleva Guthrie, Alicia M. Braxton, Lily Zheng, Pei Wang, Qianqian Song, James F. Griffin, Peter E. Chianchiano, Waki Hosoda, Noushin Niknafs, Simeon Springer, Marco Dal Molin, David Masica, Robert B. Scharpf, Elizabeth D. Thompson, Jin He, Christopher L. Wolfgang, Ralph H. Hruban, Nicholas J. Roberts, Anne Marie Lennon, Yuchen Jiao, Rachel Karchin, Laura D. Wood

Gastroenterology. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Gastroenterology. 2019 Oct; 157(4): 1123–1137.e22. Published online 2019 Jun 5. doi: 10.1053/j.gastro.2019.06.001

PMCID:: PMC6756950

Article PDF–1.4M

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