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Select item 110041591.

Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization

Longqing Wang, Wenhao Jiang, Siyuan Zhao, Dong Xie, Qing Chen, Qi Zhao, Hao Wu, Jian Luo, Lili Yang

Bone Res. 2024; 12: 24. Published online 2024 Apr 10. doi: 10.1038/s41413-024-00327-7

PMCID:: PMC11004159

Abstract Article PDF–4.7M

Select item 108870422.

The HIF-1α and mTOR Pathways Amplify Heterotopic Ossification

Haitao Wang, Frederick S. Kaplan, Robert J. Pignolo

Biomolecules. 2024 Feb; 14(2): 147. Published online 2024 Jan 24. doi: 10.3390/biom14020147

PMCID:: PMC10887042

Abstract Article PDF–940K

Select item 106198153.

PTGR1 is involved in cell proliferation in thoracic ossification of the ligamentum flavum

Kuankuan Liu, Li Shu, Ann Yehong Huang, Yanan Chang, Zhongqiang Chen, Chi Zhang

PLoS One. 2023; 18(11): e0292821. Published online 2023 Nov 1. doi: 10.1371/journal.pone.0292821

PMCID:: PMC10619815

Abstract Article PDF–968K

Select item 105435364.

Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments

Hajime Kato, Demetrios T. Braddock, Nobuaki Ito

Curr Osteoporos Rep. 2023; 21(5): 552–566. Published online 2023 Aug 2. doi: 10.1007/s11914-023-00814-6

PMCID:: PMC10543536

Abstract Article PDF–1.4M

Select item 99179085.

Regulatory Mechanism between Ferritin and Mitochondrial Reactive Oxygen Species in Spinal Ligament-Derived Cells from Ossification of Posterior Longitudinal Ligament Patient

Jong Tae Kim, Yonggoo Kim, Ji Yeon Kim, Seungok Lee, Myungshin Kim, Dong Wook Jekarl

Int J Mol Sci. 2023 Feb; 24(3): 2872. Published online 2023 Feb 2. doi: 10.3390/ijms24032872

PMCID:: PMC9917908

Abstract Article PDF–10M

Select item 96584916.

Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review

Vadim A. Byvaltsev, Andrei A. Kalinin, Phillip A. Hernandez, Valerii V. Shepelev, Yurii Y. Pestryakov, Marat A. Aliyev, Morgan B. Giers

Int J Mol Sci. 2022 Nov; 23(21): 13479. Published online 2022 Nov 3. doi: 10.3390/ijms232113479

PMCID:: PMC9658491

Abstract Article PDF–2.1M

Select item 95714567.

Exosomal miR-140-5p inhibits osteogenesis by targeting IGF1R and regulating the mTOR pathway in ossification of the posterior longitudinal ligament

Yifan Tang, Yanqing Sun, Junkai Zeng, Bo Yuan, Yin Zhao, Xiangwu Geng, Lianshun Jia, Shengyuan Zhou, Xiongsheng Chen

J Nanobiotechnology. 2022; 20: 452. Published online 2022 Oct 15. doi: 10.1186/s12951-022-01655-8

PMCID:: PMC9571456

Abstract Article PDF–5.4M

Select item 93376308.

IL-6 is involved in thoracic ossification of the ligamentum flavum

Ann Yehong Huang, Li Shu, Zhongqiang Chen, Chi Zhang

PLoS One. 2022; 17(7): e0272357. Published online 2022 Jul 29. doi: 10.1371/journal.pone.0272357

PMCID:: PMC9337630

Abstract Article PDF–1.2M

Select item 92795959.

LGR5 regulates osteogenic differentiation of human thoracic ligamentum flavum cells by Wnt signalling pathway

Xiaoxi Yang, Chuiguo Sun, Xiangyu Meng, Guanghui Chen, Tianqi Fan, Chi Zhang, Zhongqiang Chen

J Cell Mol Med. 2022 Jul; 26(14): 3862–3872. Published online 2022 Jun 6. doi: 10.1111/jcmm.17420

PMCID:: PMC9279595

Abstract Article PDF–14M

Select item 919619210.

Deciphering Obesity-Related Gene Clusters Unearths SOCS3 Immune Infiltrates and 5mC/m6A Modifiers in Ossification of Ligamentum Flavum Pathogenesis

Baoliang Zhang, Lei Yuan, Guanghui Chen, Xi Chen, Xiaoxi Yang, Tianqi Fan, Chuiguo Sun, Dongwei Fan, Zhongqiang Chen

Front Endocrinol (Lausanne) 2022; 13: 861567. Published online 2022 May 30. doi: 10.3389/fendo.2022.861567

PMCID:: PMC9196192

Abstract Article PDF–23M

Select item 907235211.

Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1

Chen Xu, Zicheng Zhang, Ning Liu, Li Li, Huajian Zhong, Ruizhe Wang, Qianghui Shi, Zifan Zhang, Leixin Wei, Bo Hu, Hao Zhang, Xiaolong Shen, Yue Wang, Yang Liu, Wen Yuan

Nat Commun. 2022; 13: 2467. Published online 2022 May 5. doi: 10.1038/s41467-022-29029-6

PMCID:: PMC9072352

Abstract Article PDF–12M

Select item 898324012.

The Effect of the NFκB-USP9X-Cx43 Axis on the Dynamic Balance of Bone Formation/Degradation during Ossification of the Posterior Longitudinal Ligament of the Cervical Spine

Xiaoqiu Yuan, Yongfei Guo, Jilu Liu, Jingchuan Sun, Lei Shi, Jinhao Miao, Jiangang Shi, Yu Chen

Oxid Med Cell Longev. 2022; 2022: 1604932. Published online 2022 Mar 29. doi: 10.1155/2022/1604932

PMCID:: PMC8983240

Abstract Article PDF–1.9M

Select item 865340013.

Extensive progressive heterotopic ossification post-Covid-19 in a man

María Lorena Brance, Nicolás M. Cóccaro, Araceli N. Casalongue, Ariel Durán, Lucas R. Brun

Bone. 2022 Feb; 155: 116287. Published online 2021 Dec 8. doi: 10.1016/j.bone.2021.116287

PMCID:: PMC8653400

Abstract Article PDF–4.1M

Select item 843693914.

Hsa-circ-0007292 promotes the osteogenic differentiation of posterior longitudinal ligament cells via regulating SATB2 by sponging miR-508-3p

Anlong Jiang, Nanxiang Wang, Xinxing Yan, Yunheng Jiang, Chengchao Song, Hui Chi, Guanghua Chen, Feng Wu, Ye Ji, Jinglong Yan

Aging (Albany NY) 2021 Aug 31; 13(16): 20192–20217. Published online 2021 Aug 23. doi: 10.18632/aging.203381

PMCID:: PMC8436939

Abstract Article PDF–8.6M

Select item 823761915.

Localized chondro-ossification underlies joint dysfunction and motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta

Joohyun Lim, Caressa Lietman, Matthew W. Grol, Alexis Castellon, Brian Dawson, Mary Adeyeye, Jyoti Rai, MaryAnn Weis, Douglas R. Keene, Ronen Schweitzer, Dongsu Park, David R. Eyre, Deborah Krakow, Brendan H. Lee

Proc Natl Acad Sci U S A. 2021 Jun 22; 118(25): e2100690118. Published online 2021 Jun 14. doi: 10.1073/pnas.2100690118