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Select item 106296251.

2-((3,5-Dinitrobenzyl)thio)quinazolinones: potent antimycobacterial agents activated by deazaflavin (F₄₂₀)-dependent nitroreductase (Ddn)

Yanlin Jian, He Eun Forbes, Fabian Hulpia, Martijn D. P. Risseeuw, Guy Caljon, Hélène Munier-Lehmann, Helena I. M. Boshoff, Serge Van Calenbergh

J Med Chem. Author manuscript; available in PMC 2023 Nov 7.

Published in final edited form as: J Med Chem. 2021 Jan 14; 64(1): 440–457. Published online 2020 Dec 21. doi: 10.1021/acs.jmedchem.0c01374

PMCID:: PMC10629625

Abstract Article PDF–1.3M

Select item 40362042.

The DDN Catalytic Motif Is Required for Metnase Functions in Non-homologous End Joining (NHEJ) Repair and Replication Restart

Hyun-Suk Kim, Qiujia Chen, Sung-Kyung Kim, Jac A. Nickoloff, Robert Hromas, Millie M. Georgiadis, Suk-Hee Lee

J Biol Chem. 2014 Apr 11; 289(15): 10930–10938. Published online 2014 Feb 25. doi: 10.1074/jbc.M113.533216

PMCID:: PMC4036204

Abstract Article PDF–1.4M

Select item 97640403.

A case of knuckle pad syndrome in a middle‐aged man

Zachary Chandler, Kimberly Seamon, Karishma Ramsubeik, Gurjit Kaeley

Clin Case Rep. 2022 Dec; 10(12): e6740. Published online 2022 Dec 20. doi: 10.1002/ccr3.6740

PMCID:: PMC9764040

Abstract Article PDF–1.7M

Select item 97650234.

The ddn Trp20Stop Mutation and Its Association with Lineage 4.5 and Resistance to Delamanid and Pretomanid in Mycobacterium tuberculosis

Mikael Mansjö, Oskar Karlsson Lindsjö, Christina Grönfors Seeth, Ramona Groenheit, Jim Werngren

Antimicrob Agents Chemother. 2022 Dec; 66(12): e01026-22. Published online 2022 Nov 21. doi: 10.1128/aac.01026-22

PMCID:: PMC9765023

Abstract Article PDF–205K

Select item 43755265.

Loss-of-Function Mutations in CAST Cause Peeling Skin, Leukonychia, Acral Punctate Keratoses, Cheilitis, and Knuckle Pads

Zhimiao Lin, Jiahui Zhao, Daniela Nitoiu, Claire A. Scott, Vincent Plagnol, Frances J.D. Smith, Neil J. Wilson, Christian Cole, Mary E. Schwartz, W.H. Irwin McLean, Huijun Wang, Cheng Feng, Lina Duo, Eray Yihui Zhou, Yali Ren, Lanlan Dai, Yulan Chen, Jianguo Zhang, Xun Xu, Edel A. O’Toole, David P. Kelsell, Yong Yang

Am J Hum Genet. 2015 Mar 5; 96(3): 440–447. doi: 10.1016/j.ajhg.2014.12.026

PMCID:: PMC4375526

Abstract Article PDF–2.2M

Select item 38539306.

Bactericidal activity of PA-824 against Mycobacterium tuberculosis under anaerobic conditions and computational analysis of its novel analogues against mutant Ddn receptor

Sulochana Somasundaram, Ramaian Santhaseela Anand, Perumal Venkatesan, Chinnambedu N Paramasivan

BMC Microbiol. 2013; 13: 218. Published online 2013 Oct 1. doi: 10.1186/1471-2180-13-218

PMCID:: PMC3853930

Abstract Article PDF–1.7M

Select item 46032327.

Knuckle pads – a rare finding

Giorgio Tamborrini, Michael Gengenbacher, Stefano Bianchi

J Ultrason. 2012 Dec; 12(51): 493–498. Published online 2012 Dec 30. doi: 10.15557/JoU.2012.0037

PMCID:: PMC4603232

Abstract Article PDF–1.4M

Select item 103786008.

Knuckle Pads Successfully Treated with 2% Crisaborole Ointment Combined with Triamcinolone Acetonide and Neomycin Plaster: A Case Report

Yimin Liang, Jingyao Liang, Qiongxiao Huang, Xin Tian, Lei Shao, Manqi Xia, Yumei Liu

Clin Cosmet Investig Dermatol. 2023; 16: 1893–1897. Published online 2023 Jul 24. doi: 10.2147/CCID.S414268

PMCID:: PMC10378600

Abstract Article PDF–3.0M

Select item 32670469.

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

Susan E. Cellitti, Jennifer Shaffer, David H. Jones, Tathagata Mukherjee, Meera Gurumurthy, Badry Bursulaya, Helena I. Boshoff, Inhee Choi, Amit Nayyar, Yong Sok Lee, Joseph Cherian, Pornwaratt Niyomrattanakit, Thomas Dick, Ujjini H. Manjunatha, Clifton E. Barry, III, Glen Spraggon, Bernhard H. Geierstanger

Structure. 2012 Jan 11; 20(1-2): 101–112. doi: 10.1016/j.str.2011.11.001

Correction in:: Structure. 2013 Jan 8; 21(1): 191.

PMCID:: PMC3267046

Abstract Article

Select item 323275710.

