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Select item 117941431.

A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones

Raúl Sánchez-Lanzas, Justin Barclay, Alexandros Hardas, Foteini Kalampalika, Amanda Jiménez-Pompa, Paolo Gallipoli, Miguel Ganuza

Leukemia. 2025; 39(2): 460–472. Published online 2024 Nov 13. doi: 10.1038/s41375-024-02464-8

PMCID:: PMC11794143

Article PDF–4.5M

Select item 117916282.

Isolated anterior cerebral artery occlusion: an atypical form of moyamoya disease

Si-Meng Liu, Gan Gao, Fang-bin Hao, Shi-tong Liu, Ri-miao Yang, Hou-di Zhang, Min-Jie Wang, Zheng-xing Zou, Dan Yu, Qian Zhang, Qing-Bao Guo, Xiao-Peng Wang, He-guan Fu, Jing-Jie Li, Cong Han, Lian Duan

Stroke Vasc Neurol. 2024 Dec; 9(6): e002992. Published online 2024 Mar 9. doi: 10.1136/svn-2023-002992

PMCID:: PMC11791628

Article PDF–1.4M

Select item 117907563.

Combined Analysis of Human and Experimental Rat Samples Identified Biomarkers for Ischemic Stroke

Qingfa Chen, Xiaolu Li, Ye Yang, Jun Ni, Jianmin Chen

Mol Neurobiol. 2025; 62(3): 3794–3812. Published online 2024 Sep 26. doi: 10.1007/s12035-024-04512-x

PMCID:: PMC11790756

Article PDF–2.4M

Select item 117905194.

BRCC3‐Associated Syndromic Moyamoya Angiopathy Diagnosed Through Clinical RNA Sequencing

Myrrhe Venema, Fatimah Albuainain, Rachel Schot, Bob Roozenbeek, Frank Sleutels, Tjakko van Ham, Tahsin Stefan Barakat

Clin Genet. 2025 Mar; 107(3): 341–347. Published online 2024 Nov 17. doi: 10.1111/cge.14650

PMCID:: PMC11790519

Article PDF–1.8M

Select item 117646295.

Recent Advances in Stroke Genetics—Unraveling the Complexity of Cerebral Infarction: A Brief Review

Takeshi Yoshimoto, Hiroshi Yamagami, Yuji Matsumaru

Genes (Basel) 2025 Jan; 16(1): 59. Published online 2025 Jan 6. doi: 10.3390/genes16010059

PMCID:: PMC11764629

Article PDF–280K

Select item 117609906.

NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL

Chunyi Li, Hui Li, Xuejiao Men, Yuge Wang, Xinmei Kang, Mengyan Hu, Xiaotao Su, Shisi Wang, Danli Lu, Shishi Shen, Huipeng Huang, Xiaohui Deng, Yuxin Liu, Lei Zhang, Wei Cai, Aimin Wu, Zhengqi Lu

CNS Neurosci Ther. 2025 Jan; 31(1): e70140. Published online 2025 Jan 24. doi: 10.1111/cns.70140

PMCID:: PMC11760990

Article PDF–13M

Select item 117240397.

Monitoring of single-nucleus chromatin landscape of ischemic stroke in mouse cerebral cortex across time

Ruolin Zhang, Sicheng Guo, Jie Zhou, Xiumei Lin, Ying Wang, Yiqi Wang, Muyang Li, Kaichen Zhao, Wendai Bao, Ke Shui, Chuanyu Liu, Chang Liu, Zhiqiang Dong

Sci Data. 2025; 12: 47. Published online 2025 Jan 11. doi: 10.1038/s41597-025-04367-4

PMCID:: PMC11724039

Article PDF–6.0M

Select item 117030898.

Deciphering the role of APOE in cerebral amyloid angiopathy: from genetic insights to therapeutic horizons

Hantian Hu, Siqi Wan, Yuetao Hu, Qi Wang, Hanyu Li, Nan Zhang

Ann Med. 2025; 57(1): 2445194. Published online 2025 Jan 2. doi: 10.1080/07853890.2024.2445194

PMCID:: PMC11703089

Article PDF–3.2M

Select item 116747929.

CADASIL: A NOTCH3-associated cerebral small vessel disease

Lamei Yuan, Xiangyu Chen, Joseph Jankovic, Hao Deng

J Adv Res. 2024 Dec; 66: 223–235. Published online 2024 Jan 2. doi: 10.1016/j.jare.2024.01.001

PMCID:: PMC11674792

Article PDF–1.9M

Select item 1166332610.

Adequate post-ischemic reperfusion of the mouse brain requires endothelial NFAT5

Reiner Kunze, Paul Wacker, Paula Breuer, Emil Nasyrov, Ivan M. Kur, Andreas Weigert, Andreas H. Wagner, Hugo H. Marti, Thomas Korff

Acta Neuropathol Commun. 2024; 12: 200. Published online 2024 Dec 22. doi: 10.1186/s40478-024-01918-5

PMCID:: PMC11663326

Article PDF–9.1M

Select item 1160747111.

