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Select item 98448201.

FANCL supports Parkin-mediated mitophagy in a ubiquitin ligase-independent manner

Swarna Beesetti, Shyam Sirasanagandla, Sadie Miki Sakurada, Shondra M. Pruett-Miller, Rhea Sumpter, Jr, Beth Levine, Malia B. Potts

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1; 1868(9): 166453. Published online 2022 May 26. doi: 10.1016/j.bbadis.2022.166453

PMCID:: PMC9844820

Article PDF–845K

Select item 73623302.

A founder variant in the South Asian population leads to a high prevalence of FANCL Fanconi anemia cases in India

Frank X. Donovan, Avani Solanki, Minako Mori, Niranjan Chavan, Merin George, Kumar C Selvaa, Yusuke Okuno, Hideki Muramastsu, Kenichi Yoshida, Akira Shimamoto, Akifumi Takaori-Kondo, Hiromasa Yabe, Seishi Ogawa, Seiji Kojima, Miharu Yabe, Ramanagouda Ramanagoudr-Bhojappa, Agata Smogorzewska, Sheila Mohan, Aruna Rajendran, Arleen D Auerbach, Minoru Takata, Settara C. Chandrasekharappa, Babu Rao Vundinti

Hum Mutat. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Hum Mutat. 2020 Jan; 41(1): 122–128. Published online 2019 Sep 26. doi: 10.1002/humu.23914

PMCID:: PMC7362330

Article PDF–508K

Select item 72739133.

Characterization of FANCL variants observed in patient cancer cells

Mark G. Frost, Amir Mahdi Mazloumi Aboukheili, Rachel Toth, Helen Walden

Biosci Rep. 2020 Jun 26; 40(6): BSR20191304. Published online 2020 Jun 4. doi: 10.1042/BSR20191304

PMCID:: PMC7273913

Article PDF–2.2M

Select item 68042434.

Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway

Matthew J. Cornwell, Graeme J. Thomson, Julia Coates, Rimma Belotserkovskaya, Ian D. Waddell, Stephen P. Jackson, Yaron Galanty

ACS Chem Biol. 2019 Oct 18; 14(10): 2148–2154. Published online 2019 Sep 16. doi: 10.1021/acschembio.9b00570

PMCID:: PMC6804243

Article PDF–5.3M

Select item 55863985.

Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair

Ji Jiang, Marina Bellani, Lin Li, Pengcheng Wang, Michael M. Seidman, Yinsheng Wang

ACS Chem Biol. Author manuscript; available in PMC 2017 Sep 6.

Published in final edited form as: ACS Chem Biol. 2017 Jul 21; 12(7): 1858–1866. Published online 2017 Jun 1. doi: 10.1021/acschembio.6b01135

PMCID:: PMC5586398

Article PDF–818K

Select item 46189106.

Hypermethylation of the FANCC and FANCL Promoter Regions in Sporadic Acute Leukaemia

C. J. Hess, N. Ameziane, G. J. Schuurhuis, A. Errami, F. Denkers, G. J. L. Kaspers, J. Cloos, H. Joenje, D. Reinhardt, G. J. Ossenkoppele, C. M. Zwaan, Q. Waisfisz

Cell Oncol. 2008; 30(4): 299–306. Published online 2008 Jul 1. doi: 10.3233/CLO-2008-0426

PMCID:: PMC4618910

Abstract PDF–272K

Select item 45436587.

The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL

Jennifer A. Miles, Mark G. Frost, Eilis Carroll, Michelle L. Rowe, Mark J. Howard, Ateesh Sidhu, Viduth K. Chaugule, Arno F. Alpi, Helen Walden

J Biol Chem. 2015 Aug 21; 290(34): 20995–21006. Published online 2015 Jul 6. doi: 10.1074/jbc.M115.675835

PMCID:: PMC4543658

Article PDF–3.1M

Select item 39791068.

Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection

Charlotte Hodson, Andrew Purkiss, Jennifer Anne Miles, Helen Walden

Structure. 2014 Feb 4; 22(2): 337–344. doi: 10.1016/j.str.2013.12.004

PMCID:: PMC3979106

Article

Select item 39326869.

UBE2W Interacts with FANCL and Regulates the Monoubiquitination of Fanconi Anemia Protein FANCD2

Yingying Zhang, Xiaowei Zhou, Lixia Zhao, Chao Li, Hengqi Zhu, Long Xu, Liran Shan, Xiang Liao, Zekun Guo, Peitang Huang

Mol Cells. 2011 Feb 28; 31(2): 113–122. doi: 10.1007/s10059-011-0015-9

PMCID:: PMC3932686

Article PDF–1.4M

Select item 374495110.

The PI3K/Akt1 pathway enhances steady-state levels of FANCL

Kim-Hien T. Dao, Michael D. Rotelli, Brieanna R. Brown, Jane E. Yates, Juha Rantala, Cristina Tognon, Jeffrey W. Tyner, Brian J. Druker, Grover C. Bagby

Mol Biol Cell. 2013 Aug 15; 24(16): 2582–2592. doi: 10.1091/mbc.E13-03-0144

PMCID:: PMC3744951

Article PDF–2.6M

Select item 346654211.

