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Items: 18

Select item 56538231.

11β-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner

L. Vandermosten, C. De Geest, S. Knoops, G. Thijs, K. E. Chapman, K. De Bosscher, G. Opdenakker, P. E. Van den Steen

Sci Rep. 2017; 7: 13835. Published online 2017 Oct 23. doi: 10.1038/s41598-017-14288-x

PMCID:: PMC5653823

Abstract Article PDF–1.6M

Select item 55743052.

Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis

Zhenguang Zhang, Agnes E Coutinho, Tak Yung Man, Tiina M J Kipari, Patrick W F Hadoke, Donald M Salter, Jonathan R Seckl, Karen E Chapman

J Endocrinol. 2017 Sep; 234(3): 291–299. Published online 2017 Jul 4. doi: 10.1530/JOE-17-0223

PMCID:: PMC5574305

Abstract Article PDF–2.5M

Select item 52446853.

Forebrain‐Specific Transgene Rescue of 11β‐HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain‐Derived Neurotrophic Factor mRNA Levels in Aged 11β‐HSD1 Deficient Mice

S. Caughey, A. P. Harris, J. R. Seckl, M. C. Holmes, J. L. W. Yau

J Neuroendocrinol. 2017 Jan; 29(1): 10.1111/jne.12447. Published online 2017 Jan 9. doi: 10.1111/jne.12447

PMCID:: PMC5244685

Abstract Article PDF–533K

Select item 51115914.

11β‐Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation

Rowan S Hardy, Craig L Doig, Zahrah Hussain, Mary O'Leary, Stuart A Morgan, Mark J Pearson, Amy Naylor, Simon W Jones, Andrew Filer, Paul M Stewart, Christopher D Buckley, Gareth G Lavery, Mark S Cooper, Karim Raza

J Pathol. 2016 Dec; 240(4): 472–483. Published online 2016 Oct 18. doi: 10.1002/path.4806

PMCID:: PMC5111591

Abstract Article PDF–2.3M

Select item 47018965.

Cardiomyocyte and Vascular Smooth Muscle-Independent 11β-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice

Christopher I. White, Maurits A. Jansen, Kieran McGregor, Katie J. Mylonas, Rachel V. Richardson, Adrian Thomson, Carmel M. Moran, Jonathan R. Seckl, Brian R. Walker, Karen E. Chapman, Gillian A. Gray

Endocrinology. 2016 Jan; 157(1): 346–357. Published online 2015 Oct 14. doi: 10.1210/en.2015-1630

PMCID:: PMC4701896

Abstract Article

Select item 39655126.

11β-Hydroxysteroid Dehydrogenase 1 Specific Inhibitor Increased Dermal Collagen Content and Promotes Fibroblast Proliferation

Mika Terao, Mamori Tani, Saori Itoi, Takuji Yoshimura, Toshimitsu Hamasaki, Hiroyuki Murota, Ichiro Katayama

PLoS One. 2014; 9(3): e93051. Published online 2014 Mar 25. doi: 10.1371/journal.pone.0093051

PMCID:: PMC3965512

Abstract Article PDF–3.8M

Select item 37701007.

Impaired oxidoreduction by 11β-hydroxysteroid dehydrogenase 1 results in the accumulation of 7-oxolithocholic acid

Carlos A. Penno, Stuart A. Morgan, Anna Vuorinen, Daniela Schuster, Gareth G. Lavery, Alex Odermatt

J Lipid Res. 2013 Oct; 54(10): 2874–2883. doi: 10.1194/jlr.M042499

PMCID:: PMC3770100

Abstract Article PDF–739K

Select item 36065288.

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

Tiina Kipari, Patrick W. F. Hadoke, Javaid Iqbal, Tak-Yung Man, Eileen Miller, Agnes E. Coutinho, Zhenguang Zhang, Katie M. Sullivan, Tijana Mitic, Dawn E. W. Livingstone, Christopher Schrecker, Kay Samuel, Christopher I. White, M. Amine Bouhlel, Giulia Chinetti-Gbaguidi, Bart Staels, Ruth Andrew, Brian R. Walker, John S. Savill, Karen E. Chapman, Jonathan R. Seckl

FASEB J. 2013 Apr; 27(4): 1519–1531. doi: 10.1096/fj.12-219105

PMCID:: PMC3606528

Abstract Article

Select item 35859599.

11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol

Tijana Mitić, Ruth Andrew, Brian R. Walker, Patrick W.F. Hadoke

Biochimie. 2013 Mar; 95(3): 548–555. doi: 10.1016/j.biochi.2012.08.007

PMCID:: PMC3585959

Abstract Article PDF–660K

Select item 354889710.