Impact of fgd1 and ddn Diversity in Mycobacterium tuberculosis Complex on In Vitro Susceptibility to PA-824

Silke Feuerriegel, Claudio U. Köser, Davide Baù, Sabine Rüsch-Gerdes, David K. Summers, John A. C. Archer, Marc A. Marti-Renom, Stefan Niemann

Antimicrob Agents Chemother. 2011 Dec; 55(12): 5718–5722. doi: 10.1128/AAC.05500-11

PMCID:: PMC3232757

Abstract Article PDF–70K

Select item 1057691811.

Palmoplantar keratoderma, pseudo-ainhum and knuckle pads in an African patient: A case report

Kellicia Courtney Govender, Somasundram Pillay

SAGE Open Med Case Rep. 2023; 11: 2050313X231204197. Published online 2023 Oct 14. doi: 10.1177/2050313X231204197

PMCID:: PMC10576918

Abstract Article PDF–3.9M

Select item 306568812.

DDN: a caBIG^® analytical tool for differential network analysis

Bai Zhang, Ye Tian, Lu Jin, Huai Li, Ie-Ming Shih, Subha Madhavan, Robert Clarke, Eric P. Hoffman, Jianhua Xuan, Leena Hilakivi-Clarke, Yue Wang

Bioinformatics. 2011 Apr 1; 27(7): 1036–1038. Published online 2011 Feb 3. doi: 10.1093/bioinformatics/btr052

PMCID:: PMC3065688

Abstract Article PDF–252K

Select item 813912013.

Successful treatment of idiopathic knuckle pads with a combination of high-dose salicylic acid and urea topical keratolytics: A case report

Davide Sogliani, Chiara Mura, Giorgio Tamborrini

Dermatol Reports. 2021 Mar 18; 13(1): 9072. Published online 2021 Apr 13. doi: 10.4081/dr.2021.9072

PMCID:: PMC8139120

Abstract Article PDF–152K

Select item 798171014.

Shave removal for videogame controller–induced knuckle pads

Kendall Flanigan, Steven Kent, Kathryn Anne Potter

Clin Case Rep. 2021 Mar; 9(3): 1812–1813. Published online 2021 Jan 28. doi: 10.1002/ccr3.3850

PMCID:: PMC7981710

Abstract Article PDF–234K

Select item 707343015.

Comparison of in vitro Susceptibility of Mycobacteria Against PA-824 to Identify Key Residues of Ddn, the Deazoflavin-Dependent Nitroreductase from Mycobacterium tuberculosis

Fuzhen Zhang, Shanshan Li, Shuan Wen, Tingting Zhang, Yuanyuan Shang, Fengmin Huo, Yi Xue, Ling Li, Yu Pang

Infect Drug Resist. 2020; 13: 815–822. Published online 2020 Mar 11. doi: 10.2147/IDR.S240716

PMCID:: PMC7073430

Abstract Article PDF–2.9M

Select item 104960416.

Familial leuconychia, knuckle pads, hearing loss, and palmoplantar hyperkeratosis: an additional family with Bart-Pumphrey syndrome.

J C Ramer, D B Vasily, R L Ladda

J Med Genet. 1994 Jan; 31(1): 68–71. doi: 10.1136/jmg.31.1.68

PMCID:: PMC1049604

Summary Page Browse PDF–1.1M

Select item 682586517.

Keratin 9 L164P mutation in a Chinese pedigree with epidermolytic palmoplantar keratoderma, cytokeratin analysis, and literature review

Xiaoliang Liu, Chuang Qiu, Rong He, Yuanyuan Zhang, Yanyan Zhao

Mol Genet Genomic Med. 2019 Nov; 7(11): e977. Published online 2019 Sep 16. doi: 10.1002/mgg3.977

PMCID:: PMC6825865

Abstract Article PDF–731K

Select item 792786818.

Mutations in fbiD (Rv2983) as a Novel Determinant of Resistance to Pretomanid and Delamanid in Mycobacterium tuberculosis

Dalin Rifat, Si-Yang Li, Thomas Ioerger, Keshav Shah, Jean-Philippe Lanoix, Jin Lee, Ghader Bashiri, James Sacchettini, Eric Nuermberger

Antimicrob Agents Chemother. 2021 Jan; 65(1): e01948-20. Prepublished online 2020 Oct 19. Published online 2020 Dec 16. doi: 10.1128/AAC.01948-20

PMCID:: PMC7927868

Abstract Article PDF–2.4M

Select item 698701519.

Effector gene expression underlying neuron subtype-specific traits in the Motor Ganglion of Ciona

Susanne Gibboney, Jameson Orvis, Kwantae Kim, Christopher J. Johnson, Paula Martinez-Feduchi, Elijah K. Lowe, Sarthak Sharma, Alberto Stolfi

Dev Biol. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: Dev Biol. 2020 Feb 1; 458(1): 52–63. Published online 2019 Oct 19. doi: 10.1016/j.ydbio.2019.10.012

PMCID:: PMC6987015

Abstract Article PDF–1.3M

Select item 703273420.

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

Brendon M. Lee, Liam K. Harold, Deepak V. Almeida, Livnat Afriat-Jurnou, Htin Lin Aung, Brian M. Forde, Kiel Hards, Sacha J. Pidot, F. Hafna Ahmed, A. Elaaf Mohamed, Matthew C. Taylor, Nicholas P. West, Timothy P. Stinear, Chris Greening, Scott A. Beatson, Eric L. Nuermberger, Gregory M. Cook, Colin J. Jackson

PLoS Pathog. 2020 Feb; 16(2): e1008287. Published online 2020 Feb 7. doi: 10.1371/journal.ppat.1008287

PMCID:: PMC7032734

Abstract Article PDF–3.3M

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