PMC Links for Nucleotide (Select 1519315322) - PMC

Select item 67426461.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 55316112.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 55225933.

Expression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical outcome in pancreatic cancer

Humair S. Quadri, Taylor J. Aiken, Michael Allgaeuer, Radim Moravec, Sean Altekruse, S. Perwez Hussain, Markku M. Miettinen, Stephen M. Hewitt, Udo Rudloff

BMC Cancer. 2017; 17: 495. Published online 2017 Jul 21. doi: 10.1186/s12885-017-3481-4

PMCID:: PMC5522593

Abstract Article PDF–1.7M

Select item 51288684.

Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions

Adrian Fischer, Bettina Warscheid, Wilfried Weber, Gerald Radziwill

Sci Rep. 2016; 6: 38155. Published online 2016 Nov 30. doi: 10.1038/srep38155

PMCID:: PMC5128868

Abstract Article PDF–2.8M

Select item 3441695.

Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways

Aron B. Jaffe, Pontus Aspenström, Alan Hall

Mol Cell Biol. 2004 Feb; 24(4): 1736–1746. doi: 10.1128/MCB.24.4.1736-1746.2004

PMCID:: PMC344169

Abstract Article PDF–572K

Select item 239356.

Functional analysis of CNK in RAS signaling

Marc Therrien, Allan M. Wong, Elaine Kwan, Gerald M. Rubin

Proc Natl Acad Sci U S A. 1999 Nov 9; 96(23): 13259–13263. doi: 10.1073/pnas.96.23.13259

PMCID:: PMC23935

Abstract Article PDF–270K

Select item 46430877.

Comprehensive Two- and Three-Dimensional RNAi Screening Identifies PI3K Inhibition as a Complement to MEK Inhibitor AS703026 for Combination Treatment of Triple-Negative Breast Cancer

Jangsoon Lee, Rachael Galloway, Geoff Grandjean, Justin Jacob, Juliane Humphries, Chandra Bartholomeusz, Samantha Goodstal, Bora Lim, Geoffrey Bartholomeusz, Naoto T. Ueno, Arvind Rao

J Cancer. 2015; 6(12): 1306–1319. Published online 2015 Oct 28. doi: 10.7150/jca.13266

PMCID:: PMC4643087

Abstract Article PDF–1.7M

Select item 26638128.

Integrated Functional, Gene Expression and Genomic Analysis for the Identification of Cancer Targets

Elizabeth Iorns, Christopher J. Lord, Anita Grigoriadis, Sarah McDonald, Kerry Fenwick, Alan MacKay, Charles A. Mein, Rachael Natrajan, Kay Savage, Narinder Tamber, Jorge S. Reis-Filho, Nicholas C. Turner, Alan Ashworth

PLoS One. 2009; 4(4): e5120. Published online 2009 Apr 9. doi: 10.1371/journal.pone.0005120

PMCID:: PMC2663812

Abstract Article PDF–605K

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