Switch of FANCL, a key FA-BRCA component, between tumor suppressor and promoter by alternative splicing

Chengfu Yuan, Ningzhi Xu, Joshua Liao

Cell Cycle. 2012 Sep 15; 11(18): 3356. doi: 10.4161/cc.21852

PMCID:: PMC3466542

Article PDF–600K

Select item 339875812.

FANCL ubiquitinates β-catenin and enhances its nuclear function

Kim-Hien T. Dao, Michael D. Rotelli, Curtis L. Petersen, Stefanie Kaech, Whitney D. Nelson, Jane E. Yates, Amy E. Hanlon Newell, Susan B. Olson, Brian J. Druker, Grover C. Bagby

Blood. 2012 Jul 12; 120(2): 323–334. Prepublished online 2012 May 31. doi: 10.1182/blood-2011-11-388355

PMCID:: PMC3398758

Article

Select item 317322713.

Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway

Charlotte Hodson, Ambrose R. Cole, Laurence P. C. Lewis, Jennifer A. Miles, Andrew Purkiss, Helen Walden

J Biol Chem. 2011 Sep 16; 286(37): 32628–32637. Published online 2011 Jul 20. doi: 10.1074/jbc.M111.244632

PMCID:: PMC3173227

Article PDF–3.8M

Select item 292945714.

The structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex

Ambrose R. Cole, Laurence P.C. Lewis, Helen Walden

Nat Struct Mol Biol. Author manuscript; available in PMC 2010 Sep 1.

Published in final edited form as: Nat Struct Mol Biol. 2010 Mar; 17(3): 294–298. Published online 2010 Feb 14. doi: 10.1038/nsmb.1759

PMCID:: PMC2929457

Article PDF–1.3M

Select item 290869015.

Sex Reversal in Zebrafish fancl Mutants Is Caused by Tp53-Mediated Germ Cell Apoptosis

Adriana Rodríguez-Marí, Cristian Cañestro, Ruth A. BreMiller, Alexandria Nguyen-Johnson, Kazuhide Asakawa, Koichi Kawakami, John H. Postlethwait

PLoS Genet. 2010 Jul; 6(7): e1001034. Published online 2010 Jul 22. doi: 10.1371/journal.pgen.1001034

PMCID:: PMC2908690

Article PDF–6.3M

Select item 276049116.

Identification and Characterization of Mutations in FANCL Gene: a Second Case of Fanconi Anemia Belonging to FA-L Complementation Group

Abdullah Mahmood Ali, Michelle Kirby, Michael Jansen, Francis P. Lach, Jennifer Schulte, Thiyam Ramsing Singh, Sat D. Batish, Arleen D. Auerbach, David A. Williams, Amom Ruhikanta Meetei

Hum Mutat. Author manuscript; available in PMC 2010 Jul 1.

Published in final edited form as: Hum Mutat. 2009 Jul; 30(7): E761–E770. doi: 10.1002/humu.21032

PMCID:: PMC2760491

Article PDF–269K

Select item 274909117.

FANCI Binds Branched DNA and Is Monoubiquitinated by UBE2T-FANCL

Simonne Longerich, Joseph San Filippo, Dongqing Liu, Patrick Sung

J Biol Chem. 2009 Aug 28; 284(35): 23182–23186. Published online 2009 Jul 8. doi: 10.1074/jbc.C109.038075

PMCID:: PMC2749091

Article PDF–1.9M

Select item 1042353818.

Profiling of the genetic features of Chinese patients with gastric cancer with HRD germline mutations in a large-scale retrospective study

Chenghai Zhang, Dandan Zhu, Yurong Qu, Min Shi, Jingjiao Ma, Yebo Peng, Bowen Zhu, Houquan Tao, Tonghui Ma, TieYing Hou

J Med Genet. 2023 Aug; 60(8): 760–768. Published online 2023 Jan 10. doi: 10.1136/jmg-2022-108816

PMCID:: PMC10423538

Article PDF–3.8M

Select item 1042353119.

Comprehensive laboratory diagnosis of Fanconi anaemia: comparison of cellular and molecular analysis

Gaurav Joshi, Nancy Beryl Janet Arthur, Thenral S Geetha, Phaneendra Venkateswara Rao Datari, Kirti Modak, Debanjan Roy, Anurag Dutta Chaudhury, Prasanth Sundaraganesan, Sweety Priyanka, Fouzia NA, Vedam Ramprasad, Aby Abraham, Vivi M Srivastava, Alok Srivastava, Uday Prakash Kulkarni, Biju George, Shaji R Velayudhan

J Med Genet. 2023 Aug; 60(8): 801–809. Published online 2023 Mar 9. doi: 10.1136/jmg-2022-108714

PMCID:: PMC10423531

Article PDF–1.7M

Select item 1027052920.

An acquired BMF with FANCL gene heterozygous mutation: Case report

Nan Zhang, Xiao Wang, Xiao-Juan Miao, Xu-Pai Zhang, Xin-Yu Xia, Li Li, Hao-Ping Sun

Medicine (Baltimore) 2023 Jun 16; 102(24): e34036. Published online 2023 Jun 16. doi: 10.1097/MD.0000000000034036

PMCID:: PMC10270529

Article PDF–773K

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