Mast Cells Express 11β-hydroxysteroid Dehydrogenase Type 1: A Role in Restraining Mast Cell Degranulation

Agnes E. Coutinho, Jeremy K. Brown, Fu Yang, David G. Brownstein, Mohini Gray, Jonathan R. Seckl, John S. Savill, Karen E. Chapman

PLoS One. 2013; 8(1): e54640. Published online 2013 Jan 18. doi: 10.1371/journal.pone.0054640

PMCID:: PMC3548897

Abstract Article PDF–715K

Select item 354748911.

Novel H6PDH mutations in two girls with premature adrenarche: ‘apparent’ and ‘true’ CRD can be differentiated by urinary steroid profiling

G G Lavery, J Idkowiak, M Sherlock, I Bujalska, J P Ride, K Saqib, M F Hartmann, B Hughes, S A Wudy, J De Schepper, W Arlt, N Krone, C H Shackleton, E A Walker, P M Stewart

Eur J Endocrinol. 2013 Feb; 168(2): K19–K26. Prepublished online 2012 Oct 8. doi: 10.1530/EJE-12-0628

PMCID:: PMC3547489

Abstract Article PDF–211K

Select item 342764312.

Biomarkers of hypothalamic–pituitary–adrenal axis activity in mice lacking 11β-HSD1 and H6PDH

Lianne Abrahams, Nina M Semjonous, Phil Guest, Agnieszka Zielinska, Beverly Hughes, Gareth G Lavery, Paul M Stewart

J Endocrinol. 2012 Sep; 214(3): 367–372. Prepublished online 2012 Jun 20. doi: 10.1530/JOE-12-0178

PMCID:: PMC3427643

Abstract Article PDF–171K

Select item 335803913.

Association study of CYP17 and HSD11B1 in polycystic ovary syndrome utilizing comprehensive gene coverage

Angela K. Chua, Ricardo Azziz, Mark O. Goodarzi

Mol Hum Reprod. 2012 Jun; 18(6): 320–324. Published online 2012 Jan 10. doi: 10.1093/molehr/gas002

PMCID:: PMC3358039

Abstract Article PDF–193K

Select item 305402314.

Cortisone-reductase deficiency associated with heterozygous mutations in 11β-hydroxysteroid dehydrogenase type 1

Alexander J. Lawson, Elizabeth A. Walker, Gareth G. Lavery, Iwona J. Bujalska, Beverly Hughes, Wiebke Arlt, Paul M. Stewart, Jonathan P. Ride

Proc Natl Acad Sci U S A. 2011 Mar 8; 108(10): 4111–4116. Published online 2011 Feb 15. doi: 10.1073/pnas.1014934108

PMCID:: PMC3054023

Abstract Article PDF–590K

Select item 302392115.

Mutations of the hexose-6-phosphate dehydrogenase gene rarely cause hyperandrogenemic polycystic ovary syndrome

Kenan Qin, Robert L Rosenfield

Steroids. Author manuscript; available in PMC 2012 Jan 1.

Published in final edited form as: Steroids. 2011 Jan; 76(1-2): 135–139. Published online 2010 Nov 2. doi: 10.1016/j.steroids.2010.10.001

PMCID:: PMC3023921

Abstract Article PDF–535K

Select item 257965116.

Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency

Gareth G. Lavery, Elizabeth A. Walker, Ana Tiganescu, Jon P. Ride, Cedric H. L. Shackleton, Jeremy W. Tomlinson, John M. C. Connell, David W. Ray, Anna Biason-Lauber, Ewa M. Malunowicz, Wiebke Arlt, Paul M. Stewart

J Clin Endocrinol Metab. 2008 Oct; 93(10): 3827–3832. Published online 2008 Jul 15. doi: 10.1210/jc.2008-0743

PMCID:: PMC2579651

Abstract Article

Select item 399937517.

Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11βHSD1-deficient mice post-MI

Sara J. McSweeney, Patrick W.F. Hadoke, Agnieszka M. Kozak, Gary R. Small, Hiba Khaled, Brian R. Walker, Gillian A. Gray

Cardiovasc Res. 2010 Oct 1; 88(1): 159–167. Published online 2010 May 21. doi: 10.1093/cvr/cvq149

PMCID:: PMC3999375

Abstract Article PDF–566K

Select item 327973718.

11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

Agnes E. Coutinho, Mohini Gray, David G. Brownstein, Donald M. Salter, Deborah A. Sawatzky, Spike Clay, James S. Gilmour, Jonathan R. Seckl, John S. Savill, Karen E. Chapman

Endocrinology. 2012 Jan; 153(1): 234–240. Published online 2011 Nov 8. doi: 10.1210/en.2011-1398