E3 Ubiquitin Ligase Ring Finger Protein 2 Alleviates Cerebral Ischemia–Reperfusion Injury by Stabilizing Mesencephalic Astrocyte‐Derived Neurotrophic Factor Through Monoubiquitination

Yujun Shen, Jinfeng Wang, Junxing Liang, Ying Chen, Xueyan Wu, Zhenhua Ren, Jiangning Zhou, Lijie Feng, Yuxian Shen

CNS Neurosci Ther. 2024 Nov; 30(11): e70136. Published online 2024 Nov 30. doi: 10.1111/cns.70136

PMCID:: PMC11607471

Article PDF–28M

Select item 1159462512.

Tlx Promotes Stroke-Induced Neurogenesis and Neuronal Repair in Young and Aged Mice

Dilaware Khan, Dagmar Bock, Hai-Kun Liu, Sajjad Muhammad

Int J Mol Sci. 2024 Nov; 25(22): 12440. Published online 2024 Nov 19. doi: 10.3390/ijms252212440

PMCID:: PMC11594625

Article PDF–5.6M

Select item 1156785013.

Cognition in (pre)symptomatic Dutch‐type hereditary and sporadic cerebral amyloid angiopathy

Rosemarie van Dort, Kanishk Kaushik, Ingeborg Rasing, Reinier G. J. van der Zwet, Manon R. Schipper, Jeroen van der Grond, Sanneke van Rooden, Erik W. van Zwet, Gisela M. Terwindt, Huub A. M. Middelkoop, Ellen P. Hart, Matthias J. P. van Osch, Marianne A. A. van Walderveen, Marieke J. H. Wermer

Alzheimers Dement. 2024 Nov; 20(11): 7518–7528. Published online 2024 Oct 10. doi: 10.1002/alz.14171

PMCID:: PMC11567850

Article PDF–702K

Select item 1155705314.

RNF213 in moyamoya disease: Genotype–phenotype association and the underlying mechanism

Jianxun Fang, Xinzhuang Yang, Jun Ni

Chin Med J (Engl) 2024 Nov 5; 137(21): 2552–2560. Published online 2024 Jan 19. doi: 10.1097/CM9.0000000000002985

PMCID:: PMC11557053

Article PDF–726K

Select item 1155500615.

HAPLN3 p.T34A contributes to incomplete penetrance of moyamoya disease in Chinese carrying RNF213 p.R4810K

Jun Xu, Zhengxing Zou, Wanyang Liu, Qian Zhang, Juan Shen, Fangbin Hao, Gan Chen, Dan Yu, Yunzhu Li, Zhengshan Zhang, Yuchen Qin, Rimiao Yang, Yue Wang, Lian Duan

Eur J Neurol. 2024 Dec; 31(12): e16473. Published online 2024 Sep 24. doi: 10.1111/ene.16473

PMCID:: PMC11555006

Article PDF–4.7M

Select item 1154214016.

Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy

Ingeborg Rasing, Naomi Vlegels, Manon R Schipper, Sabine Voigt, Emma A Koemans, Kanishk Kaushik, Rosemarie van Dort, Thijs W van Harten, Alberto De Luca, Ellis S van Etten, Erik W van Zwet, Mark A van Buchem, Huub AM Middelkoop, Geert Jan Biessels, Gisela M Terwindt, Matthias JP van Osch, Marianne AA van Walderveen, Marieke JH Wermer

J Cereb Blood Flow Metab. 2024 Jun 17 : 0271678X241261771. doi: 10.1177/0271678X241261771 [Epub ahead of print]

PMCID:: PMC11542140

Article PDF–680K

Select item 1154212617.

Abolishing UCHL1’s hydrolase activity exacerbates ischemia-induced axonal injury and functional deficits in mice

Zhiping Mi, Nadya Povysheva, Marie E Rose, Jie Ma, Dennis J Zeh, Nikitha Harikumar, Mohammad Iqbal H Bhuiyan, Steven H Graham

J Cereb Blood Flow Metab. 2024 Jun 4 : 0271678X241258809. doi: 10.1177/0271678X241258809 [Epub ahead of print]

PMCID:: PMC11542126

Article PDF–1.2M

Select item 1152513918.

The N-acetylglucosaminyltransferase Radical fringe contributes to defects in JAG1-dependent turnover and signaling of NOTCH3 CADASIL mutants

Shodai Suzuki, Taiki Mashiko, Yohei Tsukamoto, Miyu Oya, Yuki Kotani, Saki Okawara, Takemi Matsumoto, Yuki Mizue, Hideyuki Takeuchi, Tetsuya Okajima, Motoyuki Itoh

J Biol Chem. 2024 Oct; 300(10): 107787. Published online 2024 Sep 19. doi: 10.1016/j.jbc.2024.107787